BRPI0608766A8 - microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero - Google Patents

microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero Download PDF

Info

Publication number
BRPI0608766A8
BRPI0608766A8 BRPI0608766A BRPI0608766A BRPI0608766A8 BR PI0608766 A8 BRPI0608766 A8 BR PI0608766A8 BR PI0608766 A BRPI0608766 A BR PI0608766A BR PI0608766 A BRPI0608766 A BR PI0608766A BR PI0608766 A8 BRPI0608766 A8 BR PI0608766A8
Authority
BR
Brazil
Prior art keywords
methods
compositions
microspheres
composition
embolization
Prior art date
Application number
BRPI0608766A
Other languages
English (en)
Inventor
Reb Philippe
Original Assignee
Biosphere Medical Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37076051&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0608766(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biosphere Medical Sa filed Critical Biosphere Medical Sa
Publication of BRPI0608766A2 publication Critical patent/BRPI0608766A2/pt
Publication of BRPI0608766A8 publication Critical patent/BRPI0608766A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/048—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0476—Particles, beads, capsules, spheres
    • A61K49/0485—Nanoparticles, nanobeads, nanospheres, nanocapsules, i.e. having a size or diameter smaller than 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)

Abstract

microsfera substancialmente esférica, composição injetável, e, uso da microsfera ou da composição. a presente invenção refere-se a composições e métodos para tratar doenças e distúrbios, incluindo câncer e várias outras doenças dependentes de angiogênese, disfunções vasculares, malformações arteriovenosas (avm), processos hemorrágicos e tratamento da dor, em particular dor relacionada com tumor, por administração de medicamento e/ou embolização terapêutica empregando-se microsferas. mais particularmente, a invenção refere-se a microsferas contendo agentes de contraste náo-iônicos, a composições compreendendo estas microsferas, bem como métodos para preparar e utilizar tais composições para terapia de embolização. a invenção refere-se ainda a composições e métodos utilizando microsferas detectáveis para administração de medicamento alvejado, independentemente de se embolização é também necessária.
BRPI0608766A 2005-05-09 2006-05-09 microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero BRPI0608766A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67934805P 2005-05-09 2005-05-09
US60/679348 2005-05-09
PCT/EP2006/004334 WO2006119968A2 (en) 2005-05-09 2006-05-09 Compositions and methods using microspheres and non-ionic contrast agents

Publications (2)

Publication Number Publication Date
BRPI0608766A2 BRPI0608766A2 (pt) 2010-11-23
BRPI0608766A8 true BRPI0608766A8 (pt) 2018-04-17

Family

ID=37076051

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0608766A BRPI0608766A8 (pt) 2005-05-09 2006-05-09 microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero

Country Status (11)

Country Link
US (4) US8226926B2 (pt)
EP (3) EP3085362B1 (pt)
JP (3) JP2008540478A (pt)
KR (2) KR20140090270A (pt)
CN (2) CN101237857A (pt)
AU (1) AU2006245950B2 (pt)
BR (1) BRPI0608766A8 (pt)
CA (1) CA2607228C (pt)
ES (1) ES2568782T3 (pt)
MX (1) MX2007013914A (pt)
WO (1) WO2006119968A2 (pt)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
ES2254042T3 (es) 2000-03-24 2008-03-16 Biosphere Medical, Inc. Microesferas para embolizacion activa.
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US7479112B2 (en) * 2003-08-26 2009-01-20 Cardiac Pacemakers, Inc. Acoustic physiological sensor
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2368581B1 (en) * 2006-01-30 2018-08-29 Biosphere Medical, Inc. Porous intravascular embolization particles and related methods
NZ571743A (en) * 2006-03-21 2012-01-12 Mccain Foods Ltd Compositions and methods for surface modification of root vegetable products
US20100151035A1 (en) * 2007-03-13 2010-06-17 Sandoz Ag Pharmaceutical compositions of poorly soluble drugs
US8940334B2 (en) 2007-05-11 2015-01-27 Nerviano Medical Sciences S.R.L. Pharmaceutical composition of an anthracycline
US7887846B2 (en) * 2007-08-07 2011-02-15 E. I. Du Pont De Nemours And Company Process for preparation of swellable and degradable microspheres
US9987221B2 (en) * 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
US20090169591A1 (en) * 2007-12-28 2009-07-02 Boston Scientific Scimed, Inc. Medical articles for the treatment of tumors
JP5641699B2 (ja) * 2008-03-25 2014-12-17 日本合成化学工業株式会社 パール状ポリビニルアルコール粒子の製造方法および血管一時塞栓剤
CN102006863A (zh) * 2008-04-15 2011-04-06 盐野义制药株式会社 膜组合物
JP2010053222A (ja) * 2008-08-27 2010-03-11 Terumo Clinical Supply Co Ltd 吸水性ポリマー粒子及び吸水性ポリマー粒子の製造方法
JP5694167B2 (ja) 2008-09-15 2015-04-01 マリア・ストローム ビニルアルコールコポリマークリオゲル、ビニルアルコールコポリマー並びにそれらの方法及び製品
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
JP2012507562A (ja) * 2008-10-30 2012-03-29 ダビド リウ 微小球性多孔質生体適合性足場並びにその製造方法及び装置
US20120184642A1 (en) * 2009-07-07 2012-07-19 Soenke Bartling Multimodal visible polymer embolization material
SG10201503351RA (en) 2010-01-19 2015-06-29 Harvard College Engineered Opsonin for Pathogen Detection and Treatment
CN102100930B (zh) * 2010-08-27 2014-05-21 上海微创医疗器械（集团）有限公司 一种栓塞剂及其制备方法
CN102100928B (zh) * 2010-12-27 2014-05-07 上海微创医疗器械（集团）有限公司 液体栓塞材料组合物及其制备方法
US20120259401A1 (en) * 2011-04-08 2012-10-11 Gerrans Lawrence J Balloon catheter for launching drug delivery device
CA2842321C (en) 2011-07-18 2022-05-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
CN102397594B (zh) * 2011-11-11 2014-10-22 北京大学 X线下可显影的栓塞微粒及其制备方法和应用
CN102525936B (zh) * 2012-01-20 2014-11-26 丽水市中心医院 一种复方盐酸表柔比星plga纳米粒及其制备方法
CA2873646C (en) * 2012-05-18 2022-04-26 Genentech, Inc. High-concentration monoclonal antibody formulations
WO2014065513A1 (ko) * 2012-10-25 2014-05-01 서강대학교 산학협력단 약물을 함유한 나노입자가 결합된 초음파 조영제 및 이의 제조방법
US9572700B1 (en) * 2013-03-08 2017-02-21 Endobar Solutions Llc Percutaneous endovasular treatment for obesity by selectively delivering particles into the distal portion of the left gastric artery
TWI491409B (zh) * 2013-06-25 2015-07-11 Univ Nat Taiwan Science Tech 外用型超音波微氣泡對比劑
GB2521997A (en) * 2013-09-06 2015-07-15 Biocompatibles Uk Ltd Radiopaque polymers
GB2519738A (en) 2013-09-06 2015-05-06 Biocompatibles Uk Ltd Radiopaque polymers
JP6700634B2 (ja) * 2013-09-16 2020-05-27 バイオコンパティブルズ ユーケー リミテッド 油性組成物
US9408916B2 (en) 2013-09-19 2016-08-09 Microvention, Inc. Polymer films
WO2015042461A1 (en) * 2013-09-19 2015-03-26 Microvention, Inc. Polymer particles
CA2929235C (en) 2013-11-08 2018-07-17 Terumo Corporation Polymer particles
EP3083658B1 (en) 2013-12-18 2019-05-08 President and Fellows of Harvard College Crp capture/detection of gram positive bacteria
KR101647187B1 (ko) * 2014-07-17 2016-08-10 단국대학교 천안캠퍼스 산학협력단 신규한 온도감응성 및 양이온성 공중합체 및 이의 용도
WO2016154592A1 (en) 2015-03-26 2016-09-29 Microvention, Inc. Embiolic particles
WO2016167977A1 (en) * 2015-04-14 2016-10-20 Mayo Foundation For Medical Education And Research Methods and materials for delivering agents to liver tissue
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
KR101613824B1 (ko) * 2015-09-01 2016-04-19 김창보 장 검사용 의료 보조물
US10376469B2 (en) * 2016-02-17 2019-08-13 Biosphere Medical, Inc. Microspheres containing therapeutic agents and related methods of use
CN115137870B (zh) 2016-03-14 2024-05-10 生物相容性英国公司 包含颗粒的乳液
KR101698003B1 (ko) * 2016-06-20 2017-01-19 여오영 퀴닌 염 현탁액을 포함하는 항암 치료를 위한 국소 투여용 주사제 조성물
WO2018064390A1 (en) 2016-09-28 2018-04-05 Microvention, Inc. Polymer particles
RU2646832C1 (ru) * 2016-10-05 2018-03-07 Андрей Александрович Дунаев Способ получения полимерных микросфер для эмболизации и химиоэмболизации
CN106822983B (zh) * 2016-12-29 2020-09-15 苏州恒瑞迦俐生生物医药科技有限公司 一种用于微创介入疗法治疗肿瘤疾病的可显影栓塞微球及其制备方法
JP6620288B2 (ja) * 2017-10-25 2019-12-18 メディギア・インターナショナル株式会社 生体分解性及び生体代謝性の腫瘍封止剤
CN111436221B (zh) * 2017-12-08 2023-08-29 株式会社Lg新能源 二次电池电极用粘合剂和组合物、二次电池电极和二次电池、以及二次电池电极的制造方法
US11590080B2 (en) 2017-12-18 2023-02-28 C.R. Bard, Inc. Drug-loaded biodegradable microbead compositions including drug-containing vesicular agents
AU2018390560B2 (en) 2017-12-18 2024-09-19 C. R. Bard, Inc. Drug-loaded microbead compositions, embolization compositions and associated methods
KR20190081963A (ko) * 2017-12-29 2019-07-09 광주과학기술원 조영제용 생체 적합성 고분자 복합체 및 이를 포함하는 조영제
KR102076518B1 (ko) * 2018-02-08 2020-02-13 서강대학교산학협력단 수용성 항암제를 담지하는 마이크로버블을 포함하는 간동맥색전술용 조성물 및 그 제조방법
US20200368171A1 (en) * 2019-05-23 2020-11-26 Microvention, Inc. Particles
JP7148561B2 (ja) 2020-03-16 2022-10-05 日立建機株式会社 転圧車両
CN112972754B (zh) * 2021-02-24 2022-07-19 苏州微尺度科技有限公司 一种可视化岩藻多糖栓塞微球及其制备方法
KR102615727B1 (ko) * 2021-04-28 2023-12-20 주식회사 넥스트바이오메디컬 분해시간 조절이 가능한 색전용 수화겔 및 이의 제조방법
RU2768142C1 (ru) * 2021-06-07 2022-03-23 Федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования "Российская медицинская академия непрерывного профессионального образования" Министерства здравоохранения Российской Федерации (ФГБОУ ДПО РМАНПО Минздрава России) Способ определения нецелевой эмболизации маточных артерий
CN114042044B (zh) * 2021-11-26 2023-06-16 上海应用技术大学 一种可示踪的聚乳酸/利福平载药微球及其制备方法
CN114288461B (zh) * 2021-12-17 2022-11-25 上海市第一人民医院 一种多功能栓塞物的制备和同步修饰方法
CN114262279B (zh) * 2021-12-30 2022-12-16 上海汇禾医疗科技有限公司 一种x射线可显影分子、栓塞微球及其制备方法
CN115634322A (zh) * 2022-09-21 2023-01-24 海南普利制药股份有限公司 一种可显影的医用高分子复合材料及其制备方法

Family Cites Families (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US499188A (en) * 1893-06-06 Territory
US3673125A (en) 1969-05-10 1972-06-27 Kanegafuchi Spinning Co Ltd Method of producing polyvinyl acetal porous articles
US3919411A (en) 1972-01-31 1975-11-11 Bayvet Corp Injectable adjuvant and compositions including such adjuvant
JPS49108168A (pt) 1973-02-16 1974-10-15
JPS5350290Y2 (pt) 1973-11-16 1978-12-02
US4197846A (en) 1974-10-09 1980-04-15 Louis Bucalo Method for structure for situating in a living body agents for treating the body
JPS5350290A (en) 1976-10-18 1978-05-08 Sumitomo Chem Co Ltd Preparation f hydrogel
FR2378808A1 (fr) 1977-01-28 1978-08-25 Mar Pha Etu Expl Marques Nouveaux copolymeres hydrophiles a base de n-(tris(hydroxy-methyl)methyl)acrylamide ou de n-(tris (hydroxymethyl)methyl)methacrylamide, leur preparation et leur emploi dans les techniques de separation
JPS5437994A (en) 1977-08-31 1979-03-20 Kikukawa Iron Works Device for grinding rolled iron plate
FR2412960A1 (fr) * 1977-12-20 1979-07-20 Radant Etudes Dephaseur hyperfrequence et son application au balayage electronique
CS204190B1 (en) 1978-02-22 1981-03-31 Jaroslav Drobnik Activation method for hydrxyl groups containing insoluble carriers
DE2935712A1 (de) 1978-09-07 1980-03-20 Sumitomo Chemical Co Verfahren zum herstellen von stark absorbierenden polymerisaten
US4314032A (en) 1978-10-26 1982-02-02 Kureha Kagaku Kogyo Kabushiki Kaisha Crosslinked polyvinyl alcohol gel
US4268495A (en) 1979-01-08 1981-05-19 Ethicon, Inc. Injectable embolization and occlusion solution
US4306031A (en) 1979-08-14 1981-12-15 Mitsubishi Chemical Industries Limited Weakly acidic cation exchange resin and process for producing same
FR2482112B1 (fr) 1980-05-09 1985-06-07 Pharmindustrie Nouveaux copolymeres hydrophiles a base de n-(tris (hydroxymethyl) methyl) acrylamide, procedes pour leur preparation, gels aqueux desdits copolymeres et leur utilisation comme echangeurs d'ions
GB2088392B (en) 1980-12-03 1984-05-02 Sumitomo Chemical Co Production of hydrogels
JPS57128709A (en) 1981-02-03 1982-08-10 Sumitomo Chem Co Ltd Preparation of hydrogel
JPS57128709U (pt) 1981-02-05 1982-08-11
US4622362A (en) 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4500658A (en) 1983-06-06 1985-02-19 Austenal International, Inc. Radiopaque acrylic resin
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4480044A (en) 1984-02-01 1984-10-30 Corning Glass Works High expansion glass-ceramic articles
JPS615995A (ja) 1984-06-20 1986-01-11 株式会社リコー 製本機能を備えた複写機
GB8418772D0 (en) 1984-07-24 1984-08-30 Geistlich Soehne Ag Chemical substances
US4680171A (en) 1985-03-15 1987-07-14 William Shell Visualization of a bloodstream circulation with biodegradable microspheres
US5186922A (en) 1985-03-15 1993-02-16 See/Shell Biotechnology, Inc. Use of biodegradable microspheres labeled with imaging energy constrast materials
US6727405B1 (en) 1986-04-09 2004-04-27 Genzyme Corporation Transgenic animals secreting desired proteins into milk
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPS6317904A (ja) 1986-07-09 1988-01-25 Mitsubishi Chem Ind Ltd 多孔質架橋ポリビニルアルコ−ル粒子の製造法
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4795741A (en) 1987-05-06 1989-01-03 Biomatrix, Inc. Compositions for therapeutic percutaneous embolization and the use thereof
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
CA1329800C (en) 1987-12-29 1994-05-24 Hiroaki Takayanagi Composite separating agent
JPH02503205A (ja) 1988-02-12 1990-10-04 ドゥ　ツァープフェル，ブリギット 医用及びパラメディカル用の架橋親水性コポリマー
JPH064713B2 (ja) 1988-07-22 1994-01-19 テルモ株式会社 生体適合性材料
US5843156A (en) 1988-08-24 1998-12-01 Endoluminal Therapeutics, Inc. Local polymeric gel cellular therapy
JPH0286838A (ja) 1988-09-22 1990-03-27 Terumo Corp 水不溶性ヒドロゲルおよびその製造方法
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5092883A (en) 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
WO1990008756A1 (de) 1989-01-27 1990-08-09 MERCK Patent Gesellschaft mit beschränkter Haftung Biphenylylethane
FR2645866B1 (fr) 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
CA2017570C (en) 1989-05-31 2000-12-19 James R. Gross Porous structure of an absorbent polymer
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5147937A (en) 1990-03-22 1992-09-15 Rohm And Haas Company Process for making controlled, uniform-sized particles in the 1 to 50 micrometer range
ATE130517T1 (de) 1990-08-08 1995-12-15 Takeda Chemical Industries Ltd Intravaskulär embolisierendes mittel mit gehalt an einem die angiogenesis hemmenden stoff.
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5117577A (en) 1990-11-05 1992-06-02 Gary Burghoff Fish attractor device
JPH06507904A (ja) 1991-05-23 1994-09-08 イマアーレクス・フアーマシユーチカル・コーポレーシヨン 磁気共鳴画像形成用の油脂可溶化合物
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
US5554658A (en) 1991-08-06 1996-09-10 Rosenblatt; Solomon Injection molded PVA Sponge
DE69208976T2 (de) 1991-08-23 1997-04-17 Nippon Shokubai Co. Ltd., Osaka Biologisch abbaubares, hydrophiles, vernetztes Polymer, Verfahren zu seiner Herstellung und seine Verwendung
JPH082985B2 (ja) 1991-08-26 1996-01-17 東京シート株式会社 高密度表層付ウレタンフォーム成形品の製造方法
JP3356447B2 (ja) 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
US5288931A (en) 1991-12-06 1994-02-22 Genentech, Inc. Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation
PT627911E (pt) 1992-02-28 2001-04-30 Univ Texas Hidrogeis biodegradaveis fotopolimerizaveis como materiais de contacto de tecidos e veiculos de libertacao controlada
JPH0656676A (ja) 1992-08-05 1994-03-01 Hori Shinichi 血管塞栓用懸濁液
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5654006A (en) 1993-02-12 1997-08-05 Mayo Foundation For Medical Education And Research Condensed-phase microparticle composition and method
US5629327A (en) 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
ES2113094T3 (es) 1993-03-09 1998-04-16 Epic Therapeutics Inc Las microparticulas macromoleculares y metodos de obtencion.
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
WO1994021299A1 (en) 1993-03-19 1994-09-29 Medinvent A composition and a method for tissue augmentation
DE69435342D1 (de) 1993-07-19 2011-05-05 Angiotech Pharm Inc Anti-Angiogene Mittel und Verfahren zu deren Verwendung
US5716981A (en) 1993-07-19 1998-02-10 Angiogenesis Technologies, Inc. Anti-angiogenic compositions and methods of use
US20030203976A1 (en) 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US5639872A (en) 1993-07-27 1997-06-17 Hybridon, Inc. Human VEGF-specific oligonucleotides
GB2281861B (en) 1993-09-21 1997-08-20 Johnson & Johnson Medical Bioabsorbable wound implant materials containing microspheres
DE69432867T2 (de) 1993-11-18 2004-04-22 Sirtex Medical Ltd., Burswood Zubereitung mit gesteuerter freisetzung
US5698443A (en) 1995-06-27 1997-12-16 Calydon, Inc. Tissue specific viral vectors
US5830686A (en) 1994-01-13 1998-11-03 Calydon Tissue-specific enhancer active in prostate
US5583162A (en) 1994-06-06 1996-12-10 Biopore Corporation Polymeric microbeads and method of preparation
US5451406A (en) 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
UA10911C2 (uk) 1994-08-10 1996-12-25 Мале Впроваджувальне Підприємство "Іhтерфалл" Біосумісhий гідрогель
WO1996011671A1 (en) 1994-10-12 1996-04-25 Focal, Inc. Targeted delivery via biodegradable polymers
US6099864A (en) 1994-12-02 2000-08-08 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration In situ activation of microcapsules
US5955108A (en) 1994-12-16 1999-09-21 Quadrant Healthcare (Uk) Limited Cross-linked microparticles and their use as therapeutic vehicles
US5716404A (en) 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering
CA2207667A1 (en) 1995-01-27 1996-08-01 Scimed Life Systems, Inc. Embolizing system
US5855610A (en) 1995-05-19 1999-01-05 Children's Medical Center Corporation Engineering of strong, pliable tissues
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US5888546A (en) 1995-08-28 1999-03-30 The Regents Of The University Of California Embolic material for endovascular occlusion of abnormal vasculature and method for using the same
US5985177A (en) 1995-12-14 1999-11-16 Shiseido Co., Ltd. O/W/O type multiple emulsion and method of preparing the same
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
DE19601699A1 (de) 1996-01-18 1997-07-24 Wacker Chemie Gmbh Redispergierbare Polymerisatpulver und daraus erhältliche wäßrige Polymerisat-Dispersionen
US5785977A (en) 1996-02-07 1998-07-28 Breithbarth; Richard Non-metallic microparticle carrier materials
US5611344A (en) 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
NZ331734A (en) 1996-03-27 2000-01-28 Novartis Ag Process for manufacture of a porous polymer comprising dispersing a porogen in a monomer phase where the monomer has at least one perfluoropolyether unit and the porogen is a substituted polyalkleneglycol
US5823198A (en) 1996-07-31 1998-10-20 Micro Therapeutics, Inc. Method and apparatus for intravasculer embolization
US5925683A (en) 1996-10-17 1999-07-20 Target Therapeutics, Inc. Liquid embolic agents
US6083484A (en) 1996-10-17 2000-07-04 Molecular Biosystems, Inc. Microparticles stabilized by polynuclear chromium complexes and their use as ultrasound contrast agents
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
CA2288292A1 (en) * 1997-04-24 1998-10-29 Nycomed Imaging As Embolus therapy using insoluble microparticles or vesicles containing contrast agents
US5861149A (en) 1997-06-04 1999-01-19 Polyheal Ltd. Methods for wound treatment
US6048908A (en) 1997-06-27 2000-04-11 Biopore Corporation Hydrophilic polymeric material
AU9313298A (en) 1997-09-04 1999-03-22 Point Biomedical Corporation Injectable tissue reconstruction material
WO1999012577A1 (en) 1997-09-05 1999-03-18 Nycomed Imaging As Polymer particles made of polyvinyl alcohol and comprising a contrast agent for chemoembolization
US5931248A (en) * 1997-09-15 1999-08-03 The United States Of America As Represented By The Secretary Of The Navy Durable roll-stabilizing keel system for hovercraft
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6565885B1 (en) 1997-09-29 2003-05-20 Inhale Therapeutic Systems, Inc. Methods of spray drying pharmaceutical compositions
US6015541A (en) * 1997-11-03 2000-01-18 Micro Therapeutics, Inc. Radioactive embolizing compositions
GB9727518D0 (en) 1997-12-31 1998-02-25 Nycomed Imaging As Use
WO1999044643A1 (en) 1998-03-06 1999-09-10 Biosepra Medical Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US5891470A (en) 1998-04-17 1999-04-06 Advanced Polymer Systems, Inc. Softgel formulation containing retinol
US6224794B1 (en) 1998-05-06 2001-05-01 Angiotech Pharmaceuticals, Inc. Methods for microsphere production
US6165193A (en) 1998-07-06 2000-12-26 Microvention, Inc. Vascular embolization with an expansible implant
EP1109563A4 (en) 1998-08-04 2009-07-22 Madash Llp HEAT-SENSITIVE HYDROGELS WITH MODIFIED TERMINATION
US6315709B1 (en) 1998-08-07 2001-11-13 Stereotaxis, Inc. Magnetic vascular defect treatment system
CA2248592A1 (en) 1998-08-31 2000-02-29 Christopher D. Batich Microspheres for use in the treatment of cancer
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US20040047804A1 (en) * 1998-10-29 2004-03-11 The General Hospital Corporation, A Massachusetts Corporation Enhanced radiation therapy
US6955661B1 (en) 1999-01-25 2005-10-18 Atrium Medical Corporation Expandable fluoropolymer device for delivery of therapeutic agents and method of making
US6296604B1 (en) 1999-03-17 2001-10-02 Stereotaxis, Inc. Methods of and compositions for treating vascular defects
US6710126B1 (en) 1999-11-15 2004-03-23 Bio Cure, Inc. Degradable poly(vinyl alcohol) hydrogels
KR100335866B1 (ko) 2000-01-06 2002-05-10 박호군 폴리아세트산비닐 코어/폴리비닐알코올 외피의 2중 구조를갖는 미세구형 색전재료 및 그의 제조방법
US6652883B2 (en) 2000-03-13 2003-11-25 Biocure, Inc. Tissue bulking and coating compositions
JP4871476B2 (ja) * 2000-03-13 2012-02-08 バイオコンパティブルズ ユーケー リミテッド 塞栓組成物
ATE327262T1 (de) 2000-03-13 2006-06-15 Biocure Inc Zusammensetzungen zur erhöhung des gewebevolumens und beschichtungszusammensetzungen
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
AU2001249221A1 (en) 2000-03-20 2001-10-03 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
ES2254042T3 (es) * 2000-03-24 2008-03-16 Biosphere Medical, Inc. Microesferas para embolizacion activa.
US20030212022A1 (en) 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
FR2808026B1 (fr) 2000-04-25 2002-06-14 Alexandre Laurent Biomateriau a base de polymere hydrophile presentant un signal specifique en imagerie par resonance magnetique et procede de preparation d'un tel biomateriau
US6537569B2 (en) 2001-02-14 2003-03-25 Microvention, Inc. Radiation cross-linked hydrogels
WO2002100444A1 (en) 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
US6488952B1 (en) 2001-08-28 2002-12-03 John P. Kennedy Semisolid therapeutic delivery system and combination semisolid, multiparticulate, therapeutic delivery system
US6911219B2 (en) 2001-09-27 2005-06-28 Surgica Corporation Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them
EP1490120B1 (en) 2002-03-29 2009-11-11 Boston Scientific Limited Embolization
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US8012454B2 (en) * 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US20040156781A1 (en) * 2002-10-15 2004-08-12 Porter Christopher H. Polymeric materials for site specific delivery to the body
US7588825B2 (en) 2002-10-23 2009-09-15 Boston Scientific Scimed, Inc. Embolic compositions
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
US20040091553A1 (en) 2002-11-12 2004-05-13 West Agro, Inc Composition and method for mammary disinfection during winter conditions
CN106267325B (zh) 2003-02-12 2019-09-24 生物相容英国有限公司 一种组合物的生产方法
US20040161466A1 (en) 2003-02-14 2004-08-19 Biocompatibles Uk Limited Chemoembolisation
US20060057198A1 (en) 2003-02-21 2006-03-16 Biocompatibles Uk Limited Drug delivery from embolic agents
MXPA05010002A (es) 2003-03-24 2006-03-10 Biosphere Medical Inc Embolizacion temporal utilizando polimeros termosensibles inversos.
WO2005044224A2 (en) 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
JP2004345966A (ja) 2003-05-20 2004-12-09 Clinical Supply:Kk 血管塞栓用懸濁液及びその製造方法
JP4342219B2 (ja) 2003-06-13 2009-10-14 株式会社ブリヂストン 無機物鋳型配合組成物およびこれを用いたタイヤ用モールドの製造方法
CA2555866A1 (en) 2004-02-16 2005-08-25 Proteosys Ag Diagnostic markers for cancer
WO2005087193A2 (en) * 2004-03-11 2005-09-22 Biocompatibles Uk Limited Chemoembolisation involving an anthracycline compound
WO2006013376A2 (en) 2004-08-04 2006-02-09 Biocompatibles Uk Limited Drug delivery of a cox inhibitor from embolic agents
EP2269580A3 (en) 2004-09-07 2011-11-09 Biocompatibles UK Limited Compositions comprising camptothecins in microspheres
JP4885866B2 (ja) 2004-10-25 2012-02-29 セロノヴァ バイオサイエンスィズ ジャーマニー ゲーエムベーハー 治療適用および／または診断適用のための充填可能なポリホスファゼン含有粒子、ならびにその調製方法および使用方法
CN101237857A (zh) 2005-05-09 2008-08-06 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
JP4180582B2 (ja) 2005-05-16 2008-11-12 富士通株式会社 記憶装置
US7210338B2 (en) 2005-07-29 2007-05-01 Honda Motor Co., Ltd. Valve testing device having integrated purge circuit and method of valve testing
ATE468541T1 (de) 2005-08-10 2010-06-15 Nxp Bv Prüfen einer integrierten schaltung, die geheiminformationen enthält
US20090220627A1 (en) 2005-09-16 2009-09-03 Kiyotaka Hasegawa Novel vascular endothelial growth factor expression inhibitors
US20080305176A1 (en) 2006-01-24 2008-12-11 Biocompatibles Uk Limited Process For Loading Polymer Particles With Drug
US20080033366A1 (en) 2006-01-30 2008-02-07 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
EP2368581B1 (en) 2006-01-30 2018-08-29 Biosphere Medical, Inc. Porous intravascular embolization particles and related methods
GB0619869D0 (en) 2006-10-07 2006-11-15 Regentec Ltd Porous particles
JP5000969B2 (ja) 2006-10-13 2012-08-15 株式会社リコー カラー画像形成装置及び色ずれ補正方法
JP2012507562A (ja) 2008-10-30 2012-03-29 ダビド リウ 微小球性多孔質生体適合性足場並びにその製造方法及び装置
EP2351779B1 (en) 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
US9872655B2 (en) 2012-03-30 2018-01-23 Siemens Aktiengesellschaft PAE treatment for BPH
JP6352031B2 (ja) 2014-04-14 2018-07-04 株式会社ブリヂストン ピアシング装置及びピアシング方法
JP6508139B2 (ja) 2016-06-30 2019-05-08 カシオ計算機株式会社 情報処理装置及びプログラム

Also Published As

Publication number Publication date
US8709384B2 (en) 2014-04-29
US20060251582A1 (en) 2006-11-09
MX2007013914A (es) 2008-02-22
US9040022B2 (en) 2015-05-26
CA2607228C (en) 2014-09-16
US20120189552A1 (en) 2012-07-26
WO2006119968A3 (en) 2007-03-15
JP6282799B2 (ja) 2018-02-21
EP1879554B2 (en) 2018-03-07
JP6261550B2 (ja) 2018-01-17
AU2006245950A1 (en) 2006-11-16
JP2016034967A (ja) 2016-03-17
AU2006245950B2 (en) 2012-01-12
CA2607228A1 (en) 2006-11-16
EP2484344B1 (en) 2016-02-10
US20150314020A1 (en) 2015-11-05
JP2013100345A (ja) 2013-05-23
KR101429774B1 (ko) 2014-10-02
US20140314678A1 (en) 2014-10-23
JP2008540478A (ja) 2008-11-20
US10293063B2 (en) 2019-05-21
EP1879554A2 (en) 2008-01-23
ES2568782T3 (es) 2016-05-04
US8226926B2 (en) 2012-07-24
CN104815331A (zh) 2015-08-05
KR20140090270A (ko) 2014-07-16
EP3085362B1 (en) 2021-01-13
EP3085362A1 (en) 2016-10-26
EP2484344A3 (en) 2012-09-12
WO2006119968A2 (en) 2006-11-16
EP2484344A2 (en) 2012-08-08
EP1879554B1 (en) 2015-03-04
CN101237857A (zh) 2008-08-06
KR20080018185A (ko) 2008-02-27
BRPI0608766A2 (pt) 2010-11-23

Similar Documents

Publication Publication Date Title
BRPI0608766A8 (pt) microsfera substancialmente esférica, composição, e, métodos para administração de medicamento e para embolização ativa em um mamífero
BR112012024590A2 (pt) métodos de reforço da liberação de fármaco e da eficácia de agentes terapêuticos
WO2004105782A3 (en) Drug delivery systems for tumor targeting ngr-molecules and uses thereof
ATE533493T1 (de) Schäumende pharmazeutische zusammensetzungen und verfahren zur behandlung einer erkrankung
MX2009002893A (es) Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
JP2014518275A5 (pt)
AU2001245988A1 (en) Microspheres for active embolization
JP2013520504A5 (pt)
WO2010015260A2 (en) Administration by infusion for the treatment of ischemic effects
BR0316364A (pt) Combinação de terapia do câncer com um composto anticâncer ativado com gst e uma outra terapia anticâncer
BR0316057A (pt) Métodos de tratar, controlar ou prevenir um câncer especìfico e uma doença associada com angiogênese indesejada e de reduzir ou evitar um efeito adverso associado com a administração de um segundo ingrediente ativo e com a terapia de radiação, terapia hormonal, terapia biológica ou imunoterapia em um paciente sofrendo de um câncer especìfico, composição farmacêutica e kit
BRPI0411079A (pt) composições farmacêuticas compreendendo atorvastatina, fabricadas sem granulação
BRPI0511800A (pt) tratamento com irinotecano (cpt-11) e um inibidor de egfr
BR0315573A (pt) Método para tratar, prevenir, controlar e/ou modificar dor em um paciente e composição farmacêutica
BRPI0416275A (pt) métodos de tratar, controlar ou prevenir um cáncer especìfico e uma doença associada com angiogênese indesejada
BR112015007360A2 (pt) composição farmacêutica, e, método para a preparação de uma droga de combinação
Rascón-Martínez et al. Advantages of ketamine as a perioperative analgesic
WO2007087557A3 (en) Surface-layer protein coated microspheres and uses thereof
BRPI0508959A (pt) uso de azd2171 ou de um sal do mesmo farmaceuticamente aceitável, uso de sal maleato de azd2171 e oxaliplatina, composição farmacêutica, kit, e, método para a produção de um efeito antiangiogênico e/ou de redução da permeabilidade vascular em um animal de sangue quente
JP2011518165A (ja) 疼痛、炎症、ニューロンもしくは血管損傷に対する生物学的マーカーおよび治療への応答、ならびにその使用方法
BR112015009504A2 (pt) inibidores de rock
Galimberti et al. Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study
Chen et al. Percutaneous sclerotherapy of juvenile nasopharyngeal angiofibroma using fibrin glue combined with OK-432 and bleomycin
CN101181230A (zh) 一种治疗实体肿瘤的雌二醇氮芥缓释植入剂
Love et al. Nontraditional analgesic agents

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 15A ANUIDADE.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2622 DE 06-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.