CA2439655C - Method for rapid detection and identification of bioagents - Google Patents
Method for rapid detection and identification of bioagents Download PDFInfo
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- CA2439655C CA2439655C CA2439655A CA2439655A CA2439655C CA 2439655 C CA2439655 C CA 2439655C CA 2439655 A CA2439655 A CA 2439655A CA 2439655 A CA2439655 A CA 2439655A CA 2439655 C CA2439655 C CA 2439655C
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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- C12Q1/686—Polymerase chain reaction [PCR]
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| US7666592B2 (en) * | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| CA2560521C (en) * | 2004-02-18 | 2012-01-03 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US8119336B2 (en) * | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US20060057603A1 (en) * | 2004-03-11 | 2006-03-16 | The Regents Of The University Of California | Detecting Bacillus anthracis |
| ES2641832T3 (es) | 2004-05-24 | 2017-11-14 | Ibis Biosciences, Inc. | Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales |
| US20050266411A1 (en) * | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| US7888011B2 (en) * | 2004-10-18 | 2011-02-15 | U.S. Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
| WO2007053170A2 (en) * | 2005-02-09 | 2007-05-10 | Correlogic Systems, Inc. | Identification of bacteria and spores |
| US8084207B2 (en) * | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
| CA2600184A1 (en) * | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| ATE483825T1 (de) * | 2005-04-13 | 2010-10-15 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| CA2616281C (en) * | 2005-07-21 | 2014-04-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification and quantitation of mitochondrial dna variants |
| US11834720B2 (en) * | 2005-10-11 | 2023-12-05 | Geneohm Sciences, Inc. | Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx |
| GB0601302D0 (en) * | 2006-01-23 | 2006-03-01 | Semikhodskii Andrei | Diagnostic methods and apparatus |
| EP2010679A2 (en) * | 2006-04-06 | 2009-01-07 | Ibis Biosciences, Inc. | Compositions for the use in identification of fungi |
| US8455184B2 (en) * | 2006-04-18 | 2013-06-04 | The United States Of America As Represented By The Secretary Of The Air Force | Differential multiplexing with pattern recognition |
| EP2029777B1 (en) | 2006-05-31 | 2017-03-08 | Sequenom, Inc. | Methods and compositions for the extraction of nucleic acid from a sample |
| CN101501251A (zh) * | 2006-06-16 | 2009-08-05 | 塞昆纳姆股份有限公司 | 扩增、检测和定量样品中核酸的方法和组合物 |
| CA2663029C (en) * | 2006-09-14 | 2016-07-19 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US8076104B2 (en) * | 2007-01-25 | 2011-12-13 | Rogan Peter K | Rapid and comprehensive identification of prokaryotic organisms |
| WO2008104002A2 (en) * | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
| US20100204266A1 (en) * | 2007-03-23 | 2010-08-12 | Ibis Biosciences, INC | Compositions for use in identification of mixed populations of bioagents |
| AU2008230813B2 (en) | 2007-03-26 | 2014-01-30 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US7811766B2 (en) * | 2007-03-28 | 2010-10-12 | Thinkvillage, Llc | Genetic identification and validation of Echinacea species |
| US8527207B2 (en) * | 2007-05-15 | 2013-09-03 | Peter K. Rogan | Accurate identification of organisms based on individual information content |
| US20100291544A1 (en) * | 2007-05-25 | 2010-11-18 | Ibis Biosciences, Inc. | Compositions for use in identification of strains of hepatitis c virus |
| BRPI0812178A2 (pt) | 2007-06-01 | 2021-05-04 | Council Of Scientific & Industrial Research | método para detecção e discriminação simultânea de infecções bacterianas, fúngicas, parasitárias e virais no olho e sistema nervoso central |
| WO2008151023A2 (en) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| WO2009038840A2 (en) * | 2007-06-14 | 2009-03-26 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious contaminant viruses |
| EP2179041A4 (en) * | 2007-06-22 | 2010-12-22 | Ibis Biosciences Inc | COMPOSITIONS AND METHODS FOR IDENTIFYING SPECIFIC CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS |
| US7964843B2 (en) | 2008-07-18 | 2011-06-21 | The George Washington University | Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry |
| US8901487B2 (en) | 2007-07-20 | 2014-12-02 | George Washington University | Subcellular analysis by laser ablation electrospray ionization mass spectrometry |
| US8067730B2 (en) | 2007-07-20 | 2011-11-29 | The George Washington University | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry |
| EP2195452B1 (en) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US20110097704A1 (en) * | 2008-01-29 | 2011-04-28 | Ibis Biosciences, Inc. | Compositions for use in identification of picornaviruses |
| US20090263809A1 (en) * | 2008-03-20 | 2009-10-22 | Zygem Corporation Limited | Methods for Identification of Bioagents |
| US8206926B2 (en) | 2008-03-26 | 2012-06-26 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US20110143358A1 (en) * | 2008-05-30 | 2011-06-16 | Ibis Biosciences, Inc. | Compositions for use in identification of tick-borne pathogens |
| WO2009151982A1 (en) * | 2008-05-30 | 2009-12-17 | Ibis Biosciences, Inc. | Compositions for use in identification of francisella |
| US20110151437A1 (en) * | 2008-06-02 | 2011-06-23 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious viruses |
| EP2347254A2 (en) | 2008-09-16 | 2011-07-27 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
| US8534447B2 (en) | 2008-09-16 | 2013-09-17 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
| EP2349549B1 (en) | 2008-09-16 | 2012-07-18 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, and system |
| US20110200985A1 (en) * | 2008-10-02 | 2011-08-18 | Rangarajan Sampath | Compositions for use in identification of herpesviruses |
| US20110189687A1 (en) * | 2008-10-02 | 2011-08-04 | Ibis Bioscience, Inc. | Compositions for use in identification of members of the bacterial genus mycoplasma |
| US20110190170A1 (en) * | 2008-10-03 | 2011-08-04 | Ibis Biosciences, Inc. | Compositions for use in identification of antibiotic-resistant bacteria |
| US20110183343A1 (en) * | 2008-10-03 | 2011-07-28 | Rangarajan Sampath | Compositions for use in identification of members of the bacterial class alphaproteobacter |
| US20110183346A1 (en) * | 2008-10-03 | 2011-07-28 | Ibis Biosciences, Inc. | Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria |
| WO2010039848A2 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of streptococcus pneumoniae |
| WO2010039787A1 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of clostridium difficile |
| CA2741592A1 (en) * | 2008-12-19 | 2010-06-24 | Abbott Laboratories | Diagnostic test for mutations in codons 12-13 of human k-ras |
| WO2010080616A1 (en) * | 2008-12-19 | 2010-07-15 | Abbott Laboratories | Molecular assay for diagnosis of malaria |
| DE102009007266B4 (de) * | 2009-02-03 | 2012-04-19 | Bruker Daltonik Gmbh | Massenspektrometrische Identifizierung von Mikroorganismen in komplexen Proben |
| GB2510520B (en) * | 2009-02-03 | 2014-11-05 | Bruker Daltonik Gmbh | Mass spectrometric identification of microorganisms in complex samples |
| US8158936B2 (en) * | 2009-02-12 | 2012-04-17 | Ibis Biosciences, Inc. | Ionization probe assemblies |
| WO2010104798A1 (en) | 2009-03-08 | 2010-09-16 | Ibis Biosciences, Inc. | Bioagent detection methods |
| CN102428191A (zh) * | 2009-03-18 | 2012-04-25 | 塞昆纳姆股份有限公司 | 热稳定性内切核酸酶在产生报道分子中的应用 |
| US9393564B2 (en) | 2009-03-30 | 2016-07-19 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| US8771948B2 (en) | 2009-04-03 | 2014-07-08 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| WO2011008971A1 (en) * | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Lift and mount apparatus |
| WO2011008972A1 (en) | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Systems for bioagent identification |
| WO2011014811A1 (en) * | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| EP2462244B1 (en) | 2009-08-06 | 2016-07-20 | Ibis Biosciences, Inc. | Non-mass determined base compositions for nucleic acid detection |
| US20110065111A1 (en) * | 2009-08-31 | 2011-03-17 | Ibis Biosciences, Inc. | Compositions For Use In Genotyping Of Klebsiella Pneumoniae |
| US20110091882A1 (en) * | 2009-10-02 | 2011-04-21 | Ibis Biosciences, Inc. | Determination of methylation status of polynucleotides |
| ES2628739T3 (es) * | 2009-10-15 | 2017-08-03 | Ibis Biosciences, Inc. | Amplificación por desplazamiento múltiple |
| EP2545183B1 (en) | 2010-03-10 | 2017-04-19 | Ibis Biosciences, Inc. | Production of single-stranded circular nucleic acid |
| US9758840B2 (en) * | 2010-03-14 | 2017-09-12 | Ibis Biosciences, Inc. | Parasite detection via endosymbiont detection |
| US9068017B2 (en) | 2010-04-08 | 2015-06-30 | Ibis Biosciences, Inc. | Compositions and methods for inhibiting terminal transferase activity |
| JP5808398B2 (ja) | 2010-06-02 | 2015-11-10 | ジョンズ ホプキンズ ユニバーシティＪｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ | 微生物の薬物耐性を判定するシステムおよび方法 |
| EP2710144B1 (en) | 2011-05-19 | 2020-10-07 | Agena Bioscience, Inc. | Processes for multiplex nucleic acid identification |
| AR086925A1 (es) * | 2011-06-15 | 2014-01-29 | Grifols Therapeutics Inc | Metodos, composiciones y kits para determinar el virus de la inmunodeficiencia humana (vih) |
| WO2013085572A2 (en) | 2011-07-14 | 2013-06-13 | The George Washington University | Plume collimation for laser ablation electrospray ionization mass spectrometry |
| EP2753629B1 (en) | 2011-09-06 | 2016-10-19 | Ibis Biosciences, Inc. | Methods for detecting lyme disease |
| EP2753932A4 (en) * | 2011-09-07 | 2015-07-15 | Alpha Biotech Ab | DETERMINATION OF BACTERIAL INFECTIONS OF THE GENUS RICKETTSIA AND, WHERE APPROPRIATE, BORRELIA IN BLOOD-SPENDING PATIENTS WITH DISEASE SYMPTOMS |
| EP2758546B1 (en) * | 2011-09-23 | 2017-11-22 | Roche Diagnostics GmbH | Use of g-clamp for improved allele-specific pcr |
| WO2013096838A2 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
| WO2013096799A1 (en) | 2011-12-22 | 2013-06-27 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
| WO2013101935A1 (en) | 2011-12-27 | 2013-07-04 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
| WO2013101743A2 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Microorganism nucelic acid purification from host samples |
| EP2834370B1 (en) | 2012-04-03 | 2019-01-02 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and crohn's disease |
| WO2014052590A1 (en) | 2012-09-26 | 2014-04-03 | Ibis Biosciences, Inc. | Swab interface for a microfluidic device |
| EP2971169A4 (en) | 2013-03-13 | 2016-10-26 | Abbott Molecular Inc | SYSTEMS AND METHODS FOR ISOLATING NUCLEIC ACIDS |
| WO2014160117A1 (en) | 2013-03-14 | 2014-10-02 | Abbott Molecular Inc. | Multiplex methylation-specific amplification systems and methods |
| CN116218963A (zh) | 2013-03-15 | 2023-06-06 | 伯乐生命医学产品有限公司 | 关联靶的数字测定 |
| WO2014186874A1 (en) | 2013-05-23 | 2014-11-27 | Yyz Pharmatech, Inc. | Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay |
| CN103344695B (zh) * | 2013-06-18 | 2015-06-10 | 中国疾病预防控制中心传染病预防控制所 | 钩端螺旋体快速质谱检测试剂盒 |
| CN103667109B (zh) * | 2013-10-23 | 2016-02-03 | 大连市水产技术推广总站 | 一种荚膜红细菌及其应用 |
| JP2017521654A (ja) | 2014-06-27 | 2017-08-03 | アボット・ラボラトリーズＡｂｂｏｔｔ Ｌａｂｏｒａｔｏｒｉｅｓ | ヒトペギウイルス２（ＨＰｇＶ−２）を検出するための組成物および方法 |
| RU2580412C1 (ru) * | 2015-02-02 | 2016-04-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | Способ количественного определения т-2 токсина методом дифференциальной вольтамперометрии |
| WO2016172579A1 (en) | 2015-04-24 | 2016-10-27 | Agena Bioscience, Inc, | Multiplex methods for detection and quantification of minor variants |
| EP4001430A1 (en) | 2015-04-24 | 2022-05-25 | Agena Bioscience, Inc. | Multiplexed method for the identification and quantitation of minor alleles and polymorphisms |
| WO2018089978A1 (en) * | 2016-11-14 | 2018-05-17 | Wisconsin Alumni Research Foundation | Nucleic acid quantification compositions and methods |
| CN107085034A (zh) * | 2017-04-19 | 2017-08-22 | 中国人民解放军第三〇二医院 | Maldi‑tof‑ms鉴定宋内志贺菌 |
| CN107988341B (zh) * | 2018-01-03 | 2019-04-23 | 北京毅新博创生物科技有限公司 | 质谱鉴定霍乱弧菌分型的方法及产品 |
| CN108048540B (zh) * | 2018-01-03 | 2021-06-08 | 北京毅新博创生物科技有限公司 | 制备检测霍乱弧菌分型的指纹图谱库的方法 |
| JP7378712B2 (ja) * | 2019-08-07 | 2023-11-14 | 学校法人常翔学園 | 異種移植用材料の病原体感染を検査する方法、検査キット及び病原体感染が評価された異種移植用材料製品の作成方法 |
| CN112861170B (zh) * | 2020-08-03 | 2023-03-31 | 德能森智能科技（成都）有限公司 | 一种保护隐私的智慧园区管理系统 |
| CN113219115A (zh) * | 2021-05-18 | 2021-08-06 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种基于maldi-tof ms的蜡样芽胞杆菌和苏云金芽胞杆菌快速鉴定方法 |
| WO2023077489A1 (zh) * | 2021-11-06 | 2023-05-11 | 江汉大学 | 一种鼠疫杆菌的mnp标记组合、引物对组合、试剂盒及其应用 |
Family Cites Families (427)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075475A (en) | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| US5288611A (en) | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US5567587A (en) | 1983-01-10 | 1996-10-22 | Gen-Probe Incorporated | Method for detecting, the presence and amount of prokaryotic organisms using specific rRNA subsequences as probes |
| ATE167524T1 (de) * | 1983-01-10 | 1998-07-15 | Gen Probe Inc | Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| JP3116353B2 (ja) | 1986-11-24 | 2000-12-11 | ジエン‐プローブ・インコーポレイテツド | 非ウイルス微生物の検出及び／又は定量用核酸プローブ |
| DE3850273T2 (de) | 1987-03-02 | 1994-09-29 | Gen Probe Inc | Polykationische Träger zur Reinigung, Trennung und Hybridisierung von Nukleinsäure. |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| IE81145B1 (en) * | 1989-04-20 | 2000-05-03 | Thomas Gerard Barry | Generation of specific probes for target nucleotide sequences |
| JP3258658B2 (ja) | 1989-05-31 | 2002-02-18 | ジーン−トラック・システムス | ユニバーサル ユーバクテリア核酸プローブ及び方法 |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5213961A (en) | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| DE69132616T2 (de) | 1990-01-12 | 2002-02-21 | Hsc Res Dev Corp | Introns und exons des gens für cystische fibrose sowie mutationen an mehreren stellen des gens |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5143905A (en) | 1990-05-03 | 1992-09-01 | The Regents Of The University Of California | Method and means for extending the host range of insecticidal proteins |
| US5015845A (en) | 1990-06-01 | 1991-05-14 | Vestec Corporation | Electrospray method for mass spectrometry |
| US5712125A (en) | 1990-07-24 | 1998-01-27 | Cemv Bioteknik Ab | Competitive PCR for quantitation of DNA |
| DE4030262A1 (de) | 1990-09-25 | 1992-03-26 | Suedzucker Ag | Verfahren zur herstellung von rhamnose aus rhamnolipiden |
| WO1993003186A1 (en) | 1991-07-31 | 1993-02-18 | F.Hoffmann-La Roche Ag | Methods and reagents for detection of bacteria in cerebrospinal fluid |
| NL9002259A (nl) * | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties. |
| WO1992009703A1 (en) | 1990-11-26 | 1992-06-11 | Cbr Laboratories, Inc. | Testing for spirochetal nucleic acid sequences in samples |
| US5072115A (en) | 1990-12-14 | 1991-12-10 | Finnigan Corporation | Interpretation of mass spectra of multiply charged ions of mixtures |
| WO1992013629A1 (en) | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| US5866429A (en) | 1991-04-03 | 1999-02-02 | Bloch; Will | Precision and accuracy of anion-exchange separation of nucleic acids |
| US5472843A (en) | 1991-04-25 | 1995-12-05 | Gen-Probe Incorporated | Nucleic acid probes to Haemophilus influenzae |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US6055487A (en) | 1991-07-30 | 2000-04-25 | Margery; Keith S. | Interactive remote sample analysis system |
| EP0525882B1 (en) | 1991-08-02 | 2004-01-14 | bioMerieux B.V. | Quantification of nucleic acid |
| EP0787807B1 (en) | 1991-08-27 | 2003-05-28 | F. Hoffmann-La Roche Ag | Primers and probes for hepatitis C detection |
| AU2580892A (en) | 1991-09-05 | 1993-04-05 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
| ATE198773T1 (de) | 1991-10-23 | 2001-02-15 | Baylor College Medicine | Fingerabdruckartige identifikation von bakterienstämmen mittels amplifikation repetitiver dna-sequenzen |
| FR2683827B1 (fr) | 1991-11-15 | 1994-03-04 | Institut Nal Sante Recherc Medic | Procede de determination de la quantite d'un fragment d'adn d'interet par une methode d'amplification enzymatique. |
| TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US6235887B1 (en) | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| US5484908A (en) * | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| EP1256589A3 (en) * | 1991-11-26 | 2003-09-17 | Isis Pharmaceuticals, Inc. | Oligomers containing modified pyrimidines |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| EP0746857A4 (en) | 1992-03-13 | 2001-01-03 | Thermomicroscopes Corp | SCANNING PROBE MICROSCOPE |
| US5981176A (en) * | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US6303297B1 (en) | 1992-07-17 | 2001-10-16 | Incyte Pharmaceuticals, Inc. | Database for storage and analysis of full-length sequences |
| FR2694754B1 (fr) | 1992-08-12 | 1994-09-16 | Bio Merieux | Fragments d'ADN de mycobactéries, amorces d'amplification, sondes d'hybridation, réactifs et procédé de détection de détection de mycobactéries. |
| IL107026A0 (en) | 1992-09-16 | 1993-12-28 | Univ Tennessee Res Corp | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| AU5298393A (en) | 1992-10-08 | 1994-05-09 | Regents Of The University Of California, The | Pcr assays to determine the presence and concentration of a target |
| US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US6436635B1 (en) * | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US6372424B1 (en) * | 1995-08-30 | 2002-04-16 | Third Wave Technologies, Inc | Rapid detection and identification of pathogens |
| WO1994016101A2 (en) | 1993-01-07 | 1994-07-21 | Koester Hubert | Dna sequencing by mass spectrometry |
| US6194144B1 (en) * | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| FR2701961B1 (fr) | 1993-02-24 | 1995-04-21 | Bio Merieux | Procédé de destabilisation d'une structure secondaire intracaténaire d'un polynucléotide simple brin, et de capture dudit nucléotide. |
| ATE220114T1 (de) | 1993-03-19 | 2002-07-15 | Sequenom Inc | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
| US6074823A (en) * | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US6323041B1 (en) | 1993-06-11 | 2001-11-27 | Pfizer Inc. | Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity |
| JPH0775585A (ja) | 1993-06-14 | 1995-03-20 | Immuno Japan:Kk | Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法 |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6001584A (en) | 1993-07-19 | 1999-12-14 | The Regents Of The University Of California | Oncoprotein protein kinase |
| WO1995004161A1 (en) | 1993-07-29 | 1995-02-09 | Sergio Danilo Junho Pena | Method for recognition of the nucleotide sequence of a purified dna segment |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US5527675A (en) * | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US6376178B1 (en) * | 1993-09-03 | 2002-04-23 | Duke University | Method of nucleic acid sequencing |
| AU7679394A (en) | 1993-09-03 | 1995-03-22 | Duke University | A method of nucleic acid sequencing |
| US5484909A (en) * | 1993-09-10 | 1996-01-16 | Amoco Corporation | Nucleic acid probes for the detection of bacteria of the genera Pediococcus and Lactobacillus and methods for the detection of the bacterial agents causing spoilage of beer |
| US5502177A (en) * | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| WO1995011996A1 (en) | 1993-10-27 | 1995-05-04 | Cornell Research Foundation, Inc. | Detection assay for listeria and erwinia microorganisms |
| US5504327A (en) | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| DE4338119A1 (de) | 1993-11-08 | 1995-05-11 | Bayer Ag | Spezifische Gensonden und Verfahren zum quantitativen Nachweis von methicillinresistenten Staphylococcen |
| NL9301957A (nl) | 1993-11-11 | 1995-06-01 | U Gene Research Bv | Werkwijze voor het identificeren van micro-organismen, en daarvoor bruikbare hulpmiddelen. |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| JP3396942B2 (ja) | 1994-02-21 | 2003-04-14 | 三菱化学株式会社 | 芳香族ポリカーボネートの製造方法 |
| US5849492A (en) | 1994-02-28 | 1998-12-15 | Phylogenetix Laboratories, Inc. | Method for rapid identification of prokaryotic and eukaryotic organisms |
| DE4444229C2 (de) | 1994-03-10 | 1996-07-25 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer |
| US5608217A (en) | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
| US5976798A (en) | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
| AU7242994A (en) | 1994-05-20 | 1995-12-18 | United States Of America, As Represented By The Secretary Of The Army, The | Model for testing immunogenicity of peptides |
| US5814442A (en) | 1994-06-10 | 1998-09-29 | Georgetown University | Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid |
| DE4421901A1 (de) | 1994-06-23 | 1996-01-04 | Bayer Ag | Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial |
| US5541405A (en) | 1994-07-27 | 1996-07-30 | Parker-Hannifin Corporation | Method and device for continuous pattern sensing using fiber optics |
| GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
| US6001564A (en) | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| CA2118048C (en) | 1994-09-30 | 2003-04-08 | James W. Schumm | Multiplex amplification of short tandem repeat loci |
| US5753489A (en) | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5654141A (en) | 1994-11-18 | 1997-08-05 | Thomas Jefferson University | Amplification based detection of bacterial infection |
| KR100399813B1 (ko) | 1994-12-14 | 2004-06-09 | 가부시키가이샤 니콘 | 노광장치 |
| US5763169A (en) | 1995-01-13 | 1998-06-09 | Chiron Diagnostics Corporation | Nucleic acid probes for the detection and identification of fungi |
| US6180339B1 (en) | 1995-01-13 | 2001-01-30 | Bayer Corporation | Nucleic acid probes for the detection and identification of fungi |
| US5707802A (en) | 1995-01-13 | 1998-01-13 | Ciba Corning Diagnostics Corp. | Nucleic acid probes for the detection and identification of fungi |
| US5702895A (en) | 1995-01-19 | 1997-12-30 | Wakunaga Seiyaku Kabushiki Kaisha | Method and kit for detecting methicillin-resistant Staphylococcus aureus |
| US5484808A (en) | 1995-02-09 | 1996-01-16 | Eli Lilly And Company | Methods of inhibiting cell-cell adhesion |
| GB9504598D0 (en) * | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
| US6428955B1 (en) * | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| CA2218188A1 (en) | 1995-04-11 | 1996-10-17 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| US5932220A (en) | 1995-05-08 | 1999-08-03 | Board Of Regents University Of Texas System | Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov. |
| US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5830655A (en) * | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5630653A (en) * | 1995-06-02 | 1997-05-20 | Polka; John G. | Wheel cover mounting bracket |
| WO1996040906A1 (en) | 1995-06-07 | 1996-12-19 | Commonwealth Scientific And Industrial Research Organisation | Optimized minizymes and miniribozymes and uses thereof |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6218529B1 (en) | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US6146854A (en) | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| US5994066A (en) * | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5869242A (en) * | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
| US5727202A (en) | 1995-10-18 | 1998-03-10 | Palm Computing, Inc. | Method and apparatus for synchronizing information on two different computer systems |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US6312893B1 (en) * | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| GB9602028D0 (en) | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| CA2248084A1 (en) * | 1996-03-04 | 1997-09-12 | Genetrace Systems, Inc. | Methods of screening nucleic acids using mass spectrometry |
| AU2217597A (en) | 1996-03-18 | 1997-10-22 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| EP0842184B1 (fr) | 1996-03-20 | 2003-01-29 | Bio Merieux | Isolement de l'acide nucleique |
| JP3365198B2 (ja) | 1996-03-21 | 2003-01-08 | ミノルタ株式会社 | 画像形成装置 |
| US5745751A (en) | 1996-04-12 | 1998-04-28 | Nelson; Robert W. | Civil site information system |
| US6214555B1 (en) | 1996-05-01 | 2001-04-10 | Visible Genetics Inc. | Method compositions and kit for detection |
| US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| CA2257866A1 (en) * | 1996-06-10 | 1997-12-18 | University Of Utah Research Foundation | Rapid, accurate identification of dna sequence variants by electrospray mass spectrometry |
| AU4042597A (en) | 1996-07-19 | 1998-02-10 | Hybridon, Inc. | Method for sequencing nucleic acids using matrix-assisted laser desorption ionization time-of-flight mass spectrometry |
| US6563025B1 (en) | 1996-07-26 | 2003-05-13 | Board Of Trustees Of The University Of Illinois | Nucleotide sequences encoding anthranilate synthase |
| US5831046A (en) | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| DE19633436A1 (de) * | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Nukleinsäuren unter Ermittlung der Masse |
| US5965363A (en) | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| WO1998012355A1 (en) | 1996-09-19 | 1998-03-26 | Genetrace Systems | Methods of preparing nucleic acids for mass spectrometric analysis |
| US6361940B1 (en) * | 1996-09-24 | 2002-03-26 | Qiagen Genomics, Inc. | Compositions and methods for enhancing hybridization and priming specificity |
| US5864137A (en) * | 1996-10-01 | 1999-01-26 | Genetrace Systems, Inc. | Mass spectrometer |
| GB9620769D0 (en) | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Nucleic acid sequencing |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| US6110710A (en) | 1996-10-15 | 2000-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition |
| US5900481A (en) | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US6024925A (en) | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
| US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| DE19782095T1 (de) | 1996-11-06 | 2000-03-23 | Sequenom Inc | DNA-Diagnose auf der Basis von Massenspektrometrie |
| DE69735112T2 (de) | 1996-11-06 | 2006-09-07 | Sequenom, Inc., San Diego | Verfahren zur Analyse und Vorrichtung |
| US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| WO1998021066A1 (de) | 1996-11-12 | 1998-05-22 | Hp-Chemie Pelzer Research And Development Ltd. | Wiederverwertbares teppichbodenformteil |
| US6060246A (en) | 1996-11-15 | 2000-05-09 | Avi Biopharma, Inc. | Reagent and method for isolation and detection of selected nucleic acid sequences |
| ID22447A (id) | 1996-11-28 | 1999-10-14 | New Japan Chem Co Ltd | Senyawa gula, bahan pengegel, komposisi bahan pengegel, proses penyediaannya serta komposisi gel |
| US5822824A (en) | 1996-12-03 | 1998-10-20 | Dion; William D. | Mountable washing device |
| AU5794498A (en) | 1996-12-10 | 1998-07-03 | Genetrace Systems, Inc. | Releasable nonvolatile mass-label molecules |
| US5981190A (en) | 1997-01-08 | 1999-11-09 | Ontogeny, Inc. | Analysis of gene expression, methods and reagents therefor |
| US5876936A (en) * | 1997-01-15 | 1999-03-02 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators |
| US6046005A (en) * | 1997-01-15 | 2000-04-04 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group |
| NZ336769A (en) | 1997-01-15 | 2001-01-26 | Brax Group Ltd | Method of determining hybridization of a probe to a target nucleic acid |
| WO1998035057A1 (en) | 1997-02-06 | 1998-08-13 | The National University Of Singapore | Diagnosis of plasmodium infection by analysis of extrachromosomal genetic material |
| US5858062A (en) * | 1997-02-10 | 1999-01-12 | Litton Systems, Inc. | Oxygen concentrator |
| US6727061B2 (en) | 1997-02-20 | 2004-04-27 | Cabtec, Inc. | Methods for identifying species or Shigella and E. coli using operon sequence analysis |
| US5828062A (en) | 1997-03-03 | 1998-10-27 | Waters Investments Limited | Ionization electrospray apparatus for mass spectrometry |
| US6553317B1 (en) | 1997-03-05 | 2003-04-22 | Incyte Pharmaceuticals, Inc. | Relational database and system for storing information relating to biomolecular sequences and reagents |
| DE19710166C1 (de) | 1997-03-12 | 1998-12-10 | Bruker Franzen Analytik Gmbh | Zwei-Schritt-Verfahren der DNA-Amplifikation für MALDI-TOF-Messungen |
| WO1998040520A1 (en) | 1997-03-14 | 1998-09-17 | Hybridon, Inc. | Method for sequencing of modified nucleic acids using electrospray ionization-fourier transform mass spectrometry |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6018713A (en) | 1997-04-09 | 2000-01-25 | Coli; Robert D. | Integrated system and method for ordering and cumulative results reporting of medical tests |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| US20010039263A1 (en) | 1997-05-02 | 2001-11-08 | Max-Delbruck-Centrum Fur Molekulare Medizin | Chimeric oligonucleotides and the use thereof |
| US6054278A (en) * | 1997-05-05 | 2000-04-25 | The Perkin-Elmer Corporation | Ribosomal RNA gene polymorphism based microorganism identification |
| US6159681A (en) | 1997-05-28 | 2000-12-12 | Syntrix Biochip, Inc. | Light-mediated method and apparatus for the regional analysis of biologic material |
| US6994960B1 (en) | 1997-05-28 | 2006-02-07 | The Walter And Eliza Hall Institute Of Medical Research | Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage |
| CA2302036C (en) | 1997-05-30 | 2003-09-02 | Genetrace Systems, Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| US6061686A (en) | 1997-06-26 | 2000-05-09 | Digital Equipment Corporation | Updating a copy of a remote document stored in a local computer system |
| CN1270598A (zh) | 1997-07-22 | 2000-10-18 | 拉普吉恩公司 | 用于质谱分析核酸的方法和组合物 |
| DE19732086C2 (de) | 1997-07-25 | 2002-11-21 | Univ Leipzig | Verfahren zur quantitativen Bestimmung von Eubakterien |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| GB9719044D0 (en) | 1997-09-08 | 1997-11-12 | Inst Of Ophthalmology | Assay |
| US6090558A (en) * | 1997-09-19 | 2000-07-18 | Genetrace Systems, Inc. | DNA typing by mass spectrometry with polymorphic DNA repeat markers |
| US6063031A (en) | 1997-10-14 | 2000-05-16 | Assurance Medical, Inc. | Diagnosis and treatment of tissue with instruments |
| US6111096A (en) | 1997-10-31 | 2000-08-29 | Bbi Bioseq, Inc. | Nucleic acid isolation and purification |
| JP3423597B2 (ja) | 1997-11-05 | 2003-07-07 | 三井農林株式会社 | 細菌の同定方法 |
| US6028183A (en) * | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| DK1036202T3 (da) | 1997-12-05 | 2002-08-12 | Max Planck Gesellschaft | Fremgangsmåde til identifikation af nucleinsyrer ved matriksassisteret laserdesorptions/ionisationsmassespektrometri |
| US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| US6268131B1 (en) | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
| GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| US20030096232A1 (en) | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
| US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| JP3793342B2 (ja) | 1997-12-26 | 2006-07-05 | ソニーケミカル株式会社 | アクリル系エマルジョン、及び粘着テープ |
| DE19802905C2 (de) | 1998-01-27 | 2001-11-08 | Bruker Daltonik Gmbh | Verfahren zur bevorzugten Herstellung nur eines Stranges selektierten Genmaterials für massenspektrometrische Messungen |
| US6428956B1 (en) | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
| CA2322202C (en) * | 1998-03-10 | 2010-11-30 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
| US6270973B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Multiplex method for nucleic acid detection |
| US6270974B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Exogenous nucleic acid detection |
| US6268146B1 (en) * | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| US6312902B1 (en) * | 1998-03-13 | 2001-11-06 | Promega Corporation | Nucleic acid detection |
| US6277578B1 (en) * | 1998-03-13 | 2001-08-21 | Promega Corporation | Deploymerization method for nucleic acid detection of an amplified nucleic acid target |
| US6391551B1 (en) * | 1998-03-13 | 2002-05-21 | Promega Corporation | Detection of nucleic acid hybrids |
| US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| US6261769B1 (en) | 1998-03-31 | 2001-07-17 | The United States Of America As Represented By The Secretary Of Agriculture | Intergenic spacer target sequence for detecting and distinguishing Chlamydial species or strains |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US7321828B2 (en) | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6223186B1 (en) | 1998-05-04 | 2001-04-24 | Incyte Pharmaceuticals, Inc. | System and method for a precompiled database for biomolecular sequence information |
| US6723564B2 (en) | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| DE19822108A1 (de) | 1998-05-12 | 2000-02-03 | Schering Ag | Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika |
| US6221587B1 (en) | 1998-05-12 | 2001-04-24 | Isis Pharmceuticals, Inc. | Identification of molecular interaction sites in RNA for novel drug discovery |
| DE19922161A1 (de) | 1998-05-18 | 1999-12-09 | Fraunhofer Ges Forschung | Anti-Haft-Beschichtung und Verfahren zu ihrer Herstellung |
| US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
| US6104028A (en) * | 1998-05-29 | 2000-08-15 | Genetrace Systems Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| DE19824280B4 (de) | 1998-05-29 | 2004-08-19 | Bruker Daltonik Gmbh | Mutationsanalyse mittels Massenspektrometrie |
| GB2339905A (en) | 1998-06-24 | 2000-02-09 | Bruker Daltonik Gmbh | Use of mass-specrometry for detection of mutations |
| EP1092047B1 (en) | 1998-07-02 | 2009-08-26 | Gen-Probe Incorporated | Molecular torches |
| US6218118B1 (en) * | 1998-07-09 | 2001-04-17 | Agilent Technologies, Inc. | Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry |
| US6074831A (en) | 1998-07-09 | 2000-06-13 | Agilent Technologies, Inc. | Partitioning of polymorphic DNAs |
| US6432651B1 (en) * | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
| US6605433B1 (en) | 1998-08-20 | 2003-08-12 | The Johns Hopkins University | Mitochondrial dosimeter |
| US6146144A (en) * | 1998-09-29 | 2000-11-14 | Fowler; Ernest R. | Rug hooking kit and method for handicapped |
| US6610492B1 (en) | 1998-10-01 | 2003-08-26 | Variagenics, Inc. | Base-modified nucleotides and cleavage of polynucleotides incorporating them |
| WO2000020643A1 (en) * | 1998-10-05 | 2000-04-13 | Mosaic Technologies | Reverse displacement assay for detection of nucleic acid sequences |
| IT1303330B1 (it) | 1998-11-05 | 2000-11-06 | Ilpea Ind Spa | Guarnizione per frogoriferi con controporta sagomata. |
| DE19852167C2 (de) | 1998-11-12 | 2000-12-14 | Bruker Saxonia Analytik Gmbh | Einfache SNP-Analyse mittels Massenspektrometrie |
| JP2002537761A (ja) | 1998-11-24 | 2002-11-12 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | トランスジェニック循環内皮細胞 |
| US6994962B1 (en) | 1998-12-09 | 2006-02-07 | Massachusetts Institute Of Technology | Methods of identifying point mutations in a genome |
| DE19859723A1 (de) | 1998-12-23 | 2000-06-29 | Henkel Kgaa | Mittel zum Färben von keratinhaltigen Fasern |
| US7432049B2 (en) | 2001-02-28 | 2008-10-07 | Chondrogene Limited | Compositions and methods relating to osteoarthritis |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6638714B1 (en) | 1999-02-03 | 2003-10-28 | Ortho-Clinical Diagnostics, Inc. | Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof |
| US6153389A (en) * | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
| EP1035219A1 (en) | 1999-02-25 | 2000-09-13 | Universiteit Gent | Gastric helicobacter 16 S rDNA sequences from cattle and pigs and their use for detection and typing of Helicobacter strains |
| DE19910592A1 (de) | 1999-03-10 | 2000-09-14 | Volkswagen Ag | Rückhaltevorrichtung |
| US6436640B1 (en) * | 1999-03-18 | 2002-08-20 | Exiqon A/S | Use of LNA in mass spectrometry |
| US6613509B1 (en) * | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| CA2370656A1 (en) | 1999-04-21 | 2000-10-26 | Mitchell T. Gore | Magnetic dna extraction kit for plants |
| US6140067A (en) | 1999-04-30 | 2000-10-31 | Mitokor | Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus |
| US6649351B2 (en) * | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
| JP2002542808A (ja) | 1999-05-03 | 2002-12-17 | ジェン−プローブ・インコーポレーテッド | ポリヌクレオチドマトリックスに基づく微生物同定方法 |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| MXPA02000192A (es) | 1999-06-30 | 2004-08-12 | Corixa Corp | Composiciones y metodos para la terapia y diagnostico de cancer de pulmon. |
| EP1198597A1 (de) | 1999-07-22 | 2002-04-24 | Artus Gesellschaft Für Molekularbiologische Diagnostik und Entwicklung MbH. | Verfahren zum speziesspezifischen nachweis von organismen |
| US6723505B1 (en) | 1999-08-13 | 2004-04-20 | Nye Colifast As | Method for identification of the indicators of contamination in liquid samples |
| US6266144B1 (en) | 1999-08-26 | 2001-07-24 | Taiwan Semiconductor Manufacturing Company | Stepper and scanner new exposure sequence with intra-field correction |
| DE19943374A1 (de) | 1999-09-10 | 2001-03-29 | Max Planck Gesellschaft | Verfahren zum Anbinden von Nukleinsäuren an eine Festphase |
| US7005274B1 (en) | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| WO2001023608A2 (en) | 1999-09-27 | 2001-04-05 | Merck Sharp & Dohme De Espana, S.A.E. | Hybridization probes which specifically detect strains of the genera microbispora, microtetraspora, nonomuria and planobispora |
| EP2322667A3 (en) | 1999-09-28 | 2011-10-26 | Geneohm Sciences Canada, Inc. | Highly conserved gene and its use to generate species-specific, genus-specific, family-specific, group-specific and universal nucleic acid probes for microorganisms. |
| US6296188B1 (en) | 1999-10-01 | 2001-10-02 | Perfect Plastic Printing Corporation | Transparent/translucent financial transaction card including an infrared light filter |
| IL148930A0 (en) * | 1999-10-13 | 2002-09-12 | Sequenom Inc | Methods for generating databases and databases for identifying polymorphic genetic markers |
| US6787302B2 (en) | 1999-10-25 | 2004-09-07 | Genprime, Inc. | Method and apparatus for prokaryotic and eukaryotic cell quantitation |
| JP2003516129A (ja) | 1999-11-04 | 2003-05-13 | カリフォルニア・インスティテュート・オブ・テクノロジー | ポリヌクレオチド配列を解析する方法および装置 |
| US6286146B1 (en) | 1999-11-15 | 2001-09-11 | Debra Rocker | Method of wearing weighted training vest while listening to audio equipment |
| US6856914B1 (en) | 1999-11-19 | 2005-02-15 | The University Of British Columbia | Method, apparatus, media and signals for identifying associated cell signaling proteins |
| CA2393041A1 (fr) | 1999-11-29 | 2001-06-07 | Aventis Pharma S.A. | Procede d'obtention d'acides nucleiques a partir d'un echantillon de l'environnement, acides nucleiques ainsi obtenus et leur application a la synthese de nouveaux composes |
| US6608190B1 (en) * | 1999-12-16 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| EP1242630B1 (en) * | 1999-12-29 | 2006-02-01 | Keygene N.V. | Method for generating oligonucleotides, in particular for the detection of amplified restriction fragments obtained using aflp |
| SE0000061D0 (sv) | 2000-01-10 | 2000-01-10 | Bjoern Herrmann | A method for detection of pathogenic organisms |
| WO2001051661A2 (en) * | 2000-01-13 | 2001-07-19 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| AU2001228223A1 (en) | 2000-01-24 | 2001-07-31 | Sanjay Chadha | Hand-held personal computing device with microdisplay |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US20020009727A1 (en) | 2000-02-02 | 2002-01-24 | Schultz Gary A. | Detection of single nucleotide polymorphisms |
| US6453244B1 (en) | 2000-02-10 | 2002-09-17 | Stanford University | Detection of polymorphisms by denaturing high-performance liquid chromatography |
| EP1266338A2 (en) | 2000-02-14 | 2002-12-18 | First Opinion Corporation | Automated diagnostic system and method |
| US6393367B1 (en) | 2000-02-19 | 2002-05-21 | Proteometrics, Llc | Method for evaluating the quality of comparisons between experimental and theoretical mass data |
| DE10015797B4 (de) | 2000-03-26 | 2006-02-02 | Bruker Daltonik Gmbh | Multiplex-Analyse von DNA-Gemischen mittels photolytisch ablesbarer DNA-Chips |
| DE10015262A1 (de) | 2000-03-28 | 2001-10-04 | Basf Ag | Papierstreichmassen, enthaltend Bindemittel mit Makromonomeren |
| WO2001073119A2 (en) | 2000-03-29 | 2001-10-04 | Cambia | Methods for genotyping by hybridization analysis |
| DK2206791T3 (en) | 2000-04-10 | 2016-10-24 | Taxon Biosciences Inc | Methods of study and genetic analysis of populations |
| US6475736B1 (en) * | 2000-05-23 | 2002-11-05 | Variagenics, Inc. | Methods for genetic analysis of DNA using biased amplification of polymorphic sites |
| US6716634B1 (en) | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| US6507837B1 (en) | 2000-06-08 | 2003-01-14 | Hyperphrase Technologies, Llc | Tiered and content based database searching |
| AU2001268259A1 (en) | 2000-06-09 | 2001-12-24 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| US6660229B2 (en) * | 2000-06-13 | 2003-12-09 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
| EP1170379A1 (en) * | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Sample generation for genotyping by mass spectrometry |
| FR2811321A1 (fr) | 2000-07-04 | 2002-01-11 | Bio Merieux | Amplificateur d'une region ribonucleique cible d'un arn ribosomal 16s ou adn pour un tel arn d'une espece eubacterienne et detection de telles especes |
| US6504021B2 (en) | 2000-07-05 | 2003-01-07 | Edge Biosystems, Inc. | Ion exchange method for DNA purification |
| CN1451050A (zh) | 2000-07-06 | 2003-10-22 | 比奥·麦利尤股份有限公司 | 控制水相介质的微生物质量的方法及其试剂盒 |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| AU2001283056A1 (en) | 2000-07-27 | 2002-02-13 | California Institute Of Technology | A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping |
| AUPQ909000A0 (en) | 2000-07-28 | 2000-08-24 | University Of Sydney, The | A method of detecting microorganisms |
| US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| GB0021286D0 (en) | 2000-08-30 | 2000-10-18 | Gemini Genomics Ab | Identification of drug metabolic capacity |
| US20040005555A1 (en) * | 2000-08-31 | 2004-01-08 | Rothman Richard E. | Molecular diagnosis of bactermia |
| US7349808B1 (en) | 2000-09-06 | 2008-03-25 | Egenomics, Inc. | System and method for tracking and controlling infections |
| US6813615B1 (en) | 2000-09-06 | 2004-11-02 | Cellomics, Inc. | Method and system for interpreting and validating experimental data with automated reasoning |
| US20020120408A1 (en) | 2000-09-06 | 2002-08-29 | Kreiswirth Barry N. | System and method for tracking and controlling infections |
| WO2002021108A2 (en) | 2000-09-08 | 2002-03-14 | Large Scale Proteomics Corporation | Method for detecting molecules or chemical reactions by determining variation of conductance |
| SE0003286D0 (sv) | 2000-09-15 | 2000-09-15 | Ulf Gyllensten | Method and kit for human identification |
| DE60139026D1 (de) | 2000-09-25 | 2009-07-30 | Polymun Scient Immunbio Forsch | Lebender influenza impfstoff und verfahren zu seiner herstellung |
| AU2001296650A1 (en) | 2000-10-05 | 2002-04-15 | Millennium Pharmaceuticals, Inc. | Seven-transmembrane (7tm) receptors and uses thereof |
| US6996472B2 (en) | 2000-10-10 | 2006-02-07 | The United States Of America As Represented By The Department Of Health And Human Services | Drift compensation method for fingerprint spectra |
| GB2384309B8 (en) | 2000-10-13 | 2016-03-02 | Irm Llc | High throughput processing system and method of using |
| CA2426824A1 (en) | 2000-10-24 | 2002-07-25 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic dna |
| US6906316B2 (en) | 2000-10-27 | 2005-06-14 | Fuji Electric Co., Ltd. | Semiconductor device module |
| US6682889B1 (en) * | 2000-11-08 | 2004-01-27 | Becton, Dickinson And Company | Amplification and detection of organisms of the Chlamydiaceae family |
| JPWO2002050307A1 (ja) | 2000-12-12 | 2004-04-22 | 中外製薬株式会社 | 質量分析を利用してｄｎａの多型を検出する方法 |
| US6800289B2 (en) | 2000-12-21 | 2004-10-05 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Strain of the western equine encephalitis virus |
| US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| DE10108453B4 (de) | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern |
| US6699670B2 (en) | 2001-03-01 | 2004-03-02 | The Johns Hopkins University | Quantitative assay for the simultaneous detection and speciation of bacterial infections |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US20040121313A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
| AU2003298030B2 (en) | 2001-03-02 | 2009-12-10 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20040121310A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in forensic studies |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20040038206A1 (en) * | 2001-03-14 | 2004-02-26 | Jia Zhang | Method for high throughput assay of genetic analysis |
| US20030104410A1 (en) | 2001-03-16 | 2003-06-05 | Affymetrix, Inc. | Human microarray |
| DE60213826T3 (de) | 2001-03-19 | 2013-10-17 | President And Fellows Of Harvard College | Entwicklung neuer molekularer funktionen |
| CN1316034C (zh) | 2001-03-28 | 2007-05-16 | 科学与工业研究会 | 用于野生生物鉴定的通用引物 |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CA2348042A1 (en) | 2001-06-04 | 2002-12-04 | Ann Huletsky | Sequences for detection and identification of methicillin-resistant staphylococcus aureus |
| KR100704072B1 (ko) | 2001-06-06 | 2007-04-05 | 디에스엠 아이피 어셋츠 비.브이. | 개선된 이소프레노이드 제조 방법 |
| US20020187477A1 (en) * | 2001-06-06 | 2002-12-12 | Hong Xue | Method for detecting single nucleotide polymorphisms (SNPs) and point mutations |
| GB0113908D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Designing degenerate PCR primers |
| US20020187490A1 (en) | 2001-06-07 | 2002-12-12 | Michigan State University | Microbial identification chip based on DNA-DNA hybridization |
| GB0113907D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Virus detection using degenerate PCR primers |
| US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| DE10132147B4 (de) | 2001-07-03 | 2004-04-15 | Universität Leipzig | Verfahren zur schnellen quantitativen Bestimmung von Eu-Bakterien |
| GB0117054D0 (en) | 2001-07-12 | 2001-09-05 | Plant Bioscience Ltd | Methods and means for modification of plant characteristics |
| WO2003008636A2 (en) | 2001-07-19 | 2003-01-30 | Infectio Diagnostic (I.D.I.) Inc. | Universal method and composition for the rapid lysis of cells for the release of nucleic acids and their detection |
| US20040191769A1 (en) | 2001-07-24 | 2004-09-30 | Transgenomic, Inc. | Methods, compositions, and kits for mutation detection in mitochondrial DNA |
| AU2002325197A1 (en) | 2001-07-30 | 2003-02-17 | Den Kgl. Veterinaer- Og Landbohojskole | Bacterial strains belonging to lactobacillus species and their use in food and feed industry |
| US7115385B2 (en) | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| AT411174B (de) | 2001-08-09 | 2003-10-27 | Lambda Labor Fuer Molekularbio | Verfahren und chip zur analyse von nukleinsäuren |
| US20030039976A1 (en) * | 2001-08-14 | 2003-02-27 | Haff Lawrence A. | Methods for base counting |
| WO2003016546A1 (en) | 2001-08-21 | 2003-02-27 | Flinders Technologies Pty Ltd. | Method and device for simultaneously molecularly cloning and polylocus profiling of genomes or genome mixtures |
| US7105296B2 (en) | 2001-08-29 | 2006-09-12 | E. I. Du Pont De Nemours And Company | Genes encoding Baeyer-Villiger monooxygenases |
| US7049286B2 (en) | 2001-08-30 | 2006-05-23 | Diatos, S.A. | Insulin conjugates and methods of use thereof |
| JP2005514005A (ja) | 2001-09-04 | 2005-05-19 | エクシコン エ／エス | 新規のｌｎａ組成物およびその使用 |
| US20040101809A1 (en) | 2001-09-21 | 2004-05-27 | Weiss Ervin I | Device, method and materials for mobilizing substances into dentinal tubules in root canal treatment |
| DE10150121B4 (de) | 2001-10-11 | 2005-12-01 | Bernhard-Nocht-Institut für Tropenmedizin | Echtzeitdetektion von DNA-Amplifikationsprodukten |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| DE10152821B4 (de) | 2001-10-25 | 2006-11-16 | Bruker Daltonik Gmbh | Massenspektren ohne elektronisches Rauschen |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| EP1308506A1 (en) | 2001-11-06 | 2003-05-07 | Eidgenössische Technische Hochschule Zürich | Mixtures of Propionibacterium jensenii and Lactobacillus sp. with antimicrobial activities for use as a natural preservation system |
| PL220644B1 (pl) | 2001-11-13 | 2015-11-30 | Univ Pennsylvania | Wirus stowarzyszony z adenowirusem (AAV), kompozycja, wyizolowane białko kapsydowe, wyizolowane lub syntetyczne cząsteczki kwasu nukleinowego, sposób wytwarzania zrekombinowanego wirusa, komórka gospodarza |
| WO2003064993A2 (en) * | 2001-11-15 | 2003-08-07 | Whatman, Inc. | Methods and materials for detecting genetic material |
| US20040023209A1 (en) | 2001-11-28 | 2004-02-05 | Jon Jonasson | Method for identifying microorganisms based on sequencing gene fragments |
| JP3692067B2 (ja) | 2001-11-30 | 2005-09-07 | 株式会社東芝 | 銅のｃｍｐ用研磨スラリーおよびそれを用いた半導体装置の製造方法 |
| US20030148284A1 (en) * | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
| TW509116U (en) | 2001-12-18 | 2002-11-01 | Ind Tech Res Inst | Device for clipping and tightening spindle of honing and milling machine |
| US20030175709A1 (en) | 2001-12-20 | 2003-09-18 | Murphy George L. | Method and system for depleting rRNA populations |
| US7468185B2 (en) | 2001-12-21 | 2008-12-23 | Pfizer Inc. | Vaccine for periodontal disease |
| KR100444230B1 (ko) | 2001-12-27 | 2004-08-16 | 삼성전기주식회사 | 내환원성 유전체 자기 조성물 |
| WO2003060163A2 (en) | 2001-12-28 | 2003-07-24 | Keygene N.V. | Discrimination and detection of target nucleotide sequences using mass spectrometry |
| EP1333101B1 (en) | 2002-02-01 | 2007-03-28 | Bruker Daltonik GmbH | Mutation analysis by PCR and Mass spectrometry |
| CN1202204C (zh) | 2002-02-27 | 2005-05-18 | 财团法人工业技术研究院 | 红光有机电激发光化合物及用其制成的组件和装置 |
| KR100600988B1 (ko) | 2002-03-13 | 2006-07-13 | 주식회사 엘지생명과학 | Ｄｎａ 면역화에서 인플루엔자 ｎｐ 유전자 ｄｎａ를 함께투여하여 면역반응을 증가시키는 방법 |
| US7024370B2 (en) | 2002-03-26 | 2006-04-04 | P) Cis, Inc. | Methods and apparatus for early detection of health-related events in a population |
| US6897027B2 (en) | 2002-03-27 | 2005-05-24 | Decode Genetics Ehf. | Method for desalting nucleic acids |
| US20030228571A1 (en) | 2002-04-01 | 2003-12-11 | Ecker David J. | Method for rapid detection and identification of viral bioagents |
| US7539579B2 (en) | 2002-04-09 | 2009-05-26 | Beattie Kenneth L | Oligonucleotide probes for genosensor chips |
| JP2004000200A (ja) | 2002-04-19 | 2004-01-08 | Menicon Co Ltd | 微生物の検出方法 |
| FR2838740A1 (fr) | 2002-04-22 | 2003-10-24 | Centre Nat Rech Scient | Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations |
| GB0209812D0 (en) | 2002-04-30 | 2002-06-05 | Renovo Ltd | Genetic testing |
| US6906319B2 (en) | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| DE10222632B4 (de) | 2002-05-17 | 2006-03-09 | Con Cipio Gmbh | Mikrosatellitenmarker für genetische Analysen und zur Unterscheidung von Rosen |
| EP1365031A1 (en) | 2002-05-21 | 2003-11-26 | MTM Laboratories AG | Method for detection of somatic mutations using mass spectometry |
| US20040014957A1 (en) | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
| US20030220844A1 (en) * | 2002-05-24 | 2003-11-27 | Marnellos Georgios E. | Method and system for purchasing genetic data |
| NZ536874A (en) | 2002-05-29 | 2005-03-24 | Aresa Biodetection Aps | Reporter system for plants |
| GB0212666D0 (en) | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
| AU2003238930A1 (en) | 2002-06-07 | 2003-12-22 | Incyte Corporation | Enzymes |
| WO2004005458A2 (en) | 2002-06-13 | 2004-01-15 | Regulome Corporation | Functional sites |
| KR100484144B1 (ko) | 2002-06-20 | 2005-04-18 | 삼성전자주식회사 | 원격 관리 서버 및 원격 관리 방법 |
| EP1539944A4 (en) | 2002-07-01 | 2005-12-28 | Univ Wayne State | METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF ANTIBIOTICS WHICH DO NOT RESPOND TO ANTIBIOTIC RESISTANCE |
| WO2004009849A1 (en) | 2002-07-19 | 2004-01-29 | Isis Pharmaceuticals, Inc. | Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform |
| US6916483B2 (en) * | 2002-07-22 | 2005-07-12 | Biodynamics, Llc | Bioabsorbable plugs containing drugs |
| GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
| US20040022764A1 (en) | 2002-07-31 | 2004-02-05 | Hanan Polansky | Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease |
| US7172868B2 (en) | 2002-08-01 | 2007-02-06 | The Regents Of The University Of California | Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis |
| US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
| CN1703521B (zh) | 2002-09-06 | 2011-11-16 | 波士顿大学信托人 | 基因表达的定量 |
| CA2410795A1 (en) | 2002-11-01 | 2004-05-01 | University Of Ottawa | A method for the amplification of multiple genetic targets |
| JP2006505275A (ja) | 2002-11-12 | 2006-02-16 | ジェノライフ | 工業製品において微生物を普遍的に検出するための一段階リアルタイムｒｔ−ｐｃｒキット |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| EP1572977B1 (en) | 2002-11-15 | 2010-03-03 | Gen-Probe Incorporated | Assay and compositions for detection of bacillus anthracis nucleic acid |
| US6680476B1 (en) | 2002-11-22 | 2004-01-20 | Agilent Technologies, Inc. | Summed time-of-flight mass spectrometry utilizing thresholding to reduce noise |
| JP2006516193A (ja) | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
| JP2004201679A (ja) | 2002-12-10 | 2004-07-22 | Kao Corp | Ｐｃｒ法によるフゾバクテリウム・ニュークレタム菌の検出用プライマー及びその検出方法 |
| US20040117354A1 (en) | 2002-12-16 | 2004-06-17 | Azzaro Steven Hector | Process for tagging and measuring quality |
| US20040121329A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby |
| US20040122598A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby |
| US20040121312A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of the absence of bioagents |
| US20040121315A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby |
| US20040122857A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby |
| US20040121340A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| JP2004201641A (ja) | 2002-12-26 | 2004-07-22 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | 真菌検出方法 |
| US20040170954A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Pathogen inactivation assay |
| US20040170981A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Real-time polymerase chain reaction using large target amplicons |
| US20040185438A1 (en) | 2003-03-10 | 2004-09-23 | Ecker David J. | Methods of detection and notification of bioagent contamination |
| US20050065813A1 (en) | 2003-03-11 | 2005-03-24 | Mishelevich David J. | Online medical evaluation system |
| US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| CA2523490A1 (en) * | 2003-04-25 | 2004-11-11 | Sequenom, Inc. | Fragmentation-based methods and systems for de novo sequencing |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| WO2005009202A2 (en) | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| DE602004009075D1 (de) | 2003-07-03 | 2007-10-31 | Danmarks Og Gronlands Geol Und | Verfahren zur selektiven detektion einer zielnukleinsäure |
| WO2005017173A1 (en) | 2003-07-29 | 2005-02-24 | Sigma Aldrich Co. | Methods and compositions for amplification of dna |
| JP4304292B2 (ja) | 2003-07-30 | 2009-07-29 | 日本電気株式会社 | 移動通信システム、移動通信端末及びそれに用いるパワーコントロール方法並びにそのプログラム |
| KR100632429B1 (ko) | 2003-08-01 | 2006-10-09 | 프로테온 주식회사 | 프라이머 특이성 유무에 의한 멀티플렉스 역전사 중합효소연쇄반응을 이용한 재조합 독감 바이러스의 스크리닝 방법 |
| US20060240412A1 (en) | 2003-09-11 | 2006-10-26 | Hall Thomas A | Compositions for use in identification of adenoviruses |
| US20120122099A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
| US20050142584A1 (en) | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| WO2005036369A2 (en) | 2003-10-09 | 2005-04-21 | Isis Pharmaceuticals, Inc. | Database for microbial investigations |
| FR2861743B1 (fr) | 2003-11-04 | 2007-10-19 | Univ Aix Marseille Ii | Identification moleculaire des bacteries du genre corynebacterium |
| JP3861871B2 (ja) | 2003-11-26 | 2006-12-27 | サンケン電気株式会社 | スイッチング電源装置 |
| US8163895B2 (en) | 2003-12-05 | 2012-04-24 | Ibis Biosciences, Inc. | Compositions for use in identification of orthopoxviruses |
| US20050250125A1 (en) | 2003-12-19 | 2005-11-10 | Novakoff James L | Method for conducting pharmacogenomics-based studies |
| JP4619368B2 (ja) | 2004-02-10 | 2011-01-26 | エフ．ホフマン−ラ ロシュ アーゲー | パルボウイルスｂ１９の検出のための新規なプライマーおよびプローブ |
| US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| CA2560521C (en) | 2004-02-18 | 2012-01-03 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US7312036B2 (en) | 2004-03-22 | 2007-12-25 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of viral hemorrhagic fever viruses |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7627437B2 (en) | 2005-01-14 | 2009-12-01 | Idaho Research Foundation | Categorization of microbial communities |
| DE102005008583B4 (de) | 2005-02-24 | 2007-10-25 | Johannes-Gutenberg-Universität Mainz | Verfahren zur Typisierung eines Individuums mittels short tandem repeat (STR)-Loci der genomischen DNA |
| CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| ATE483825T1 (de) | 2005-04-13 | 2010-10-15 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| EP1882045B1 (en) | 2005-04-21 | 2012-08-29 | Ibis Biosciences, Inc. | COMPOSITION FOR IDENTIFICATION OF Staphylococcus aureus |
| CA2616281C (en) | 2005-07-21 | 2014-04-22 | Isis Pharmaceuticals, Inc. | Methods for rapid identification and quantitation of mitochondrial dna variants |
| US20070026435A1 (en) | 2005-07-28 | 2007-02-01 | Polysciences, Inc. | Hydroxysilane functionalized magnetic particles and nucleic acid separation method |
| WO2008104002A2 (en) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
| US20100204266A1 (en) | 2007-03-23 | 2010-08-12 | Ibis Biosciences, INC | Compositions for use in identification of mixed populations of bioagents |
| JP5067239B2 (ja) | 2008-03-28 | 2012-11-07 | 富士通株式会社 | ケーブルマネージメント装置および電子機器装置 |
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