BRPI9811688A - benzamidas bicíclicas gastrocinéticas de derivados de piperidina 3- ou 4- substituídos com 4-aminometil), processo para preparação das mesmas, composições farmacêuticas compreendendo as mesmas e processo para preparação das referidas composições. - Google Patents
benzamidas bicíclicas gastrocinéticas de derivados de piperidina 3- ou 4- substituídos com 4-aminometil), processo para preparação das mesmas, composições farmacêuticas compreendendo as mesmas e processo para preparação das referidas composições.Info
- Publication number
- BRPI9811688A BRPI9811688A BRPI9811688A BRPI9811688A BRPI9811688A BR PI9811688 A BRPI9811688 A BR PI9811688A BR PI9811688 A BRPI9811688 A BR PI9811688A BR PI9811688 A BRPI9811688 A BR PI9811688A BR PI9811688 A BRPI9811688 A BR PI9811688A
- Authority
- BR
- Brazil
- Prior art keywords
- hydrogen
- alkyl
- alk
- cycloalkyl
- preparing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/48—Oxygen atoms attached in position 4 having an acyclic carbon atom attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/12—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/14—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/16—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
patente de invenção: <b>"benzamidas bicíclicas gastrocinéticas de derivados de piperidina 3- ou 4- substituídos com 4-(amimo-metil)"<d>. a presente invenção de compostos da fórmula (i) uma forma estereoquimicamente isomérica dos mesmos, uma forma de n-óxido dos mesmos ou um sal de adição ácido dos mesmos, r¹ e r² tomados em conjunto formam um radical bivalente da fórmula, em que no referido radical bivalente um ou dois átomos de hidrogênio podem ser substituídos com c~ 1-6~ alquila; r³ é hidrogênio ou halo; r^ 4^ é hidrogênio ou c~ 1-6~ alquila; l é c~ 3-6~ cicloalquila, c~ 5-6~ cicloalcanona, c~ 2-6~ alquenila, ou l é um radical da fórmula -alk-r^ 6^, -alk-x-r^ 7^, -alk-y-c(=o)-r^ 9^, ou -alk-y-c(=o)-nr^ 11^r^ 12^ em que cada alk é c~ 1-12~ alcanodiíla; e r~ 6~ é hidrogênio, ciano, c~ 1-6~ alquilsulfonilamino, c~ 3-6~ cicloalquila, c~ 5-6~ cicloalcanona ou um sistema de anel heterocíclico; r^ 7^ é hidrogênio, c~ 1-6~ alquila, hidróxic~ 1-6~ alquila, c~ 3-6~ cicloalquila, ou um sistema de anel heterocíclico; x é o, s, so~ 2~ ou nr^ 8^, o referido r^ 8^ sendo hidrogênio ou c~ 1-6~ alquila; r^ 9^ é hidrogênio, c~ 1-6~ alquila, c~ 3-6~ cicloalquila, c~ 1-6~ alquilóxi ou hidróxi; y é nr^ 10^ ou uma ligação direta; o referido r^ 10^ sendo hidrogênio, ou c~ 1-6~ alquila; r^ 11^ e r^ 12^ cada um, de forma independente são hidrogênio, c~ 1-6~ alquila, c~ 3-6~ cicloalquila, ou r^ 11^ e r^ 12^ combinados com o átomo de nitrogênio podem formar um anel de pirrolidinila, piperidinila, piperazinila ou 4-morfolinila opcionalmente substituído. são descritos processos para a preparação dos referidos produtos, formulações que compreendem os referidos e o uso dos mesmos como um medicamento, de forma específica para o tratamento de condições que estão relacionadas com a dificuldade de esvaziamento gástrico.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202180 | 1997-07-11 | ||
EP98200624 | 1998-02-27 | ||
PCT/EP1998/004190 WO1999002156A1 (en) | 1997-07-11 | 1998-07-07 | Gastrokinetic bicyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivates |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI9811688A true BRPI9811688A (pt) | 2000-09-26 |
BRPI9811688B1 BRPI9811688B1 (pt) | 2011-10-18 |
BRPI9811688B8 BRPI9811688B8 (pt) | 2021-07-06 |
Family
ID=26146699
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9811688 BRPI9811688B8 (pt) | 1997-07-11 | 1998-07-07 | benzamidas bicìclicas gastrocinéticas de derivados de piperidina 3- ou 4- substituìdos com 4-aminometil), processo para preparação das mesmas, composições farmacêuticas compreendendo as mesmas e processo para preparação das referidas composições. |
BR9811687-8A BR9811687A (pt) | 1997-07-11 | 1998-07-07 | Benzamidas monocìclicas gastrocinéticas de derivados de 4-(aminometil) piperidina 3 ou 4-substituìda |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811687-8A BR9811687A (pt) | 1997-07-11 | 1998-07-07 | Benzamidas monocìclicas gastrocinéticas de derivados de 4-(aminometil) piperidina 3 ou 4-substituìda |
Country Status (34)
Country | Link |
---|---|
US (10) | US6452013B1 (pt) |
EP (3) | EP1206938A1 (pt) |
JP (2) | JP4530530B2 (pt) |
KR (2) | KR100500372B1 (pt) |
CN (2) | CN1195736C (pt) |
AR (2) | AR013361A1 (pt) |
AT (2) | ATE255092T1 (pt) |
AU (2) | AU734475B2 (pt) |
BG (2) | BG63709B1 (pt) |
BR (2) | BRPI9811688B8 (pt) |
CA (2) | CA2295088C (pt) |
CZ (2) | CZ297298B6 (pt) |
DE (2) | DE69820065T2 (pt) |
DK (2) | DK0991410T3 (pt) |
EA (1) | EA002619B1 (pt) |
EE (1) | EE04178B1 (pt) |
ES (2) | ES2212330T3 (pt) |
HK (2) | HK1025047A1 (pt) |
HR (2) | HRP20000006B1 (pt) |
HU (2) | HUP0004564A3 (pt) |
ID (2) | ID24481A (pt) |
IL (2) | IL133918A (pt) |
MY (2) | MY123199A (pt) |
NO (2) | NO317467B1 (pt) |
NZ (2) | NZ502209A (pt) |
PL (2) | PL190310B1 (pt) |
PT (2) | PT1000028E (pt) |
RU (1) | RU2213089C2 (pt) |
SI (2) | SI1000028T1 (pt) |
SK (2) | SK284942B6 (pt) |
TR (2) | TR200000022T2 (pt) |
TW (2) | TW402591B (pt) |
UA (1) | UA67745C2 (pt) |
WO (2) | WO1999002156A1 (pt) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW402591B (en) | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
TW570920B (en) * | 1998-12-22 | 2004-01-11 | Janssen Pharmaceutica Nv | 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders |
US20080219928A1 (en) * | 2003-02-26 | 2008-09-11 | Becker Jane A | Measuring Gastrointestinal Parameters |
US20040253179A1 (en) * | 2003-02-26 | 2004-12-16 | Acm Medical Technologies, Inc. | Measuring gastrointestinal parameters |
US7652040B2 (en) | 2003-06-19 | 2010-01-26 | Janssen Pharmaceutica N.V. | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists |
CA2528642C (en) * | 2003-06-19 | 2011-12-13 | Janssen Pharmaceutica N.V. | Heterocyclic substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
DE602004009069T2 (de) * | 2003-06-19 | 2008-06-19 | Janssen Pharmaceutica N.V. | 4-(aminomethyl)-piperidinbenzamide als 5ht4-antagonisten |
JO2478B1 (en) * | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
DE602005005167T2 (de) * | 2004-01-29 | 2009-04-30 | Pfizer Inc. | 1-isopropyl-2-oxo-1,2-dihydropyridin-3-carbonsäureamidderivate mit agonistischer wirkung am 5-ht4-rezeptor |
TW200533348A (en) * | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
WO2005092882A1 (en) * | 2004-03-01 | 2005-10-06 | Pfizer Japan, Inc. | 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7728006B2 (en) * | 2004-04-07 | 2010-06-01 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US8309575B2 (en) | 2004-04-07 | 2012-11-13 | Theravance, Inc. | Quinolinone-carboxamide compounds as 5-HT4 receptor agonists |
US9635429B2 (en) | 2004-07-30 | 2017-04-25 | Broadband Itv, Inc. | Dynamic adjustment of electronic program guide displays based on viewer preferences for minimizing navigation in VOD program selection |
US7399862B2 (en) * | 2004-11-05 | 2008-07-15 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
ATE431824T1 (de) * | 2004-11-05 | 2009-06-15 | Theravance Inc | Chinolinon-carboxamid-verbindungen |
US20070020330A1 (en) | 2004-11-24 | 2007-01-25 | Medpointe Healthcare Inc. | Compositions comprising azelastine and methods of use thereof |
SI2486942T1 (sl) | 2004-11-24 | 2019-03-29 | Meda Pharmaceuticals Inc. | Sestavki, ki obsegajo azelastin, in postopki za njihovo uporabo |
JP5159317B2 (ja) * | 2004-12-22 | 2013-03-06 | セラヴァンス, インコーポレーテッド | インダゾール−カルボキサミド化合物 |
WO2006094063A1 (en) * | 2005-03-02 | 2006-09-08 | Theravance, Inc. | Quinolinone compounds as 5-ht4 receptor agonists |
TWI377206B (en) * | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
GB0603550D0 (en) * | 2006-02-22 | 2006-04-05 | Glaxo Group Ltd | Novel compounds |
US8642772B2 (en) | 2008-10-14 | 2014-02-04 | Sk Biopharmaceuticals Co., Ltd. | Piperidine compounds, pharmaceutical composition comprising the same and its use |
US20110313319A1 (en) * | 2008-11-07 | 2011-12-22 | SAND COUNTY BIOTECHNOLOGY, Inc. | Measuring method for the concentration of intragastric contents |
US8232315B2 (en) | 2009-06-26 | 2012-07-31 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating drug addiction and improving addiction-related behavior |
CN102762201B (zh) | 2009-11-06 | 2013-12-18 | 爱思开生物制药株式会社 | 注意力缺陷/多动症的治疗方法 |
CA2779442A1 (en) | 2009-11-06 | 2011-05-12 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating fibromyalgia syndrome |
KR101180174B1 (ko) | 2010-04-23 | 2012-09-05 | 동아제약주식회사 | 신규한 벤즈아미드 유도체 |
US9610274B2 (en) | 2010-06-30 | 2017-04-04 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating bipolar disorder |
US8623913B2 (en) | 2010-06-30 | 2014-01-07 | Sk Biopharmaceuticals Co., Ltd. | Methods for treating restless legs syndrome |
JP6182989B2 (ja) | 2012-06-28 | 2017-08-23 | セントラル硝子株式会社 | 1,3,3,3−テトラフルオロプロペンの製造方法 |
WO2014083003A1 (en) | 2012-11-27 | 2014-06-05 | Shire International Gmbh | Pro-cognitive compound |
CN105636946B (zh) * | 2013-07-25 | 2017-12-19 | 东亚St 株式会社 | 制备苯甲酰胺衍生物的方法、用于制备苯甲酰胺的新型中间体以及制备新型中间体的方法 |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1046052B (it) | 1973-10-12 | 1980-06-30 | Sigurta Farmaceutici Spa | Processo per la preparazione di i aralchil 4 aminometil piperidin 4 oli |
US4348763A (en) * | 1980-08-07 | 1982-09-07 | Hewlett-Packard Company | Multiple stripe leaky mode laser |
US4711703A (en) | 1982-02-03 | 1987-12-08 | Orbisphere Corporation Wilmington, Succursale De Collonge-Bellerive | Thermal protection method for electroanalytical cell |
DE3416224C2 (de) * | 1983-05-06 | 1994-05-05 | Mitsubishi Chem Ind | Verfahren zur Herstellung eines Kohleverflüssigungsöls |
US4772630A (en) | 1984-11-23 | 1988-09-20 | Ciba-Geigy Corp. | Benzamides and their salts |
US4722630A (en) | 1985-09-20 | 1988-02-02 | The Garrett Corporation | Ceramic-metal braze joint |
GB8527052D0 (en) | 1985-11-02 | 1985-12-04 | Beecham Group Plc | Compounds |
US4910312A (en) * | 1985-11-08 | 1990-03-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
US4910193A (en) | 1985-12-16 | 1990-03-20 | Sandoz Ltd. | Treatment of gastrointestinal disorders |
US4746655A (en) | 1987-06-10 | 1988-05-24 | A. H. Robins Company, Incorporated | Fused aromatic-spiropiperidine oxazepinones(and thiones) |
BE1000689A6 (fr) | 1987-07-14 | 1989-03-14 | Donnay Donnay S A Ets | Raquette de tennis, de squash ou sport analogue. |
US4906643A (en) | 1987-07-17 | 1990-03-06 | Janssen Pharmaceutica N.V. | Substituted N-(3-hydroxy-4-piperidinyl)benzamides as gastrointestinal agents |
NZ225152A (en) * | 1987-07-17 | 1990-04-26 | Janssen Pharmaceutica Nv | Heterocyclically substituted piperidinyl benzamides as pharmaceuticals |
US5130312A (en) | 1987-07-17 | 1992-07-14 | Janssen Pharmaceutica N.V. | Substituted N-(3-hydroxy-4-piperidinyl)benzamides |
JPH0719937B2 (ja) * | 1987-09-24 | 1995-03-06 | 三井石油化学工業株式会社 | 高周波用積層板およびその製造方法 |
CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
US5041454A (en) | 1987-09-25 | 1991-08-20 | Janssen Pharmaceutica N.V. | Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
US4975439A (en) | 1987-09-25 | 1990-12-04 | Janssen Pharmaceutical N.V. | Novel substituted N-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
JP2573017B2 (ja) | 1988-03-08 | 1997-01-16 | 三洋電機株式会社 | ディスクプレーヤ |
US5053412A (en) | 1990-04-10 | 1991-10-01 | Israel Institute For Biological Research | Spiro nitrogen-bridged heterocyclic compounds |
US5374637A (en) * | 1989-03-22 | 1994-12-20 | Janssen Pharmaceutica N.V. | N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives |
GB9005014D0 (en) | 1990-03-06 | 1990-05-02 | Janssen Pharmaceutica Nv | N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives |
US5103141A (en) | 1990-03-08 | 1992-04-07 | U.S. Philips Corporation | Switching arrangement for increasing the white life of a high pressure sodium lamp |
US5534520A (en) | 1990-04-10 | 1996-07-09 | Fisher; Abraham | Spiro compounds containing five-membered rings |
US5407938A (en) | 1990-04-10 | 1995-04-18 | Israel Institute For Biological Research | Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines) |
TW243449B (pt) * | 1991-02-15 | 1995-03-21 | Hokuriku Pharmaceutical | |
CA2116024A1 (en) | 1991-08-20 | 1993-03-04 | Francis David King | 5-ht4 receptor antagonists |
WO1993005038A1 (en) | 1991-09-12 | 1993-03-18 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
IT1252567B (it) * | 1991-12-20 | 1995-06-19 | Italfarmaco Spa | Derivati di 5-isochinolinsolfonammidi inibitori delle protein-chinasi |
WO1993013101A1 (en) * | 1991-12-27 | 1993-07-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Pyridonecarboxylate compound, pharmaceutical use thereof, and spiro compound |
AU667874B2 (en) | 1992-02-06 | 1996-04-18 | Smithkline Beecham Plc | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
JPH05236345A (ja) | 1992-02-21 | 1993-09-10 | Nec Ic Microcomput Syst Ltd | 画像用垂直フィルタ回路 |
MX9306311A (es) | 1992-10-13 | 1994-04-29 | Smithkline Beecham Plc | Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen |
JPH08502741A (ja) | 1992-11-05 | 1996-03-26 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5−ht▲下4▼レセプターアンタゴニスト用のピペリジン誘導体 |
US6127379A (en) * | 1993-02-01 | 2000-10-03 | Smithkline Beecham P.L.C. | Benzopyran, benzothiopyran and benzofuran derivatives as 5-HT4 antagonists |
US5864039A (en) * | 1994-03-30 | 1999-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and use thereof as medicaments |
KR970702247A (ko) * | 1994-03-30 | 1997-05-13 | 고야 마사시 | 벤조산 화합물 및 이들의 약제로서의 용도(benzoic acid compound and use thereof as medicine) |
TW490465B (en) * | 1994-11-24 | 2002-06-11 | Janssen Pharmaceutica Nv | Enterokinetic benzamide, the preparation process and the pharmaceutical compositions thereof |
GB9507882D0 (en) * | 1995-04-18 | 1995-05-31 | Pharmacia Spa | Substituted dihydrobenzofuran derivatives as 5-ht4 agonists |
AU7001796A (en) * | 1995-09-22 | 1997-04-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and medicinal use thereof |
US6096761A (en) * | 1996-02-15 | 2000-08-01 | Janssen Pharmaceutica N.V. | Esters of 3-hydroxy-piperidinemethanol derivatives |
EP0977558B1 (en) * | 1996-02-15 | 2003-10-01 | Janssen Pharmaceutica N.V. | Use of 5ht4 receptor antagonists for overcoming gastrointestinal effects of serotonin reuptake inhibitors |
TW402591B (en) * | 1997-07-11 | 2000-08-21 | Janssen Pharmaceutica Nv | Monocyclic benzamides of 3- or 4-substituted 4-(aminomethyl)-piperidine derivatives |
CN1242863A (zh) | 1997-10-31 | 2000-01-26 | 大宇电子株式会社 | 带有由单一驱动源操纵的驱动机构的光盘换盘装置 |
ATE357443T1 (de) * | 1998-09-10 | 2007-04-15 | Hoffmann La Roche | Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten |
-
1998
- 1998-06-12 TW TW087109332A patent/TW402591B/zh not_active IP Right Cessation
- 1998-06-12 TW TW087109331A patent/TW548103B/zh not_active IP Right Cessation
- 1998-07-07 NZ NZ502209A patent/NZ502209A/xx not_active IP Right Cessation
- 1998-07-07 TR TR2000/00022T patent/TR200000022T2/xx unknown
- 1998-07-07 DK DK98940158T patent/DK0991410T3/da active
- 1998-07-07 CZ CZ0463899A patent/CZ297298B6/cs not_active IP Right Cessation
- 1998-07-07 SI SI9830579T patent/SI1000028T1/xx unknown
- 1998-07-07 EA EA200000110A patent/EA002619B1/ru not_active IP Right Cessation
- 1998-07-07 TR TR2000/00023T patent/TR200000023T2/xx unknown
- 1998-07-07 EP EP02075710A patent/EP1206938A1/en not_active Ceased
- 1998-07-07 CA CA002295088A patent/CA2295088C/en not_active Expired - Lifetime
- 1998-07-07 SI SI9830311T patent/SI0991410T1/xx unknown
- 1998-07-07 SK SK1840-99A patent/SK284942B6/sk not_active IP Right Cessation
- 1998-07-07 ID IDW20000036D patent/ID24481A/id unknown
- 1998-07-07 EE EEP200000015A patent/EE04178B1/xx unknown
- 1998-07-07 AT AT98939620T patent/ATE255092T1/de not_active IP Right Cessation
- 1998-07-07 JP JP2000502022A patent/JP4530530B2/ja not_active Expired - Lifetime
- 1998-07-07 PL PL98338005A patent/PL190310B1/pl not_active IP Right Cessation
- 1998-07-07 UA UA2000010195A patent/UA67745C2/uk unknown
- 1998-07-07 JP JP50812599A patent/JP2002508000A/ja active Pending
- 1998-07-07 DE DE69820065T patent/DE69820065T2/de not_active Expired - Lifetime
- 1998-07-07 AU AU88574/98A patent/AU734475B2/en not_active Expired
- 1998-07-07 DE DE69809050T patent/DE69809050T2/de not_active Expired - Lifetime
- 1998-07-07 EP EP98939620A patent/EP1000028B1/en not_active Expired - Lifetime
- 1998-07-07 AT AT98940158T patent/ATE226820T1/de active
- 1998-07-07 US US09/462,287 patent/US6452013B1/en not_active Expired - Lifetime
- 1998-07-07 HU HU0004564A patent/HUP0004564A3/hu unknown
- 1998-07-07 CN CNB988069571A patent/CN1195736C/zh not_active Expired - Lifetime
- 1998-07-07 CN CN98806950A patent/CN1117568C/zh not_active Expired - Lifetime
- 1998-07-07 PT PT98939620T patent/PT1000028E/pt unknown
- 1998-07-07 CZ CZ19994587A patent/CZ295506B6/cs not_active IP Right Cessation
- 1998-07-07 ID IDW2000030A patent/ID24161A/id unknown
- 1998-07-07 WO PCT/EP1998/004190 patent/WO1999002156A1/en active IP Right Grant
- 1998-07-07 IL IL13391898A patent/IL133918A/en not_active IP Right Cessation
- 1998-07-07 PT PT98940158T patent/PT991410E/pt unknown
- 1998-07-07 ES ES98939620T patent/ES2212330T3/es not_active Expired - Lifetime
- 1998-07-07 ES ES98940158T patent/ES2187051T3/es not_active Expired - Lifetime
- 1998-07-07 CA CA002295087A patent/CA2295087C/en not_active Expired - Lifetime
- 1998-07-07 EP EP98940158A patent/EP0991410B1/en not_active Expired - Lifetime
- 1998-07-07 NZ NZ502208A patent/NZ502208A/en unknown
- 1998-07-07 AU AU88063/98A patent/AU747199B2/en not_active Expired
- 1998-07-07 BR BRPI9811688 patent/BRPI9811688B8/pt not_active IP Right Cessation
- 1998-07-07 SK SK1734-99A patent/SK284632B6/sk not_active IP Right Cessation
- 1998-07-07 KR KR10-1999-7012492A patent/KR100500372B1/ko not_active IP Right Cessation
- 1998-07-07 WO PCT/EP1998/004189 patent/WO1999002494A1/en active IP Right Grant
- 1998-07-07 BR BR9811687-8A patent/BR9811687A/pt active Search and Examination
- 1998-07-07 PL PL98338008A patent/PL190611B1/pl unknown
- 1998-07-07 HU HU0002539A patent/HU227424B1/hu unknown
- 1998-07-07 KR KR1019997012486A patent/KR100885658B1/ko not_active IP Right Cessation
- 1998-07-07 DK DK98939620T patent/DK1000028T3/da active
- 1998-07-07 RU RU2000103212/04A patent/RU2213089C2/ru active
- 1998-07-07 IL IL13391798A patent/IL133917A/xx not_active IP Right Cessation
- 1998-07-08 MY MYPI98003106A patent/MY123199A/en unknown
- 1998-07-08 MY MYPI98003107A patent/MY117803A/en unknown
- 1998-07-10 AR ARP980103374A patent/AR013361A1/es active IP Right Grant
- 1998-07-10 AR ARP980103373A patent/AR016324A1/es active IP Right Grant
-
1999
- 1999-12-10 BG BG103983A patent/BG63709B1/bg unknown
- 1999-12-10 BG BG103984A patent/BG64230B1/bg unknown
-
2000
- 2000-01-05 HR HR20000006A patent/HRP20000006B1/xx not_active IP Right Cessation
- 2000-01-05 HR HR20000005A patent/HRP20000005B1/xx not_active IP Right Cessation
- 2000-01-10 NO NO20000116A patent/NO317467B1/no not_active IP Right Cessation
- 2000-01-10 NO NO20000115A patent/NO314662B1/no not_active IP Right Cessation
- 2000-07-08 HK HK00104203A patent/HK1025047A1/xx not_active IP Right Cessation
- 2000-07-08 HK HK00104201A patent/HK1025093A1/xx not_active IP Right Cessation
-
2001
- 2001-02-22 US US09/791,227 patent/US6635643B2/en not_active Ceased
-
2002
- 2002-06-05 US US10/162,802 patent/US6750349B2/en not_active Expired - Lifetime
-
2003
- 2003-08-19 US US10/643,506 patent/US20040058958A1/en not_active Abandoned
-
2005
- 2005-10-26 US US11/259,719 patent/USRE40793E1/en not_active Expired - Lifetime
-
2006
- 2006-02-16 US US11/355,326 patent/US20060142341A1/en not_active Abandoned
- 2006-02-17 US US11/357,884 patent/US20060142342A1/en not_active Abandoned
- 2006-10-20 US US11/584,732 patent/US7790750B2/en not_active Expired - Fee Related
-
2010
- 2010-05-04 US US12/773,183 patent/US8063070B2/en not_active Expired - Fee Related
-
2011
- 2011-09-20 US US13/237,330 patent/US8318742B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI9811688A (pt) | benzamidas bicíclicas gastrocinéticas de derivados de piperidina 3- ou 4- substituídos com 4-aminometil), processo para preparação das mesmas, composições farmacêuticas compreendendo as mesmas e processo para preparação das referidas composições. | |
BR9916491A (pt) | 4-(aminometil)-piperidina benzamidas para tratamento de distúrbios gastrintestinais | |
SE9904738D0 (sv) | Novel compounds | |
IE850042L (en) | Disubstituted piperidines | |
IL115040A (en) | Substituted piperidines useful for the treatment of allergic diseases process for their preparation and pharmaceutical compositions containing them | |
IL74017A (en) | N-(4-piperidinyl)bicyclic condensed 2-imidazol amine derivatives,their preparation and pharmaceutical compositions containing them | |
BR0010746A (pt) | Derivados heterocìclicos úteis com agentes anticâncer | |
HU9303145D0 (en) | Process for producing of fibrinogen receptor antagonist compounds and pharmaceutical compositions containing them as medical agent | |
DE69327394T2 (de) | 4-(1H-2-METHYLIMIDAZO [4,5-c] PYRIDINYLMETHYL) PHENYLSULFONAMIDDERIVATE ALS PAF ANTAGONISTEN | |
ES2056214T3 (es) | Compuestos de benzopirido-piperidina, -piperidilideno y -piperazina, composiciones, metodos de preparacion y metodos de uso. | |
ES8606306A1 (es) | Un procedimiento para preparar nuevos derivados de benzo- triazol- y benzoxazolamina | |
ES2087038A1 (es) | Nuevas piperidinas con actividad antagonista del paf. | |
IL111355A0 (en) | Pharmaceutical compositions containing aminoquinoline derivatives, certain such novel compounds and their preparation | |
BR9803497A (pt) | Compostos, composições farmacêuticas, e processos para preparar os compostos e as composições e para tratar distúrbio do sistema nervoso central. | |
KR950701332A (ko) | 세로토닌 5HT₂길항제로서의 4-이미도메틸-1-[2'페닐-2'옥소에틸-]피페리딘, 이의 제조방법 및 치료에서의 용도(4-Imidomethyl-1-[2'phenyl-2'oxoethyl-] piperidines as serotonin 5HT₂-antagonists, their preparation and use in therapy) | |
AR003412A1 (es) | Derivados de 1,3-dihidro-1-(fenilalquenil)-2h-imidazol-2-ona, procedimiento para su preparacion, composicion que los comprenden, procedimiento para obtenerdicha composicion y uso de dichos compuestos para preparar medicamentos. | |
MD522G2 (ro) | Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice | |
NO164474C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive heksahydropyrrolo(2,1-a)isokinolin-derivater. | |
BR0011296A (pt) | Derivados de espiroimidazolidina, preparação dos mesmos, utilização dos mesmos e preparações farmacêuticas compreendendo os mesmos | |
HUT45059A (en) | Process for producing abeoergoline derivatives | |
TH54463A3 (th) | 4-(อะมิโนเมธิล)-พิเพอริดีน เบนแซมีด สำหรับรักษาโรคเกี่ยวกับกระเพาะอาหารและลำไส้ | |
TH29792B (th) | ไบไซคลิกเบนซาไมด์ของอนุพันธ์ 4-(อะมิโนเมทิล)-พิเพอริดีน ซึ่งได้รับการแทนที่ที่ 3 หรือ 4 | |
AR034004A1 (es) | Derivados de amidoalquil-piperidina y amidoalquil-piperazina y su uso en la fabricacion de medicamentos | |
AR035578A1 (es) | Ariloxialquilaminas sustituidas, composiciones farmaceuticas que las comprenden, y, uso de dichos compuestos en la fabricacion de medicamentos | |
TH45377A (th) | ไบไซคลิกเบนซาไมด์ของอนุพันธ์ 4-(อะมิโนเมทิล)-พิเพอริดีน ซึ่งได้รับการแทนที่ที่ 3 หรือ 4 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/10/2011, OBSERVADAS AS CONDICOES LEGAIS. |
|
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 07/07/98, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
|
B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 07.07.2018 |