JPS5932411U
(ja)
|
1982-08-24 |
1984-02-29 |
エヌオーケー株式会社 |
離型装置
|
US4689299A
(en)
|
1982-09-30 |
1987-08-25 |
University Of Rochester |
Human monoclonal antibodies against bacterial toxins
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US4801687A
(en)
|
1986-10-27 |
1989-01-31 |
Bioprobe International, Inc. |
Monoclonal antibody purification process using protein A
|
US4851341A
(en)
|
1986-12-19 |
1989-07-25 |
Immunex Corporation |
Immunoaffinity purification system
|
JPH01144991A
(ja)
|
1987-12-02 |
1989-06-07 |
Kagaku Oyobi Ketsusei Riyouhou Kenkyusho |
血液凝固第8因子の精製方法
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
JPH0636741B2
(ja)
|
1989-11-08 |
1994-05-18 |
帝人株式会社 |
ヒト・プロテインcの分離方法
|
US5130129A
(en)
|
1990-03-06 |
1992-07-14 |
The Regents Of The University Of California |
Method for enhancing antibody transport through capillary barriers
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
EP0546073B1
(en)
|
1990-08-29 |
1997-09-10 |
GenPharm International, Inc. |
production and use of transgenic non-human animals capable of producing heterologous antibodies
|
WO1994025585A1
(en)
|
1993-04-26 |
1994-11-10 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
WO1993006213A1
(en)
|
1991-09-23 |
1993-04-01 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
AU3328493A
(en)
|
1991-12-17 |
1993-07-19 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
WO1993019172A1
(en)
|
1992-03-24 |
1993-09-30 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
EP0652950B1
(en)
|
1992-07-24 |
2007-12-19 |
Amgen Fremont Inc. |
Generation of xenogeneic antibodies
|
US7393682B1
(en)
|
1993-03-19 |
2008-07-01 |
The Johns Hopkins University School Of Medicine |
Polynucleotides encoding promyostatin polypeptides
|
EP0690873B1
(en)
|
1993-03-19 |
2003-06-11 |
The Johns Hopkins University School Of Medicine |
Growth differentiation factor-8
|
GB9313509D0
(en)
|
1993-06-30 |
1993-08-11 |
Medical Res Council |
Chemisynthetic libraries
|
FR2707189B1
(fr)
|
1993-07-09 |
1995-10-13 |
Gradient Ass |
Procédé de traitement de résidus de combustion et installation de mise en Óoeuvre dudit procédé.
|
GB9314271D0
(en)
|
1993-07-09 |
1993-08-18 |
Inst Of Cancer The Research |
Cell growth factor receptors
|
US5421161A
(en)
|
1993-09-27 |
1995-06-06 |
Minnesota Valley Engineering, Inc. |
Storage system for cryogenic fluids
|
IL107742A0
(en)
|
1993-11-24 |
1994-02-27 |
Yeda Res & Dev |
Chemically-modified binding proteins
|
AU690171B2
(en)
|
1993-12-03 |
1998-04-23 |
Medical Research Council |
Recombinant binding proteins and peptides
|
US6074642A
(en)
|
1994-05-02 |
2000-06-13 |
Alexion Pharmaceuticals, Inc. |
Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis
|
JP3865418B2
(ja)
|
1994-07-13 |
2007-01-10 |
中外製薬株式会社 |
ヒトインターロイキン−8に対する再構成ヒト抗体
|
TW416960B
(en)
|
1994-07-13 |
2001-01-01 |
Chugai Pharmaceutical Co Ltd |
Reshaped human antibody to human interleukin-8
|
US6048972A
(en)
|
1994-07-13 |
2000-04-11 |
Chugai Pharmaceutical Co., Ltd. |
Recombinant materials for producing humanized anti-IL-8 antibodies
|
CA2194907A1
(en)
|
1994-07-13 |
1996-02-01 |
Kouji Matsushima |
Reshaped human antibody against human interleukin-8
|
CN1156460A
(zh)
|
1994-07-13 |
1997-08-06 |
中外制药株式会社 |
抗人白细胞介素-8的重构人抗体
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
EP0739981A1
(en)
|
1995-04-25 |
1996-10-30 |
Vrije Universiteit Brussel |
Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes
|
JP4312259B2
(ja)
|
1995-04-27 |
2009-08-12 |
アムジェン フレモント インク. |
免疫したゼノマウス(XenoMouse)に由来するヒト抗体
|
AU2466895A
(en)
|
1995-04-28 |
1996-11-18 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
CA2249195A1
(en)
|
1996-03-18 |
1997-09-25 |
Board Of Regents, The University Of Texas System |
Immunoglobin-like domains with increased half lives
|
JP2001506967A
(ja)
|
1996-08-02 |
2001-05-29 |
ブリストル―マイヤーズ・スクイブ・カンパニー |
治療およびインビボ診断における免疫グロブリンの使用の結果としての免疫グロブリン誘発毒性の抑制方法
|
US7247302B1
(en)
|
1996-08-02 |
2007-07-24 |
Bristol-Myers Squibb Company |
Method for inhibiting immunoglobulin-induced toxicity resulting from the use of immunoglobulins in therapy and in vivo diagnosis
|
US6025158A
(en)
|
1997-02-21 |
2000-02-15 |
Genentech, Inc. |
Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
US7951917B1
(en)
|
1997-05-02 |
2011-05-31 |
Genentech, Inc. |
Method for making multispecific antibodies having heteromultimeric and common components
|
CN1068524C
(zh)
|
1997-06-23 |
2001-07-18 |
叶庆炜 |
一种治疗顽症牛皮癣的药物
|
US6670453B2
(en)
|
1997-10-27 |
2003-12-30 |
Unilever Patent Holdings B.V. |
Multivalent antigen-binding proteins
|
US6458355B1
(en)
|
1998-01-22 |
2002-10-01 |
Genentech, Inc. |
Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
|
WO1999040117A1
(en)
|
1998-02-06 |
1999-08-12 |
Ilexus Pty. Limited |
THREE-DIMENSIONAL STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF
|
CA2323757C
(en)
|
1998-04-02 |
2011-08-02 |
Genentech, Inc. |
Antibody variants and fragments thereof
|
GB9809951D0
(en)
|
1998-05-08 |
1998-07-08 |
Univ Cambridge Tech |
Binding molecules
|
JP2002524504A
(ja)
|
1998-09-11 |
2002-08-06 |
イレクサス・ピーティーワイ・リミテッド |
Fc受容体調節剤およびそれの使用
|
RU2236222C2
(ru)
|
1998-09-11 |
2004-09-20 |
Айлексус Пти Лимитед |
Модуляторы fc-рецептора и их применение
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
EP1141024B1
(en)
|
1999-01-15 |
2018-08-08 |
Genentech, Inc. |
POLYPEPTIDE COMPRISING A VARIANT HUMAN IgG1 Fc REGION
|
AU2006225302B2
(en)
|
1999-03-25 |
2010-08-12 |
AbbVie Deutschland GmbH & Co. KG |
Human antibodies that bind human IL-12 and methods for producing
|
DK1266006T3
(da)
|
2000-03-22 |
2006-01-16 |
Octagene Gmbh |
Fremstilling af rekombinante muteiner af blodkoagulationsfaktor VIII i humane cellelinier
|
FR2807767B1
(fr)
|
2000-04-12 |
2005-01-14 |
Lab Francais Du Fractionnement |
Anticorps monoclonaux anti-d
|
AU2011244851A1
(en)
|
2000-07-27 |
2011-11-24 |
The John Hopkins University School Of Medicine |
Promyostatin peptides and methods of using same
|
AU2002218166A1
(en)
|
2000-09-08 |
2002-03-22 |
Universitat Zurich |
Collections of repeat proteins comprising repeat modules
|
JP2004526419A
(ja)
|
2000-10-16 |
2004-09-02 |
フィロス インク. |
抗体模倣物および他の結合タンパク質のためのタンパク質骨格
|
PT1355919E
(pt)
|
2000-12-12 |
2011-03-02 |
Medimmune Llc |
Moléculas com semivida longa, composições que as contêm e suas utilizações
|
US20040002450A1
(en)
|
2000-12-29 |
2004-01-01 |
Janette Lazarovits |
Y17 - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
US20040001822A1
(en)
|
2000-12-29 |
2004-01-01 |
Avigdor Levanon |
Y1-isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
US20040001839A1
(en)
|
2000-12-29 |
2004-01-01 |
Avigdor Levanon |
Multimers - isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
US20030157561A1
(en)
|
2001-11-19 |
2003-08-21 |
Kolkman Joost A. |
Combinatorial libraries of monomer domains
|
EP1399484B1
(en)
|
2001-06-28 |
2010-08-11 |
Domantis Limited |
Dual-specific ligand and its use
|
WO2004058821A2
(en)
|
2002-12-27 |
2004-07-15 |
Domantis Limited |
Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand
|
US7320789B2
(en)
|
2001-09-26 |
2008-01-22 |
Wyeth |
Antibody inhibitors of GDF-8 and uses thereof
|
WO2003029462A1
(en)
|
2001-09-27 |
2003-04-10 |
Pieris Proteolab Ag |
Muteins of human neutrophil gelatinase-associated lipocalin and related proteins
|
WO2003048731A2
(en)
|
2001-12-03 |
2003-06-12 |
Abgenix, Inc. |
Antibody categorization based on binding characteristics
|
EP1464702A4
(en)
|
2001-12-28 |
2005-09-21 |
Chugai Pharmaceutical Co Ltd |
METHOD FOR PROTEIN STABILIZATION
|
AR038568A1
(es)
|
2002-02-20 |
2005-01-19 |
Hoffmann La Roche |
Anticuerpos anti-a beta y su uso
|
US8188231B2
(en)
|
2002-09-27 |
2012-05-29 |
Xencor, Inc. |
Optimized FC variants
|
US7317091B2
(en)
|
2002-03-01 |
2008-01-08 |
Xencor, Inc. |
Optimized Fc variants
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
US7662925B2
(en)
|
2002-03-01 |
2010-02-16 |
Xencor, Inc. |
Optimized Fc variants and methods for their generation
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
US20080199471A1
(en)
|
2002-03-01 |
2008-08-21 |
Bernett Matthew J |
Optimized cd40 antibodies and methods of using the same
|
JP4468803B2
(ja)
|
2002-05-31 |
2010-05-26 |
ジーイー・ヘルスケア・バイオ−サイエンシーズ・アーベー |
結合剤を基板表面にカップリングさせる方法
|
WO2003105757A2
(en)
|
2002-06-12 |
2003-12-24 |
Genencor International, Inc. |
Methods and compositions for milieu-dependent binding of a targeted agent to a target
|
ITMI20021527A1
(it)
|
2002-07-11 |
2004-01-12 |
Consiglio Nazionale Ricerche |
Anticorpi anti componente c5 del complemento e loro uso
|
US8193318B2
(en)
|
2002-08-14 |
2012-06-05 |
Macrogenics, Inc. |
FcγRIIB specific antibodies and methods of use thereof
|
ES2344734T3
(es)
|
2002-09-16 |
2010-09-06 |
Johns Hopkins University |
Activacion de miostatina por metaloproteasa, y metodos para modular la actividad de miostatina.
|
RU2325186C2
(ru)
|
2002-09-27 |
2008-05-27 |
Ксенкор, Инк. |
АНТИТЕЛО, СОДЕРЖАЩЕЕ Fc-ВАРИАНТНУЮ ЧАСТЬ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ АНТИТЕЛО, И СПОСОБ ЛЕЧЕНИЯ МЛЕКОПИТАЮЩЕГО
|
EP2364996B1
(en)
|
2002-09-27 |
2016-11-09 |
Xencor Inc. |
Optimized FC variants and methods for their generation
|
US7217797B2
(en)
|
2002-10-15 |
2007-05-15 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
DE60334141D1
(de)
|
2002-10-15 |
2010-10-21 |
Facet Biotech Corp |
VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE
|
AR047392A1
(es)
|
2002-10-22 |
2006-01-18 |
Wyeth Corp |
Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines
|
AU2003299641C1
(en)
|
2002-12-16 |
2016-06-02 |
Cormorant Pharmaceuticals Ab |
Human monoclonal antibodies against interleukin 8 (IL-8)
|
JP2006524039A
(ja)
|
2003-01-09 |
2006-10-26 |
マクロジェニクス,インコーポレーテッド |
変異型Fc領域を含む抗体の同定および作製ならびにその利用法
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
US8388955B2
(en)
|
2003-03-03 |
2013-03-05 |
Xencor, Inc. |
Fc variants
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
US9051373B2
(en)
|
2003-05-02 |
2015-06-09 |
Xencor, Inc. |
Optimized Fc variants
|
CA2766627C
(en)
|
2003-05-02 |
2019-12-03 |
Xencor, Inc. |
Optimized fc variants and methods for their generation
|
EP1635870A2
(en)
|
2003-06-02 |
2006-03-22 |
Wyeth |
Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders
|
WO2005023193A2
(en)
|
2003-09-04 |
2005-03-17 |
Interleukin Genetics, Inc. |
Methods of treating endometriosis
|
AU2004273791A1
(en)
|
2003-09-05 |
2005-03-31 |
Genentech, Inc. |
Antibodies with altered effector functions
|
US8101720B2
(en)
|
2004-10-21 |
2012-01-24 |
Xencor, Inc. |
Immunoglobulin insertions, deletions and substitutions
|
US7288638B2
(en)
|
2003-10-10 |
2007-10-30 |
Bristol-Myers Squibb Company |
Fully human antibodies against human 4-1BB
|
CA2545539A1
(en)
|
2003-10-15 |
2005-04-28 |
Pdl Biopharma, Inc. |
Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig
|
EP1675878A2
(en)
|
2003-10-24 |
2006-07-05 |
Avidia, Inc. |
Ldl receptor class a and egf domain monomers and multimers
|
AU2004291341B2
(en)
|
2003-11-05 |
2010-08-05 |
Ares Trading S.A. |
Process for the purification of IL-18 binding protein
|
WO2005063815A2
(en)
|
2003-11-12 |
2005-07-14 |
Biogen Idec Ma Inc. |
Fcϝ receptor-binding polypeptide variants and methods related thereto
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
EP1697415A1
(en)
|
2003-11-12 |
2006-09-06 |
Biogen Idec MA Inc. |
NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO
|
US20050142133A1
(en)
|
2003-12-03 |
2005-06-30 |
Xencor, Inc. |
Optimized proteins that target the epidermal growth factor receptor
|
EP2221315A1
(en)
|
2003-12-04 |
2010-08-25 |
Xencor, Inc. |
Methods of generating variant proteins with increased host string content and compositions thereof
|
EP2418220B1
(en)
|
2003-12-10 |
2017-08-02 |
E. R. Squibb & Sons, L.L.C. |
Interferon alpha antibodies and their uses
|
WO2005077981A2
(en)
|
2003-12-22 |
2005-08-25 |
Xencor, Inc. |
Fc POLYPEPTIDES WITH NOVEL Fc LIGAND BINDING SITES
|
CN1902221A
(zh)
|
2003-12-31 |
2007-01-24 |
先灵-普劳有限公司 |
基于中和表位的生长增强疫苗
|
UA86605C2
(ru)
|
2004-01-12 |
2009-05-12 |
Аплайд Молекьюлер Иволюшн, Инк. |
Антитело, которое содержит вариант исходного человеческого fс-участка
|
MXPA06010929A
(es)
|
2004-03-23 |
2007-01-16 |
Lilly Co Eli |
Anticuerpos anti-miostatina.
|
US7276585B2
(en)
|
2004-03-24 |
2007-10-02 |
Xencor, Inc. |
Immunoglobulin variants outside the Fc region
|
US20050260711A1
(en)
|
2004-03-30 |
2005-11-24 |
Deepshikha Datta |
Modulating pH-sensitive binding using non-natural amino acids
|
WO2005123780A2
(en)
|
2004-04-09 |
2005-12-29 |
Protein Design Labs, Inc. |
Alteration of fcrn binding affinities or serum half-lives of antibodies by mutagenesis
|
EP1747237A4
(en)
|
2004-04-16 |
2008-05-21 |
Macrogenics Inc |
SPECIFIC GAMMA FC ANTIBODIES AND METHODS OF USING THE SAME
|
RU2006142852A
(ru)
|
2004-05-05 |
2008-06-10 |
Ксенкор, Инк. (Us) |
Оптимизированные fc-варианты
|
US20070048785A1
(en)
|
2004-06-09 |
2007-03-01 |
Lin Laura L |
Anti-IL-13 antibodies and complexes
|
EP1771205B1
(en)
|
2004-06-18 |
2016-10-26 |
Ambrx, Inc. |
Novel antigen-binding polypeptides and their uses
|
WO2006088478A2
(en)
|
2004-06-18 |
2006-08-24 |
Novartis Vaccines And Diagnostics Inc. |
Methods and reagents for diagnosing hantavirus infection
|
JP2008504289A
(ja)
|
2004-06-25 |
2008-02-14 |
メディミューン,インコーポレーテッド |
部位特異的突然変異誘発による哺乳動物細胞における組換え抗体の産生の増加
|
WO2006085967A2
(en)
|
2004-07-09 |
2006-08-17 |
Xencor, Inc. |
OPTIMIZED ANTI-CD20 MONOCONAL ANTIBODIES HAVING Fc VARIANTS
|
CN101189028B
(zh)
*
|
2004-07-12 |
2013-05-29 |
马克罗基因公司 |
具有变异Fc区的抗体的鉴定和工程化以及使用方法
|
CN103351434B
(zh)
|
2004-07-15 |
2015-09-30 |
赞科股份有限公司 |
优化的Fc变体
|
GEP20115195B
(en)
|
2004-07-30 |
2011-04-11 |
Rinat Neuroscience Corp |
Antibodies directed against amyloid-beta peptide and use thereof
|
BR122018016031B8
(pt)
|
2004-08-04 |
2021-07-27 |
Applied Molecular Evolution Inc |
processo para produzir um anticorpo monoclonal variante com resposta de adcc realçada
|
RS51326B
(sr)
|
2004-08-05 |
2010-12-31 |
Genentech Inc. |
Humanizovani anti-cmet antagonisti
|
CN101080421A
(zh)
|
2004-08-11 |
2007-11-28 |
三菱化学株式会社 |
抗体以及其利用
|
AU2005277641A1
(en)
|
2004-08-16 |
2006-03-02 |
Medimmune, Llc |
Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity
|
WO2006031370A2
(en)
|
2004-08-19 |
2006-03-23 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
WO2006047350A2
(en)
|
2004-10-21 |
2006-05-04 |
Xencor, Inc. |
IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION
|
CN101132811B
(zh)
|
2004-10-22 |
2012-05-30 |
米迪缪尼有限公司 |
抗hmgb1的高亲和力抗体及其用法
|
AU2005302453A1
(en)
|
2004-10-29 |
2006-05-11 |
Medimmune, Llc |
Methods of preventing and treating RSV infections and related conditions
|
AU2005335714B2
(en)
|
2004-11-10 |
2012-07-26 |
Macrogenics, Inc. |
Engineering Fc antibody regions to confer effector function
|
US8367805B2
(en)
|
2004-11-12 |
2013-02-05 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8802820B2
(en)
|
2004-11-12 |
2014-08-12 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
RU2412200C2
(ru)
|
2004-11-12 |
2011-02-20 |
Ксенкор, Инк. |
Fc-ВАРИАНТЫ С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ С FcRn
|
US9200079B2
(en)
|
2004-11-12 |
2015-12-01 |
Xencor, Inc. |
Fc variants with altered binding to FcRn
|
US8329186B2
(en)
|
2004-12-20 |
2012-12-11 |
Isu Abxis Co., Ltd |
Treatment of inflammation using BST2 inhibitor
|
JPWO2006067847A1
(ja)
|
2004-12-22 |
2008-06-12 |
中外製薬株式会社 |
フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法
|
AU2005321974B2
(en)
|
2004-12-27 |
2011-11-17 |
Progenics Pharmaceuticals (Nevada), Inc. |
Orally deliverable and anti-toxin antibodies and methods for making and using them
|
PT1699826E
(pt)
|
2005-01-05 |
2009-06-17 |
F Star Biotech Forsch & Entw |
Domínios de imunoglobulina sintética com propriedades de ligação construídos em regiões da molécula diferentes das regiões determinantes de complementaridade
|
US20060275282A1
(en)
|
2005-01-12 |
2006-12-07 |
Xencor, Inc. |
Antibodies and Fc fusion proteins with altered immunogenicity
|
NZ538097A
(en)
|
2005-02-07 |
2006-07-28 |
Ovita Ltd |
Method and compositions for improving wound healing
|
JP5153613B2
(ja)
|
2005-03-18 |
2013-02-27 |
メディミューン,エルエルシー |
抗体のフレームワーク・シャッフル
|
EP3050963B1
(en)
|
2005-03-31 |
2019-09-18 |
Chugai Seiyaku Kabushiki Kaisha |
Process for production of polypeptide by regulation of assembly
|
EP1871808A2
(en)
|
2005-03-31 |
2008-01-02 |
Xencor, Inc. |
Fc VARIANTS WITH OPTIMIZED PROPERTIES
|
MX2007013058A
(es)
|
2005-04-20 |
2008-02-22 |
Amgen Fremont Inc |
Anticuerpos monoclonales de alta afinidad completamente humanos para interleucina-8 y epitopes para dichos anticuerpos.
|
MX2007013217A
(es)
|
2005-04-25 |
2008-03-11 |
Pfizer |
Anticuerpos contra miostatina.
|
US8008443B2
(en)
|
2005-04-26 |
2011-08-30 |
Medimmune, Llc |
Modulation of antibody effector function by hinge domain engineering
|
CN101228189A
(zh)
*
|
2005-05-09 |
2008-07-23 |
格黎卡特生物技术股份公司 |
具有修饰的fc区域和改变的与fc受体的结合的抗原结合分子
|
WO2006130834A2
(en)
|
2005-05-31 |
2006-12-07 |
Board Of Regents, The University Of Texas System |
IGGl ANTIBODIES WITH MUTATED FC PORTION FOR INCREASED BINDING TO FCRN RECEPTOR AND USES THEREOF
|
WO2006133486A1
(en)
|
2005-06-14 |
2006-12-21 |
The Macfarlane Burnet Institute For Medical Research And Public Health Limited |
CRYSTAL STRUCTURES AND MODELS FOR Fc RECEPTOR:Fc COMPLEXES AND USES THEREOF
|
US7557190B2
(en)
|
2005-07-08 |
2009-07-07 |
Xencor, Inc. |
Optimized proteins that target Ep-CAM
|
PT2573114T
(pt)
|
2005-08-10 |
2016-07-13 |
Macrogenics Inc |
Identificação e manipulação de anticorpos com regiões fc variantes e métodos de utilização dos mesmos
|
CN103450359B
(zh)
|
2005-08-19 |
2018-07-24 |
惠氏有限责任公司 |
抗gdf-8的拮抗剂抗体以及在als和其他gdf-8-相关病症治疗中的用途
|
WO2007022520A2
(en)
|
2005-08-19 |
2007-02-22 |
Cerus Corporation |
Antibody-mediated enhancement of immune response
|
CA2624189A1
(en)
|
2005-10-03 |
2007-04-12 |
Xencor, Inc. |
Fc variants with optimized fc receptor binding properties
|
CN101277976B
(zh)
|
2005-10-06 |
2012-04-11 |
伊莱利利公司 |
抗肌抑制素抗体
|
CA2625998C
(en)
|
2005-10-06 |
2015-12-01 |
Xencor, Inc. |
Optimized anti-cd30 antibodies
|
UA92504C2
(en)
|
2005-10-12 |
2010-11-10 |
Эли Лилли Энд Компани |
Anti-myostatin monoclonal antibody
|
WO2007047578A2
(en)
|
2005-10-14 |
2007-04-26 |
Medimmune, Inc. |
Cell display of antibody libraries
|
EP2465870A1
(en)
|
2005-11-07 |
2012-06-20 |
Genentech, Inc. |
Binding polypeptides with diversified and consensus VH/VL hypervariable sequences
|
US20080311122A1
(en)
|
2005-11-28 |
2008-12-18 |
Medimmune, Llc |
Antagonists of Hmgb1 and/or Rage and Methods of Use Thereof
|
EP1959995A1
(en)
|
2005-11-30 |
2008-08-27 |
Can-Fite Biopharma Ltd. |
Therapeutic uses of a3 adenosine receptor antibodies
|
JP2009525986A
(ja)
|
2006-02-03 |
2009-07-16 |
メディミューン,エルエルシー |
タンパク質製剤
|
US20070190056A1
(en)
|
2006-02-07 |
2007-08-16 |
Ravi Kambadur |
Muscle regeneration compositions and uses therefor
|
CN103073639A
(zh)
|
2006-03-17 |
2013-05-01 |
比奥根艾迪克Ma公司 |
稳定的多肽组合物
|
AU2007245164A1
(en)
|
2006-03-28 |
2007-11-08 |
Biogen Idec Ma Inc. |
Anti-IGF-IR antibodies and uses thereof
|
EP3345616A1
(en)
|
2006-03-31 |
2018-07-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody modification method for purifying bispecific antibody
|
IN2014DN10515A
(pt)
|
2006-03-31 |
2015-08-21 |
Chugai Pharmaceutical Co Ltd |
|
TWI395754B
(zh)
|
2006-04-24 |
2013-05-11 |
Amgen Inc |
人類化之c-kit抗體
|
WO2008105886A2
(en)
|
2006-05-26 |
2008-09-04 |
Macrogenics, Inc. |
HUMANIZED FCγRIIB-SPECIFIC ANTIBODIES AND METHODS OF USE THEREOF
|
TW200817006A
(en)
|
2006-06-23 |
2008-04-16 |
Smithkline Beecham Corp |
IL-8 receptor antagonist
|
WO2008002933A2
(en)
|
2006-06-26 |
2008-01-03 |
Macrogenics, Inc. |
Combination of fcgammariib antibodies and cd20-specific antibodies and methods of use thereof
|
DK2049564T3
(en)
|
2006-08-02 |
2017-07-24 |
Uab Res Found |
METHODS AND COMPOSITIONS RELATED TO SOLUBLE MONOCLONAL VARIABLE Lymphocyte RECEPTORS WITH DEFINED ANTIGEN SPECIFICITY
|
AR062223A1
(es)
|
2006-08-09 |
2008-10-22 |
Glycart Biotechnology Ag |
Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
|
WO2008022152A2
(en)
|
2006-08-14 |
2008-02-21 |
Xencor, Inc. |
Optimized antibodies that target cd19
|
CA2661836A1
(en)
|
2006-09-05 |
2008-03-13 |
Eli Lilly And Company |
Anti-myostatin antibodies
|
KR101456728B1
(ko)
|
2006-09-08 |
2014-10-31 |
메디뮨 엘엘씨 |
인간화 항-cd19 항체, 및 이것의 종양학, 이식 및 자가면역 질환의 치료에서의 용도
|
AU2007299843B2
(en)
|
2006-09-18 |
2012-03-08 |
Xencor, Inc |
Optimized antibodies that target HM1.24
|
US20100034194A1
(en)
|
2006-10-11 |
2010-02-11 |
Siemens Communications Inc. |
Eliminating unreachable subscribers in voice-over-ip networks
|
WO2008121160A2
(en)
|
2006-11-21 |
2008-10-09 |
Xencor, Inc. |
Optimized antibodies that target cd5
|
CN100455598C
(zh)
|
2006-11-29 |
2009-01-28 |
中国抗体制药有限公司 |
功能人源化抗人cd20抗体及其应用
|
WO2008140603A2
(en)
|
2006-12-08 |
2008-11-20 |
Macrogenics, Inc. |
METHODS FOR THE TREATMENT OF DISEASE USING IMMUNOGLOBULINS HAVING FC REGIONS WITH ALTERED AFFINITIES FOR FCγR ACTIVATING AND FCγR INHIBITING
|
WO2008091798A2
(en)
|
2007-01-22 |
2008-07-31 |
Xencor, Inc. |
Optimized ca9 antibodies and methods of using the same
|
CA2669412A1
(en)
|
2007-01-23 |
2008-07-31 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
WO2008092117A2
(en)
|
2007-01-25 |
2008-07-31 |
Xencor, Inc. |
Immunoglobulins with modifications in the fcr binding region
|
WO2008098115A2
(en)
|
2007-02-07 |
2008-08-14 |
Xencor, Inc. |
Optimized igf-1r antibodies and methods of using the same
|
WO2008114011A2
(en)
|
2007-03-19 |
2008-09-25 |
Medimmune Limited |
Fc polypeptide variants obtained by ribosome display methodology
|
AU2008234248C1
(en)
|
2007-03-29 |
2015-01-22 |
Genmab A/S |
Bispecific antibodies and methods for production thereof
|
CL2008001071A1
(es)
|
2007-04-17 |
2009-05-22 |
Smithkline Beecham Corp |
Metodo para obtener anticuerpo penta-especifico contra il-8/cxcl8, gro-alfa/cxcl1, gro-beta/cxcl2), gro-gama/cxcl3 y ena-78/cxcl5 humanas; anticuerpo penta-especifico; proceso de produccion del mismo; vector, hbridoma o celela que lo comprende; composicion farmceutica; uso para tratar copd, otras enfermedades.
|
MX2009012343A
(es)
|
2007-05-14 |
2010-02-10 |
Biogen Idec Inc |
Regiones fc (sc fc) de cadena sencilla, polipeptidos de enlace que comprenden las mismas, y metodos relacionados con ello.
|
EP2176298B1
(en)
|
2007-05-30 |
2017-11-15 |
Xencor, Inc. |
Methods and compositions for inhibiting cd32b expressing cells
|
WO2009000098A2
(en)
|
2007-06-25 |
2008-12-31 |
Esbatech Ag |
Sequence based engineering and optimization of single chain antibodies
|
US20090074780A1
(en)
|
2007-06-25 |
2009-03-19 |
David Urech |
Methods of modifying antibodies, and modified antibodies with improved functional properties
|
WO2009008529A1
(ja)
|
2007-07-06 |
2009-01-15 |
Tokyo Metropolitan Organization For Medical Research |
Tdp-43凝集物に特異的に結合する抗体
|
US20110105724A1
(en)
|
2007-08-16 |
2011-05-05 |
Stephanie Jane Clegg |
Novel compounds
|
JOP20080381B1
(ar)
|
2007-08-23 |
2023-03-28 |
Amgen Inc |
بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
|
WO2009032782A2
(en)
|
2007-08-28 |
2009-03-12 |
Biogen Idec Ma Inc. |
Compositions that bind multiple epitopes of igf-1r
|
JP2010537985A
(ja)
|
2007-08-28 |
2010-12-09 |
バイオジェン アイデック マサチューセッツ インコーポレイテッド |
抗igf−1r抗体およびその使用
|
AR068564A1
(es)
|
2007-09-26 |
2009-11-18 |
Chugai Pharmaceutical Co Ltd |
Anticuerpo anti- receptor de il-6 (interleuquina 6)
|
CA2700701C
(en)
|
2007-09-26 |
2020-12-29 |
Chugai Seiyaku Kabushiki Kaisha |
Method of modifying isoelectric point of antibody via amino acid substitution in cdr
|
PL3059246T3
(pl)
|
2007-09-26 |
2018-11-30 |
Chugai Seiyaku Kabushiki Kaisha |
Zmodyfikowany region stały przeciwciała
|
EP2584043A3
(en)
|
2007-09-28 |
2013-10-02 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-glypican 3 antibody having improved kinetics in plasma
|
KR100888133B1
(ko)
|
2007-10-02 |
2009-03-13 |
에스케이에너지 주식회사 |
4종의 금속성분으로 구성된 다성분계 비스무스몰리브데이트 촉매 제조방법 및 상기촉매를 이용하여1,3-부타디엔을 제조하는 방법
|
EP2203474A1
(en)
|
2007-10-22 |
2010-07-07 |
Merck Serono S.A. |
Method for purifying fc-fusion proteins
|
PE20091163A1
(es)
|
2007-11-01 |
2009-08-09 |
Wyeth Corp |
Anticuerpos para gdf8
|
WO2009062051A2
(en)
|
2007-11-08 |
2009-05-14 |
Pikamab, Inc. |
Methods and compositions for antibody therapy
|
EP4098661A1
(en)
|
2007-12-26 |
2022-12-07 |
Xencor, Inc. |
Fc variants with altered binding to fcrn
|
DK2235064T3
(en)
|
2008-01-07 |
2016-01-11 |
Amgen Inc |
A process for the preparation of heterodimeric Fc molecules using electrostatic control effects
|
WO2009089846A1
(en)
|
2008-01-18 |
2009-07-23 |
Stichting Sanquin Bloedvoorziening |
Methods for increasing the therapeutic efficacy of immunoglobulin g class 3 (igg3) antibodies
|
WO2009094391A1
(en)
|
2008-01-23 |
2009-07-30 |
Xencor, Inc. |
Optimized cd40 antibodies and methods of using the same
|
US20110183861A1
(en)
|
2008-01-29 |
2011-07-28 |
Ablynn N.V. |
Methods to stabilize proteins and polypeptides
|
AU2015227424A1
(en)
|
2008-04-11 |
2015-10-01 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
SG189775A1
(en)
|
2008-04-11 |
2013-05-31 |
Chugai Pharmaceutical Co Ltd |
Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
|
KR102072896B1
(ko)
|
2008-04-25 |
2020-02-03 |
다이액스 코포레이션 |
Fcrn에 대한 항체 및 이들의 용도
|
CA2722600C
(en)
|
2008-05-01 |
2014-01-21 |
Amgen Inc. |
Anti-hepcidin antibodies and methods of use
|
RU2519645C2
(ru)
|
2008-05-14 |
2014-06-20 |
Эгрикалчер Виктория Сервисиз Пти Лтд |
Применение ангиогенина или агонистов ангиогенина для лечения заболеваний и нарушений
|
AU2009259901B2
(en)
|
2008-06-20 |
2016-02-04 |
Massachusetts Institute Of Technology |
Immunoglobulins with reduced aggregation
|
EP2815766B1
(en)
|
2008-08-05 |
2017-07-05 |
Novartis AG |
Compositions and methods for antibodies targeting complement protein C5
|
CA2736511C
(en)
|
2008-09-17 |
2017-06-13 |
Xencor, Inc. |
Novel compositions and methods for treating ige-mediated disorders
|
TWI440469B
(zh)
|
2008-09-26 |
2014-06-11 |
Chugai Pharmaceutical Co Ltd |
Improved antibody molecules
|
JP5028372B2
(ja)
|
2008-09-26 |
2012-09-19 |
京セラドキュメントソリューションズ株式会社 |
画像処理装置、画像処理方法及び画像処理プログラム
|
KR102100066B1
(ko)
|
2008-10-14 |
2020-04-10 |
제넨테크, 인크. |
이뮤노글로불린 변이체 및 그의 용도
|
WO2010058860A1
(ja)
|
2008-11-18 |
2010-05-27 |
株式会社シノテスト |
試料中のc反応性蛋白質の測定方法及び測定試薬
|
JO3672B1
(ar)
|
2008-12-15 |
2020-08-27 |
Regeneron Pharma |
أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
|
UY32341A
(es)
|
2008-12-19 |
2010-07-30 |
Glaxo Group Ltd |
Proteínas de unión antígeno novedosas
|
BRPI1006141B8
(pt)
|
2009-01-12 |
2021-05-25 |
Cytomx Therapeutics Llc |
composições de anticorpo modificado, métodos para preparar e usar as mesmas
|
US20120100140A1
(en)
|
2009-01-23 |
2012-04-26 |
Biogen Idec Ma Inc. |
Stabilized fc polypeptides with reduced effector function and methods of use
|
EP2400981A4
(en)
|
2009-02-26 |
2013-02-27 |
Lpath Inc |
DESGIN FOR HUMANIZED THROMBOZYTE ACTIVATION FACTOR ANTIBODIES BY ANTI-LIPID ANTIBODY TEMPLATES
|
TWI646193B
(zh)
|
2009-03-19 |
2019-01-01 |
中外製藥股份有限公司 |
抗體恆定區域改變體
|
WO2010106812A1
(en)
|
2009-03-19 |
2010-09-23 |
Chugai Seiyaku Kabushiki Kaisha |
Pharmaceutical formulation containing improved antibody molecules
|
EP2409991B1
(en)
|
2009-03-19 |
2017-05-03 |
Chugai Seiyaku Kabushiki Kaisha |
Antibody constant region variant
|
EP2233500A1
(en)
|
2009-03-20 |
2010-09-29 |
LFB Biotechnologies |
Optimized Fc variants
|
JP2010250827A
(ja)
|
2009-04-16 |
2010-11-04 |
Accenture Global Services Gmbh |
タッチポイントをカスタマイズするシステム
|
CN102459344A
(zh)
|
2009-05-15 |
2012-05-16 |
中外制药株式会社 |
抗axl抗体
|
HUP0900319A2
(en)
|
2009-05-25 |
2011-01-28 |
Eotvos Lorand Tudomanyegyetem |
New peptides, method of producing therof and use thereof
|
US20120303083A1
(en)
|
2009-05-26 |
2012-11-29 |
The Johns Hopkins University |
Novel desmin phosphorylation sites useful in diagnosis and intervention of cardiac disease
|
US8609097B2
(en)
|
2009-06-10 |
2013-12-17 |
Hoffmann-La Roche Inc. |
Use of an anti-Tau pS422 antibody for the treatment of brain diseases
|
US8945511B2
(en)
|
2009-06-25 |
2015-02-03 |
Paul Weinberger |
Sensitive methods for detecting the presence of cancer associated with the over-expression of galectin-3 using biomarkers derived from galectin-3
|
MY164121A
(en)
|
2009-06-26 |
2017-11-30 |
Regeneron Pharma |
Readily isolated bispecific antibodies with native immunoglobulin format
|
EP2448972A4
(en)
|
2009-06-30 |
2012-11-28 |
Res Dev Foundation |
IMMUNOGLOBULIN FC POLYPEPTIDES
|
GB0914691D0
(en)
|
2009-08-21 |
2009-09-30 |
Lonza Biologics Plc |
Immunoglobulin variants
|
AU2010289677B2
(en)
|
2009-09-03 |
2014-07-31 |
Merck Sharp & Dohme Llc |
Anti-GITR antibodies
|
US8568726B2
(en)
|
2009-10-06 |
2013-10-29 |
Medimmune Limited |
RSV specific binding molecule
|
JP5734988B2
(ja)
|
2009-10-06 |
2015-06-17 |
メディミューン リミテド |
Rsv特異的結合分子
|
DK2486141T3
(en)
|
2009-10-07 |
2018-04-23 |
Macrogenics Inc |
FC-REGION-CONTAINING POLYPEPTIDES THAT PROVIDE IMPROVED EFFECTOR FUNCTION BASED ON CHANGES OF THE SCOPE OF FUCOSYLATION AND PROCEDURES FOR THEIR USE
|
CN102781963B
(zh)
|
2009-10-27 |
2018-02-16 |
Ucb医药有限公司 |
功能修饰性NAv1.7抗体
|
MX340971B
(es)
|
2009-11-23 |
2016-08-02 |
Amgen Inc * |
Fragmento cristalizable (fc) de anticuerpo monomerico.
|
US8362210B2
(en)
|
2010-01-19 |
2013-01-29 |
Xencor, Inc. |
Antibody variants with enhanced complement activity
|
US20120315267A1
(en)
|
2010-02-09 |
2012-12-13 |
Glaxosmithkline Llc |
Novel uses
|
HUE030100T2
(en)
|
2010-02-19 |
2017-04-28 |
Xencor Inc |
New CTLA4-IG immunoadhesins
|
EP2542577A1
(en)
|
2010-03-01 |
2013-01-09 |
Lostam Biopharmaceuticals Ltd |
Improved therapeutic antibodies against flagellated pseudomonas aeruginosa
|
JP5889181B2
(ja)
|
2010-03-04 |
2016-03-22 |
中外製薬株式会社 |
抗体定常領域改変体
|
CN102844332B
(zh)
|
2010-03-11 |
2015-08-19 |
瑞纳神经科学公司 |
呈pH依赖性抗原结合的抗体
|
JP2011184418A
(ja)
|
2010-03-11 |
2011-09-22 |
Tokyo Institute Of Technology |
親和性可変抗体
|
TWI667346B
(zh)
|
2010-03-30 |
2019-08-01 |
中外製藥股份有限公司 |
促進抗原消失之具有經修飾的FcRn親和力之抗體
|
CA2794860C
(en)
|
2010-03-30 |
2022-05-17 |
Chugai Seiyaku Kabushiki Kaisha |
Antibodies with modified affinity to fcrn that promote antigen clearance
|
KR101930964B1
(ko)
|
2010-04-20 |
2018-12-19 |
젠맵 에이/에스 |
이종이량체 항체 fc-함유 단백질 및 그의 생산 방법
|
JO3340B1
(ar)
|
2010-05-26 |
2019-03-13 |
Regeneron Pharma |
مضادات حيوية لـعامل تمايز النمو 8 البشري
|
TW201210612A
(en)
|
2010-06-03 |
2012-03-16 |
Glaxo Group Ltd |
Humanised antigen binding proteins
|
DK3029066T3
(da)
|
2010-07-29 |
2019-05-20 |
Xencor Inc |
Antistoffer med modificerede isoelektriske punkter
|
AU2011292197B2
(en)
|
2010-08-16 |
2015-05-28 |
Amgen Inc. |
Antibodies that bind myostatin, compositions and methods
|
KR20130096731A
(ko)
|
2010-09-08 |
2013-08-30 |
할로자임, 아이엔씨 |
조건부 활성 치료적 단백질을 평가,확인 또는 진화시키는 방법
|
RU2551963C2
(ru)
|
2010-09-09 |
2015-06-10 |
Пфайзер Инк. |
Молекулы, связывающиеся с 4-1вв
|
JP6173911B2
(ja)
|
2010-09-10 |
2017-08-09 |
メディミューン リミテド |
抗体誘導体
|
EP2622074B1
(en)
|
2010-09-30 |
2014-11-12 |
Board Of Trustees Of Northern Illinois University |
Library-based methods and compositions for introducing molecular switch functionality into protein affinity reagents
|
DK2635607T3
(da)
|
2010-11-05 |
2019-11-18 |
Zymeworks Inc |
Stabilt heterodimert antistofdesign med mutationer i fc-domænet
|
CN103328632A
(zh)
|
2010-11-30 |
2013-09-25 |
中外制药株式会社 |
与多分子的抗原重复结合的抗原结合分子
|
JP6043629B2
(ja)
|
2011-01-07 |
2016-12-14 |
中外製薬株式会社 |
抗体の物性を改善させる方法
|
SG192945A1
(en)
|
2011-02-25 |
2013-09-30 |
Chugai Pharmaceutical Co Ltd |
Fcgriib-specific fc antibody
|
WO2012132067A1
(ja)
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
WO2012133782A1
(ja)
*
|
2011-03-30 |
2012-10-04 |
中外製薬株式会社 |
抗原結合分子の血漿中滞留性と免疫原性を改変する方法
|
JP5972915B2
(ja)
|
2011-03-16 |
2016-08-17 |
アムジエン・インコーポレーテツド |
Fc変異体
|
JP6125489B2
(ja)
|
2011-04-29 |
2017-05-10 |
アペクシジェン, インコーポレイテッド |
抗cd40抗体および使用方法
|
CN107011443B
(zh)
|
2011-05-04 |
2021-04-30 |
奥默罗斯公司 |
用于抑制masp-2依赖的补体活化的组合物
|
CA2834589A1
(en)
|
2011-05-25 |
2012-11-29 |
Merck Sharp & Dohme Corp. |
Method for preparing fc-containing polypeptides having improved properties
|
CA2839539C
(en)
|
2011-06-30 |
2021-06-08 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
UA117901C2
(uk)
|
2011-07-06 |
2018-10-25 |
Ґенмаб Б.В. |
Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
|
WO2013012733A1
(en)
|
2011-07-15 |
2013-01-24 |
Biogen Idec Ma Inc. |
Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
|
KR102492584B1
(ko)
|
2011-09-30 |
2023-01-27 |
추가이 세이야쿠 가부시키가이샤 |
표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
|
KR102528622B1
(ko)
|
2011-09-30 |
2023-05-04 |
추가이 세이야쿠 가부시키가이샤 |
이온 농도 의존성 결합 분자 라이브러리
|
TW201817744A
(zh)
|
2011-09-30 |
2018-05-16 |
日商中外製藥股份有限公司 |
具有促進抗原清除之FcRn結合域的治療性抗原結合分子
|
TW201726745A
(zh)
|
2011-09-30 |
2017-08-01 |
中外製藥股份有限公司 |
促進抗原消失的抗原結合分子
|
EP3939996A1
(en)
|
2011-09-30 |
2022-01-19 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities
|
JP6271251B2
(ja)
|
2011-10-05 |
2018-01-31 |
中外製薬株式会社 |
糖鎖受容体結合ドメインを含む抗原の血漿中からの消失を促進する抗原結合分子
|
ES2899956T3
(es)
|
2011-11-04 |
2022-03-15 |
Zymeworks Inc |
Diseño de anticuerpo heterodimérico estable con mutaciones en el dominio Fc
|
RU2739792C1
(ru)
|
2011-11-30 |
2020-12-28 |
Чугаи Сейяку Кабусики Кайся |
Содержащий лекарственное средство переносчик в клетку для формирования иммунного комплекса
|
US20150210763A1
(en)
|
2012-02-09 |
2015-07-30 |
Chugai Seiyaku Kabushiki Kaisha |
MODIFIED Fc REGION OF ANTIBODY
|
JP6138108B2
(ja)
|
2012-02-24 |
2017-05-31 |
中外製薬株式会社 |
FcγRIIBを介して抗原の消失を促進する抗原結合分子
|
CN104302169B
(zh)
|
2012-03-16 |
2017-11-17 |
瑞泽恩制药公司 |
组氨酸工程改造的轻链抗体和用于生成所述抗体的经基因修饰的非人动物
|
AU2013204581B2
(en)
|
2012-03-16 |
2015-06-25 |
Regeneron Pharmaceuticals, Inc. |
Non-human animals expressing pH-sensitive immunoglobulin sequences
|
RS59076B1
(sr)
|
2012-03-16 |
2019-09-30 |
Regeneron Pharma |
Glodari koji eksprimiraju imunoglobulinske sekvence senzitivne na ph
|
TWI619729B
(zh)
|
2012-04-02 |
2018-04-01 |
再生元醫藥公司 |
抗-hla-b*27抗體及其用途
|
US9605058B2
(en)
|
2012-05-01 |
2017-03-28 |
Glaxosmithkline Llc |
Antibodies against the CXC-ELR family of chemokines
|
US9255154B2
(en)
|
2012-05-08 |
2016-02-09 |
Alderbio Holdings, Llc |
Anti-PCSK9 antibodies and use thereof
|
WO2013180200A1
(ja)
*
|
2012-05-30 |
2013-12-05 |
中外製薬株式会社 |
標的組織特異的抗原結合分子
|
EP3892638A1
(en)
|
2012-05-30 |
2021-10-13 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule for eliminating aggregated antigens
|
US11142563B2
(en)
|
2012-06-14 |
2021-10-12 |
Chugai Seiyaku Kabushiki Kaisha |
Antigen-binding molecule containing modified Fc region
|
SA113340642B1
(ar)
|
2012-06-15 |
2015-09-15 |
فايزر إنك |
أجسام مضادة معارضة محسنة ضد gdf-8 واستخداماتها
|
KR102339315B1
(ko)
|
2012-06-18 |
2021-12-15 |
오메로스 코포레이션 |
다양한 질환 및 장애의 치료를 위해 masp-1 및/또는 masp-2 및/또는 masp-3를 억제하는 조성물 및 방법
|
SG11201408646VA
(en)
|
2012-07-06 |
2015-01-29 |
Genmab Bv |
Dimeric protein with triple mutations
|
EA028244B1
(ru)
|
2012-08-13 |
2017-10-31 |
Ридженерон Фармасьютикалз, Инк. |
АНТИТЕЛА К PCSK9 C pH-ЗАВИСИМЫМИ ХАРАКТЕРИСТИКАМИ СВЯЗЫВАНИЯ
|
DK2889377T3
(da)
|
2012-08-24 |
2020-03-30 |
Chugai Pharmaceutical Co Ltd |
Fc?RIIb-Specifik Fc-regionsvariant
|
WO2014030750A1
(ja)
|
2012-08-24 |
2014-02-27 |
中外製薬株式会社 |
マウスFcγRII特異的Fc抗体
|
TWI595007B
(zh)
|
2012-09-10 |
2017-08-11 |
Neotope Biosciences Ltd |
抗mcam抗體及相關使用方法
|
CA2884730C
(en)
|
2012-09-13 |
2023-07-04 |
Bristol-Myers Squibb Company |
Fibronectin based scaffold domain proteins that bind to myostatin
|
CA3124553A1
(en)
|
2012-10-25 |
2014-05-01 |
Bioverativ Usa Inc. |
Anti-complement c1s antibodies and uses thereof
|
DK2914291T3
(da)
|
2012-11-02 |
2022-05-16 |
Bioverativ Usa Inc |
Anti-komplement-c1s-antistoffer og anvendelser deraf
|
EP2916867A4
(en)
|
2012-11-06 |
2016-10-05 |
Scholar Rock Inc |
COMPOSITIONS AND METHOD FOR MODULATING CELL SIGNALING
|
AR094271A1
(es)
|
2012-12-21 |
2015-07-22 |
Aveo Pharmaceuticals Inc |
Anticuerpos anti-gdf15
|
US10766960B2
(en)
|
2012-12-27 |
2020-09-08 |
Chugai Seiyaku Kabushiki Kaisha |
Heterodimerized polypeptide
|
US9701759B2
(en)
|
2013-01-14 |
2017-07-11 |
Xencor, Inc. |
Heterodimeric proteins
|
CN105051064A
(zh)
|
2013-01-24 |
2015-11-11 |
葛兰素史克知识产权开发有限公司 |
抗TNF-α抗原结合蛋白
|
JO3532B1
(ar)
|
2013-03-13 |
2020-07-05 |
Regeneron Pharma |
الأجسام المضادة لمضاد انترلوكين-33 واستعمالاتها
|
US9481725B2
(en)
|
2013-03-14 |
2016-11-01 |
Alderbio Holdings, Llc |
Antibodies to HGF and compositions containing
|
KR102191654B1
(ko)
|
2013-03-15 |
2020-12-16 |
애피바디 에이비 |
신규 폴리펩티드
|
ES2657304T3
(es)
|
2013-03-15 |
2018-03-02 |
Bayer Healthcare Llc |
Variantes de anticuerpo anti TFPI con unión diferencial a lo largo del intervalo de pH para mejorar la farmacocinética
|
CN105530949A
(zh)
|
2013-03-15 |
2016-04-27 |
安姆根有限公司 |
人类受试者中的肌抑素拮抗作用
|
LT2951203T
(lt)
|
2013-03-15 |
2019-09-10 |
Xencor, Inc. |
Heterodimeriniai baltymai
|
US10858417B2
(en)
|
2013-03-15 |
2020-12-08 |
Xencor, Inc. |
Heterodimeric proteins
|
JP2016514668A
(ja)
|
2013-03-15 |
2016-05-23 |
アムジエン・インコーポレーテツド |
プロタンパク質コンベルターゼスブチリシンケクシン9型に結合するヒト抗原結合タンパク質
|
US20160031985A1
(en)
|
2013-03-15 |
2016-02-04 |
Katherine S. Bowdish |
Charge-engineered antibodies or compositions of penetration-enhanced targeting proteins and methods of use
|
US20160032014A1
(en)
|
2013-03-15 |
2016-02-04 |
Amgen Inc. |
Human antigen binding proteins that bind to proprotein convertase subtilisin kexin type 9
|
WO2014163101A1
(ja)
|
2013-04-02 |
2014-10-09 |
中外製薬株式会社 |
Fc領域改変体
|
EP2983710B1
(en)
|
2013-04-09 |
2019-07-31 |
Annexon, Inc. |
Methods of treatment for neuromyelitis optica
|
EP2981822B1
(en)
|
2013-05-06 |
2020-09-02 |
Scholar Rock, Inc. |
Compositions and methods for growth factor modulation
|
WO2014186622A2
(en)
|
2013-05-15 |
2014-11-20 |
Annexon, Inc. |
Methods of treatment for guillain-barre syndrome
|
AU2014267171A1
(en)
|
2013-05-17 |
2015-12-10 |
Centre National De La Recherche Scientifique (Cnrs) |
Anti-CXCL1, CXCL7 and CXCL8 antibodies and their applications
|
US10111953B2
(en)
|
2013-05-30 |
2018-10-30 |
Regeneron Pharmaceuticals, Inc. |
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9)
|
ES2736326T3
(es)
|
2013-05-31 |
2019-12-27 |
Zymeworks Inc |
Heteromultímeros con función efectora reducida o silenciada
|
PT3406633T
(pt)
|
2013-07-25 |
2022-05-04 |
Cytomx Therapeutics Inc |
Anticorpos multi-específicos, anticorpos ativáveis multi-específicos e métodos de utilização dos mesmos
|
TN2016000057A1
(en)
|
2013-08-14 |
2017-07-05 |
Novartis Ag |
Methods of treating sporadic inclusion body myositis
|
CN111019953A
(zh)
|
2013-09-18 |
2020-04-17 |
瑞泽恩制药公司 |
组氨酸工程改造的轻链抗体和用于生成所述抗体的经基因修饰的非人动物
|
EP2853898B1
(en)
|
2013-09-27 |
2017-01-04 |
Medizinische Hochschule Hannover |
Analysis of myostatin in serum
|
SG10201803449VA
(en)
|
2013-09-27 |
2018-05-30 |
Chugai Pharmaceutical Co Ltd |
Method for producing polypeptide heteromultimer
|
EP3071600B1
(en)
|
2013-11-20 |
2020-06-17 |
Regeneron Pharmaceuticals, Inc. |
Aplnr modulators and uses thereof
|
TWI702316B
(zh)
|
2013-12-04 |
2020-08-21 |
日商中外製藥股份有限公司 |
因應化合物濃度使抗原結合能力變化的抗原結合分子及其資料庫
|
WO2015111008A2
(en)
|
2014-01-27 |
2015-07-30 |
Novartis Ag |
Biomarkers predictive of muscle atrophy, method and use
|
NZ711451A
(en)
|
2014-03-07 |
2016-05-27 |
Alexion Pharma Inc |
Anti-c5 antibodies having improved pharmacokinetics
|
TW201622746A
(zh)
|
2014-04-24 |
2016-07-01 |
諾華公司 |
改善或加速髖部骨折術後身體復原之方法
|
JP6715491B2
(ja)
|
2014-06-11 |
2020-07-01 |
Idacセラノスティクス株式会社 |
免疫チェックポイント制御剤の副作用低減方法
|
US10183994B2
(en)
|
2014-06-30 |
2019-01-22 |
Merck Patent Gmbh |
Anti-TNFα antibodies with pH-dependent antigen binding for improved target clearence
|
WO2016073906A2
(en)
|
2014-11-06 |
2016-05-12 |
Scholar Rock, Inc. |
Transforming growth factor-related immunoassays
|
US10307480B2
(en)
|
2014-11-06 |
2019-06-04 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
RU2017123880A
(ru)
|
2014-12-08 |
2019-01-10 |
Новартис Аг |
Антагонисты миостатина или активина для лечения саркопении
|
US9765135B2
(en)
|
2014-12-19 |
2017-09-19 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-C5 antibodies
|
CR20170326A
(es)
|
2014-12-19 |
2017-08-22 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos antimiostatina, polipéptidos que contienen regiones fc variantes, y métodos de uso
|
WO2016125495A1
(en)
|
2015-02-05 |
2016-08-11 |
Chugai Seiyaku Kabushiki Kaisha |
Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof
|
LT3280440T
(lt)
|
2015-04-06 |
2023-02-27 |
Bioverativ Usa Inc. |
Humanizuoti antikūnai prieš c1s ir jų panaudojimo būdai
|
WO2016168613A1
(en)
|
2015-04-15 |
2016-10-20 |
Regeneron Pharmaceuticals, Inc. |
Methods of increasing strength and functionality with gdf8 inhibitors
|
SG11201707832RA
(en)
|
2015-04-22 |
2017-11-29 |
Curevac Ag |
Rna containing composition for treatment of tumor diseases
|
US20180171017A1
(en)
|
2015-06-05 |
2018-06-21 |
Chugai Seiyaku Kabushiki Kaisha |
Combined use of immune activators
|
US10940126B2
(en)
|
2015-07-03 |
2021-03-09 |
Camilla Svensson |
Inhibition of IL-8 in the treatment of pain and/or bone loss
|
CA3036652A1
(en)
|
2015-09-15 |
2017-03-23 |
Scholar Rock, Inc. |
Anti-pro/latent-myostatin antibodies and uses thereof
|
MX2018003005A
(es)
|
2015-09-18 |
2018-04-11 |
Chugai Pharmaceutical Co Ltd |
Anticuerpos que se unen a interleucina 8 (il-8) y sus usos.
|
US10723788B2
(en)
|
2015-11-24 |
2020-07-28 |
Annexon, Inc. |
Anti-complement factor C1q Fab fragments and uses thereof
|
JP6142069B1
(ja)
|
2015-12-18 |
2017-06-07 |
中外製薬株式会社 |
抗ミオスタチン抗体、変異Fc領域を含むポリペプチド、および使用方法
|
WO2017110981A1
(en)
|
2015-12-25 |
2017-06-29 |
Chugai Seiyaku Kabushiki Kaisha |
Anti-myostatin antibodies and methods of use
|
WO2017120523A2
(en)
|
2016-01-08 |
2017-07-13 |
Scholar Rock, Inc. |
Anti-pro/latent myostatin antibodies and methods of use thereof
|
EP4218804A3
(en)
|
2016-06-13 |
2023-09-13 |
Scholar Rock, Inc. |
Use of myostatin inhibitors and combination therapies
|
JP6196411B1
(ja)
|
2016-06-17 |
2017-09-13 |
中外製薬株式会社 |
抗ミオスタチン抗体および使用方法
|
KR20230079499A
(ko)
|
2016-08-05 |
2023-06-07 |
추가이 세이야쿠 가부시키가이샤 |
Il-8 관련 질환의 치료용 또는 예방용 조성물
|
JP7211961B2
(ja)
|
2017-03-14 |
2023-01-24 |
ファイヴ プライム セラピューティクス インク |
酸性pHでVISTAに結合する抗体
|
CN111556895A
(zh)
|
2017-11-14 |
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