JP2515473B2 - 血管作働性環状ペプチド - Google Patents

血管作働性環状ペプチド

Info

Publication number
JP2515473B2
JP2515473B2 JP4297835A JP29783592A JP2515473B2 JP 2515473 B2 JP2515473 B2 JP 2515473B2 JP 4297835 A JP4297835 A JP 4297835A JP 29783592 A JP29783592 A JP 29783592A JP 2515473 B2 JP2515473 B2 JP 2515473B2
Authority
JP
Japan
Prior art keywords
lys
boc
mmol
seq
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP4297835A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05213996A (ja
Inventor
デイビツド・ロバート・ボーリン
マーガレツト・オドーネル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of JPH05213996A publication Critical patent/JPH05213996A/ja
Application granted granted Critical
Publication of JP2515473B2 publication Critical patent/JP2515473B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP4297835A 1991-10-11 1992-10-09 血管作働性環状ペプチド Expired - Fee Related JP2515473B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77374791A 1991-10-11 1991-10-11
US773747 1991-10-11

Publications (2)

Publication Number Publication Date
JPH05213996A JPH05213996A (ja) 1993-08-24
JP2515473B2 true JP2515473B2 (ja) 1996-07-10

Family

ID=25099195

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4297835A Expired - Fee Related JP2515473B2 (ja) 1991-10-11 1992-10-09 血管作働性環状ペプチド

Country Status (26)

Country Link
US (1) US5677419A (enExample)
EP (1) EP0536741B1 (enExample)
JP (1) JP2515473B2 (enExample)
KR (1) KR970001580B1 (enExample)
CN (3) CN1034943C (enExample)
AT (1) ATE132165T1 (enExample)
AU (1) AU656230B2 (enExample)
BG (1) BG61125B2 (enExample)
BR (1) BR9203959A (enExample)
CA (1) CA2080272C (enExample)
CZ (1) CZ281818B6 (enExample)
DE (1) DE69207138T2 (enExample)
DK (1) DK0536741T3 (enExample)
ES (1) ES2082317T3 (enExample)
FI (2) FI111646B (enExample)
GR (1) GR3019326T3 (enExample)
HU (2) HUT62606A (enExample)
IL (3) IL103396A (enExample)
MX (1) MX9205822A (enExample)
NO (3) NO304523B1 (enExample)
NZ (1) NZ244644A (enExample)
RU (1) RU2095368C1 (enExample)
SK (1) SK279399B6 (enExample)
TW (1) TW305846B (enExample)
UY (2) UY23488A1 (enExample)
ZA (1) ZA927724B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872803B1 (en) 1993-09-21 2005-03-29 Kyowa Hakko Kogyo Co., Ltd. Peptides
EP0879246B1 (en) * 1996-02-09 2006-05-31 F. Hoffmann-La Roche Ag Synthesis of vip analog
ES2297862T3 (es) * 1996-07-12 2008-05-01 Immunomedics, Inc. Analogos de peptidos que se unen a radiometales.
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
PE20010612A1 (es) * 1999-09-28 2001-07-12 Bayer Corp Agonistas del receptor 3 (r3) del peptido activador de la adenilato ciclasa de la pituitaria y su uso farmacologico
ATE355304T1 (de) 2000-02-18 2006-03-15 Dabur Res Foundation Radiomarkierte vip-analoge zur diagnose und therapie
WO2001060862A1 (en) 2000-02-18 2001-08-23 Dabur Research Foundation Vasoactive intestinal peptide analogs
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
US7507714B2 (en) * 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
CN1487952A (zh) 2000-11-28 2004-04-07 �ɶ����＼��ʵ���� 具有血管活性肠肽的生物学活性的用于治疗肺动脉和小动脉高压的化合物
CN1313149C (zh) 2002-06-10 2007-05-02 蒙杜生物科技安斯塔特实验室 具有血管活性肠肽的生物学活性的化合物在治疗结节病中的用途
KR20070009554A (ko) * 2004-01-27 2007-01-18 바이엘 파마슈티칼스 코포레이션 뇌하수체 아데닐레이트 사이클라제 활성화 펩티드(ｐａｃａｐ) 수용체 (ｖｐａｃ２) 작용제 및 이의약리학적 사용 방법
US20080085860A1 (en) * 2004-08-18 2008-04-10 Eli Lilly And Company Selective Vpac2 Receptor Peptide Agonists
CA2576755A1 (en) * 2004-08-18 2006-03-02 Eli Lilly And Company Selective vpac2 receptor peptide agonists
RU2304146C2 (ru) * 2005-10-17 2007-08-10 Закрытое акционерное общество "Эпитек" Способ стабилизации петлеобразной структуры синтетических пептидов с помощью n- и c-концевых модификаций
BRPI0708341A2 (pt) * 2006-02-28 2011-05-24 Lilly Co Eli agonistas peptìdicos seletivos do receptor vpac2
JP2009542593A (ja) * 2006-07-06 2009-12-03 エフ．ホフマン−ラ ロシュ アーゲー 血管作動性腸管ペプチドの類似体
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
MX366935B (es) 2009-08-14 2019-07-31 Phasebio Pharmaceuticals Inc Peptidos intestinales vasoactivos modificados.
US9782454B2 (en) * 2010-04-22 2017-10-10 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
US9561262B2 (en) 2011-06-06 2017-02-07 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
EP2968469A4 (en) 2013-03-15 2016-08-31 Longevity Biotech Inc PEPTIDES COMPRISING NON-ENDOGENIC AMINO ACIDS AND METHODS OF MAKING AND USING SAME
GB201421647D0 (en) 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
WO2016130518A2 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
CA3036768A1 (en) 2016-09-30 2018-04-05 Fujifilm Corporation Cyclic peptide, affinity chromatography support, labeled antibody, antibody drug conjugate, and pharmaceutical preparation
EP4108676A4 (en) * 2020-02-22 2024-06-05 JCR Pharmaceuticals Co., Ltd. HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
US4835252A (en) * 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
CZ281818B6 (cs) 1997-02-12
NO980377D0 (no) 1998-01-28
DK0536741T3 (da) 1996-04-22
FI20002041L (fi) 2000-09-15
IL117252A0 (en) 1996-06-18
NO975023L (no) 1993-04-13
ZA927724B (en) 1994-04-07
DE69207138D1 (de) 1996-02-08
CA2080272C (en) 2002-09-17
CN1198841C (zh) 2005-04-27
KR930007972A (ko) 1993-05-20
NO923929D0 (no) 1992-10-09
IL103396A0 (en) 1993-03-15
MX9205822A (es) 1993-06-01
FI924580L (fi) 1993-04-12
FI111646B (fi) 2003-08-29
CN1072415A (zh) 1993-05-26
NZ244644A (en) 1995-04-27
CN1225473C (zh) 2005-11-02
SK308692A3 (en) 1995-03-08
DE69207138T2 (de) 1996-06-13
EP0536741A2 (en) 1993-04-14
NO980377L (no) 1993-04-13
NO975023D0 (no) 1997-10-31
FI924580A0 (fi) 1992-10-09
CN1153785A (zh) 1997-07-09
UY25084A1 (es) 1998-12-21
CZ308692A3 (en) 1993-08-11
IL103396A (en) 1997-11-20
CN1034943C (zh) 1997-05-21
UY23488A1 (es) 1993-04-20
ATE132165T1 (de) 1996-01-15
TW305846B (enExample) 1997-05-21
ES2082317T3 (es) 1996-03-16
RU2095368C1 (ru) 1997-11-10
NO923929L (no) 1993-04-13
SK279399B6 (sk) 1998-11-04
NO304523B1 (no) 1999-01-04
EP0536741B1 (en) 1995-12-27
HUT62606A (en) 1993-05-28
CN1152579A (zh) 1997-06-25
EP0536741A3 (enExample) 1994-04-06
FI20002041A7 (fi) 2000-09-15
HU9203194D0 (en) 1992-12-28
IL117252A (en) 1999-11-30
AU656230B2 (en) 1995-01-27
JPH05213996A (ja) 1993-08-24
AU2622892A (en) 1993-04-22
GR3019326T3 (en) 1996-06-30
KR970001580B1 (ko) 1997-02-11
CA2080272A1 (en) 1993-04-12
BR9203959A (pt) 1993-04-27
BG61125B2 (bg) 1996-11-29
HU211534A9 (en) 1995-12-28
US5677419A (en) 1997-10-14

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