US6479484B1
(en)
|
1997-11-21 |
2002-11-12 |
Euro-Celtique S.A. |
Substituted 2-aminoacetamides and the use thereof
|
GB9727523D0
(en)
|
1997-12-31 |
1998-02-25 |
Pharmacia & Upjohn Spa |
Alpha-aminoamide derivatives useful as analgesic agents
|
CA2319195A1
(en)
*
|
1998-02-02 |
1999-08-05 |
Trustees Of Tufts College |
Method of regulating glucose metabolism, and reagents related thereto
|
AU2007202745B2
(en)
*
|
1998-02-02 |
2010-11-18 |
1149336 Ontario, Inc. |
Method of regulating glucose metabolism, and reagents related thereto
|
DE19823831A1
(de)
*
|
1998-05-28 |
1999-12-02 |
Probiodrug Ges Fuer Arzneim |
Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen
|
DE19828113A1
(de)
|
1998-06-24 |
2000-01-05 |
Probiodrug Ges Fuer Arzneim |
Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
|
DE19828114A1
(de)
|
1998-06-24 |
2000-01-27 |
Probiodrug Ges Fuer Arzneim |
Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
|
DE19834591A1
(de)
*
|
1998-07-31 |
2000-02-03 |
Probiodrug Ges Fuer Arzneim |
Verfahren zur Steigerung des Blutglukosespiegels in Säugern
|
CO5150173A1
(es)
*
|
1998-12-10 |
2002-04-29 |
Novartis Ag |
Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
|
US6281211B1
(en)
|
1999-02-04 |
2001-08-28 |
Euro-Celtique S.A. |
Substituted semicarbazides and the use thereof
|
WO2000053171A1
(en)
*
|
1999-03-05 |
2000-09-14 |
Molteni L. E C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. |
Use of metformin in the preparation of pharmaceutical compositions capable of inhibiting the enzyme dipeptidyl peptidase iv
|
GB9906714D0
(en)
*
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for improving fertility
|
GB9906715D0
(en)
*
|
1999-03-23 |
1999-05-19 |
Ferring Bv |
Compositions for promoting growth
|
US6110949A
(en)
*
|
1999-06-24 |
2000-08-29 |
Novartis Ag |
N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
US6617340B1
(en)
|
1999-07-29 |
2003-09-09 |
Novartis Ag |
N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
DE19940130A1
(de)
|
1999-08-24 |
2001-03-01 |
Probiodrug Ges Fuer Arzneim |
Neue Effektoren der Dipeptidyl Peptidase IV zur topischen Anwendung
|
US6211384B1
(en)
|
1999-08-30 |
2001-04-03 |
Novartis Pharmaceuticals Corp. |
Methods for the acylation of amine compounds
|
GB9925264D0
(en)
*
|
1999-10-26 |
1999-12-29 |
Zeneca Ltd |
Chemical compounds
|
JP2003535034A
(ja)
*
|
1999-11-12 |
2003-11-25 |
ギルフォード ファーマシューティカルズ インコーポレイテッド |
ジペプチジルペプチダーゼiv阻害剤並びにジペプチジルペプチダーゼiv阻害剤の製造及び使用法
|
GB9928330D0
(en)
|
1999-11-30 |
2000-01-26 |
Ferring Bv |
Novel antidiabetic agents
|
KR20020063260A
(ko)
*
|
1999-12-23 |
2002-08-01 |
노파르티스 아게 |
당 대사 장애를 치료하기 위한 혈당강하제의 용도
|
US6380398B2
(en)
|
2000-01-04 |
2002-04-30 |
Novo Nordisk A/S |
Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV
|
US20080076811A1
(en)
*
|
2000-01-21 |
2008-03-27 |
Bork Balkan |
Combinations comprising depeptidypeptidase-iv inhibitors and antidiabetic agents
|
DE122008000018I1
(de)
*
|
2000-01-21 |
2008-08-14 |
Novartis Pharma Ag |
Zusammensetzungen bestehend aus Dipeptidylpeptidase-IV Inhibitoren und Antidiabetica
|
AU2001228309A1
(en)
*
|
2000-01-24 |
2001-08-07 |
Novo-Nordisk A/S |
N-substituted 2-cyanopyroles and -pyrrolines which are inhibitors of the enzyme dpp-iv
|
AU2001233622A1
(en)
*
|
2000-02-25 |
2001-09-03 |
Novo-Nordisk A/S |
Inhibition of beta cell degeneration
|
US7064145B2
(en)
*
|
2000-02-25 |
2006-06-20 |
Novo Nordisk A/S |
Inhibition of beta cell degeneration
|
US6395767B2
(en)
*
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
WO2001072290A2
(en)
*
|
2000-03-31 |
2001-10-04 |
Probiodrug Ag |
Method for the improvement of islet signaling in diabetes mellitus and for its prevention
|
GB0010183D0
(en)
*
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
GB0010188D0
(en)
|
2000-04-26 |
2000-06-14 |
Ferring Bv |
Inhibitors of dipeptidyl peptidase IV
|
US6432969B1
(en)
|
2000-06-13 |
2002-08-13 |
Novartis Ag |
N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
|
TW583185B
(en)
*
|
2000-06-13 |
2004-04-11 |
Novartis Ag |
N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
|
US7078397B2
(en)
|
2000-06-19 |
2006-07-18 |
Smithkline Beecham Corporation |
Combinations of dipeptidyl peptidase IV inhibitors and other antidiabetic agents for the treatment of diabetes mellitus
|
GB0014969D0
(en)
|
2000-06-19 |
2000-08-09 |
Smithkline Beecham Plc |
Novel method of treatment
|
PL360856A1
(en)
|
2000-07-04 |
2004-09-20 |
Novo Nordisk A/S |
Purine-2,6-diones which are inhibitors of the enzyme dipeptidyl peptidase iv (dpp-iv)
|
WO2002006245A1
(en)
*
|
2000-07-05 |
2002-01-24 |
Synaptic Pharmarceutical Corporation |
Selective melanin concentrating hormone-1 (mch1) receptor antagonists and uses thereof
|
NZ524618A
(en)
*
|
2000-08-10 |
2004-08-27 |
Mitsubishi Pharma Corp |
Proline derivatives and use thereof as drugs
|
PE20020617A1
(es)
|
2000-08-22 |
2002-08-05 |
Novartis Ag |
Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
|
DE60135764D1
(de)
|
2000-10-06 |
2008-10-23 |
Mitsubishi Tanabe Pharma Corp |
Stickstoffhaltige, fünfgliedrige ringverbindungen
|
EP1891948A1
(en)
|
2000-10-27 |
2008-02-27 |
Probiodrug AG |
Treatment of neurological and neuropsychological disorders
|
US7132104B1
(en)
|
2000-10-27 |
2006-11-07 |
Probiodrug Ag |
Modulation of central nervous system (CNS) dipeptidyl peptidase IV (DPIV) -like activity for the treatment of neurological and neuropsychological disorders
|
TWI243162B
(en)
*
|
2000-11-10 |
2005-11-11 |
Taisho Pharmaceutical Co Ltd |
Cyanopyrrolidine derivatives
|
UA74023C2
(en)
*
|
2000-11-10 |
2005-10-17 |
Taisho Pharmaceutical Co Ltd |
Cyanopyrrolidine derivatives
|
EP1354882A1
(en)
*
|
2000-12-27 |
2003-10-22 |
Kyowa Hakko Kogyo Co., Ltd. |
Dipeptidyl peptidase iv inhibitor
|
DE10100053A1
(de)
*
|
2001-01-02 |
2002-08-22 |
Keyneurotek Ag I G |
Verwendung von Enzyminhibitoren der Dipeptidylpeptidase IV sowie der Aminopeptidase N und pharmazeutischen Zubereitungen daraus zur Prävention und/oder Therapie Ischämie-bedingter akuter und chronischer neurodegenerativer Prozesse und Erkrankungen
|
WO2002067918A1
(fr)
*
|
2001-02-27 |
2002-09-06 |
Banyu Pharmaceutical Co., Ltd. |
Nouveau derive de diallylmethylamine
|
US7026316B2
(en)
|
2001-03-27 |
2006-04-11 |
Merck & Co., Inc. |
Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
FR2822826B1
(fr)
*
|
2001-03-28 |
2003-05-09 |
Servier Lab |
Nouveaux derives sulfonyles d'alpha-amino-acides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
US6890905B2
(en)
|
2001-04-02 |
2005-05-10 |
Prosidion Limited |
Methods for improving islet signaling in diabetes mellitus and for its prevention
|
DE60224189T2
(de)
|
2001-06-20 |
2008-12-11 |
Merck & Co., Inc. |
Dipeptidylpeptidase-hemmer zur behandlung von diabetes
|
ES2257555T3
(es)
|
2001-06-20 |
2006-08-01 |
MERCK & CO., INC. |
Inhibidores de dipeptidilpeptidasa para el tratamiento de la diabetes.
|
DE10150203A1
(de)
|
2001-10-12 |
2003-04-17 |
Probiodrug Ag |
Peptidylketone als Inhibitoren der DPIV
|
US7196201B2
(en)
|
2001-06-27 |
2007-03-27 |
Smithkline Beecham Corporation |
Pyrrolidines as dipeptidyl peptidase inhibitors
|
ES2291477T3
(es)
*
|
2001-06-27 |
2008-03-01 |
Smithkline Beecham Corporation |
Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
|
ES2339813T3
(es)
|
2001-06-27 |
2010-05-25 |
Glaxosmithkline Llc |
Fluoropirrolidinas como inhibidores de dipeptidil peptidasas.
|
US7368421B2
(en)
|
2001-06-27 |
2008-05-06 |
Probiodrug Ag |
Use of dipeptidyl peptidase IV inhibitors in the treatment of multiple sclerosis
|
US20030130199A1
(en)
|
2001-06-27 |
2003-07-10 |
Von Hoersten Stephan |
Dipeptidyl peptidase IV inhibitors and their uses as anti-cancer agents
|
UA74912C2
(en)
|
2001-07-06 |
2006-02-15 |
Merck & Co Inc |
Beta-aminotetrahydroimidazo-(1,2-a)-pyrazines and tetratriazolo-(4,3-a)-pyrazines as inhibitors of dipeptylpeptidase for the treatment or prevention of diabetes
|
AU2002333374B2
(en)
|
2001-09-03 |
2007-03-22 |
Newron Pharmaceuticals S.P.A. |
Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use
|
US6844316B2
(en)
|
2001-09-06 |
2005-01-18 |
Probiodrug Ag |
Inhibitors of dipeptidyl peptidase I
|
KR20040033048A
(ko)
|
2001-09-14 |
2004-04-17 |
미츠비시 웰파마 가부시키가이샤 |
티아졸리딘 유도체 및 이의 약학적 용도
|
US6861440B2
(en)
|
2001-10-26 |
2005-03-01 |
Hoffmann-La Roche Inc. |
DPP IV inhibitors
|
WO2003045228A2
(en)
|
2001-11-26 |
2003-06-05 |
Trustees Of Tufts College |
Methods for treating autoimmune disorders, and reagents related thereto
|
EP2316470A3
(en)
|
2001-11-26 |
2011-08-24 |
Trustees Of Tufts College |
Peptidomimetic inhibitors of post-proline cleaving enzymes
|
GB0129988D0
(en)
*
|
2001-12-14 |
2002-02-06 |
Ferring Bv |
Imidazolidineacetic acid derivatives
|
US6727261B2
(en)
|
2001-12-27 |
2004-04-27 |
Hoffman-La Roche Inc. |
Pyrido[2,1-A]Isoquinoline derivatives
|
ES2252656T3
(es)
|
2002-02-13 |
2006-05-16 |
F. Hoffmann-La Roche Ag |
Nuevos derivados de piridina y quinolina.
|
PL371678A1
(en)
|
2002-02-13 |
2005-06-27 |
F.Hoffmann-La Roche Ag |
Novel pyridin- and pyrimidin-derivatives
|
EA007434B1
(ru)
|
2002-02-28 |
2006-10-27 |
Прозидион Лимитед |
Ингибиторы dpiv на основе глутаминила
|
HUP0200849A2
(hu)
*
|
2002-03-06 |
2004-08-30 |
Sanofi-Synthelabo |
N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
|
JPWO2003095425A1
(ja)
*
|
2002-05-09 |
2005-09-15 |
大正製薬株式会社 |
シアノピロリジン誘導体
|
US6710040B1
(en)
|
2002-06-04 |
2004-03-23 |
Pfizer Inc. |
Fluorinated cyclic amides as dipeptidyl peptidase IV inhibitors
|
HUP0202001A2
(hu)
|
2002-06-14 |
2005-08-29 |
Sanofi-Aventis |
DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
|
WO2004007446A1
(ja)
*
|
2002-07-10 |
2004-01-22 |
Yamanouchi Pharmaceutical Co., Ltd. |
新規なアゼチジン誘導体又はその塩
|
US7208498B2
(en)
|
2002-07-15 |
2007-04-24 |
Merck & Co., Inc. |
Piperidino pyrimidine dipeptidyl peptidase inhibitors for the treatment of diabetes
|
TW200401635A
(en)
|
2002-07-23 |
2004-02-01 |
Yamanouchi Pharma Co Ltd |
2-Cyano-4-fluoropyrrolidine derivative or salt thereof
|
JP4542757B2
(ja)
*
|
2002-08-08 |
2010-09-15 |
武田薬品工業株式会社 |
縮合複素環化合物
|
US7547710B2
(en)
|
2002-08-08 |
2009-06-16 |
Takeda Pharmaceutical Company Limited |
Fused heterocyclic compounds as peptidase inhibitors
|
DK1528931T3
(da)
*
|
2002-08-09 |
2008-09-08 |
Prosidion Ltd |
Dipeptidylpeptidase-IV-inhibitorer til reduktion af hastigheden af kronisk vægtforögelse
|
JP3746063B2
(ja)
*
|
2002-08-29 |
2006-02-15 |
大正製薬株式会社 |
4−フルオロ−2−シアノピロリジン誘導体ベンゼンスルホン酸塩
|
US7262207B2
(en)
|
2002-09-19 |
2007-08-28 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
DE60315687T2
(de)
|
2002-10-07 |
2008-06-05 |
Merck & Co., Inc. |
Antidiabetische heterocyclische beta-aminoverbindungen als inhibitoren von dipeptidylpeptidase
|
ATE390416T1
(de)
|
2002-10-18 |
2008-04-15 |
Merck & Co Inc |
Heterozyklische beta-aminoverbindungen als inhibitoren des dipeptidylpeptidase zur behandlung bzw. prevention von diabetes
|
BR0315796A
(pt)
|
2002-11-07 |
2005-09-13 |
Merck & Co Inc |
Composto, composição farmacêutica, e, métodos para tratar diabetes, para tratar hiperglicemia, e para tratar obesidade em um mamìfero
|
ATE374766T1
(de)
|
2003-01-14 |
2007-10-15 |
Arena Pharm Inc |
1,2,3-trisubstituierte aryl- und heteroarylderivate als modulatoren des metabolismus zur vorbeugung und behandlung von metabolismus-bedingten krankheiten wie diabetes oder hyperglykämie
|
EP1438956A1
(en)
|
2003-01-16 |
2004-07-21 |
Newron Pharmaceuticals S.p.A. |
Alpha-aminoamide derivatives useful as antimigraine agents
|
JP4564952B2
(ja)
|
2003-01-17 |
2010-10-20 |
メルク・シャープ・エンド・ドーム・コーポレイション |
糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体
|
WO2004067509A1
(ja)
|
2003-01-31 |
2004-08-12 |
Sanwa Kagaku Kenkyusho Co., Ltd. |
ジペプチジルペプチダーゼivを阻害する化合物
|
JP2006516573A
(ja)
|
2003-01-31 |
2006-07-06 |
メルク エンド カムパニー インコーポレーテッド |
糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての3−アミノ−4−フェニルブタン酸誘導体
|
DE10308355A1
(de)
|
2003-02-27 |
2004-12-23 |
Aventis Pharma Deutschland Gmbh |
Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
|
DE10308353A1
(de)
|
2003-02-27 |
2004-12-02 |
Aventis Pharma Deutschland Gmbh |
Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
US7148246B2
(en)
|
2003-02-27 |
2006-12-12 |
Sanofi-Aventis Deutschland Gmbh |
Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals
|
DE10308351A1
(de)
|
2003-02-27 |
2004-11-25 |
Aventis Pharma Deutschland Gmbh |
1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
|
DE10308352A1
(de)
|
2003-02-27 |
2004-09-09 |
Aventis Pharma Deutschland Gmbh |
Arylcycloalkylderivate mit verzweigten Seitenketten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
|
WO2004089362A1
(en)
*
|
2003-04-11 |
2004-10-21 |
Novo Nordisk A/S |
2-cyanopyrroles and their analogues as ddp-iv inhibitors
|
PE20050021A1
(es)
*
|
2003-04-16 |
2005-03-15 |
Novartis Ag |
Procedimiento para la preparacion de 2-cianopirrolidina n-sustituida
|
GB0308854D0
(en)
*
|
2003-04-16 |
2003-05-21 |
Novartis Ag |
Organic compounds
|
DE602004026289D1
(de)
|
2003-05-05 |
2010-05-12 |
Probiodrug Ag |
Glutaminylcyclase-hemmer
|
KR20060009902A
(ko)
|
2003-05-05 |
2006-02-01 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도
|
EP1620082B9
(en)
|
2003-05-05 |
2010-08-25 |
Probiodrug AG |
Medical use of inhibitors of glutaminyl and glutamate cyclases for treating alzheimer's disease and down syndrome
|
ATE447574T1
(de)
|
2003-05-14 |
2009-11-15 |
Merck & Co Inc |
3-amino-4-phenylbutansäurederivate als dipeptidylpeptidase-hemmer zur behandlung oder vorbeugung von diabetes
|
KR20060009933A
(ko)
*
|
2003-05-15 |
2006-02-01 |
다이쇼 세이야꾸 가부시끼가이샤 |
시아노플루오로피롤리딘 유도체
|
CA2526770A1
(en)
|
2003-06-06 |
2004-12-23 |
Merck & Co., Inc. |
Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
|
CN1809544A
(zh)
|
2003-06-17 |
2006-07-26 |
麦克公司 |
作为二肽基肽酶抑制剂用于治疗或预防糖尿病的环己基甘氨酸衍生物
|
ES2327740T3
(es)
|
2003-06-20 |
2009-11-03 |
F. Hoffmann-La Roche Ag |
Hexahidropiridoisoquinolinas como inhibidoras de la dpp-iv.
|
AU2004251830B8
(en)
|
2003-06-20 |
2009-11-26 |
F. Hoffmann-La Roche Ag |
Pyrido[2, 1-A]-isoquinoline derivatives as DPP-IV inhibitors
|
EP1651623B1
(en)
|
2003-07-31 |
2008-12-17 |
Merck & Co., Inc. |
Hexahydrodiazepinones as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
US7205409B2
(en)
|
2003-09-04 |
2007-04-17 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
WO2005033099A2
(en)
*
|
2003-10-03 |
2005-04-14 |
Glenmark Pharmaceuticals Ltd. |
Novel dipeptidyl peptidase iv inhibitors; processes for their preparation and compositions thereof
|
KR20120007079A
(ko)
|
2003-10-15 |
2012-01-19 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
|
ZA200603165B
(en)
|
2003-11-03 |
2007-07-25 |
Probiodrug Ag |
Combinations useful for the treatment of neuronal disorders
|
US7576121B2
(en)
|
2003-11-12 |
2009-08-18 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
US7767828B2
(en)
|
2003-11-12 |
2010-08-03 |
Phenomix Corporation |
Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
US7317109B2
(en)
|
2003-11-12 |
2008-01-08 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
CA2545311C
(en)
|
2003-11-12 |
2012-01-03 |
Phenomix Corporation |
Heterocyclic boronic acid compounds
|
KR20120008093A
(ko)
|
2003-11-17 |
2012-01-25 |
노파르티스 아게 |
디펩티딜 펩티다제 ⅳ 억제제의 용도
|
LT3366283T
(lt)
|
2004-01-20 |
2021-12-10 |
Novartis Ag |
Tiesioginio presavimo formulė ir procesas
|
US7241787B2
(en)
|
2004-01-25 |
2007-07-10 |
Sanofi-Aventis Deutschland Gmbh |
Substituted N-cycloexylimidazolinones, process for their preparation and their use as medicaments
|
US7230002B2
(en)
|
2004-02-03 |
2007-06-12 |
Glenmark Pharmaceuticals Ltd. |
Dipeptidyl peptidase IV inhibitors; processes for their preparation and compositions thereof
|
CN1918131B
(zh)
|
2004-02-05 |
2011-05-04 |
前体生物药物股份公司 |
谷氨酰胺酰基环化酶抑制剂
|
SI1712547T1
(sl)
|
2004-02-05 |
2012-04-30 |
Kyorin Seiyaku Kk |
Bicikloestrski derivat
|
EP1717225A4
(en)
|
2004-02-18 |
2009-10-21 |
Kyorin Seiyaku Kk |
BICYCLIC AMIDE DERIVATIVES
|
BRPI0507905A
(pt)
*
|
2004-02-20 |
2007-07-10 |
Novartis Ag |
uso de compostos orgánicos
|
WO2005082847A1
(ja)
*
|
2004-02-27 |
2005-09-09 |
Kyorin Pharmaceutical Co., Ltd. |
ビシクロ誘導体
|
DE602004004631D1
(de)
|
2004-04-01 |
2007-03-22 |
Sanofi Aventis Deutschland |
Oxadiazolone, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Pharmazeutika
|
US7687492B2
(en)
|
2004-05-04 |
2010-03-30 |
Merck Sharp & Dohme Corp. |
1,2,4-Oxadiazole derivatives as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes
|
EP1756106A4
(en)
|
2004-05-18 |
2008-12-17 |
Merck & Co Inc |
CYCLOHEXYLALANINE DERIVATIVES AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV FOR THE TREATMENT OR PREVENTION OF DIABETES
|
FR2870538B1
(fr)
*
|
2004-05-19 |
2006-07-14 |
Servier Lab |
Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
EP1598341A1
(en)
*
|
2004-05-21 |
2005-11-23 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
EP1604980A1
(en)
*
|
2004-06-08 |
2005-12-14 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
EP1604989A1
(en)
*
|
2004-06-08 |
2005-12-14 |
Santhera Pharmaceuticals (Deutschland) Aktiengesellschaft |
DPP-IV inhibitors
|
JP2008505975A
(ja)
|
2004-07-12 |
2008-02-28 |
フェノミックス コーポレーション |
制約されたシアノ化合物
|
JP2008507541A
(ja)
|
2004-07-23 |
2008-03-13 |
ロイヤルティ,スーザン・マリー |
ペプチダーゼ阻害剤
|
PE20060652A1
(es)
|
2004-08-27 |
2006-08-11 |
Novartis Ag |
Composiciones farmaceuticas de liberacion inmediata que comprenden granulos de fusion
|
AP2007003973A0
(en)
|
2004-10-12 |
2007-07-30 |
Glenmark Pharmaceuticals Sa |
Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation
|
RU2396257C2
(ru)
|
2004-12-20 |
2010-08-10 |
Ф.Хоффманн-Ля Рош Аг |
Производные 4-аминопиперидина
|
US7411093B2
(en)
|
2004-12-20 |
2008-08-12 |
Hoffman-La Roche Inc. |
Aminocycloalkanes as DPP-IV inhibitors
|
DOP2006000008A
(es)
|
2005-01-10 |
2006-08-31 |
Arena Pharm Inc |
Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
|
US8003790B2
(en)
|
2005-02-18 |
2011-08-23 |
Mitsubishi Tanabe Pharma Corporation |
Salt of proline derivative, solvate thereof, and production method thereof
|
CN101146801A
(zh)
*
|
2005-03-22 |
2008-03-19 |
霍夫曼-拉罗奇有限公司 |
新型的dpp-iv抑制剂的盐和多晶型物
|
US7825139B2
(en)
|
2005-05-25 |
2010-11-02 |
Forest Laboratories Holdings Limited (BM) |
Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
DE102005026762A1
(de)
|
2005-06-09 |
2006-12-21 |
Sanofi-Aventis Deutschland Gmbh |
Azolopyridin-2-on-derivate als Inhibitoren von Lipasen und Phospholipasen
|
MY152185A
(en)
|
2005-06-10 |
2014-08-29 |
Novartis Ag |
Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
|
EP1910317B1
(en)
|
2005-07-20 |
2013-07-03 |
Eli Lilly And Company |
1-amino linked compounds
|
GT200600381A
(es)
|
2005-08-25 |
2007-03-28 |
|
Compuestos organicos
|
MY147393A
(en)
|
2005-09-14 |
2012-11-30 |
Takeda Pharmaceutical |
Administration of dipeptidyl peptidase inhibitors
|
CN102675221A
(zh)
|
2005-09-16 |
2012-09-19 |
武田药品工业株式会社 |
用于制备嘧啶二酮衍生物的方法中的中间体
|
GB0526291D0
(en)
|
2005-12-23 |
2006-02-01 |
Prosidion Ltd |
Therapeutic method
|
AU2007224066B2
(en)
|
2006-03-08 |
2011-10-27 |
Kyorin Pharmaceutical Co., Ltd. |
Method for producing aminoacetylpyrrolidinecarbonitrile derivative and production intermediate thereof
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
DK2004601T3
(da)
*
|
2006-04-03 |
2011-06-27 |
Matrix Lab Ltd |
Nye dipeptidylpeptidase-IV-inhibitorer samt fremgangsmåder til deres fremstilling og farmaceutiske sammensætninger indeholdende dem
|
CN101050194B
(zh)
|
2006-04-05 |
2013-08-21 |
上海恒瑞医药有限公司 |
双环辛烷类衍生物、其制备方法及其在医药上的用途
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
MEP27308A
(en)
|
2006-04-11 |
2010-06-10 |
Arena Pharm Inc |
Methods of using gpr119 receptor to identify compounds useful for increasing bone mass in an individual
|
US7728146B2
(en)
|
2006-04-12 |
2010-06-01 |
Probiodrug Ag |
Enzyme inhibitors
|
JP5379692B2
(ja)
|
2006-11-09 |
2013-12-25 |
プロビオドルグ エージー |
潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体
|
TW200838536A
(en)
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
ATE554085T1
(de)
|
2006-11-30 |
2012-05-15 |
Probiodrug Ag |
Neue inhibitoren von glutaminylcyclase
|
CN101230058A
(zh)
|
2007-01-23 |
2008-07-30 |
上海恒瑞医药有限公司 |
双环氮杂烷类衍生物、其制备方法及其在医药上的用途
|
JPWO2008114857A1
(ja)
|
2007-03-22 |
2010-07-08 |
杏林製薬株式会社 |
アミノアセチルピロリジンカルボニトリル誘導体の製造方法
|
AU2008233548B2
(en)
|
2007-04-03 |
2011-12-01 |
Mitsubishi Tanabe Pharma Corporation |
Combined use of dipeptidyl peptidase IV inhibitor compound and sweetener
|
DK2142514T3
(da)
|
2007-04-18 |
2015-03-23 |
Probiodrug Ag |
Thioureaderivater som glutaminylcyclase-inhibitorer
|
US8338450B2
(en)
|
2007-09-21 |
2012-12-25 |
Lupin Limited |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
CN101468988A
(zh)
|
2007-12-26 |
2009-07-01 |
上海恒瑞医药有限公司 |
哌嗪类衍生物,其制备方法及其在医药上的应用
|
CL2008003653A1
(es)
|
2008-01-17 |
2010-03-05 |
Mitsubishi Tanabe Pharma Corp |
Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
|
EP2246347B1
(en)
|
2008-01-23 |
2016-09-28 |
Shanghai Hengrui Pharmaceutical Co. Ltd. |
Dicycloazaalkane derivates, preparation processes and medical uses thereof
|
US8551524B2
(en)
|
2008-03-14 |
2013-10-08 |
Iycus, Llc |
Anti-diabetic combinations
|
EP2108960A1
(en)
|
2008-04-07 |
2009-10-14 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
|
US8476470B2
(en)
|
2008-08-07 |
2013-07-02 |
Kyorin Pharmaceutical Co., Ltd. |
Process for production of bicyclo[2.2.2]octylamine derivative
|
CZ2008512A3
(cs)
|
2008-08-26 |
2010-03-10 |
Zentiva, A. S |
Zpusob prípravy vysoce cistého vildagliptinu
|
JO2870B1
(en)
|
2008-11-13 |
2015-03-15 |
ميرك شارب اند دوهم كورب |
Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes
|
TW201024283A
(en)
*
|
2008-12-01 |
2010-07-01 |
Targacept Inc |
Synthesis and novel salt forms of (R)-3-((E)-2-(pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine
|
US8404727B2
(en)
|
2009-01-07 |
2013-03-26 |
Glenmark Pharmaceuticals S.A. |
Pharmaceutical composition that includes a dipeptidyl peptidase-IV inhibitor
|
CN102272099A
(zh)
|
2009-01-09 |
2011-12-07 |
幽兰研究实验室有限公司 |
二肽基肽酶iv抑制剂
|
CN101824036A
(zh)
|
2009-03-05 |
2010-09-08 |
上海恒瑞医药有限公司 |
四氢咪唑并[1,5-a]吡嗪衍生物的盐,其制备方法及其在医药上的应用
|
JPWO2010110436A1
(ja)
|
2009-03-27 |
2012-10-04 |
杏林製薬株式会社 |
塩基性添加剤を含有するマトリックス型徐放性製剤
|
BRPI1010600A2
(pt)
|
2009-05-15 |
2016-03-15 |
Novartis Ag |
aril piridina como inibidores de aldosterona sintase
|
AU2010247391A1
(en)
|
2009-05-15 |
2011-12-01 |
Novartis Ag |
Benzoxazolone derivatives as aldosterone synthase inhibitors
|
MA33364B1
(fr)
|
2009-05-28 |
2012-06-01 |
Novartis Ag |
Dérivés aminobutyriques substitués en tant qu'inhibiteurs de néprilysine
|
EA019511B1
(ru)
|
2009-05-28 |
2014-04-30 |
Новартис Аг |
Замещенные производные аминопропионовой кислоты в качестве ингибиторов неприлизина
|
WO2010142985A1
(en)
*
|
2009-06-10 |
2010-12-16 |
Astrazeneca Ab |
Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761
|
GB2483614B
(en)
|
2009-06-18 |
2014-12-03 |
Lupin Ltd |
2-Amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors
|
AR077642A1
(es)
|
2009-07-09 |
2011-09-14 |
Arena Pharm Inc |
Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
|
EP2473047B1
(en)
|
2009-09-02 |
2014-08-13 |
Merck Sharp & Dohme Corp. |
Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes
|
US8486940B2
(en)
|
2009-09-11 |
2013-07-16 |
Probiodrug Ag |
Inhibitors
|
AU2010295646B2
(en)
|
2009-09-15 |
2016-02-11 |
Ellipses Pharma Limited |
Treatment of cancer
|
EP2993169B1
(en)
|
2009-11-17 |
2017-12-20 |
Novartis AG |
Aryl-pyridine derivatives as aldosterone synthase inhibitors
|
JO2967B1
(en)
|
2009-11-20 |
2016-03-15 |
نوفارتس ايه جي |
Acetic acid derivatives of carbamoyl methyl amino are substituted as new NEP inhibitors
|
AU2010321533A1
(en)
|
2009-11-23 |
2012-05-31 |
Cerulean Pharma Inc. |
Cyclodextrin-based polymers for therapeutic delivery
|
EP2507234B1
(en)
|
2009-11-30 |
2014-03-12 |
Novartis AG |
Imidazole derivatives as aldosterone synthase inhibitors
|
WO2011090940A1
(en)
|
2010-01-19 |
2011-07-28 |
Cerulean Pharma Inc. |
Cyclodextrin-based polymers for therapeutic delivery
|
EP2538783B1
(en)
|
2010-02-22 |
2016-06-01 |
Merck Sharp & Dohme Corp. |
Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
EP2542549B1
(en)
|
2010-03-03 |
2016-05-11 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
BR112012022478B1
(pt)
|
2010-03-10 |
2021-09-21 |
Probiodrug Ag |
Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica
|
EP2556056A1
(en)
|
2010-04-06 |
2013-02-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
US8581001B2
(en)
|
2010-04-16 |
2013-11-12 |
Codman & Shurtleff |
Metformin-cysteine prodrug
|
US8541596B2
(en)
|
2010-04-21 |
2013-09-24 |
Probiodrug Ag |
Inhibitors
|
US8980929B2
(en)
|
2010-05-21 |
2015-03-17 |
Merck Sharp & Dohme Corp. |
Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes
|
CA2812061A1
(en)
|
2010-09-22 |
2012-03-29 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2012049566A1
(en)
|
2010-10-14 |
2012-04-19 |
Japan Tobacco Inc. |
Combination therapy for use in treating diabetes
|
US8877815B2
(en)
|
2010-11-16 |
2014-11-04 |
Novartis Ag |
Substituted carbamoylcycloalkyl acetic acid derivatives as NEP
|
US8673974B2
(en)
|
2010-11-16 |
2014-03-18 |
Novartis Ag |
Substituted amino bisphenyl pentanoic acid derivatives as NEP inhibitors
|
US8530670B2
(en)
|
2011-03-16 |
2013-09-10 |
Probiodrug Ag |
Inhibitors
|
WO2012135570A1
(en)
|
2011-04-01 |
2012-10-04 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
US20140066369A1
(en)
|
2011-04-19 |
2014-03-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
US20140051714A1
(en)
|
2011-04-22 |
2014-02-20 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
WO2012145603A1
(en)
|
2011-04-22 |
2012-10-26 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
US9051329B2
(en)
|
2011-07-05 |
2015-06-09 |
Merck Sharp & Dohme Corp. |
Tricyclic heterocycles useful as dipeptidyl peptidase-IV inhibitors
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
US9115082B2
(en)
*
|
2012-01-18 |
2015-08-25 |
Catherine Yang |
Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
|
EP2814485A4
(en)
|
2012-02-17 |
2015-08-26 |
Merck Sharp & Dohme |
DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
|
CN103509023B
(zh)
|
2012-06-20 |
2014-08-27 |
成都苑东药业有限公司 |
黄嘌呤衍生物
|
US9567300B2
(en)
|
2012-06-25 |
2017-02-14 |
Sunshine Lake Pharma Co., Ltd. |
Hexahydropentaleno derivatives, preparation method and use in medicine thereof
|
EP2874622A4
(en)
|
2012-07-23 |
2015-12-30 |
Merck Sharp & Dohme |
TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS
|
EA021236B1
(ru)
*
|
2012-10-03 |
2015-05-29 |
Дафот Энтерпраизес Лимитед |
Nα-АЦИЛЬНЫЕ ПРОИЗВОДНЫЕ АМИНОАЦИЛ-2-ЦИАНОПИРРОЛИДИНА - ИНГИБИТОРЫ ПРОЛИЛЭНДОПЕПТИДАЗЫ И ДИПЕПТИДИЛПЕПТИДАЗЫ-IV, ОБЛАДАЮЩИЕ ГИПОГЛИКЕМИЧЕСКИМ, ПРОТИВОГИПОКСИЧЕСКИМ, НЕЙРОПРОТЕКТОРНЫМ И УЛУЧШАЮЩИМ КОГНИТИВНЫЕ ФУНКЦИИ ДЕЙСТВИЕМ
|
TWI500613B
(zh)
|
2012-10-17 |
2015-09-21 |
Cadila Healthcare Ltd |
新穎之雜環化合物
|
WO2014074668A1
(en)
|
2012-11-08 |
2014-05-15 |
Arena Pharmaceuticals, Inc. |
Modulators of gpr119 and the treatment of disorders related thereto
|
UY35144A
(es)
|
2012-11-20 |
2014-06-30 |
Novartis Ag |
Miméticos lineales sintéticos de apelina para el tratamiento de insuficiencia cardiaca
|
CN103922986B
(zh)
*
|
2013-01-16 |
2017-02-15 |
上海彩迩文生化科技有限公司 |
维大列汀及其类似物、中间体及其制备方法和应用
|
SI2956464T1
(en)
|
2013-02-14 |
2018-08-31 |
Novartis Ag |
Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors (neutral endopeptidases)
|
SG11201600211XA
(en)
|
2013-07-25 |
2016-02-26 |
Novartis Ag |
Cyclic polypeptides for the treatment of heart failure
|
UY35671A
(es)
|
2013-07-25 |
2015-02-27 |
Novartis Ag |
Bioconjugados de polipéptidos de apelina sintética
|
WO2015145467A1
(en)
*
|
2014-03-28 |
2015-10-01 |
Laurus Labs Private Limited |
An improved process for preparing vildagliptin
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
CN104557667A
(zh)
*
|
2014-12-12 |
2015-04-29 |
山东省药学科学院 |
2-氰基吡咯烷类化合物、制备方法及其应用
|
CN107405332A
(zh)
|
2015-01-06 |
2017-11-28 |
艾尼纳制药公司 |
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|
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(zh)
*
|
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|
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|
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|
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(fr)
|
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|
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(ko)
|
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|
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(zh)
|
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|
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(en)
|
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|
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(ar)
|
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|
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(en)
|
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|
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(ja)
|
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|
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(en)
|
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|
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(es)
|
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|
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(es)
|
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|
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(es)
|
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|
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(es)
|
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|
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(en)
|
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|
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(ja)
|
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|
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(en)
*
|
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|
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(en)
|
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|
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|
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|
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|
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|
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*
|
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|