BE864810A - Procede de preparation d'acides 7-substitue-3-cephem (ou cepham)-4-carboxyliques, de leurs sels et de leurs bioprecurseurs, et nouveaux produits ainsi obtenus, a activite antimicrobienne - Google Patents
Procede de preparation d'acides 7-substitue-3-cephem (ou cepham)-4-carboxyliques, de leurs sels et de leurs bioprecurseurs, et nouveaux produits ainsi obtenus, a activite antimicrobienneInfo
- Publication number
- BE864810A BE864810A BE185864A BE185864A BE864810A BE 864810 A BE864810 A BE 864810A BE 185864 A BE185864 A BE 185864A BE 185864 A BE185864 A BE 185864A BE 864810 A BE864810 A BE 864810A
- Authority
- BE
- Belgium
- Prior art keywords
- substitue
- cepham
- bioprecursors
- cephem
- salts
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/01—Five-membered rings
- C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
- C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
- C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB10699/77A GB1600735A (en) | 1977-03-14 | 1977-03-14 | Cephem and cephem compounds and processes for preparation thereof |
GB2924577 | 1977-07-12 | ||
GB4231577 | 1977-10-11 | ||
GB7578 | 1978-01-03 | ||
KR7802782A KR820001285B1 (ko) | 1977-03-14 | 1978-09-13 | 세펨화합물의 제조방법 |
KR1019820000231A KR830000455B1 (ko) | 1977-03-14 | 1982-01-18 | 세펨화합물의 제조방법 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE864810A true BE864810A (fr) | 1978-09-13 |
Family
ID=27546433
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE185864A BE864810A (fr) | 1977-03-14 | 1978-03-13 | Procede de preparation d'acides 7-substitue-3-cephem (ou cepham)-4-carboxyliques, de leurs sels et de leurs bioprecurseurs, et nouveaux produits ainsi obtenus, a activite antimicrobienne |
Country Status (21)
Country | Link |
---|---|
US (7) | US4425341A (sv) |
JP (7) | JPS53137988A (sv) |
AR (2) | AR230452A1 (sv) |
AT (1) | AT364456B (sv) |
BE (1) | BE864810A (sv) |
CA (1) | CA1321580C (sv) |
CH (1) | CH637138A5 (sv) |
CS (1) | CS217961B2 (sv) |
DD (2) | DD144772A5 (sv) |
DE (1) | DE2810922C2 (sv) |
DK (1) | DK163832C (sv) |
ES (8) | ES467828A1 (sv) |
FI (1) | FI65779C (sv) |
FR (1) | FR2383951A1 (sv) |
GR (1) | GR63619B (sv) |
NL (2) | NL182401C (sv) |
NZ (2) | NZ186679A (sv) |
PH (2) | PH17188A (sv) |
PT (1) | PT67773A (sv) |
SE (3) | SE438677B (sv) |
YU (3) | YU41586B (sv) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007470A3 (en) * | 1978-07-10 | 1980-04-16 | Fujisawa Pharmaceutical Co. Ltd. | Cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
EP0013762A3 (en) * | 1978-12-29 | 1980-10-01 | Fujisawa Pharmaceutical Co. Ltd. | Cephem and cepham compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
US4298529A (en) | 1978-09-12 | 1981-11-03 | Fujisawa Pharmaceutical Co., Ltd. | Alkoxyimino dioxy butyric acid derivatives |
US4372952A (en) | 1978-07-31 | 1983-02-08 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE878433A (fr) * | 1978-08-31 | 1980-02-25 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne |
US4464369A (en) * | 1977-03-14 | 1984-08-07 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-cephem-4-carboxylic acid derivatives and pharmaceutical compositions |
US4399133A (en) * | 1977-03-14 | 1983-08-16 | Fujisawa Pharmaceutical Company, Limited | Cephem compounds |
US4409217A (en) | 1977-03-14 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
FR2399418A1 (fr) * | 1977-03-14 | 1979-03-02 | Fujisawa Pharmaceutical Co | Procede de preparation d'acides iminoacetiques et nouveaux produits ainsi obtenus, utilises pour la synthese d'acides cepham- ou cephem-carboxyliques |
SE439312B (sv) * | 1977-03-25 | 1985-06-10 | Roussel Uclaf | Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
JPS5498795A (en) * | 1978-01-13 | 1979-08-03 | Takeda Chem Ind Ltd | Cephalosporin derivative and its preparation |
FR2432521A1 (fr) * | 1978-03-31 | 1980-02-29 | Roussel Uclaf | Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2421907A1 (fr) * | 1978-04-07 | 1979-11-02 | Roussel Uclaf | Nouvelles cephalosporines derivees de l'acide 7-/2-(2-amino 4-thiazolyl)2-(carboxymethoxyimino/acetamido 3-substitue cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4305937A (en) * | 1978-08-17 | 1981-12-15 | Fujisawa Pharmaceutical Co., Ltd. | 2-Lower alkyl-7-substituted-2 or 3-cephem-4-carboxylic acid compounds and antibacterial pharmaceutical compositions containing them |
FR2453161A1 (fr) * | 1978-08-31 | 1980-10-31 | Fujisawa Pharmaceutical Co | Procede de preparation de derives d'acide thiazolylacetique et nouveaux produits ainsi obtenus |
US4703046A (en) * | 1978-09-08 | 1987-10-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds and processes for preparation thereof |
US4341775A (en) * | 1978-09-11 | 1982-07-27 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
DE2945248A1 (de) * | 1978-11-13 | 1980-05-22 | Fujisawa Pharmaceutical Co | Cephem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende antibakterielle pharmazeutische mittel |
FR2444032A2 (fr) * | 1978-12-13 | 1980-07-11 | Roussel Uclaf | Nouveaux produits derives de l'acide 2-(2-tritylamino-4-thiazolyl) acetique et leur procede de preparation |
FR2448543A1 (fr) * | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2461713A1 (fr) * | 1979-07-19 | 1981-02-06 | Roussel Uclaf | Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
EP0025017A1 (de) * | 1979-08-28 | 1981-03-11 | Ciba-Geigy Ag | Polyazathiaverbindungen, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend solche Verbindungen und Verwendung von letzteren |
DE3069560D1 (en) * | 1979-09-03 | 1984-12-06 | Fujisawa Pharmaceutical Co | Cephem compounds, processes for their preparation and pharmaceutical compositions containing them |
CH645906A5 (de) * | 1979-10-02 | 1984-10-31 | Glaxo Group Ltd | Cephalosporinantibiotika. |
US4409214A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical, Co., Ltd. | 7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof |
US4409215A (en) * | 1979-11-19 | 1983-10-11 | Fujisawa Pharmaceutical Co., Ltd. | 7-Acylamino-3-substituted cephalosporanic acid derivatives and processes for the preparation thereof |
GR78221B (sv) | 1980-02-01 | 1984-09-26 | Ciba Geigy Ag | |
FR2476087A1 (fr) * | 1980-02-18 | 1981-08-21 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-alkyloxy ou 3-alkyl-thiomethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
JPS56131591A (en) * | 1980-02-20 | 1981-10-15 | Fujisawa Pharmaceut Co Ltd | 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent |
JPS5726692A (en) * | 1980-07-22 | 1982-02-12 | Fujisawa Pharmaceut Co Ltd | Preparation of stable crystal of salt of ceftizoxime |
DK416681A (da) * | 1980-09-26 | 1982-03-27 | Fujisawa Pharmaceutical Co | Femgangsmaade til fremstilling af cephemforbindelser |
DE3177090D1 (en) * | 1980-12-31 | 1989-09-28 | Fujisawa Pharmaceutical Co | 7-acylaminocephalosporanic acid derivatives and processes for the preparation thereof |
JPS58986A (ja) * | 1981-05-07 | 1983-01-06 | Fujisawa Pharmaceut Co Ltd | セフェム化合物 |
JPS57193489A (en) * | 1981-05-21 | 1982-11-27 | Fujisawa Pharmaceut Co Ltd | Syn-isomer of 7-substituted-3-cephem-4-carboxylic acid ester and its preparation |
FR2506307A1 (fr) * | 1981-05-22 | 1982-11-26 | Roussel Uclaf | Nouveaux derives substitues de l'acide 2-(2-amino 4-thiazolyl) 2-hydroxyimino acetique et leur procede de preparation |
JPS5849382A (ja) * | 1981-09-18 | 1983-03-23 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
JPS5874680A (ja) * | 1981-10-01 | 1983-05-06 | Kyowa Hakko Kogyo Co Ltd | β−ラクタム化合物 |
EP0088183B1 (en) * | 1981-11-13 | 1985-08-07 | Glaxo Group Limited | Thiazole derivatives and their use in the manufacture of beta lactam antibiotics |
ATE18219T1 (de) * | 1981-11-13 | 1986-03-15 | Glaxo Group Ltd | Thiazol-derivate und ihre verwendung bei der herstellung von beta-lactam-antibiotika. |
JPS58135894A (ja) * | 1982-01-22 | 1983-08-12 | Fujisawa Pharmaceut Co Ltd | 7―置換ブチルアミド―3―ビニルセファロスポラン酸誘導体 |
JPS58210074A (ja) * | 1982-06-02 | 1983-12-07 | Sankyo Co Ltd | チアゾ−ル酢酸誘導体およびその製造法 |
FR2532936A1 (fr) * | 1982-09-13 | 1984-03-16 | Roussel Uclaf | Nouveaux derives de l'acide 2-amino-thiazolyl-4-yl acetique comportant une fonction oxime substituee et leur procede de preparation |
JPS59116291A (ja) * | 1982-12-06 | 1984-07-05 | Fujisawa Pharmaceut Co Ltd | 7−置換−3−セフエム−4−カルボン酸エステルおよびその製法 |
EP0115770B2 (en) * | 1983-01-07 | 1996-06-19 | Takeda Chemical Industries, Ltd. | Thiazole Derivatives |
US4480120A (en) * | 1983-03-24 | 1984-10-30 | Eastman Kodak Company | Process for the preparation of alkyl-2-alkoxyimino-3-oxo-4-chlorobutyrates |
GB8318846D0 (en) * | 1983-07-12 | 1983-08-10 | Fujisawa Pharmaceutical Co | Prophylactic/therapeutic agent against fish diseases |
JPS6064986A (ja) * | 1983-09-20 | 1985-04-13 | Toyama Chem Co Ltd | セファロスポリン類の製造法 |
GB8406231D0 (en) * | 1984-03-09 | 1984-04-11 | Fujisawa Pharmaceutical Co | Cephem compounds |
AT382149B (de) * | 1984-04-10 | 1987-01-12 | Biochemie Gmbh | Verfahren zur herstellung von syn-isomeren von thioessigsaeureestern |
GB8410992D0 (en) * | 1984-04-30 | 1984-06-06 | Glaxo Group Ltd | Process |
GB8410991D0 (en) * | 1984-04-30 | 1984-06-06 | Glaxo Group Ltd | Process |
JPH0645625B2 (ja) * | 1984-12-28 | 1994-06-15 | 塩野義製薬株式会社 | ヒドロキシセフアムカルボン酸エステルの製造法 |
DK500285A (da) * | 1984-11-02 | 1986-05-03 | Glaxo Group Ltd | Cephalosporinantibiotika |
GB8432295D0 (en) * | 1984-12-20 | 1985-01-30 | Fujisawa Pharmaceutical Co | Cephem compounds |
GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
CN86107947A (zh) * | 1985-11-22 | 1987-05-27 | 藤沢药品工业株式会社 | 新的头孢烯化合物及其制备方法 |
JPH0631258B2 (ja) * | 1985-11-29 | 1994-04-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体の製造法 |
US5373000A (en) * | 1985-12-26 | 1994-12-13 | Eisai Co., Ltd. | 7Beta-(thiadiazolyl)-2-iminoacetamido-3cephem compounds |
DE3775798D1 (de) | 1986-03-19 | 1992-02-20 | Banyu Pharma Co Ltd | Cephalosporinverbindungen, verfahren zu ihrer herstellung und antibakterielle mittel. |
US4777332A (en) * | 1987-06-22 | 1988-10-11 | Tandem Computers Incorporated | Apparatus for controlling the connection of an electrical module to an electrical receptacle |
JP2003001718A (ja) * | 2001-06-20 | 2003-01-08 | Aron Kasei Co Ltd | ますの製造方法 |
WO2004083216A1 (en) * | 2003-03-20 | 2004-09-30 | Orchid Chemicals & Pharmaceuticals Ltd | A process for the preparation of cephalosporins |
EA028342B1 (ru) | 2011-09-09 | 2017-11-30 | Мерк Шарп И Доум Корп. | Способы лечения пневмонии |
US8809314B1 (en) | 2012-09-07 | 2014-08-19 | Cubist Pharmacueticals, Inc. | Cephalosporin compound |
US8476425B1 (en) | 2012-09-27 | 2013-07-02 | Cubist Pharmaceuticals, Inc. | Tazobactam arginine compositions |
CN102993117A (zh) * | 2012-11-28 | 2013-03-27 | 张家港市大伟助剂有限公司 | 2-胺基-5-(4-胺基苯基)-噻唑的制备方法 |
CN102977121A (zh) * | 2012-12-25 | 2013-03-20 | 菏泽睿智科技开发有限公司 | 一种头孢唑肟酸的合成方法 |
NZ700372A (en) | 2013-03-15 | 2016-01-29 | Merck Sharp & Dohme | Ceftolozane antibiotic compositions |
US9872906B2 (en) | 2013-03-15 | 2018-01-23 | Merck Sharp & Dohme Corp. | Ceftolozane antibiotic compositions |
US20140274997A1 (en) | 2013-03-15 | 2014-09-18 | Cubist Pharmaceuticals, Inc. | Cephalosporin pharmaceutical compositions |
EP3043797B1 (en) | 2013-09-09 | 2020-04-08 | Merck Sharp & Dohme Corp. | Treating infections with ceftolozane/tazobactam in subjects having impaired renal function |
US8906898B1 (en) | 2013-09-27 | 2014-12-09 | Calixa Therapeutics, Inc. | Solid forms of ceftolozane |
JP6377570B2 (ja) * | 2014-04-28 | 2018-08-22 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | 2−置換セフェム化合物を含有する医薬組成物 |
CN105315299B (zh) * | 2015-09-22 | 2017-06-27 | 盐城开元医药化工有限公司 | 一种头孢唑肟母核7‑anca的合成方法 |
CN114105903B (zh) * | 2021-12-16 | 2023-06-27 | 河北合佳医药科技集团股份有限公司 | 一种高纯度去甲基氨噻肟酸乙酯的制备方法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3660396A (en) * | 1970-03-04 | 1972-05-02 | Lilly Co Eli | Cephalosporin intermediates and process therefor |
GB1399086A (en) | 1971-05-14 | 1975-06-25 | Glaxo Lab Ltd | Cephalosporin compounds |
AR206201A1 (es) * | 1972-06-29 | 1976-07-07 | Ciba Geigy Ag | Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos |
SE428022B (sv) * | 1972-06-29 | 1983-05-30 | Ciba Geigy Ag | 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat |
AR208068A1 (es) * | 1973-02-23 | 1976-11-30 | Lilly Co Eli | Un procedimiento para preparar derivados de acidos 7-acilamido-3-halo-cefem-4-carboxilico los esteres y las sales farmaceuticamente aceptables de los mismos |
DE2460537C2 (de) | 1973-12-21 | 1987-01-22 | Glaxo Laboratories Ltd., Greenford, Middlesex | 7-β-Acylamido-3-em-4-carbonsäure-Antibiotika |
NZ176206A (en) | 1973-12-25 | 1978-03-06 | Takeda Chemical Industries Ltd | Cephalosporins |
DK154939C (da) | 1974-12-19 | 1989-06-12 | Takeda Chemical Industries Ltd | Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf |
GB1536281A (en) * | 1975-06-09 | 1978-12-20 | Takeda Chemical Industries Ltd | Cephem compounds |
AT342197B (de) * | 1975-02-20 | 1978-03-28 | Ciba Geigy Ag | Neues verfahren zur herstellung von 3-cephemverbindungen |
JPS5919114B2 (ja) * | 1975-08-25 | 1984-05-02 | 武田薬品工業株式会社 | セフアロスポリンの製造法 |
DE2760123C2 (de) | 1976-01-23 | 1986-04-30 | Roussel-Uclaf, Paris | 7-Aminothiazolyl-syn-oxyiminoacetamidocephalosporansäuren, ihre Herstellung und sie enthaltende pharmazeutische Zusammensetzungen |
FR2408613A2 (fr) * | 1977-07-19 | 1979-06-08 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
SE440655B (sv) | 1976-01-23 | 1985-08-12 | Roussel Uclaf | Sett att framstella nya oximderivat av 7-amino-tiazolyl-acetamido-cefalosporansyra |
FR2340093A1 (fr) * | 1976-02-05 | 1977-09-02 | Roussel Uclaf | Derives de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4299829A (en) * | 1976-03-12 | 1981-11-10 | Fujisawa Pharmaceutical Co., Ltd. | 2-Lower alkyl-7-substituted-2 or 3-cephem 4-carboxylic acid compounds |
FR2345153A1 (fr) * | 1976-03-25 | 1977-10-21 | Roussel Uclaf | Nouvelles alcoyloximes derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4166115A (en) * | 1976-04-12 | 1979-08-28 | Fujisawa Pharmaceutical Co., Ltd. | Syn 7-oxoimino substituted derivatives of cephalosporanic acid |
US4304770A (en) * | 1976-04-12 | 1981-12-08 | Fujisawa Pharmaceutical Co., Ltd. | Syn-isomer of 3,7-disubstituted-3-cephem-4-carboxylic acid compounds and processes for the preparation thereof |
DK162391C (da) | 1976-04-12 | 1992-03-09 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af syn-isomerer af 3,7-disubstituerede 3-cephem-4-carboxylsyreforbindelser |
FR2361895A1 (fr) * | 1976-08-20 | 1978-03-17 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-carbamoyloxymethyl 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
JPS6011713B2 (ja) * | 1976-09-08 | 1985-03-27 | 武田薬品工業株式会社 | セフアロスポリン誘導体およびその製造法 |
JPS53103493A (en) | 1977-02-18 | 1978-09-08 | Takeda Chem Ind Ltd | Cephalosporin derivatives and process for their preparation |
SE439312B (sv) | 1977-03-25 | 1985-06-10 | Roussel Uclaf | Sett att framstella nya oximderivat av 3-acetoximetyl-7-aminotiazolylacetamido cefalosporansyra |
FR2384779A1 (fr) * | 1977-03-25 | 1978-10-20 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-chloro ou 3-methoxy 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
DE2714880A1 (de) * | 1977-04-02 | 1978-10-26 | Hoechst Ag | Cephemderivate und verfahren zu ihrer herstellung |
DE2716677C2 (de) * | 1977-04-15 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Cephemderivate und Verfahren zu ihrer Herstellung |
FR2410655A1 (fr) | 1977-12-05 | 1979-06-29 | Roussel Uclaf | Nouvelles oximes derivees de l'acide 3-substitue 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
US4284631A (en) | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
US4379922A (en) * | 1978-09-12 | 1983-04-12 | Fujisawa Pharmaceutical Co., Ltd. | Cepham compounds |
JPS5543011A (en) * | 1978-09-20 | 1980-03-26 | Shionogi & Co Ltd | 7-halothiazolylalkoxyiminoacetamido-3-cephem compound |
FR2448543A1 (fr) | 1979-02-09 | 1980-09-05 | Roussel Uclaf | Nouvelles oximes o-substituees par un radical comportant un ammonium quaternaire et derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
FR2461713A1 (fr) * | 1979-07-19 | 1981-02-06 | Roussel Uclaf | Nouvelles alcoyloximes substituees derivees de l'acide 7-(2-amino 4-thiazolyl) acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments |
JPS56125392A (en) * | 1980-03-06 | 1981-10-01 | Fujisawa Pharmaceut Co Ltd | Cepham and cephem compound and preparation thereof |
JPS6238569A (ja) * | 1985-08-13 | 1987-02-19 | Nec Corp | 磁気デイスク制御装置 |
US5059611A (en) * | 1988-11-18 | 1991-10-22 | Allergan, Inc. | Anti-inflammatory 5-hydroxy-2-furanones |
-
1978
- 1978-03-04 PH PH20877A patent/PH17188A/en unknown
- 1978-03-13 BE BE185864A patent/BE864810A/xx not_active IP Right Cessation
- 1978-03-14 AT AT0181378A patent/AT364456B/de not_active IP Right Cessation
- 1978-03-14 AR AR271413A patent/AR230452A1/es active
- 1978-03-14 CS CS781614A patent/CS217961B2/cs unknown
- 1978-03-14 PT PT67773A patent/PT67773A/pt unknown
- 1978-03-14 YU YU608/78A patent/YU41586B/xx unknown
- 1978-03-14 DD DD78214239A patent/DD144772A5/de unknown
- 1978-03-14 FI FI780801A patent/FI65779C/fi not_active IP Right Cessation
- 1978-03-14 FR FR7807360A patent/FR2383951A1/fr active Granted
- 1978-03-14 SE SE7802933A patent/SE438677B/sv not_active IP Right Cessation
- 1978-03-14 US US05/886,340 patent/US4425341A/en not_active Expired - Lifetime
- 1978-03-14 DD DD78204164A patent/DD136839A5/xx unknown
- 1978-03-14 DK DK114878A patent/DK163832C/da not_active IP Right Cessation
- 1978-03-14 CA CA000298883A patent/CA1321580C/en not_active Expired - Lifetime
- 1978-03-14 NL NLAANVRAGE7802792,A patent/NL182401C/xx not_active IP Right Cessation
- 1978-03-14 DE DE2810922A patent/DE2810922C2/de not_active Expired
- 1978-03-14 NZ NZ186679A patent/NZ186679A/xx unknown
- 1978-03-14 NZ NZ199860A patent/NZ199860A/en unknown
- 1978-03-14 GR GR55704A patent/GR63619B/el unknown
- 1978-03-14 ES ES467828A patent/ES467828A1/es not_active Expired
- 1978-03-14 CH CH278078A patent/CH637138A5/de not_active IP Right Cessation
- 1978-03-14 JP JP2916978A patent/JPS53137988A/ja active Granted
- 1978-12-07 PH PH21907A patent/PH17064A/en unknown
-
1979
- 1979-05-16 ES ES480598A patent/ES480598A1/es not_active Expired
- 1979-10-16 AR AR278528A patent/AR226423A1/es active
-
1980
- 1980-01-16 ES ES487737A patent/ES487737A0/es active Granted
- 1980-01-16 ES ES487736A patent/ES487736A0/es active Granted
- 1980-02-21 US US06/123,481 patent/US4294960A/en not_active Expired - Lifetime
- 1980-05-06 ES ES80491184A patent/ES8103753A1/es not_active Expired
- 1980-05-06 ES ES491183A patent/ES491183A0/es active Granted
- 1980-05-06 ES ES80491182A patent/ES8103751A1/es not_active Expired
- 1980-11-24 ES ES497084A patent/ES497084A0/es active Granted
-
1981
- 1981-09-15 US US06/302,682 patent/US4447430A/en not_active Expired - Lifetime
-
1982
- 1982-09-30 US US06/428,664 patent/US4460583A/en not_active Expired - Lifetime
- 1982-12-13 YU YU2745/82A patent/YU42061B/xx unknown
- 1982-12-13 YU YU02746/82A patent/YU274682A/xx unknown
-
1983
- 1983-08-29 SE SE8304670A patent/SE8304670L/sv not_active Application Discontinuation
- 1983-08-29 SE SE8304671A patent/SE456909B/sv not_active IP Right Cessation
- 1983-10-19 US US06/543,297 patent/US4604456A/en not_active Expired - Lifetime
- 1983-11-18 US US06/553,402 patent/US4563522A/en not_active Expired - Lifetime
-
1985
- 1985-05-23 NL NL8501475A patent/NL8501475A/nl not_active Application Discontinuation
-
1986
- 1986-02-19 US US06/830,973 patent/US4822888A/en not_active Expired - Lifetime
-
1987
- 1987-02-20 JP JP62038569A patent/JPS6434974A/ja active Pending
-
1990
- 1990-07-24 JP JP2193989A patent/JPH03115288A/ja active Granted
- 1990-07-24 JP JP2193985A patent/JPH0639464B2/ja not_active Expired - Fee Related
- 1990-07-24 JP JP2193987A patent/JPH0720947B2/ja not_active Expired - Lifetime
- 1990-07-24 JP JP2193986A patent/JPH03135972A/ja active Pending
- 1990-07-24 JP JP2193988A patent/JPH03115256A/ja active Granted
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0007470A3 (en) * | 1978-07-10 | 1980-04-16 | Fujisawa Pharmaceutical Co. Ltd. | Cephem compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
EP0036673A1 (en) * | 1978-07-10 | 1981-09-30 | Fujisawa Pharmaceutical Co., Ltd. | New thiadiazol compounds and processes for their preparation |
US4284631A (en) * | 1978-07-31 | 1981-08-18 | Fujisawa Pharmaceutical Co., Ltd. | 7-Substituted cephem compounds and pharmaceutical antibacterial compositions containing them |
US4372952A (en) | 1978-07-31 | 1983-02-08 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
US4298529A (en) | 1978-09-12 | 1981-11-03 | Fujisawa Pharmaceutical Co., Ltd. | Alkoxyimino dioxy butyric acid derivatives |
EP0013762A3 (en) * | 1978-12-29 | 1980-10-01 | Fujisawa Pharmaceutical Co. Ltd. | Cephem and cepham compounds, processes for their preparation, pharmaceutical compositions containing them and their starting compounds |
EP0064582A1 (en) * | 1978-12-29 | 1982-11-17 | Fujisawa Pharmaceutical Co., Ltd. | Starting compounds for preparing cephem compounds and processes for their preparation |
US4521413A (en) * | 1981-09-14 | 1985-06-04 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BE864810A (fr) | Procede de preparation d'acides 7-substitue-3-cephem (ou cepham)-4-carboxyliques, de leurs sels et de leurs bioprecurseurs, et nouveaux produits ainsi obtenus, a activite antimicrobienne | |
FR2345452A1 (fr) | Procede de preparation d'arylmalonamido-1-oxadethiacephalosporines et nouveaux produits ainsi obtenus, a activite antibacterienne | |
PT82930A (fr) | Procede pour la preparation de phenylethanolaminotetralines a activite lypolytique | |
FR2343747A1 (fr) | Procede de preparation de composes d'acide 3-cephem-4-carboxylique 3,7-disubstitue et nouveaux produits ainsi obtenus, a activite antimicrobienne | |
FR2507183B1 (fr) | Procede de preparation d'acides 6,8-difluoro-1,4-dihydro-4-oxo-quinoleine-3-carboxyliques | |
BE873199A (fr) | Procede de preparation de sels sesquisodiques de n-phosphonomethylglycine et nouveaux produits ainsi obtenus | |
FR2550200B1 (fr) | Procede de preparation de composes de cephem a activite antimicrobienne et nouveaux produits ainsi obtenus | |
FR2338930A1 (fr) | Procede de preparation de composes d'azetidinone et nouveaux produits ainsi obtenus, a activite antibacterienne | |
FR2318642A1 (fr) | Procede de cyclisation pour l'obtention de noyaux de cephem et nouveaux produits ainsi obtenus, a activite antibacterienne | |
BE868608A (fr) | Produits a fumer a base de cellulose et de sels d'acides carboxyliques et leur procede de preparation | |
PT87010A (pt) | Process for the preparation of cyanoimidazole by products with fungicidal activity | |
BE879360A (fr) | Procede de production d'une substance presentant une activite bacteriostatique | |
BE825150A (fr) | Nouveaux acides amidocarbonylthiobarbituriques et leurs sels, leur procede de preparation et leur application,comme insecticides,acaricides et fongicides | |
FR2489821B1 (fr) | Procede de preparation de derives d'acide quinoleinecarboxylique a proprietes antimicrobiennes | |
FR2504533B1 (fr) | Procede de preparation de composes de dioxolanylazetidinone et nouveaux produits ainsi obtenus, a activite antibacterienne | |
PT74767A (fr) | Procede de preparation de nouveaux derives d'acides phenyl aliphatique carboxyliques | |
FR2537975B1 (fr) | Procede de preparation de composes de cephem a groupe 2,2-dihalovinyle ou ethynyle et nouveaux produits ainsi obtenus, a activite antimicrobienne | |
FR2635334B1 (fr) | Procede de production d'acide lactique par fermentation | |
BE864265A (fr) | Procede de preparation d'acides alcoyl-carboxyliques superieurs | |
RO81103A (ro) | Procedeu de preparare a unor 5-fenoxi-2-nitro-benzoati cu activitate erbicida | |
BE878433A (fr) | Procede de preparation de derives d'acide 3-cephem-4-carboxylique 3,7-disubstitue, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne | |
BE878514A (fr) | Procede de preparation de composes d'acide 3-cephem-4-carboxylique a disubstitution en positions 3 et 7, nouveaux produits ainsi obtenus et leur utilisation pour leur activite antibacterienne | |
LU78973A1 (fr) | Procede de preparation de carboxylates d'alpha-trifluoromethyl-3-phenoxybenzyle a activite insecticide | |
PT68002B (fr) | Procede de preparation de produits racemiques ou optiquement actifs pentacyliques du groupe de l'acide apovincaminique | |
FR2306192A1 (fr) | Procede de preparation d'acides arylpropioniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Owner name: FUJISAWA PHARMACEUTICAL CO. LTD Effective date: 19970331 |