MD522G2 - New thioindol piperidine derivatives processes for preparation thereof, pharmaceutical compositions and use thereof as analgetics - Google Patents

New thioindol piperidine derivatives processes for preparation thereof, pharmaceutical compositions and use thereof as analgetics

Info

Publication number
MD522G2
MD522G2 MD95-0083A MD950083A MD522G2 MD 522 G2 MD522 G2 MD 522G2 MD 950083 A MD950083 A MD 950083A MD 522 G2 MD522 G2 MD 522G2
Authority
MD
Moldova
Prior art keywords
thioindol
analgetics
preparation
new
pharmaceutical compositions
Prior art date
Application number
MD95-0083A
Other languages
Romanian (ro)
Russian (ru)
Other versions
MD522F1 (en
Inventor
Nicole Bru-Magniez
Dominique Potin
Jean-Marie Teulon
Original Assignee
Laboratoires Upsa, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Upsa, S.A. filed Critical Laboratoires Upsa, S.A.
Publication of MD522F1 publication Critical patent/MD522F1/en
Publication of MD522G2 publication Critical patent/MD522G2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Prezenta invenţie se referă la derivaţii cu formula:precum şi la sărurile sale aditive şi utilizarea lor în terapeutică ca medicamente cu proprietăţi analgezice.The present invention relates to derivatives of the formula: as well as to its additive salts and their use in therapeutics as drugs with analgesic properties.

MD95-0083A 1993-05-18 1994-12-30 New thioindol piperidine derivatives processes for preparation thereof, pharmaceutical compositions and use thereof as analgetics MD522G2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9305966A FR2705346B1 (en) 1993-05-18 1993-05-18 New derivatives of piperidinyl thio indole, processes for their preparation, pharmaceutical compositions containing them, useful in particular as analgesics.
PCT/FR1994/000410 WO1994026736A1 (en) 1993-05-18 1994-04-13 Thioindole pyperidinyl derivatives used as antalgics

Publications (2)

Publication Number Publication Date
MD522F1 MD522F1 (en) 1996-04-30
MD522G2 true MD522G2 (en) 1997-01-31

Family

ID=9447241

Family Applications (1)

Application Number Title Priority Date Filing Date
MD95-0083A MD522G2 (en) 1993-05-18 1994-12-30 New thioindol piperidine derivatives processes for preparation thereof, pharmaceutical compositions and use thereof as analgetics

Country Status (15)

Country Link
US (1) US5317025A (en)
EP (1) EP0699195A1 (en)
JP (1) JPH09500611A (en)
CN (1) CN1124026A (en)
AU (1) AU6571594A (en)
CA (1) CA2161021A1 (en)
CZ (1) CZ304195A3 (en)
EE (1) EE9400296A (en)
FI (1) FI954931A7 (en)
FR (1) FR2705346B1 (en)
HU (1) HUT74866A (en)
MD (1) MD522G2 (en)
NZ (1) NZ265304A (en)
TW (1) TW257756B (en)
WO (1) WO1994026736A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK139593D0 (en) * 1993-12-16 1993-12-16 Lundbeck & Co As H COMPOUNDS
JPH10503501A (en) * 1994-08-03 1998-03-31 アスタ メディカ アクチエンゲゼルシャフト Indole, indazole, pyridopyrrole and pyridopyrazole derivatives having anti-asthma, anti-allergy, anti-inflammatory and immunomodulatory effects
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
CZ288897A3 (en) * 1995-03-20 1998-02-18 Eli Lilly And Company In position 5-substituted 3-(1,2,3,6-tetrahydropyridin-4-yl)indole and 3-(piperidin-4-yl)indole, as well as pharmaceutical composition containing thereof
TWI328009B (en) 2003-05-21 2010-08-01 Glaxo Group Ltd Quinoline derivatives as phosphodiesterase inhibitors
JP4980928B2 (en) * 2004-12-24 2012-07-18 プロシディオン・リミテッド G protein-coupled receptor (GPR116) agonist and use thereof for the treatment of obesity and diabetes
CA2613235A1 (en) * 2005-06-30 2007-01-11 Prosidion Limited Gpcr agonists
AR064735A1 (en) * 2007-01-04 2009-04-22 Prosidion Ltd GPCR AGONISTS AND PHARMACEUTICAL COMPOSITION BASED ON THE COMPOUND
CL2008000017A1 (en) * 2007-01-04 2008-08-01 Prosidion Ltd COMPOUNDS DERIVED FROM NITROGEN AND OXYGEN HETEROCICLES, GPCR AGONISTS; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND FOR THE TREATMENT OF OBESITY, DIABETES, METABOLIC SYNDROME, HYPERLIPIDEMIA, TOLERANCE
WO2011140164A1 (en) * 2010-05-06 2011-11-10 Merck Sharp & Dohme Corp. Aza-indole derivatives useful as modulators of faah
TWI759267B (en) 2015-07-02 2022-04-01 美商地平線罕見醫學製藥有限責任公司 Ado-resistant cysteamine analogs and uses thereof
CN104945305A (en) * 2015-07-03 2015-09-30 北京石油化工学院 Method for achieving indole derivative selective aromatic thiolation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3264311A (en) * 1963-05-02 1966-08-02 Upjohn Co Esters of 3-(aminosulfinyl) indole-2-carboxylic acids

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives

Also Published As

Publication number Publication date
US5317025A (en) 1994-05-31
FI954931A0 (en) 1995-10-17
JPH09500611A (en) 1997-01-21
CZ304195A3 (en) 1996-03-13
NZ265304A (en) 1997-02-24
EP0699195A1 (en) 1996-03-06
FI954931L (en) 1995-11-20
HU9503281D0 (en) 1996-01-29
FI954931A7 (en) 1995-11-20
CA2161021A1 (en) 1994-11-24
FR2705346B1 (en) 1995-08-11
CN1124026A (en) 1996-06-05
MD522F1 (en) 1996-04-30
EE9400296A (en) 1996-04-15
TW257756B (en) 1995-09-21
HUT74866A (en) 1997-02-28
FR2705346A1 (en) 1994-11-25
WO1994026736A1 (en) 1994-11-24
AU6571594A (en) 1994-12-12

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Legal Events

Date Code Title Description
FG3A Granted patent for invention
IF99 Valid patent on 19990615

Free format text: EXPIRES: 20141230