BG102875A - Метод за получаване на дисперсионни макромолекулни състави - Google Patents

Метод за получаване на дисперсионни макромолекулни състави

Info

Publication number
BG102875A
BG102875A BG102875A BG10287598A BG102875A BG 102875 A BG102875 A BG 102875A BG 102875 A BG102875 A BG 102875A BG 10287598 A BG10287598 A BG 10287598A BG 102875 A BG102875 A BG 102875A
Authority
BG
Bulgaria
Prior art keywords
drying
preparation
methods
application
macromolecular compositions
Prior art date
Application number
BG102875A
Other languages
English (en)
Other versions
BG64113B1 (bg
Inventor
Robert Platz
Thomas Brewer
Terence BOARDMAN
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of BG102875A publication Critical patent/BG102875A/bg
Publication of BG64113B1 publication Critical patent/BG64113B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers

Landscapes

  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Glanulating (AREA)

Abstract

Изобретението се отнася до метод за получаване намакромолекулни композиции и до приложението им в медицината. С метода се получават състави, съдържащи ултрафин сух прах от биологични макромолекули, предназначени за пулмонарен прием на пациенти за разнообразни терапевтични и клинични цели при контролиране на праховите характеристики, както в композициите сами по себе си, така и в пакетирани композиции, включващи единични дозировъчни форми, коетоподобрява използването на праховете и увеличава възможността да се осигури тяхното производство с желаните характеристики в достатъчно количество за нуждите на пазара. Методът включва етапи на осигуряване на изпаряема течна среда, пулверизиране и изсушаване. Течната среда съдържа предварително определена концентрация на биологична макромолекула, имаща молекулно тегло, по-голямо от 2 kD, която впоследствие се пулверизира и се подлага на изсушаване на капчиците в нагрят газов поток до получаване на частици с грапавост поне 2,0, измерена чрез въздушна проницаемост, влагосъдържание под 10% тегл. и размер, по-малък от 10.
BG102875A 1996-05-08 1998-10-28 Метод за получаване на дисперсионни макромолекулни състави BG64113B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/644,681 US6051256A (en) 1994-03-07 1996-05-08 Dispersible macromolecule compositions and methods for their preparation and use
PCT/US1997/007779 WO1997041833A1 (en) 1996-05-08 1997-05-07 Dispersible macromolecule compositions and methods for their preparation and use

Publications (2)

Publication Number Publication Date
BG102875A true BG102875A (bg) 1999-05-31
BG64113B1 BG64113B1 (bg) 2004-01-30

Family

ID=24585923

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102875A BG64113B1 (bg) 1996-05-08 1998-10-28 Метод за получаване на дисперсионни макромолекулни състави

Country Status (30)

Country Link
US (5) US6051256A (bg)
EP (1) EP0948317A4 (bg)
JP (2) JP2000510471A (bg)
CN (1) CN1138531C (bg)
AP (1) AP987A (bg)
AU (1) AU730059B2 (bg)
BG (1) BG64113B1 (bg)
BR (1) BR9709057A (bg)
CA (1) CA2253393C (bg)
CZ (1) CZ295644B6 (bg)
EA (1) EA000956B1 (bg)
EE (1) EE03591B1 (bg)
GE (1) GEP20012345B (bg)
HK (1) HK1020319A1 (bg)
IL (1) IL126754A (bg)
IS (1) IS4879A (bg)
LT (1) LT4553B (bg)
LV (1) LV12231B (bg)
NO (1) NO985196L (bg)
NZ (1) NZ332480A (bg)
OA (1) OA10914A (bg)
PL (1) PL190732B1 (bg)
RO (1) RO118523B1 (bg)
SI (1) SI9720031A (bg)
SK (1) SK285400B6 (bg)
TR (1) TR199802247T2 (bg)
TW (1) TW550089B (bg)
UA (1) UA65538C2 (bg)
WO (1) WO1997041833A1 (bg)
YU (1) YU49206B (bg)

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