KR970001580B1 - 환상 혈관활성 펩티드 - Google Patents

환상 혈관활성 펩티드 Download PDF

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Publication number
KR970001580B1
KR970001580B1 KR1019920018660A KR920018660A KR970001580B1 KR 970001580 B1 KR970001580 B1 KR 970001580B1 KR 1019920018660 A KR1019920018660 A KR 1019920018660A KR 920018660 A KR920018660 A KR 920018660A KR 970001580 B1 KR970001580 B1 KR 970001580B1
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KR
South Korea
Prior art keywords
boc
mmol
lys
peptide
ala
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019920018660A
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English (en)
Korean (ko)
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KR930007972A (ko
Inventor
로버트 볼린 데이비드
오'도넬 마가렛트
Original Assignee
에프.호프만-라 롯슈 아크티엔게젤샤프트
프리돌린 클라우스너, 롤란드 보러
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Application filed by 에프.호프만-라 롯슈 아크티엔게젤샤프트, 프리돌린 클라우스너, 롤란드 보러 filed Critical 에프.호프만-라 롯슈 아크티엔게젤샤프트
Publication of KR930007972A publication Critical patent/KR930007972A/ko
Application granted granted Critical
Publication of KR970001580B1 publication Critical patent/KR970001580B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019920018660A 1991-10-11 1992-10-10 환상 혈관활성 펩티드 Expired - Fee Related KR970001580B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77374791A 1991-10-11 1991-10-11
US773,747 1991-10-11

Publications (2)

Publication Number Publication Date
KR930007972A KR930007972A (ko) 1993-05-20
KR970001580B1 true KR970001580B1 (ko) 1997-02-11

Family

ID=25099195

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920018660A Expired - Fee Related KR970001580B1 (ko) 1991-10-11 1992-10-10 환상 혈관활성 펩티드

Country Status (26)

Country Link
US (1) US5677419A (enExample)
EP (1) EP0536741B1 (enExample)
JP (1) JP2515473B2 (enExample)
KR (1) KR970001580B1 (enExample)
CN (3) CN1034943C (enExample)
AT (1) ATE132165T1 (enExample)
AU (1) AU656230B2 (enExample)
BG (1) BG61125B2 (enExample)
BR (1) BR9203959A (enExample)
CA (1) CA2080272C (enExample)
CZ (1) CZ281818B6 (enExample)
DE (1) DE69207138T2 (enExample)
DK (1) DK0536741T3 (enExample)
ES (1) ES2082317T3 (enExample)
FI (2) FI111646B (enExample)
GR (1) GR3019326T3 (enExample)
HU (2) HUT62606A (enExample)
IL (3) IL117252A (enExample)
MX (1) MX9205822A (enExample)
NO (3) NO304523B1 (enExample)
NZ (1) NZ244644A (enExample)
RU (1) RU2095368C1 (enExample)
SK (1) SK279399B6 (enExample)
TW (1) TW305846B (enExample)
UY (2) UY23488A1 (enExample)
ZA (1) ZA927724B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6872803B1 (en) 1993-09-21 2005-03-29 Kyowa Hakko Kogyo Co., Ltd. Peptides
WO1997029126A1 (en) * 1996-02-09 1997-08-14 F. Hoffmann-La Roche Ag Synthesis of vip analog
JP3647881B2 (ja) * 1996-07-12 2005-05-18 イムノメディクス，インコーポレイテッド 放射性金属元素結合ペプチドの類似化合物
WO1998002453A2 (en) * 1996-07-15 1998-01-22 Universite Libre De Bruxelles Peptidic ligands having a higher selectivity for the vip1 receptor than for the vip2 receptor
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
RU2269354C2 (ru) * 1999-09-28 2006-02-10 Байер Корпорейшн Агонисты рецептора-3(r3) пептида-активатора гипофизарной аденилатциклазы(расар) и способы их фармакологического применения
EP1257576B1 (en) 2000-02-18 2004-09-15 Dabur Research Foundation Vasoactive intestinal peptide analogs
AU2000263935A1 (en) 2000-02-18 2001-08-27 Dabur Research Foundation Radiolabeled vasoactive intestinal peptide analogs for diagnosis and radiotherapy
US6828304B1 (en) 2000-07-31 2004-12-07 Dabur Research Foundation Peptides for treatment of cancer
US7507714B2 (en) * 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
AU2072002A (en) 2000-11-28 2002-06-11 Mondobiotech Sa Compounds with the biological activity of vasoactive intestinal peptide for the treatment of pulmonary and arteriolar hypertension
CA2488358A1 (en) 2002-06-10 2003-12-18 Mondobiotech Laboratories Anstalt Use of compounds having the biological activity of vasoactive intestinal peptide for the treatment of sarcoidosis
EP1713493A4 (en) * 2004-01-27 2009-06-24 Bayer Pharmaceuticals Corp PEPTIDE-RECEPTOR (VPAC2) AGONISTS THAT ACTIVATE HYPOPHYSIC ADENYLATE CYCLASE (PACAP) AND PHARMACOLOGICAL METHODS OF USING THESE AGONISTS
CA2577326A1 (en) * 2004-08-18 2006-03-02 Eli Lilly & Company Selective vpac2 receptor peptide agonists
US20080085860A1 (en) * 2004-08-18 2008-04-10 Eli Lilly And Company Selective Vpac2 Receptor Peptide Agonists
RU2304146C2 (ru) * 2005-10-17 2007-08-10 Закрытое акционерное общество "Эпитек" Способ стабилизации петлеобразной структуры синтетических пептидов с помощью n- и c-концевых модификаций
US20100048460A1 (en) * 2006-02-28 2010-02-25 Lianshan Zhang Selective vpac2 receptor peptide agonists
JP2009542593A (ja) * 2006-07-06 2009-12-03 エフ．ホフマン−ラ ロシュ アーゲー 血管作動性腸管ペプチドの類似体
CN101906144B (zh) * 2009-06-03 2013-06-19 首都医科大学 一根Arg-Gly-Asp-Val链通过Asp与两根脂肪醇链的偶联物、它们的合成及在医学中的应用
WO2011020091A1 (en) 2009-08-14 2011-02-17 Phasebio Pharmaceuticals, Inc. Modified vasoactive intestinal peptides
US9782454B2 (en) * 2010-04-22 2017-10-10 Longevity Biotech, Inc. Highly active polypeptides and methods of making and using the same
EP2717902B1 (en) 2011-06-06 2018-01-24 Phasebio Pharmaceuticals, Inc. Use of modified vasoactive intestinal peptides in the treatment of hypertension
WO2014145718A2 (en) 2013-03-15 2014-09-18 Longevity Biotech, Inc. Peptides comprising non-natural amino acids and methods of making and using the same
GB201421647D0 (en) * 2014-12-05 2015-01-21 Amcure Gmbh And Ruprecht-Karls-Universitat And Karlsruher Institut F�R Technologie CD44v6-derived cyclic peptides for treating cancers and angiogenesis related diseases
CA2976038A1 (en) 2015-02-09 2016-08-18 Phasebio Pharmaceuticals, Inc. Methods and compositions for treating muscle disease and disorders
EP3521300A4 (en) 2016-09-30 2019-12-25 FUJIFILM Corporation CYCLIC PEPTIDE, AFFINITY CHROMATOGRAPHY CARRIER, MARKED ANTIBODY, ANTIBODY-ACTIVE SUBSTANCE CONJUGATE AND PHARMACEUTICAL PREPARATION
TW202140513A (zh) * 2020-02-22 2021-11-01 日商Ｊｃｒ製藥股份有限公司 人類運鐵蛋白受體結合肽

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
US4835252A (en) * 1987-02-26 1989-05-30 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
GB8729802D0 (en) * 1987-12-22 1988-02-03 Beecham Group Plc Novel compounds
US5084442A (en) * 1988-09-06 1992-01-28 Hoffmann-La Roche Inc. Cyclic growth hormone releasing factor analogs and method for the manufacture thereof
US5141924A (en) * 1989-06-30 1992-08-25 Hoffmann-La Roche, Inc. Synthetic vasoactive intestinal peptide analogs

Also Published As

Publication number Publication date
HUT62606A (en) 1993-05-28
FI111646B (fi) 2003-08-29
AU2622892A (en) 1993-04-22
GR3019326T3 (en) 1996-06-30
CZ308692A3 (en) 1993-08-11
IL103396A0 (en) 1993-03-15
NO923929L (no) 1993-04-13
DE69207138T2 (de) 1996-06-13
ES2082317T3 (es) 1996-03-16
CN1072415A (zh) 1993-05-26
EP0536741A2 (en) 1993-04-14
ATE132165T1 (de) 1996-01-15
TW305846B (enExample) 1997-05-21
JPH05213996A (ja) 1993-08-24
BG61125B2 (bg) 1996-11-29
NO975023D0 (no) 1997-10-31
KR930007972A (ko) 1993-05-20
CA2080272A1 (en) 1993-04-12
CN1198841C (zh) 2005-04-27
FI924580A0 (fi) 1992-10-09
IL117252A0 (en) 1996-06-18
AU656230B2 (en) 1995-01-27
CN1225473C (zh) 2005-11-02
SK279399B6 (sk) 1998-11-04
UY25084A1 (es) 1998-12-21
CZ281818B6 (cs) 1997-02-12
FI20002041A7 (fi) 2000-09-15
HU9203194D0 (en) 1992-12-28
JP2515473B2 (ja) 1996-07-10
CN1153785A (zh) 1997-07-09
RU2095368C1 (ru) 1997-11-10
DE69207138D1 (de) 1996-02-08
FI924580L (fi) 1993-04-12
FI20002041L (fi) 2000-09-15
ZA927724B (en) 1994-04-07
NO923929D0 (no) 1992-10-09
HU211534A9 (en) 1995-12-28
DK0536741T3 (da) 1996-04-22
NZ244644A (en) 1995-04-27
EP0536741A3 (enExample) 1994-04-06
IL117252A (en) 1999-11-30
NO980377D0 (no) 1998-01-28
CN1152579A (zh) 1997-06-25
IL103396A (en) 1997-11-20
CA2080272C (en) 2002-09-17
BR9203959A (pt) 1993-04-27
NO980377L (no) 1993-04-13
MX9205822A (es) 1993-06-01
NO975023L (no) 1993-04-13
SK308692A3 (en) 1995-03-08
EP0536741B1 (en) 1995-12-27
US5677419A (en) 1997-10-14
CN1034943C (zh) 1997-05-21
NO304523B1 (no) 1999-01-04
UY23488A1 (es) 1993-04-20

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