BR112017028448A2 - análogos de cisteamina resistentes a ado e usos dos mesmos - Google Patents
análogos de cisteamina resistentes a ado e usos dos mesmosInfo
- Publication number
- BR112017028448A2 BR112017028448A2 BR112017028448-0A BR112017028448A BR112017028448A2 BR 112017028448 A2 BR112017028448 A2 BR 112017028448A2 BR 112017028448 A BR112017028448 A BR 112017028448A BR 112017028448 A2 BR112017028448 A2 BR 112017028448A2
- Authority
- BR
- Brazil
- Prior art keywords
- ado
- resistant
- analogs
- cysteamine analogs
- resistant cysteamine
- Prior art date
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
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- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
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- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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Abstract
a presente invenção refere-se aos métodos para o tratamento de doenças para as quais cisteamina é indicado e compostos úteis em tais métodos.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562187939P | 2015-07-02 | 2015-07-02 | |
US62/187,939 | 2015-07-02 | ||
US201562387337P | 2015-12-23 | 2015-12-23 | |
US62/387,337 | 2015-12-23 | ||
PCT/US2016/040637 WO2017004485A1 (en) | 2015-07-02 | 2016-07-01 | Ado-resistant cysteamine analogs and uses thereof |
Publications (1)
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BR112017028448-0A BR112017028448A2 (pt) | 2015-07-02 | 2016-07-01 | análogos de cisteamina resistentes a ado e usos dos mesmos |
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US (2) | US10906904B2 (pt) |
EP (1) | EP3316877B1 (pt) |
JP (2) | JP2018525350A (pt) |
KR (1) | KR20180034466A (pt) |
CN (1) | CN108289867A (pt) |
AU (2) | AU2016288230A1 (pt) |
BR (1) | BR112017028448A2 (pt) |
CA (1) | CA2991099A1 (pt) |
ES (1) | ES2770113T3 (pt) |
IL (1) | IL256553B (pt) |
MX (2) | MX2018000202A (pt) |
RU (2) | RU2766579C2 (pt) |
TW (2) | TWI759267B (pt) |
WO (1) | WO2017004485A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2766579C2 (ru) | 2015-07-02 | 2022-03-15 | ХОРАЙЗОН ОРФАН ЭлЭлСи | Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение |
CN110996929A (zh) * | 2017-04-24 | 2020-04-10 | 麦凯特探索公司 | 使用硫醇化合物治疗神经系统疾病 |
US11690813B2 (en) | 2018-03-01 | 2023-07-04 | Obvia Pharmaceuticals Ltd | Aminothiol reduction of ischemia-reperfusion-induced cell death |
WO2019210035A1 (en) * | 2018-04-25 | 2019-10-31 | Horizon Orphan Llc | Methods of treating excitotoxicity disorders |
Family Cites Families (108)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2834785A (en) | 1954-11-16 | 1958-05-13 | Lakeside Lab Inc | N-substituted-3-thiol piperidines and thioesters thereof |
GB780027A (en) | 1955-01-20 | 1957-07-31 | Schering Corp | 3-piperidyl ethers and thioethers |
US2809918A (en) | 1955-10-17 | 1957-10-15 | Victor M Hermelin | Sustained release pharmaceutical preparations |
DE2010416B2 (de) | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
FR2471186A1 (fr) | 1979-12-10 | 1981-06-19 | Roussel Uclaf | Nouveaux comprimes a delitescence colique, ainsi que leur procede de preparation |
US4301146A (en) | 1980-07-29 | 1981-11-17 | G. D. Searle & Co. | Stabilization of 16-oxygenated prostanoic acid derivatives |
FR2549064B1 (fr) | 1983-07-13 | 1985-10-25 | Rhone Poulenc Sante | Nouveaux derives de synergistines utiles pour la preparation de nouveaux medicaments antimicrobiens et leur preparation |
PH23995A (en) | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
DE3586746D1 (de) | 1984-04-03 | 1992-11-19 | Takeda Chemical Industries Ltd | Lipidderivate, ihre produktion und verwendung. |
PH22302A (en) | 1985-02-11 | 1988-07-22 | Fujisawa Pharmaceutical Co | Piperidine compounds |
US4728512A (en) | 1985-05-06 | 1988-03-01 | American Home Products Corporation | Formulations providing three distinct releases |
US4794001A (en) | 1986-03-04 | 1988-12-27 | American Home Products Corporation | Formulations providing three distinct releases |
US5151424A (en) | 1987-07-01 | 1992-09-29 | Janssen Pharmaceutica N.V. | Pharmacologically active (Bicyclic heterocyclyl)methyl and -hetero) substituted hexahydro-1H-azepines and pyrrolidines |
US5071846A (en) | 1987-07-01 | 1991-12-10 | Janssen Pharmaceutica N.V. | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines |
US4988689A (en) | 1987-07-01 | 1991-01-29 | Janssen Pharmaceutica N.V. | ((Pharmacologically active bicyclic heterocyclic)methyl and -heteroatom) substituted hexahydro-1H-azepines and pyrrolidines |
GB2206879A (en) | 1987-07-07 | 1989-01-18 | May & Baker Ltd | Novel pristinamycin IIB derivatives, their preparation and pharmaceutical compositions containing them |
DE3808678A1 (de) | 1988-03-11 | 1989-09-21 | Schering Ag | Anellierte imino-azole, verfahren zu ihrer herstellung und ihre verwendung als mittel mit herbizider wirkung |
EP0339406A1 (en) | 1988-04-19 | 1989-11-02 | Hokuriku Pharmaceutical Co.,Ltd | Quinoline-3-carboxylic acid derivatives, process for preparing the same, and composition exhibiting excellent antibacterial effect containing the same |
FR2635524B1 (fr) | 1988-08-19 | 1992-04-24 | Adir | Nouveaux derives de benzopyrrolidinone, leur procede de preparation et les compositions pharmaceutiques les renfermant |
US5272150A (en) | 1989-04-07 | 1993-12-21 | Janssen Pharmaceutica N.V. | Hydroxyalkylfuranyl derivatives |
CA2015949A1 (en) | 1989-05-22 | 1990-11-22 | Yasuo Ito | Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same |
JPH03118319A (ja) * | 1989-09-30 | 1991-05-20 | Green Cross Corp:The | 抗炎症剤、胃液分泌抑制剤または活性酸素産生抑制剤 |
FR2655649B1 (fr) | 1989-12-12 | 1994-07-08 | Adir | Nouveaux derives de la piperidine, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
US5217980A (en) | 1990-07-19 | 1993-06-08 | Janssen Pharmaceutica N.V. | Oxazolyl and piperidinyl substituted benimidazolyl compounds |
TW198027B (pt) | 1990-08-26 | 1993-01-11 | Sankyo Co | |
KR950005301B1 (ko) | 1990-09-04 | 1995-05-23 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
JPH04334357A (ja) | 1991-05-02 | 1992-11-20 | Fujirebio Inc | 酵素阻害作用を有するアシル誘導体 |
US5554655A (en) * | 1991-09-30 | 1996-09-10 | Jess G. Thoene | Method of treating HIV infection |
US5225202A (en) | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
PT100914A (pt) * | 1991-09-30 | 1993-10-29 | Jess G Thoene | Uso de compostos capazes de sofrer uma permuta mista com dissulfureto, com uma ligacao dissulfureto, no tratamento de infeccao por hiv |
DK0623615T3 (da) | 1993-05-01 | 1999-12-13 | Merck Patent Gmbh | Adhæsionsreceptor-antagonister |
FR2705346B1 (fr) | 1993-05-18 | 1995-08-11 | Union Pharma Scient Appl | Nouveaux dérivés de pipéridinyl thio indole, leurs procédés de préparation, compositions pharmaceutiques les contenant, utiles notamment comme antalgiques . |
US5783703A (en) | 1993-07-01 | 1998-07-21 | Lederle (Japan), Ltd. | Sulfur-containing compounds method for their use and prodction |
EP0804434A1 (en) | 1994-08-02 | 1997-11-05 | MERCK SHARP & DOHME LTD. | Azetidine, pyrrolidine and piperidine derivatives |
US5821370A (en) | 1994-10-24 | 1998-10-13 | Eli Lilly And Company | Heterocyclic compounds and their preparation and use |
CA2164918C (en) | 1994-12-12 | 2007-09-25 | Kazuhiko Hayashi | Thiol compounds |
JP3724854B2 (ja) | 1995-09-11 | 2005-12-07 | ワイス株式会社 | 1−アザビシクロ[1.1.0]ブタンの製造法 |
GB9523243D0 (en) | 1995-11-14 | 1996-01-17 | Merck Sharp & Dohme | Therapeutic agents |
JP3209679B2 (ja) | 1996-04-05 | 2001-09-17 | 日本ワイスレダリー株式会社 | ジスルフィド化合物およびその製造法 |
GB9610979D0 (en) | 1996-05-24 | 1996-07-31 | Merck Sharp & Dohme | Therapeutic agents |
JPH1143792A (ja) | 1997-07-23 | 1999-02-16 | Asahi Kagaku Kogyo Co Ltd | 酸洗促進剤、酸洗促進剤を含んだ酸洗液組成物およびこれを用いる酸洗方法 |
US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
AU2114199A (en) | 1998-01-13 | 1999-08-02 | Trustees Of The University Of Pennsylvania, The | Novel dopamine re-uptake inhibitors and methods of synthesizing and using the same |
EP1087937A1 (en) | 1998-06-17 | 2001-04-04 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
KR20010079713A (ko) | 1998-09-10 | 2001-08-22 | 마쓰자와 도로, 하야시 지로 | 카르바페넴 화합물 |
AU6508899A (en) * | 1998-10-13 | 2000-05-01 | Du Pont Pharmaceuticals Company | Selective eradication of virally-infected cells by combined use of a cytotoxic agent and an antiviral agent |
WO2000025776A1 (en) * | 1998-10-30 | 2000-05-11 | Nitromed, Inc. | Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use |
BR9806353A (pt) * | 1998-11-10 | 2000-06-20 | Univ Minas Gerais | Processo para a preparação e aplicação farmacológica de novos beta-aminotióis e respectivos sais |
JP2001131067A (ja) * | 1999-08-26 | 2001-05-15 | Sankyo Co Ltd | 血小板凝集抑制剤又は動脈硬化進展抑制剤 |
US6455573B1 (en) | 2000-01-07 | 2002-09-24 | Simon Fraser University | Glycosidase inhibitors and methods of synthesizing same |
US6369243B1 (en) | 2000-01-18 | 2002-04-09 | The Regents Of The Univerisity Of California | Chemical transformation of substrates using nonmetallic, organic catalyst compositions |
GB0013060D0 (en) | 2000-05-31 | 2000-07-19 | Astrazeneca Ab | Chemical compounds |
CN100406439C (zh) | 2000-07-19 | 2008-07-30 | 霍夫曼-拉罗奇有限公司 | 作为金属蛋白酶抑制剂的吡咯烷衍生物 |
WO2003007875A2 (en) | 2001-07-16 | 2003-01-30 | Hoegestaett Edward | Compounds with analgesic, antipyretic and/or anti-inflammatory activity |
JP2003183280A (ja) | 2001-12-21 | 2003-07-03 | Wyeth Lederle Japan Ltd | カルバペネム化合物 |
JP2003183281A (ja) | 2001-12-21 | 2003-07-03 | Wyeth Lederle Japan Ltd | カルバペネム化合物 |
WO2003062224A1 (en) | 2002-01-17 | 2003-07-31 | Eli Lilly And Company | Aza-cyclic compounds as modulators of acetylcholine receptors |
US6743864B2 (en) | 2002-03-12 | 2004-06-01 | Basell Poliolefine Italia S.P.A. | Polyolefin compositions having high tenacity |
US20030139427A1 (en) | 2002-08-23 | 2003-07-24 | Osi Pharmaceuticals Inc. | Bicyclic pyrimidinyl derivatives and methods of use thereof |
SE0300812D0 (sv) | 2003-03-24 | 2003-03-24 | Karolinska Innovations Ab | Use of chemical compounds for preparing pharmaceutical compositions, and method of testing substances for medical effect |
WO2004094380A1 (en) | 2003-04-18 | 2004-11-04 | Eli Lilly And Company | (piperidinyloxy)phenyl, (piperidinyloxy)pyridinyl, (piperidinylsulfanyl)phenyl and (piperidinylsulfanyl)pyridinyl compounds as 5-ht1f agonists |
WO2005014524A2 (en) * | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
ATE450535T1 (de) | 2003-09-03 | 2009-12-15 | Glaxo Group Ltd | Neues verfahren zur herstellung von pleuromutilinderivaten |
DE10348044A1 (de) | 2003-10-15 | 2005-05-19 | Imtm Gmbh | Duale Alanyl-Aminopeptidase- und Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen |
DK1675578T3 (da) * | 2003-10-15 | 2013-08-26 | Probiodrug Ag | Inhibitorer af glutaminyl- og glutamatcyclaser til behandling af de neurodegenerative sygdomme FBD og FDD |
EP1541143A1 (en) | 2003-12-09 | 2005-06-15 | Graffinity Pharmaceuticals Aktiengesellschaft | Dpp-iv inhibitors |
EP1696897B1 (en) | 2003-12-19 | 2011-07-06 | Omega Bio-Pharma (I.P.3) Limited | Compositions for treating diabetes |
BRPI0510613A (pt) | 2004-05-03 | 2007-10-30 | Omega Bio Pharma Ip3 Ltd | cisteaminas para tratar complicações de hipercolesterolemia e diabete |
JP2006001841A (ja) | 2004-06-15 | 2006-01-05 | Sumitomo Chemical Co Ltd | 含窒素へテロ環化合物の製造方法 |
EP1637141B1 (en) | 2004-09-21 | 2011-11-16 | Trobio AB | Stabilized protease composition comprising a serine protease, morpholino derivatives and reversible inhibitors of said serine protease |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
AR055837A1 (es) | 2005-01-13 | 2007-09-12 | Wyeth Corp | Procedimientos para la preparacion de alc0holes aminoetoxibencilicos |
KR101368988B1 (ko) | 2005-09-16 | 2014-02-28 | 다케다 야쿠힌 고교 가부시키가이샤 | 디펩티딜 펩티다제 억제제 |
CN101196230A (zh) | 2006-01-06 | 2008-06-11 | 赵文利 | 机械动力多司调制技术 |
MX2008009647A (es) | 2006-01-27 | 2008-09-25 | Univ California | Cisteamina recubierta entéricamente, cistamina y derivados de ella. |
TWI389917B (zh) | 2006-04-13 | 2013-03-21 | Sigma Tau Ind Farmaceuti | 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物 |
GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
CA2682539A1 (en) * | 2007-04-19 | 2008-10-30 | Ucb Pharma S.A. | Compounds comprising a cyclobutoxy group |
US20090163705A1 (en) | 2007-05-21 | 2009-06-25 | Alnylam Pharmaceuticals, Inc. | Cationic lipids |
GB0712494D0 (en) | 2007-06-27 | 2007-08-08 | Isis Innovation | Substrate reduction therapy |
DE102008032561A1 (de) | 2007-07-16 | 2009-01-22 | Basf Se | Verfahren und Mischung zur Reinigung von Alkinen |
US8026285B2 (en) | 2007-09-04 | 2011-09-27 | Bezwada Biomedical, Llc | Control release of biologically active compounds from multi-armed oligomers |
KR20100091219A (ko) * | 2007-11-30 | 2010-08-18 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 시스테아민 산물을 이용한 비-알코올성 지방성간염(nash) 치료 방법 |
JP2011518127A (ja) | 2008-03-31 | 2011-06-23 | エヴォテック・アクチエンゲゼルシャフト | ヒスタミンh3受容体アンタゴニストとしてのテトラヒドロナフチリジンおよびそれらのアザ誘導体 |
EP2323651A2 (en) | 2008-08-05 | 2011-05-25 | Summit Corporation Plc | Compounds for the treatment of flaviviral infections |
WO2010015816A2 (en) | 2008-08-06 | 2010-02-11 | Summit Corporation Plc | Treatment of lysosomal storage disorders and other proteostatic diseases |
WO2010026113A1 (en) | 2008-09-03 | 2010-03-11 | Evotec Neurosciences Gmbh | Acyl- and sufonyl tetrahydronaphthyridines and aza derivatives thereof as histamine h3 receptor antagonists |
WO2010029313A1 (en) | 2008-09-11 | 2010-03-18 | Summit Corporation Plc. | Antiinfective compounds |
AR073578A1 (es) | 2008-09-15 | 2010-11-17 | Priaxon Ag | Pirrolidin-2-onas |
WO2010041964A1 (en) | 2008-10-09 | 2010-04-15 | Victoria Link Limited | Methods for the preparation of alkenylamines, cyclic carbamates or dithiocarbamates, and aminoalcohols or aminothiols |
WO2010049678A2 (en) | 2008-10-31 | 2010-05-06 | Summit Corporation Plc | Treatment of energy utilization diseases |
JP5747331B2 (ja) | 2008-11-27 | 2015-07-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 6,7,8,9−テトラヒドロ−5H−1,4,7,10a−テトラアザ−シクロヘプタ[f]インデン誘導体、これらの化合物を含有する医薬組成物、それらの使用及びそれらの調製方法 |
CA2767478A1 (en) | 2009-07-11 | 2011-01-20 | Bayer Pharma Aktiengesellschaft | Radiolabelling method using cycloalkyl groups |
AU2010320963B2 (en) | 2009-11-18 | 2015-07-09 | Fab Pharma Sas | Novel heterocyclic acrylamides and their use as pharmaceuticals |
UY33176A (es) | 2010-01-13 | 2011-08-31 | Sanofi Aventis | Derivados de oxazolopirimidina sustituida en 2, 5, 7. |
WO2011133871A2 (en) | 2010-04-22 | 2011-10-27 | Alnylam Pharmaceuticals, Inc. | 5'-end derivatives |
US20130316961A1 (en) * | 2010-10-25 | 2013-11-28 | Université D'aix-Marseille | Treatment of mecp-2 associated disorders |
US20120309785A1 (en) * | 2010-12-03 | 2012-12-06 | Bill Piu Chan | Use of Cysteamine in Treating Parkinson's Disease |
CA2732440C (en) * | 2011-02-23 | 2017-10-31 | Universite Laval | Cystamine analogues for the treatment of parkinson`s disease |
WO2013024376A1 (en) | 2011-08-16 | 2013-02-21 | Mahesh Kandula | Compositions and methods for the treatment of atherothrombosis |
CA2853484C (en) * | 2011-10-26 | 2018-08-21 | Seattle Children's Research Institute | Cysteamine in the treatment of fibrotic disease |
KR20140097132A (ko) * | 2011-11-22 | 2014-08-06 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 허혈성 손상을 치료하기 위한 시스테아민 및/또는 시스타민 |
EP2601940A1 (en) * | 2011-12-05 | 2013-06-12 | Lacer, S.A. | (4-mercapto-piperidin-4-yl)-aminoacetic acid derivatives, pharmaceutical compositions and uses thereof |
US20150125526A1 (en) * | 2013-11-06 | 2015-05-07 | Raptor Pharmaceuticals Inc. | Use of Cysteamine and Derivatives Thereof to Treat Mitochondrial Diseases |
US20170165240A1 (en) | 2014-04-01 | 2017-06-15 | Université Libre de Bruxelles | New strategies for treating melanoma |
BR112016026291A2 (pt) | 2014-05-19 | 2017-08-15 | Rempex Pharmaceuticals Inc | Derivados do ácido borônico e usos terapêuticos dos mesmos |
GB201416727D0 (en) * | 2014-09-22 | 2014-11-05 | Novabiotics Ltd | Use |
RU2766579C2 (ru) | 2015-07-02 | 2022-03-15 | ХОРАЙЗОН ОРФАН ЭлЭлСи | Цистеаминдиоксигеназа-резистентные аналоги цистеамина и их применение |
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RU2766579C2 (ru) | 2022-03-15 |
AU2021200321A1 (en) | 2021-03-18 |
AU2016288230A1 (en) | 2018-01-25 |
MX2021008819A (es) | 2021-08-24 |
KR20180034466A (ko) | 2018-04-04 |
ES2770113T3 (es) | 2020-06-30 |
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WO2017004485A1 (en) | 2017-01-05 |
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US11505550B2 (en) | 2022-11-22 |
CA2991099A1 (en) | 2017-01-05 |
RU2018103901A3 (pt) | 2020-05-25 |
CN108289867A (zh) | 2018-07-17 |
MX2018000202A (es) | 2018-06-27 |
US10906904B2 (en) | 2021-02-02 |
JP2018525350A (ja) | 2018-09-06 |
RU2022103033A (ru) | 2022-04-01 |
TWI759267B (zh) | 2022-04-01 |
TW201713324A (zh) | 2017-04-16 |
TW202247838A (zh) | 2022-12-16 |
US20220024920A1 (en) | 2022-01-27 |
JP2021152087A (ja) | 2021-09-30 |
EP3316877A1 (en) | 2018-05-09 |
IL256553B (en) | 2021-03-25 |
EP3316877B1 (en) | 2019-10-30 |
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