MD522G2 - Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice - Google Patents

Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice

Info

Publication number
MD522G2
MD522G2 MD95-0083A MD950083A MD522G2 MD 522 G2 MD522 G2 MD 522G2 MD 950083 A MD950083 A MD 950083A MD 522 G2 MD522 G2 MD 522G2
Authority
MD
Moldova
Prior art keywords
thioindol
analgetics
preparation
new
pharmaceutical compositions
Prior art date
Application number
MD95-0083A
Other languages
English (en)
Russian (ru)
Other versions
MD522F1 (ro
Inventor
Nicole Bru-Magniez
Dominique Potin
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD522F1 publication Critical patent/MD522F1/ro
Publication of MD522G2 publication Critical patent/MD522G2/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Prezenta invenţie se referă la derivaţii cu formula:precum şi la sărurile sale aditive şi utilizarea lor în terapeutică ca medicamente cu proprietăţi analgezice.
MD95-0083A 1993-05-18 1994-12-30 Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice MD522G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9305966A FR2705346B1 (fr) 1993-05-18 1993-05-18 Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques .
PCT/FR1994/000410 WO1994026736A1 (fr) 1993-05-18 1994-04-13 Derives de piperidinyl thio indole comme antalgiques

Publications (2)

Publication Number Publication Date
MD522F1 MD522F1 (ro) 1996-04-30
MD522G2 true MD522G2 (ro) 1997-01-31

Family

ID=9447241

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0083A MD522G2 (ro) 1993-05-18 1994-12-30 Noi derivaţi de piperidinii tioindol, procedeu de preparare a lor, compoziţii farmaceutice care le conţin, utilizare a lor ca analgezice

Country Status (15)

Country Link
US (1) US5317025A (ro)
EP (1) EP0699195A1 (ro)
JP (1) JPH09500611A (ro)
CN (1) CN1124026A (ro)
AU (1) AU6571594A (ro)
CA (1) CA2161021A1 (ro)
CZ (1) CZ304195A3 (ro)
EE (1) EE9400296A (ro)
FI (1) FI954931A7 (ro)
FR (1) FR2705346B1 (ro)
HU (1) HUT74866A (ro)
MD (1) MD522G2 (ro)
NZ (1) NZ265304A (ro)
TW (1) TW257756B (ro)
WO (1) WO1994026736A1 (ro)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
US5965582A (en) * 1994-08-03 1999-10-12 Asta Medica Aktiengesellschaft N-benzylindole and benzopyrazole derivatives with anti-asthmatic, anti-allergic, anti-inflammatory and immunemodulating effect
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
PL322843A1 (en) * 1995-03-20 1998-02-16 Lilly Co Eli 5-substituted 3-91,2,3,6-tetrahydropyridin-4-yl)- and 3-9piperydin-4-4-yl0-1h-indoles nevel 5-htif natagonists
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
KR20070091038A (ko) * 2004-12-24 2007-09-06 프로시디온 리미티드 Ｇ-단백질 결합 수용체(ｇｐｒ116) 효능제 및 비만 및당뇨병을 치료하기 위한 이의 용도
BRPI0613505A2 (pt) * 2005-06-30 2011-01-11 Prosidion Ltd agonistas de gpcr
CL2008000018A1 (es) * 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
CL2008000017A1 (es) * 2007-01-04 2008-08-01 Prosidion Ltd Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci
BR112012028055A2 (pt) * 2010-05-06 2019-09-24 Merck Sharp & Dohme composto, uso do mesmo, composição farmacêutica, e, métodos de tratar uma doença mediada
TWI759267B (zh) 2015-07-02 2022-04-01 美商地平線罕見醫學製藥有限責任公司 Ａｄｏ抗性半胱胺類似物及其用途
CN104945305A (zh) * 2015-07-03 2015-09-30 北京石油化工学院 一种实现吲哚类化合物选择性芳巯基化的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264311A (en) * 1963-05-02 1966-08-02 Upjohn Co Esters of 3-(aminosulfinyl) indole-2-carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Also Published As

Publication number Publication date
FI954931L (fi) 1995-11-20
MD522F1 (ro) 1996-04-30
NZ265304A (en) 1997-02-24
CA2161021A1 (en) 1994-11-24
EP0699195A1 (fr) 1996-03-06
HU9503281D0 (en) 1996-01-29
TW257756B (ro) 1995-09-21
FR2705346B1 (fr) 1995-08-11
US5317025A (en) 1994-05-31
CN1124026A (zh) 1996-06-05
WO1994026736A1 (fr) 1994-11-24
FI954931A0 (fi) 1995-10-17
FI954931A7 (fi) 1995-11-20
EE9400296A (et) 1996-04-15
CZ304195A3 (en) 1996-03-13
FR2705346A1 (fr) 1994-11-25
AU6571594A (en) 1994-12-12
JPH09500611A (ja) 1997-01-21
HUT74866A (en) 1997-02-28

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230