MD522G2 - Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice - Google Patents

Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice

Info

Publication number
MD522G2
MD522G2 MD95-0083A MD950083A MD522G2 MD 522 G2 MD522 G2 MD 522G2 MD 950083 A MD950083 A MD 950083A MD 522 G2 MD522 G2 MD 522G2
Authority
MD
Moldova
Prior art keywords
thioindol
analgetics
preparation
new
pharmaceutical compositions
Prior art date
Application number
MD95-0083A
Other languages
English (en)
Russian (ru)
Other versions
MD522F1 (ro
Inventor
Nicole Bru-Magniez
Dominique Potin
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD522F1 publication Critical patent/MD522F1/ro
Publication of MD522G2 publication Critical patent/MD522G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Prezenta invenţie se referă la derivaţii cu formula:precum şi la sărurile sale aditive şi utilizarea lor în terapeutică ca medicamente cu proprietăţi analgezice.
MD95-0083A 1993-05-18 1994-12-30 Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice MD522G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9305966A FR2705346B1 (fr) 1993-05-18 1993-05-18 Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
PCT/FR1994/000410 WO1994026736A1 (fr) 1993-05-18 1994-04-13 Derives de piperidinyl thio indole comme antalgiques

Publications (2)

Publication Number Publication Date
MD522F1 MD522F1 (ro) 1996-04-30
MD522G2 true MD522G2 (ro) 1997-01-31

Family

ID=9447241

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0083A MD522G2 (ro) 1993-05-18 1994-12-30 Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice

Country Status (15)

Country Link
US (1) US5317025A (ro)
EP (1) EP0699195A1 (ro)
JP (1) JPH09500611A (ro)
CN (1) CN1124026A (ro)
AU (1) AU6571594A (ro)
CA (1) CA2161021A1 (ro)
CZ (1) CZ304195A3 (ro)
EE (1) EE9400296A (ro)
FI (1) FI954931A7 (ro)
FR (1) FR2705346B1 (ro)
HU (1) HUT74866A (ro)
MD (1) MD522G2 (ro)
NZ (1) NZ265304A (ro)
TW (1) TW257756B (ro)
WO (1) WO1994026736A1 (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
AU3162695A (en) * 1994-08-03 1996-03-04 Asta Medica Aktiengesellschaft Indol, indazol, pyridopyrrol and pyridopyrazol derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunomodulating effects
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
AU702322B2 (en) * 1995-03-20 1999-02-18 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
WO2006067531A1 (en) * 2004-12-24 2006-06-29 Prosidion Ltd G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes
NZ564759A (en) * 2005-06-30 2011-08-26 Prosidion Ltd GPCR agonists
AR064736A1 (es) * 2007-01-04 2009-04-22 Prosidion Ltd Agonistas de gpcr
CL2008000018A1 (es) * 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
CA2797281A1 (en) * 2010-05-06 2011-11-10 Merck Sharp & Dohme Corp. Aza-indole derivatives useful as modulators of faah
JP2018525350A (ja) 2015-07-02 2018-09-06 ホライズン オルファン エルエルシー Ａｄｏ耐性システアミン類似体およびその使用
CN104945305A (zh) * 2015-07-03 2015-09-30 北京石油化工学院 一种实现吲哚类化合物选择性芳巯基化的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264311A (en) * 1963-05-02 1966-08-02 Upjohn Co Esters of 3-(aminosulfinyl) indole-2-carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Also Published As

Publication number Publication date
TW257756B (ro) 1995-09-21
NZ265304A (en) 1997-02-24
CN1124026A (zh) 1996-06-05
FR2705346A1 (fr) 1994-11-25
MD522F1 (ro) 1996-04-30
JPH09500611A (ja) 1997-01-21
CA2161021A1 (en) 1994-11-24
FI954931A0 (fi) 1995-10-17
EE9400296A (et) 1996-04-15
US5317025A (en) 1994-05-31
EP0699195A1 (fr) 1996-03-06
FI954931L (fi) 1995-11-20
FR2705346B1 (fr) 1995-08-11
HUT74866A (en) 1997-02-28
HU9503281D0 (en) 1996-01-29
WO1994026736A1 (fr) 1994-11-24
CZ304195A3 (en) 1996-03-13
FI954931A7 (fi) 1995-11-20
AU6571594A (en) 1994-12-12

Similar Documents

Publication Publication Date Title
ATE327977T1 (de) Tetrahydrochinolin-derivate als crth2 antagonisten
HU224496B1 (hu) Pirrolidin-3-il-alkil-piperidin-származékok és e vegyületeket tartalmazó gyógyászati készítmények
DK0891325T3 (da) Para-substituerede phenylpropansyrederivater som integrinantagonister
HUT68769A (en) FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
ES2160949T3 (es) Derivados de fenilen-sulfonamida sustituidos en meta.
BR9814018A (pt) Derivados de tienopirimidina e tienopiridina úteis como agentes anticâncer
DE60322359D1 (de) Imidazopyridinderivate als kinaseinhibitoren
NO20024339L (no) 1,2,3,4-Tetrahydroisokinolin-derivater
NO20062098L (no) Faststofftilstandmontelukast
FI810604L (fi) Foerfarande foer framstaellning av indanderivat
RU94038064A (ru) Производные пиперазина и пиперидина, их применение в качестве противопсихотических средств, способ их получения фармацевтическая композиция
EP0915094A4 (en) MORPHINANE DERIVATIVES AND MEDICAL USE THEREOF
ES2168581T3 (es) Derivados de indazol sustituidos.
ES2087038A1 (es) Nuevas piperidinas con actividad antagonista del paf.
TR200000153T2 (tr) İl-5 inhibite eden 6-azaurasil türevleri.
EA200200232A1 (ru) Интерлейкин-5 ингибирующие производные 6-азаурацила
FR2685918B1 (fr) Nouveaux derives de l'adenosine, leurs procedes de preparation, compositions pharmaceutiques les contenant.
MXPA02004441A (es) Derivados de isoxazol como inhibidores de la fosfodiesterasa.
EP1404652A4 (en) NEW ALKALOID DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
MD522F1 (ro) Noi derivati de piperidinil tioindol, procedeu de preparare a lor, compozitii farmaceutice care le contin, utilizare a lor ca analgezice
NO972377D0 (no) Indolderivater og medisinsk anvendelse derav
JPS6450819A (en) Antidementia agent
MY134325A (en) Quinoline derivatives
UA70986C2 (uk) Похідні (1-арацил-3-арил-3-піперидилетил)піперидину, спосіб їх отримання та фармацевтична композиція, що має у своєму складі такі похідні
ATE248165T1 (de) Komplexe von paroxetin mit cyclodextrin oder cyclodextrin derivaten

Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230