BG61125B2 - Циклични вазоактивни пептидни аналози - Google Patents

Циклични вазоактивни пептидни аналози Download PDF

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Publication number
BG61125B2
BG61125B2 BG098608A BG9860894A BG61125B2 BG 61125 B2 BG61125 B2 BG 61125B2 BG 098608 A BG098608 A BG 098608A BG 9860894 A BG9860894 A BG 9860894A BG 61125 B2 BG61125 B2 BG 61125B2
Authority
BG
Bulgaria
Prior art keywords
lys
asp
ala
peptide
seq
Prior art date
Application number
BG098608A
Other languages
Bulgarian (bg)
English (en)
Inventor
David Bolin
Margaret O'donnell
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of BG61125B2 publication Critical patent/BG61125B2/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57563Vasoactive intestinal peptide [VIP]; Related peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02Muscle relaxants, e.g. for tetanus or cramps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/17Vasoactive intestinal peptides; related peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/27Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BG098608A 1991-10-11 1994-02-28 Циклични вазоактивни пептидни аналози BG61125B2 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77374791A 1991-10-11 1991-10-11

Publications (1)

Publication Number Publication Date
BG61125B2 true BG61125B2 (bg) 1996-11-29

Family

ID=25099195

Family Applications (1)

Application Number Title Priority Date Filing Date
BG098608A BG61125B2 (bg) 1991-10-11 1994-02-28 Циклични вазоактивни пептидни аналози

Country Status (26)

Country Link
US (1) US5677419A (enExample)
EP (1) EP0536741B1 (enExample)
JP (1) JP2515473B2 (enExample)
KR (1) KR970001580B1 (enExample)
CN (3) CN1034943C (enExample)
AT (1) ATE132165T1 (enExample)
AU (1) AU656230B2 (enExample)
BG (1) BG61125B2 (enExample)
BR (1) BR9203959A (enExample)
CA (1) CA2080272C (enExample)
CZ (1) CZ281818B6 (enExample)
DE (1) DE69207138T2 (enExample)
DK (1) DK0536741T3 (enExample)
ES (1) ES2082317T3 (enExample)
FI (2) FI111646B (enExample)
GR (1) GR3019326T3 (enExample)
HU (2) HUT62606A (enExample)
IL (3) IL103396A (enExample)
MX (1) MX9205822A (enExample)
NO (3) NO304523B1 (enExample)
NZ (1) NZ244644A (enExample)
RU (1) RU2095368C1 (enExample)
SK (1) SK279399B6 (enExample)
TW (1) TW305846B (enExample)
UY (2) UY23488A1 (enExample)
ZA (1) ZA927724B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872803B1 (en) 1993-09-21 2005-03-29 Kyowa Hakko Kogyo Co., Ltd. Peptides
EP0879246B1 (en) * 1996-02-09 2006-05-31 F. Hoffmann-La Roche Ag Synthesis of vip analog
ES2297862T3 (es) * 1996-07-12 2008-05-01 Immunomedics, Inc. Analogos de peptidos que se unen a radiometales.
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
PE20010612A1 (es) * 1999-09-28 2001-07-12 Bayer Corp Agonistas del receptor 3 (r3) del peptido activador de la adenilato ciclasa de la pituitaria y su uso farmacologico
ATE355304T1 (de) 2000-02-18 2006-03-15 Dabur Res Foundation Radiomarkierte vip-analoge zur diagnose und therapie
WO2001060862A1 (en) 2000-02-18 2001-08-23 Dabur Research Foundation Vasoactive intestinal peptide analogs
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
US7507714B2 (en) * 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
CN1487952A (zh) 2000-11-28 2004-04-07 �ɶ����\��ʵ���� 具有血管活性肠肽的生物学活性的用于治疗肺动脉和小动脉高压的化合物
CN1313149C (zh) 2002-06-10 2007-05-02 蒙杜生物科技安斯塔特实验室 具有血管活性肠肽的生物学活性的化合物在治疗结节病中的用途
KR20070009554A (ko) * 2004-01-27 2007-01-18 바이엘 파마슈티칼스 코포레이션 뇌하수체 아데닐레이트 사이클라제 활성화 펩티드(pacap) 수용체 (vpac2) 작용제 및 이의약리학적 사용 방법
US20080085860A1 (en) * 2004-08-18 2008-04-10 Eli Lilly And Company Selective Vpac2 Receptor Peptide Agonists
CA2576755A1 (en) * 2004-08-18 2006-03-02 Eli Lilly And Company Selective vpac2 receptor peptide agonists
RU2304146C2 (ru) * 2005-10-17 2007-08-10 Закрытое акционерное общество "Эпитек" Способ стабилизации петлеобразной структуры синтетических пептидов с помощью n- и c-концевых модификаций
BRPI0708341A2 (pt) * 2006-02-28 2011-05-24 Lilly Co Eli agonistas peptìdicos seletivos do receptor vpac2
JP2009542593A (ja) * 2006-07-06 2009-12-03 エフ.ホフマン−ラ ロシュ アーゲー 血管作動性腸管ペプチドの類似体
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
MX366935B (es) 2009-08-14 2019-07-31 Phasebio Pharmaceuticals Inc Peptidos intestinales vasoactivos modificados.
US9782454B2 (en) * 2010-04-22 2017-10-10 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
EP2968469A4 (en) 2013-03-15 2016-08-31 Longevity Biotech Inc PEPTIDES COMPRISING NON-ENDOGENIC AMINO ACIDS AND METHODS OF MAKING AND USING SAME
GB201421647D0 (en) 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
WO2016130518A2 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
CA3036768A1 (en) 2016-09-30 2018-04-05 Fujifilm Corporation Cyclic peptide, affinity chromatography support, labeled antibody, antibody drug conjugate, and pharmaceutical preparation
EP4108676A4 (en) * 2020-02-22 2024-06-05 JCR Pharmaceuticals Co., Ltd. HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
US4835252A (en) * 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
CZ281818B6 (cs) 1997-02-12
NO980377D0 (no) 1998-01-28
DK0536741T3 (da) 1996-04-22
FI20002041L (fi) 2000-09-15
IL117252A0 (en) 1996-06-18
NO975023L (no) 1993-04-13
ZA927724B (en) 1994-04-07
DE69207138D1 (de) 1996-02-08
CA2080272C (en) 2002-09-17
CN1198841C (zh) 2005-04-27
KR930007972A (ko) 1993-05-20
NO923929D0 (no) 1992-10-09
IL103396A0 (en) 1993-03-15
MX9205822A (es) 1993-06-01
FI924580L (fi) 1993-04-12
FI111646B (fi) 2003-08-29
CN1072415A (zh) 1993-05-26
NZ244644A (en) 1995-04-27
CN1225473C (zh) 2005-11-02
SK308692A3 (en) 1995-03-08
DE69207138T2 (de) 1996-06-13
EP0536741A2 (en) 1993-04-14
NO980377L (no) 1993-04-13
NO975023D0 (no) 1997-10-31
FI924580A0 (fi) 1992-10-09
CN1153785A (zh) 1997-07-09
UY25084A1 (es) 1998-12-21
CZ308692A3 (en) 1993-08-11
IL103396A (en) 1997-11-20
CN1034943C (zh) 1997-05-21
UY23488A1 (es) 1993-04-20
ATE132165T1 (de) 1996-01-15
TW305846B (enExample) 1997-05-21
ES2082317T3 (es) 1996-03-16
RU2095368C1 (ru) 1997-11-10
NO923929L (no) 1993-04-13
SK279399B6 (sk) 1998-11-04
NO304523B1 (no) 1999-01-04
EP0536741B1 (en) 1995-12-27
HUT62606A (en) 1993-05-28
CN1152579A (zh) 1997-06-25
EP0536741A3 (enExample) 1994-04-06
FI20002041A7 (fi) 2000-09-15
HU9203194D0 (en) 1992-12-28
IL117252A (en) 1999-11-30
AU656230B2 (en) 1995-01-27
JPH05213996A (ja) 1993-08-24
AU2622892A (en) 1993-04-22
GR3019326T3 (en) 1996-06-30
KR970001580B1 (ko) 1997-02-11
CA2080272A1 (en) 1993-04-12
BR9203959A (pt) 1993-04-27
JP2515473B2 (ja) 1996-07-10
HU211534A9 (en) 1995-12-28
US5677419A (en) 1997-10-14

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