AU2002244250B2 - Method for rapid detection and identification of bioagents - Google Patents
Method for rapid detection and identification of bioagents Download PDFInfo
- Publication number
- AU2002244250B2 AU2002244250B2 AU2002244250A AU2002244250A AU2002244250B2 AU 2002244250 B2 AU2002244250 B2 AU 2002244250B2 AU 2002244250 A AU2002244250 A AU 2002244250A AU 2002244250 A AU2002244250 A AU 2002244250A AU 2002244250 B2 AU2002244250 B2 AU 2002244250B2
- Authority
- AU
- Australia
- Prior art keywords
- bioagent
- nucleic acid
- pair
- base
- amplification product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 title claims description 129
- 238000001514 detection method Methods 0.000 title description 36
- 150000007523 nucleic acids Chemical class 0.000 claims description 93
- 239000013615 primer Substances 0.000 claims description 90
- 108020004707 nucleic acids Proteins 0.000 claims description 82
- 102000039446 nucleic acids Human genes 0.000 claims description 82
- 239000000203 mixture Substances 0.000 claims description 75
- 230000003321 amplification Effects 0.000 claims description 70
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 70
- 108090000623 proteins and genes Proteins 0.000 claims description 49
- 238000003752 polymerase chain reaction Methods 0.000 claims description 44
- 241000193738 Bacillus anthracis Species 0.000 claims description 40
- 238000004949 mass spectrometry Methods 0.000 claims description 33
- 125000003729 nucleotide group Chemical group 0.000 claims description 29
- 239000003155 DNA primer Substances 0.000 claims description 28
- 241000894007 species Species 0.000 claims description 27
- 239000002773 nucleotide Substances 0.000 claims description 26
- 108020004418 ribosomal RNA Proteins 0.000 claims description 21
- 102000004169 proteins and genes Human genes 0.000 claims description 17
- 241000700605 Viruses Species 0.000 claims description 16
- 229940065181 bacillus anthracis Drugs 0.000 claims description 16
- 230000001580 bacterial effect Effects 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 14
- 108091034117 Oligonucleotide Proteins 0.000 claims description 14
- 239000003795 chemical substances by application Substances 0.000 claims description 14
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 claims description 13
- 238000000132 electrospray ionisation Methods 0.000 claims description 13
- 241000193755 Bacillus cereus Species 0.000 claims description 12
- 238000004252 FT/ICR mass spectrometry Methods 0.000 claims description 12
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 claims description 12
- 230000007918 pathogenicity Effects 0.000 claims description 12
- 108060004795 Methyltransferase Proteins 0.000 claims description 11
- 108700012359 toxins Proteins 0.000 claims description 11
- 230000003115 biocidal effect Effects 0.000 claims description 10
- 210000004027 cell Anatomy 0.000 claims description 9
- MWWATHDPGQKSAR-UHFFFAOYSA-N propyne Chemical compound CC#C MWWATHDPGQKSAR-UHFFFAOYSA-N 0.000 claims description 9
- 241000193830 Bacillus <bacterium> Species 0.000 claims description 8
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims description 8
- 230000010076 replication Effects 0.000 claims description 8
- 238000013518 transcription Methods 0.000 claims description 8
- 230000035897 transcription Effects 0.000 claims description 8
- 238000013519 translation Methods 0.000 claims description 8
- UHDGCWIWMRVCDJ-ZAKLUEHWSA-N cytidine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-ZAKLUEHWSA-N 0.000 claims description 7
- 230000037356 lipid metabolism Effects 0.000 claims description 7
- 230000037360 nucleotide metabolism Effects 0.000 claims description 7
- 230000006798 recombination Effects 0.000 claims description 7
- 238000005215 recombination Methods 0.000 claims description 7
- 230000008439 repair process Effects 0.000 claims description 7
- 230000028327 secretion Effects 0.000 claims description 7
- UHDGCWIWMRVCDJ-UHFFFAOYSA-N 1-beta-D-Xylofuranosyl-NH-Cytosine Natural products O=C1N=C(N)C=CN1C1C(O)C(O)C(CO)O1 UHDGCWIWMRVCDJ-UHFFFAOYSA-N 0.000 claims description 6
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 claims description 6
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 claims description 6
- UHDGCWIWMRVCDJ-PSQAKQOGSA-N Cytidine Natural products O=C1N=C(N)C=CN1[C@@H]1[C@@H](O)[C@@H](O)[C@H](CO)O1 UHDGCWIWMRVCDJ-PSQAKQOGSA-N 0.000 claims description 6
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 claims description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims description 6
- 241000606701 Rickettsia Species 0.000 claims description 6
- 241000607626 Vibrio cholerae Species 0.000 claims description 6
- 241000607479 Yersinia pestis Species 0.000 claims description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 6
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 claims description 6
- 229940029575 guanosine Drugs 0.000 claims description 6
- 238000007834 ligase chain reaction Methods 0.000 claims description 6
- 229940104230 thymidine Drugs 0.000 claims description 6
- 230000001018 virulence Effects 0.000 claims description 6
- 241000588724 Escherichia coli Species 0.000 claims description 5
- 102000004167 Ribonuclease P Human genes 0.000 claims description 5
- 108090000621 Ribonuclease P Proteins 0.000 claims description 5
- 230000037354 amino acid metabolism Effects 0.000 claims description 5
- 230000000295 complement effect Effects 0.000 claims description 5
- 238000006073 displacement reaction Methods 0.000 claims description 5
- 238000010265 fast atom bombardment Methods 0.000 claims description 5
- 150000002991 phenoxazines Chemical class 0.000 claims description 5
- 230000014616 translation Effects 0.000 claims description 5
- 229940118696 vibrio cholerae Drugs 0.000 claims description 5
- LOJNBPNACKZWAI-UHFFFAOYSA-N 3-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C=1C=CNC=1 LOJNBPNACKZWAI-UHFFFAOYSA-N 0.000 claims description 4
- OZFPSOBLQZPIAV-UHFFFAOYSA-N 5-nitro-1h-indole Chemical compound [O-][N+](=O)C1=CC=C2NC=CC2=C1 OZFPSOBLQZPIAV-UHFFFAOYSA-N 0.000 claims description 4
- MSSXOMSJDRHRMC-UHFFFAOYSA-N 9H-purine-2,6-diamine Chemical compound NC1=NC(N)=C2NC=NC2=N1 MSSXOMSJDRHRMC-UHFFFAOYSA-N 0.000 claims description 4
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 4
- 229930024421 Adenine Natural products 0.000 claims description 4
- 241000606161 Chlamydia Species 0.000 claims description 4
- 241000193155 Clostridium botulinum Species 0.000 claims description 4
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims description 4
- 229930010555 Inosine Natural products 0.000 claims description 4
- 241000589242 Legionella pneumophila Species 0.000 claims description 4
- 241000204031 Mycoplasma Species 0.000 claims description 4
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims description 4
- 241000607764 Shigella dysenteriae Species 0.000 claims description 4
- 241000187747 Streptomyces Species 0.000 claims description 4
- 229960000643 adenine Drugs 0.000 claims description 4
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 238000003795 desorption Methods 0.000 claims description 4
- 229960003786 inosine Drugs 0.000 claims description 4
- 238000005040 ion trap Methods 0.000 claims description 4
- 229940115932 legionella pneumophila Drugs 0.000 claims description 4
- 239000011159 matrix material Substances 0.000 claims description 4
- 229940007046 shigella dysenteriae Drugs 0.000 claims description 4
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims description 4
- 229940045145 uridine Drugs 0.000 claims description 4
- 241000589291 Acinetobacter Species 0.000 claims description 3
- 241000589567 Brucella abortus Species 0.000 claims description 3
- 241001453380 Burkholderia Species 0.000 claims description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 3
- 241001445332 Coxiella <snail> Species 0.000 claims description 3
- 241000233866 Fungi Species 0.000 claims description 3
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 229960005305 adenosine Drugs 0.000 claims description 3
- 229940056450 brucella abortus Drugs 0.000 claims description 3
- 108091036078 conserved sequence Proteins 0.000 claims description 3
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims description 3
- 241000607534 Aeromonas Species 0.000 claims description 2
- 241001148106 Brucella melitensis Species 0.000 claims description 2
- 241001148111 Brucella suis Species 0.000 claims description 2
- 241000722910 Burkholderia mallei Species 0.000 claims description 2
- 241001647372 Chlamydia pneumoniae Species 0.000 claims description 2
- 241000193403 Clostridium Species 0.000 claims description 2
- 241000606678 Coxiella burnetii Species 0.000 claims description 2
- 241000194033 Enterococcus Species 0.000 claims description 2
- 241000588722 Escherichia Species 0.000 claims description 2
- 241000605909 Fusobacterium Species 0.000 claims description 2
- 241000589989 Helicobacter Species 0.000 claims description 2
- 241000589902 Leptospira Species 0.000 claims description 2
- 241000186781 Listeria Species 0.000 claims description 2
- 241000191023 Rhodobacter capsulatus Species 0.000 claims description 2
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims description 2
- 241000607768 Shigella Species 0.000 claims description 2
- 241000607762 Shigella flexneri Species 0.000 claims description 2
- 241001478878 Streptobacillus Species 0.000 claims description 2
- 241000202898 Ureaplasma Species 0.000 claims description 2
- 241000607734 Yersinia <bacteria> Species 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims description 2
- 229940038698 brucella melitensis Drugs 0.000 claims description 2
- 229940074375 burkholderia mallei Drugs 0.000 claims description 2
- 238000010353 genetic engineering Methods 0.000 claims description 2
- 239000003550 marker Substances 0.000 claims description 2
- 241000606660 Bartonella Species 0.000 claims 1
- 241000589968 Borrelia Species 0.000 claims 1
- 241000589562 Brucella Species 0.000 claims 1
- 241000589876 Campylobacter Species 0.000 claims 1
- 241000589601 Francisella Species 0.000 claims 1
- 241000606790 Haemophilus Species 0.000 claims 1
- 241000588748 Klebsiella Species 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 208000016604 Lyme disease Diseases 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 241000588653 Neisseria Species 0.000 claims 1
- 241000588769 Proteus <enterobacteria> Species 0.000 claims 1
- 241000589516 Pseudomonas Species 0.000 claims 1
- 241000191025 Rhodobacter Species 0.000 claims 1
- 101710089766 Ribonuclease P protein component Proteins 0.000 claims 1
- 241000607142 Salmonella Species 0.000 claims 1
- 241000191940 Staphylococcus Species 0.000 claims 1
- 241000589886 Treponema Species 0.000 claims 1
- 241000607598 Vibrio Species 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 244000045947 parasite Species 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 101150063176 sspE gene Proteins 0.000 claims 1
- 150000002500 ions Chemical class 0.000 description 23
- 239000000523 sample Substances 0.000 description 15
- 239000012634 fragment Substances 0.000 description 12
- 238000001228 spectrum Methods 0.000 description 12
- 108020004414 DNA Proteins 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 108020004465 16S ribosomal RNA Proteins 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 9
- 241001493065 dsRNA viruses Species 0.000 description 9
- 238000001425 electrospray ionisation time-of-flight mass spectrometry Methods 0.000 description 9
- 238000005259 measurement Methods 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000012163 sequencing technique Methods 0.000 description 7
- 230000004304 visual acuity Effects 0.000 description 7
- 239000002028 Biomass Substances 0.000 description 6
- 238000007476 Maximum Likelihood Methods 0.000 description 6
- 238000010586 diagram Methods 0.000 description 6
- 238000010494 dissociation reaction Methods 0.000 description 6
- 230000005593 dissociations Effects 0.000 description 6
- 244000052769 pathogen Species 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- 241000589602 Francisella tularensis Species 0.000 description 5
- 241000282414 Homo sapiens Species 0.000 description 5
- 201000010099 disease Diseases 0.000 description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 5
- 229940118764 francisella tularensis Drugs 0.000 description 5
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 description 5
- 102000054765 polymorphisms of proteins Human genes 0.000 description 5
- 238000004885 tandem mass spectrometry Methods 0.000 description 5
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 description 5
- 241000193388 Bacillus thuringiensis Species 0.000 description 4
- 241001509415 Clostridium botulinum A Species 0.000 description 4
- 241000186367 Mycobacterium avium Species 0.000 description 4
- 241000606697 Rickettsia prowazekii Species 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 4
- 230000007613 environmental effect Effects 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 229940046939 rickettsia prowazekii Drugs 0.000 description 4
- 238000000926 separation method Methods 0.000 description 4
- 230000003595 spectral effect Effects 0.000 description 4
- 238000006467 substitution reaction Methods 0.000 description 4
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000202934 Mycoplasma pneumoniae Species 0.000 description 3
- 241000606695 Rickettsia rickettsii Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000187180 Streptomyces sp. Species 0.000 description 3
- 241000607272 Vibrio parahaemolyticus Species 0.000 description 3
- -1 acyclic nucleoside Chemical class 0.000 description 3
- 229940097012 bacillus thuringiensis Drugs 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000004422 calculation algorithm Methods 0.000 description 3
- 238000002330 electrospray ionisation mass spectrometry Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 230000000155 isotopic effect Effects 0.000 description 3
- 238000001819 mass spectrum Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000035772 mutation Effects 0.000 description 3
- 239000002777 nucleoside Substances 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 238000012545 processing Methods 0.000 description 3
- 229940075118 rickettsia rickettsii Drugs 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 235000011178 triphosphate Nutrition 0.000 description 3
- 239000001226 triphosphate Substances 0.000 description 3
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 2
- 102100025230 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial Human genes 0.000 description 2
- 241000607528 Aeromonas hydrophila Species 0.000 description 2
- 108010087522 Aeromonas hydrophilia lipase-acyltransferase Proteins 0.000 description 2
- 241000588779 Bordetella bronchiseptica Species 0.000 description 2
- 241000589969 Borreliella burgdorferi Species 0.000 description 2
- 241000589875 Campylobacter jejuni Species 0.000 description 2
- 101710132601 Capsid protein Proteins 0.000 description 2
- 101710094648 Coat protein Proteins 0.000 description 2
- 241000223205 Coccidioides immitis Species 0.000 description 2
- 208000035473 Communicable disease Diseases 0.000 description 2
- 241000709687 Coxsackievirus Species 0.000 description 2
- 238000000018 DNA microarray Methods 0.000 description 2
- 230000006820 DNA synthesis Effects 0.000 description 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 2
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 2
- 241001466953 Echovirus Species 0.000 description 2
- 241000194032 Enterococcus faecalis Species 0.000 description 2
- 241000991587 Enterovirus C Species 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 102100021181 Golgi phosphoprotein 3 Human genes 0.000 description 2
- 241000711549 Hepacivirus C Species 0.000 description 2
- 241000709721 Hepatovirus A Species 0.000 description 2
- 206010023927 Lassa fever Diseases 0.000 description 2
- 241000589929 Leptospira interrogans Species 0.000 description 2
- 101710125418 Major capsid protein Proteins 0.000 description 2
- 241000186362 Mycobacterium leprae Species 0.000 description 2
- 241000204051 Mycoplasma genitalium Species 0.000 description 2
- 241000588652 Neisseria gonorrhoeae Species 0.000 description 2
- 101710141454 Nucleoprotein Proteins 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 2
- 101710083689 Probable capsid protein Proteins 0.000 description 2
- 241000588767 Proteus vulgaris Species 0.000 description 2
- 239000004098 Tetracycline Substances 0.000 description 2
- 108091036066 Three prime untranslated region Proteins 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 230000004913 activation Effects 0.000 description 2
- 239000012491 analyte Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003491 array Methods 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 150000001768 cations Chemical class 0.000 description 2
- 238000012512 characterization method Methods 0.000 description 2
- 230000002759 chromosomal effect Effects 0.000 description 2
- NHVNXKFIZYSCEB-XLPZGREQSA-N dTTP Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)C1 NHVNXKFIZYSCEB-XLPZGREQSA-N 0.000 description 2
- 238000012217 deletion Methods 0.000 description 2
- 230000037430 deletion Effects 0.000 description 2
- 238000002239 electrospray ionisation Fourier transform ion cyclotron resonance mass spectrometry Methods 0.000 description 2
- 229940032049 enterococcus faecalis Drugs 0.000 description 2
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 2
- 229960004198 guanidine Drugs 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000007403 mPCR Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 238000010369 molecular cloning Methods 0.000 description 2
- 125000003835 nucleoside group Chemical group 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 229940007042 proteus vulgaris Drugs 0.000 description 2
- 108700022487 rRNA Genes Proteins 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000007056 sickle cell anemia Diseases 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960002180 tetracycline Drugs 0.000 description 2
- 229930101283 tetracycline Natural products 0.000 description 2
- 235000019364 tetracycline Nutrition 0.000 description 2
- 150000003522 tetracyclines Chemical class 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- IMFACGCPASFAPR-UHFFFAOYSA-O tributylazanium Chemical compound CCCC[NH+](CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-O 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- HCGYMSSYSAKGPK-UHFFFAOYSA-N 2-nitro-1h-indole Chemical class C1=CC=C2NC([N+](=O)[O-])=CC2=C1 HCGYMSSYSAKGPK-UHFFFAOYSA-N 0.000 description 1
- 108020003589 5' Untranslated Regions Proteins 0.000 description 1
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 1
- 108020005075 5S Ribosomal RNA Proteins 0.000 description 1
- 108010066676 Abrin Proteins 0.000 description 1
- 241000588624 Acinetobacter calcoaceticus Species 0.000 description 1
- 241000607525 Aeromonas salmonicida Species 0.000 description 1
- 229930195730 Aflatoxin Natural products 0.000 description 1
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 description 1
- 108700028369 Alleles Proteins 0.000 description 1
- 241000710929 Alphavirus Species 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 241001035438 Anthracus Species 0.000 description 1
- 241000712891 Arenavirus Species 0.000 description 1
- 201000009695 Argentine hemorrhagic fever Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- 241000194107 Bacillus megaterium Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 241000606108 Bartonella quintana Species 0.000 description 1
- 208000003508 Botulism Diseases 0.000 description 1
- 101100439426 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) groEL4 gene Proteins 0.000 description 1
- 206010006500 Brucellosis Diseases 0.000 description 1
- 206010069747 Burkholderia mallei infection Diseases 0.000 description 1
- 206010069748 Burkholderia pseudomallei infection Diseases 0.000 description 1
- 101710098119 Chaperonin GroEL 2 Proteins 0.000 description 1
- 241000407176 Chiba virus Species 0.000 description 1
- 241001493955 Chitta virus Species 0.000 description 1
- 108090000227 Chymases Proteins 0.000 description 1
- 102100025566 Chymotrypsin-like protease CTRL-1 Human genes 0.000 description 1
- 241000193163 Clostridioides difficile Species 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- 241001522882 Clostridium perfringens A Species 0.000 description 1
- 108020004705 Codon Proteins 0.000 description 1
- 206010010685 Congo-Crimean haemorrhagic fever Diseases 0.000 description 1
- 208000000307 Crimean Hemorrhagic Fever Diseases 0.000 description 1
- 201000003075 Crimean-Congo hemorrhagic fever Diseases 0.000 description 1
- 102000012410 DNA Ligases Human genes 0.000 description 1
- 108010061982 DNA Ligases Proteins 0.000 description 1
- 108010063113 DNA Polymerase II Proteins 0.000 description 1
- 102000010567 DNA Polymerase II Human genes 0.000 description 1
- 102000003915 DNA Topoisomerases Human genes 0.000 description 1
- 108090000323 DNA Topoisomerases Proteins 0.000 description 1
- 230000004543 DNA replication Effects 0.000 description 1
- 241000408659 Darpa Species 0.000 description 1
- 241000725619 Dengue virus Species 0.000 description 1
- AUGQEEXBDZWUJY-ZLJUKNTDSA-N Diacetoxyscirpenol Chemical compound C([C@]12[C@]3(C)[C@H](OC(C)=O)[C@@H](O)[C@H]1O[C@@H]1C=C(C)CC[C@@]13COC(=O)C)O2 AUGQEEXBDZWUJY-ZLJUKNTDSA-N 0.000 description 1
- AUGQEEXBDZWUJY-UHFFFAOYSA-N Diacetoxyscirpenol Natural products CC(=O)OCC12CCC(C)=CC1OC1C(O)C(OC(C)=O)C2(C)C11CO1 AUGQEEXBDZWUJY-UHFFFAOYSA-N 0.000 description 1
- 241000710945 Eastern equine encephalitis virus Species 0.000 description 1
- 241001115402 Ebolavirus Species 0.000 description 1
- 208000032163 Emerging Communicable disease Diseases 0.000 description 1
- 208000031912 Endemic Flea-Borne Typhus Diseases 0.000 description 1
- 241000988559 Enterovirus A Species 0.000 description 1
- 206010066919 Epidemic polyarthritis Diseases 0.000 description 1
- 206010014979 Epidemic typhus Diseases 0.000 description 1
- 108050004280 Epsilon toxin Proteins 0.000 description 1
- 101000867232 Escherichia coli Heat-stable enterotoxin II Proteins 0.000 description 1
- 108700039887 Essential Genes Proteins 0.000 description 1
- 108060002716 Exonuclease Proteins 0.000 description 1
- 241000711950 Filoviridae Species 0.000 description 1
- 241000710831 Flavivirus Species 0.000 description 1
- 241000190598 Flexal mammarenavirus Species 0.000 description 1
- 201000003641 Glanders Diseases 0.000 description 1
- 241000606768 Haemophilus influenzae Species 0.000 description 1
- 241001235200 Haemophilus influenzae Rd KW20 Species 0.000 description 1
- 241000150562 Hantaan orthohantavirus Species 0.000 description 1
- 102000002812 Heat-Shock Proteins Human genes 0.000 description 1
- 108010004889 Heat-Shock Proteins Proteins 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 241000893570 Hendra henipavirus Species 0.000 description 1
- 241000711557 Hepacivirus Species 0.000 description 1
- 241000724675 Hepatitis E virus Species 0.000 description 1
- 244000309467 Human Coronavirus Species 0.000 description 1
- 241001479210 Human astrovirus Species 0.000 description 1
- 241000699727 Human echovirus Species 0.000 description 1
- 241001207270 Human enterovirus Species 0.000 description 1
- 241000430519 Human rhinovirus sp. Species 0.000 description 1
- 241000947839 Human torovirus Species 0.000 description 1
- 208000026350 Inborn Genetic disease Diseases 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 241000710842 Japanese encephalitis virus Species 0.000 description 1
- 241000588747 Klebsiella pneumoniae Species 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 241000589927 Leptospira borgpetersenii Species 0.000 description 1
- 241000712899 Lymphocytic choriomeningitis mammarenavirus Species 0.000 description 1
- 241000608292 Mayaro virus Species 0.000 description 1
- 102000016397 Methyltransferase Human genes 0.000 description 1
- 241000588655 Moraxella catarrhalis Species 0.000 description 1
- 206010028282 Murine typhus Diseases 0.000 description 1
- 241000710908 Murray Valley encephalitis virus Species 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 241000202936 Mycoplasma mycoides Species 0.000 description 1
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- 102000006746 NADH Dehydrogenase Human genes 0.000 description 1
- 108010086428 NADH Dehydrogenase Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000187678 Nocardia asteroides Species 0.000 description 1
- 241000714209 Norwalk virus Species 0.000 description 1
- 241000710944 O'nyong-nyong virus Species 0.000 description 1
- 108700026244 Open Reading Frames Proteins 0.000 description 1
- 241000713112 Orthobunyavirus Species 0.000 description 1
- 241000150452 Orthohantavirus Species 0.000 description 1
- 241000150218 Orthonairovirus Species 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 101800004803 Papain-like protease Proteins 0.000 description 1
- 241000873939 Parechovirus A Species 0.000 description 1
- 102000010562 Peptide Elongation Factor G Human genes 0.000 description 1
- 108010077742 Peptide Elongation Factor G Proteins 0.000 description 1
- 102000008153 Peptide Elongation Factor Tu Human genes 0.000 description 1
- 108010049977 Peptide Elongation Factor Tu Proteins 0.000 description 1
- 241000713137 Phlebovirus Species 0.000 description 1
- 102000011755 Phosphoglycerate Kinase Human genes 0.000 description 1
- 206010035148 Plague Diseases 0.000 description 1
- 206010035664 Pneumonia Diseases 0.000 description 1
- 241000589776 Pseudomonas putida Species 0.000 description 1
- 206010037688 Q fever Diseases 0.000 description 1
- 230000006819 RNA synthesis Effects 0.000 description 1
- 108010039491 Ricin Proteins 0.000 description 1
- 208000000705 Rift Valley Fever Diseases 0.000 description 1
- 241000907332 Rocio virus Species 0.000 description 1
- 241000710942 Ross River virus Species 0.000 description 1
- 241000710799 Rubella virus Species 0.000 description 1
- 241000710801 Rubivirus Species 0.000 description 1
- 241000192617 Sabia mammarenavirus Species 0.000 description 1
- 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
- 238000012300 Sequence Analysis Methods 0.000 description 1
- 108010079723 Shiga Toxin Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000710888 St. Louis encephalitis virus Species 0.000 description 1
- 241000201788 Staphylococcus aureus subsp. aureus Species 0.000 description 1
- 101000588258 Taenia solium Paramyosin Proteins 0.000 description 1
- 108010006785 Taq Polymerase Proteins 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 101001099217 Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) Triosephosphate isomerase Proteins 0.000 description 1
- 241000589884 Treponema pallidum Species 0.000 description 1
- 208000034784 Tularaemia Diseases 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 108091023045 Untranslated Region Proteins 0.000 description 1
- 241000202921 Ureaplasma urealyticum Species 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000700647 Variola virus Species 0.000 description 1
- 241000710959 Venezuelan equine encephalitis virus Species 0.000 description 1
- 108010067390 Viral Proteins Proteins 0.000 description 1
- 241000710886 West Nile virus Species 0.000 description 1
- 241000710772 Yellow fever virus Species 0.000 description 1
- 101000847822 Yersinia pestis Anthranilate synthase component 2 Proteins 0.000 description 1
- 241000607477 Yersinia pseudotuberculosis Species 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- OTHKFLICFZRFGK-PJKMHFRUSA-N [hydroxy-[[(2R,3S,5S)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)-5-(trifluoromethyl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate Chemical compound P(O)(=O)(OP(=O)(O)OP(=O)(O)O)OC[C@@H]1[C@H](C[C@@](O1)(N1C(=O)NC(=O)C(C)=C1)C(F)(F)F)O OTHKFLICFZRFGK-PJKMHFRUSA-N 0.000 description 1
- 150000003838 adenosines Chemical class 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 238000000137 annealing Methods 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 244000309743 astrovirus Species 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 229940092523 bartonella quintana Drugs 0.000 description 1
- 239000003124 biologic agent Substances 0.000 description 1
- 238000009582 blood typing Methods 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001793 charged compounds Chemical class 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 238000007635 classification algorithm Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 201000003486 coccidioidomycosis Diseases 0.000 description 1
- 238000002485 combustion reaction Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000014670 detection of bacterium Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 201000005901 endemic typhus Diseases 0.000 description 1
- 230000000369 enteropathogenic effect Effects 0.000 description 1
- 238000009585 enzyme analysis Methods 0.000 description 1
- 208000028104 epidemic louse-borne typhus Diseases 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 238000000105 evaporative light scattering detection Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 102000013165 exonuclease Human genes 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 208000016361 genetic disease Diseases 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 238000012268 genome sequencing Methods 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 101150077981 groEL gene Proteins 0.000 description 1
- 229940047650 haemophilus influenzae Drugs 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 229920006158 high molecular weight polymer Polymers 0.000 description 1
- 238000004896 high resolution mass spectrometry Methods 0.000 description 1
- 238000013537 high throughput screening Methods 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 238000000752 ionisation method Methods 0.000 description 1
- 238000001840 matrix-assisted laser desorption--ionisation time-of-flight mass spectrometry Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000004015 melioidosis Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000001823 molecular biology technique Methods 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- ARMVRBCQDUGXOL-UHFFFAOYSA-N n,n-dibutylbutan-1-amine;2,2,2-trifluoroacetic acid Chemical compound [O-]C(=O)C(F)(F)F.CCCC[NH+](CCCC)CCCC ARMVRBCQDUGXOL-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000007899 nucleic acid hybridization Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- AHLBNYSZXLDEJQ-FWEHEUNISA-N orlistat Chemical compound CCCCCCCCCCC[C@H](OC(=O)[C@H](CC(C)C)NC=O)C[C@@H]1OC(=O)[C@H]1CCCCCC AHLBNYSZXLDEJQ-FWEHEUNISA-N 0.000 description 1
- 230000002974 pharmacogenomic effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 description 1
- 201000009430 pneumonic plague Diseases 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003212 purines Chemical class 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 102220275721 rs1238575890 Human genes 0.000 description 1
- 102220037560 rs6089898 Human genes 0.000 description 1
- 102220076685 rs796052312 Human genes 0.000 description 1
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 description 1
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- CFMYXEVWODSLAX-QOZOJKKESA-N tetrodotoxin Chemical compound O([C@@]([C@H]1O)(O)O[C@H]2[C@@]3(O)CO)[C@H]3[C@@H](O)[C@]11[C@H]2[C@@H](O)N=C(N)N1 CFMYXEVWODSLAX-QOZOJKKESA-N 0.000 description 1
- 229950010357 tetrodotoxin Drugs 0.000 description 1
- CFMYXEVWODSLAX-UHFFFAOYSA-N tetrodotoxin Natural products C12C(O)NC(=N)NC2(C2O)C(O)C3C(CO)(O)C1OC2(O)O3 CFMYXEVWODSLAX-UHFFFAOYSA-N 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
- C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2003297687A AU2003297687B2 (en) | 2001-03-02 | 2003-12-05 | Methods for rapid identification of pathogens in humans and animals |
| AU2003298030A AU2003298030B2 (en) | 2001-03-02 | 2003-12-05 | Methods for rapid identification of pathogens in humans and animals |
| AU2010200686A AU2010200686B2 (en) | 2001-03-02 | 2010-02-25 | Methods for rapid identification of pathogens in humans and animals |
| AU2010200893A AU2010200893B2 (en) | 2001-03-02 | 2010-03-10 | Methods for rapid identification of pathogens in humans and animals |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/798,007 US20030027135A1 (en) | 2001-03-02 | 2001-03-02 | Method for rapid detection and identification of bioagents |
| US09/798,007 | 2001-03-02 | ||
| PCT/US2002/006763 WO2002070664A2 (en) | 2001-03-02 | 2002-03-04 | Method for rapid detection and identification of bioagents |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2003298030A Division AU2003298030B2 (en) | 2001-03-02 | 2003-12-05 | Methods for rapid identification of pathogens in humans and animals |
| AU2003297687A Division AU2003297687B2 (en) | 2001-03-02 | 2003-12-05 | Methods for rapid identification of pathogens in humans and animals |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2002244250A1 AU2002244250A1 (en) | 2003-03-13 |
| AU2002244250B2 true AU2002244250B2 (en) | 2006-11-09 |
Family
ID=25172308
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2002244250A Ceased AU2002244250B2 (en) | 2001-03-02 | 2002-03-04 | Method for rapid detection and identification of bioagents |
| AU2010200893A Ceased AU2010200893B2 (en) | 2001-03-02 | 2010-03-10 | Methods for rapid identification of pathogens in humans and animals |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2010200893A Ceased AU2010200893B2 (en) | 2001-03-02 | 2010-03-10 | Methods for rapid identification of pathogens in humans and animals |
Country Status (13)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7956175B2 (en) | 2003-09-11 | 2011-06-07 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
| CN112861170A (zh) * | 2020-08-03 | 2021-05-28 | 德能森智能科技（成都）有限公司 | 一种保护隐私的智慧园区管理系统 |
Families Citing this family (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110166040A1 (en) * | 1997-09-05 | 2011-07-07 | Ibis Biosciences, Inc. | Compositions for use in identification of strains of e. coli o157:h7 |
| AU2003298030B2 (en) * | 2001-03-02 | 2009-12-10 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US7666588B2 (en) * | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20040121313A1 (en) * | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
| CA2348042A1 (en) | 2001-06-04 | 2002-12-04 | Ann Huletsky | Sequences for detection and identification of methicillin-resistant staphylococcus aureus |
| US7217510B2 (en) * | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| US8073627B2 (en) * | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| WO2004046385A1 (en) * | 2002-11-15 | 2004-06-03 | Biotage Ab | A method for inter-species differentiation and identification of a gram-positive bacteria |
| JP2006516193A (ja) * | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
| US8046171B2 (en) * | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| US8158354B2 (en) * | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US7964343B2 (en) * | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| AU2004279358A1 (en) * | 2003-09-05 | 2005-04-21 | The General Hospital Corporation | Photodynamic inactivation of bacterial spores |
| US20060240412A1 (en) * | 2003-09-11 | 2006-10-26 | Hall Thomas A | Compositions for use in identification of adenoviruses |
| US20100035239A1 (en) * | 2003-09-11 | 2010-02-11 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of bacteria |
| US20100129811A1 (en) * | 2003-09-11 | 2010-05-27 | Ibis Biosciences, Inc. | Compositions for use in identification of pseudomonas aeruginosa |
| US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US20080138808A1 (en) * | 2003-09-11 | 2008-06-12 | Hall Thomas A | Methods for identification of sepsis-causing bacteria |
| US20050142584A1 (en) * | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| US7163611B2 (en) * | 2003-12-03 | 2007-01-16 | Palo Alto Research Center Incorporated | Concentration and focusing of bio-agents and micron-sized particles using traveling wave grids |
| US7309410B2 (en) | 2003-12-03 | 2007-12-18 | Palo Alto Research Center Incorporated | Traveling wave grids and algorithms for biomolecule separation, transport and focusing |
| JP2007525978A (ja) * | 2004-02-18 | 2007-09-13 | アイシス ファーマシューティカルズ インコーポレイテッド | 細菌の同定で用いられる組成物 |
| US7666592B2 (en) * | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| US8119336B2 (en) * | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US20060057603A1 (en) * | 2004-03-11 | 2006-03-16 | The Regents Of The University Of California | Detecting Bacillus anthracis |
| EP1766659A4 (en) * | 2004-05-24 | 2009-09-30 | Ibis Biosciences Inc | MASS SPECTROMETRY WITH SELECTIVE ION FILTRATION THROUGH DIGITAL THRESHOLD COMPARISON |
| US20050266411A1 (en) * | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| WO2006135400A2 (en) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of recombinant organisms |
| WO2006044728A2 (en) * | 2004-10-18 | 2006-04-27 | U.S.Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
| JP2008530555A (ja) * | 2005-02-09 | 2008-08-07 | コレロジック システムズ，インコーポレイテッド | 細菌及び芽胞の同定 |
| US8084207B2 (en) * | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
| CA2600184A1 (en) * | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| DE602006017365D1 (de) * | 2005-04-13 | 2010-11-18 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| JP2009502137A (ja) * | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| US11834720B2 (en) * | 2005-10-11 | 2023-12-05 | Geneohm Sciences, Inc. | Sequences for detection and identification of methicillin-resistant Staphylococcus aureus (MRSA) of MREJ types xi to xx |
| GB0601302D0 (en) * | 2006-01-23 | 2006-03-01 | Semikhodskii Andrei | Diagnostic methods and apparatus |
| EP2010679A2 (en) * | 2006-04-06 | 2009-01-07 | Ibis Biosciences, Inc. | Compositions for the use in identification of fungi |
| US8455184B2 (en) * | 2006-04-18 | 2013-06-04 | The United States Of America As Represented By The Secretary Of The Air Force | Differential multiplexing with pattern recognition |
| EP2602321B1 (en) | 2006-05-31 | 2017-08-23 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| AU2007260750A1 (en) * | 2006-06-16 | 2007-12-21 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
| CA2663029C (en) * | 2006-09-14 | 2016-07-19 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US8076104B2 (en) * | 2007-01-25 | 2011-12-13 | Rogan Peter K | Rapid and comprehensive identification of prokaryotic organisms |
| WO2008104002A2 (en) * | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
| WO2008118809A1 (en) * | 2007-03-23 | 2008-10-02 | Ibis Biosciences, Inc. | Compositions for use in identification of mixed populations of bioagents |
| US8652780B2 (en) | 2007-03-26 | 2014-02-18 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US7811766B2 (en) * | 2007-03-28 | 2010-10-12 | Thinkvillage, Llc | Genetic identification and validation of Echinacea species |
| US8527207B2 (en) * | 2007-05-15 | 2013-09-03 | Peter K. Rogan | Accurate identification of organisms based on individual information content |
| US20100291544A1 (en) * | 2007-05-25 | 2010-11-18 | Ibis Biosciences, Inc. | Compositions for use in identification of strains of hepatitis c virus |
| US9598724B2 (en) | 2007-06-01 | 2017-03-21 | Ibis Biosciences, Inc. | Methods and compositions for multiple displacement amplification of nucleic acids |
| CN101541979B (zh) | 2007-06-01 | 2014-11-05 | 科学与工业研究委员会 | 同时检测和鉴别眼睛和中枢神经系统的细菌、真菌、寄生虫和病毒感染的方法 |
| WO2009038840A2 (en) * | 2007-06-14 | 2009-03-26 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious contaminant viruses |
| EP2179041A4 (en) * | 2007-06-22 | 2010-12-22 | Ibis Biosciences Inc | COMPOSITIONS AND METHODS FOR IDENTIFYING SPECIFIC CHARACTERISTICS OF MYCOBACTERIUM TUBERCULOSIS |
| US8067730B2 (en) | 2007-07-20 | 2011-11-29 | The George Washington University | Laser ablation electrospray ionization (LAESI) for atmospheric pressure, In vivo, and imaging mass spectrometry |
| US7964843B2 (en) | 2008-07-18 | 2011-06-21 | The George Washington University | Three-dimensional molecular imaging by infrared laser ablation electrospray ionization mass spectrometry |
| US8901487B2 (en) | 2007-07-20 | 2014-12-02 | George Washington University | Subcellular analysis by laser ablation electrospray ionization mass spectrometry |
| WO2009032781A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US20110097704A1 (en) * | 2008-01-29 | 2011-04-28 | Ibis Biosciences, Inc. | Compositions for use in identification of picornaviruses |
| US20090263809A1 (en) * | 2008-03-20 | 2009-10-22 | Zygem Corporation Limited | Methods for Identification of Bioagents |
| US8206926B2 (en) | 2008-03-26 | 2012-06-26 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| US20110177515A1 (en) * | 2008-05-30 | 2011-07-21 | Ibis Biosciences, Inc. | Compositions for use in identification of francisella |
| WO2009155103A2 (en) * | 2008-05-30 | 2009-12-23 | Ibis Biosciences, Inc. | Compositions for use in identification of tick-borne pathogens |
| WO2009148995A2 (en) * | 2008-06-02 | 2009-12-10 | Ibis Biosciences, Inc. | Compositions for use in identification of adventitious viruses |
| US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
| WO2010033625A1 (en) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Microplate handling systems and related computer program products and methods |
| EP2347254A2 (en) | 2008-09-16 | 2011-07-27 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
| WO2010039755A1 (en) * | 2008-10-02 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of members of the bacterial genus mycoplasma |
| US20110200985A1 (en) * | 2008-10-02 | 2011-08-18 | Rangarajan Sampath | Compositions for use in identification of herpesviruses |
| US20110183343A1 (en) * | 2008-10-03 | 2011-07-28 | Rangarajan Sampath | Compositions for use in identification of members of the bacterial class alphaproteobacter |
| US20110183345A1 (en) * | 2008-10-03 | 2011-07-28 | Ibis Biosciences, Inc. | Compositions for use in identification of streptococcus pneumoniae |
| WO2010039787A1 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of clostridium difficile |
| US20110183346A1 (en) * | 2008-10-03 | 2011-07-28 | Ibis Biosciences, Inc. | Compositions for use in identification of neisseria, chlamydia, and/or chlamydophila bacteria |
| WO2010039763A2 (en) * | 2008-10-03 | 2010-04-08 | Ibis Biosciences, Inc. | Compositions for use in identification of antibiotic-resistant bacteria |
| WO2010080616A1 (en) * | 2008-12-19 | 2010-07-15 | Abbott Laboratories | Molecular assay for diagnosis of malaria |
| CA2741592A1 (en) * | 2008-12-19 | 2010-06-24 | Abbott Laboratories | Diagnostic test for mutations in codons 12-13 of human k-ras |
| GB2510520B (en) * | 2009-02-03 | 2014-11-05 | Bruker Daltonik Gmbh | Mass spectrometric identification of microorganisms in complex samples |
| DE102009007266B4 (de) * | 2009-02-03 | 2012-04-19 | Bruker Daltonik Gmbh | Massenspektrometrische Identifizierung von Mikroorganismen in komplexen Proben |
| US8158936B2 (en) | 2009-02-12 | 2012-04-17 | Ibis Biosciences, Inc. | Ionization probe assemblies |
| WO2010104798A1 (en) | 2009-03-08 | 2010-09-16 | Ibis Biosciences, Inc. | Bioagent detection methods |
| CN102428191A (zh) * | 2009-03-18 | 2012-04-25 | 塞昆纳姆股份有限公司 | 热稳定性内切核酸酶在产生报道分子中的应用 |
| US9393564B2 (en) | 2009-03-30 | 2016-07-19 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| EP2414545B1 (en) | 2009-04-03 | 2017-01-11 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| WO2011008971A1 (en) * | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Lift and mount apparatus |
| WO2011008972A1 (en) | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Systems for bioagent identification |
| US9416409B2 (en) * | 2009-07-31 | 2016-08-16 | Ibis Biosciences, Inc. | Capture primers and capture sequence linked solid supports for molecular diagnostic tests |
| WO2011017656A2 (en) | 2009-08-06 | 2011-02-10 | Ibis Biosciences, Inc. | Non-mass determined base compositions for nucleic acid detection |
| US20110065111A1 (en) * | 2009-08-31 | 2011-03-17 | Ibis Biosciences, Inc. | Compositions For Use In Genotyping Of Klebsiella Pneumoniae |
| WO2011041695A1 (en) * | 2009-10-02 | 2011-04-07 | Ibis Biosciences, Inc. | Determination of methylation status of polynucleotides |
| US9890408B2 (en) * | 2009-10-15 | 2018-02-13 | Ibis Biosciences, Inc. | Multiple displacement amplification |
| EP2545183B1 (en) | 2010-03-10 | 2017-04-19 | Ibis Biosciences, Inc. | Production of single-stranded circular nucleic acid |
| WO2011115840A2 (en) * | 2010-03-14 | 2011-09-22 | Ibis Biosciences, Inc. | Parasite detection via endosymbiont detection |
| US9068017B2 (en) | 2010-04-08 | 2015-06-30 | Ibis Biosciences, Inc. | Compositions and methods for inhibiting terminal transferase activity |
| WO2011152899A1 (en) | 2010-06-02 | 2011-12-08 | Johns Hopkins University | System and methods for determining drug resistance in microorganisms |
| EA027558B1 (ru) | 2011-05-19 | 2017-08-31 | Эйджена Байосайенс, Инк. | Способ обнаружения мультиплексных нуклеиновых кислот |
| US9273366B2 (en) * | 2011-06-15 | 2016-03-01 | Grifols Therapeutics Inc. | Methods, compositions, and kits for determining human immunodeficiency virus (HIV) |
| WO2013085572A2 (en) | 2011-07-14 | 2013-06-13 | The George Washington University | Plume collimation for laser ablation electrospray ionization mass spectrometry |
| EP2753629B1 (en) | 2011-09-06 | 2016-10-19 | Ibis Biosciences, Inc. | Methods for detecting lyme disease |
| WO2013036187A1 (en) * | 2011-09-07 | 2013-03-14 | Alpha Biotech Ab | Determination of bacterial infections of the genus rickettsia and possibly borrelia, in patients exhibiting symptoms of disease and being blood donors |
| JP6050820B2 (ja) * | 2011-09-23 | 2016-12-21 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 改良された対立遺伝子特異的ｐｃｒのためのｇ−クランプの使用 |
| US9334491B2 (en) | 2011-12-22 | 2016-05-10 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids from cellular samples |
| US9803188B2 (en) | 2011-12-22 | 2017-10-31 | Ibis Biosciences, Inc. | Systems and methods for isolating nucleic acids |
| WO2013101935A1 (en) | 2011-12-27 | 2013-07-04 | Ibis Biosciences, Inc. | Bioagent detection oligonucleotides |
| WO2013101741A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Molecular, Inc. | Channels with cross-sectional thermal gradients |
| EP2834370B1 (en) | 2012-04-03 | 2019-01-02 | The Regents Of The University Of Michigan | Biomarker associated with irritable bowel syndrome and crohn's disease |
| US20150241319A1 (en) | 2012-09-26 | 2015-08-27 | Thomas N. Chiesl | Swab interface for a microfluidic device |
| CN105378108A (zh) | 2013-03-13 | 2016-03-02 | 雅培分子公司 | 用于分离核酸的系统和方法 |
| JP2016512437A (ja) | 2013-03-14 | 2016-04-28 | アボツト・モレキユラー・インコーポレイテツド | 多重メチル化特異的増幅システムおよび方法 |
| WO2014146025A1 (en) * | 2013-03-15 | 2014-09-18 | Bio-Rad Laboratories, Inc. | Digital assays with associated targets |
| WO2014186874A1 (en) | 2013-05-23 | 2014-11-27 | Yyz Pharmatech, Inc. | Methods and compositions for enzyme linked immuno and hybridization mass spectrometric assay |
| CN103344695B (zh) * | 2013-06-18 | 2015-06-10 | 中国疾病预防控制中心传染病预防控制所 | 钩端螺旋体快速质谱检测试剂盒 |
| CN103667109B (zh) * | 2013-10-23 | 2016-02-03 | 大连市水产技术推广总站 | 一种荚膜红细菌及其应用 |
| BR112016030008A2 (pt) | 2014-06-27 | 2017-10-24 | Abbott Lab | método para a detecção de infecção por pegivirus humano 2 em um indivíduo, para a detecção de ácido nucleico de pegivirus humano 2 e para a detecção de pegivirus humano 2 em uma amostra, e, composição |
| RU2580412C1 (ru) * | 2015-02-02 | 2016-04-10 | Федеральное государственное автономное образовательное учреждение высшего образования "Национальный исследовательский Томский политехнический университет" | Способ количественного определения т-2 токсина методом дифференциальной вольтамперометрии |
| WO2016172579A1 (en) | 2015-04-24 | 2016-10-27 | Agena Bioscience, Inc, | Multiplex methods for detection and quantification of minor variants |
| CN107406882B (zh) | 2015-04-24 | 2022-03-01 | 基纳生物技术有限公司 | 用于次要等位基因和多态性的鉴定和定量的多重化方法 |
| WO2018089978A1 (en) * | 2016-11-14 | 2018-05-17 | Wisconsin Alumni Research Foundation | Nucleic acid quantification compositions and methods |
| CN107085034A (zh) * | 2017-04-19 | 2017-08-22 | 中国人民解放军第三〇二医院 | Maldi‑tof‑ms鉴定宋内志贺菌 |
| CN107988341B (zh) * | 2018-01-03 | 2019-04-23 | 北京毅新博创生物科技有限公司 | 质谱鉴定霍乱弧菌分型的方法及产品 |
| CN108048540B (zh) * | 2018-01-03 | 2021-06-08 | 北京毅新博创生物科技有限公司 | 制备检测霍乱弧菌分型的指纹图谱库的方法 |
| JP7378712B2 (ja) | 2019-08-07 | 2023-11-14 | 学校法人常翔学園 | 異種移植用材料の病原体感染を検査する方法、検査キット及び病原体感染が評価された異種移植用材料製品の作成方法 |
| CN113219115A (zh) * | 2021-05-18 | 2021-08-06 | 广东省科学院微生物研究所(广东省微生物分析检测中心) | 一种基于maldi-tof ms的蜡样芽胞杆菌和苏云金芽胞杆菌快速鉴定方法 |
| WO2023077489A1 (zh) * | 2021-11-06 | 2023-05-11 | 江汉大学 | 一种鼠疫杆菌的mnp标记组合、引物对组合、试剂盒及其应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
Family Cites Families (426)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4075475A (en) * | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
| ATE202801T1 (de) * | 1983-01-10 | 2001-07-15 | Gen Probe Inc | Verfahren zum nachweis, identifizieren und quantifizieren von organismen und viren |
| US5612183A (en) | 1983-01-10 | 1997-03-18 | Gen-Probe Incorporated | Method for determining the effect of antimicrobial agents on growth using ribosomal nucleic acid subunit subsequence specific probes |
| US5288611A (en) * | 1983-01-10 | 1994-02-22 | Gen-Probe Incorporated | Method for detecting, identifying, and quantitating organisms and viruses |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| WO1988003957A1 (en) | 1986-11-24 | 1988-06-02 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| KR960000479B1 (ko) | 1987-03-02 | 1996-01-08 | 젠-프로우브 인코오퍼레이티드 | 핵산 정제,분리 및 혼성체 형성용 다가양이온성 지지체 |
| US5188963A (en) | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
| US5270030A (en) | 1988-12-29 | 1993-12-14 | Bio-Technology General Corp. | Fibrin binding domain polypeptide and method of producing |
| US5198543A (en) | 1989-03-24 | 1993-03-30 | Consejo Superior Investigaciones Cientificas | PHI29 DNA polymerase |
| IE81145B1 (en) * | 1989-04-20 | 2000-05-03 | Thomas Gerard Barry | Generation of specific probes for target nucleotide sequences |
| EP0431149B1 (en) | 1989-05-31 | 1995-09-06 | Amoco Corporation | Universal eubacteria nucleic acid probes and methods |
| US5219727A (en) | 1989-08-21 | 1993-06-15 | Hoffmann-Laroche Inc. | Quantitation of nucleic acids using the polymerase chain reaction |
| US5192659A (en) * | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5213961A (en) * | 1989-08-31 | 1993-05-25 | Brigham And Women's Hospital | Accurate quantitation of RNA and DNA by competetitive polymerase chain reaction |
| AU7060591A (en) | 1990-01-12 | 1991-08-05 | Hsc Research Development Corporation | Introns and exons of the cystic fibrosis gene and mutations at various positions of the gene |
| US5770029A (en) | 1996-07-30 | 1998-06-23 | Soane Biosciences | Integrated electrophoretic microdevices |
| US5143905A (en) | 1990-05-03 | 1992-09-01 | The Regents Of The University Of California | Method and means for extending the host range of insecticidal proteins |
| US5015845A (en) * | 1990-06-01 | 1991-05-14 | Vestec Corporation | Electrospray method for mass spectrometry |
| US5712125A (en) * | 1990-07-24 | 1998-01-27 | Cemv Bioteknik Ab | Competitive PCR for quantitation of DNA |
| DE4030262A1 (de) | 1990-09-25 | 1992-03-26 | Suedzucker Ag | Verfahren zur herstellung von rhamnose aus rhamnolipiden |
| NL9002259A (nl) | 1990-10-17 | 1992-05-18 | Eurodiagnostics B V | Werkwijze voor het bepalen van een genotype door het vergelijken van de nucleotidensequentie van leden van een genfamilie, alsmede kit voor het opsporen van genetische variaties. |
| WO1992009703A1 (en) | 1990-11-26 | 1992-06-11 | Cbr Laboratories, Inc. | Testing for spirochetal nucleic acid sequences in samples |
| US5072115A (en) | 1990-12-14 | 1991-12-10 | Finnigan Corporation | Interpretation of mass spectra of multiply charged ions of mixtures |
| WO1992013629A1 (en) | 1991-01-31 | 1992-08-20 | Wayne State University | A method for analyzing an organic sample |
| US5866429A (en) * | 1991-04-03 | 1999-02-02 | Bloch; Will | Precision and accuracy of anion-exchange separation of nucleic acids |
| US5472843A (en) | 1991-04-25 | 1995-12-05 | Gen-Probe Incorporated | Nucleic acid probes to Haemophilus influenzae |
| US5213796A (en) | 1991-05-06 | 1993-05-25 | Dana Farber Cancer Institute | Assay for polyomavirus in humans and uses thereof |
| US6055487A (en) | 1991-07-30 | 2000-04-25 | Margery; Keith S. | Interactive remote sample analysis system |
| EP0613502B1 (en) | 1991-07-31 | 1998-10-21 | F. Hoffmann-La Roche Ag | Methods and reagents for detection of bacteria in cerebrospinal fluid |
| ES2214472T3 (es) | 1991-08-02 | 2004-09-16 | Biomerieux B.V. | Cuantificacion de acidos nucleicos. |
| ES2198514T3 (es) | 1991-08-27 | 2004-02-01 | F. Hoffmann-La Roche Ag | Cebadores y sondas para la deteccion de la hepatitis c. |
| WO1993005182A1 (en) * | 1991-09-05 | 1993-03-18 | Isis Pharmaceuticals, Inc. | Determination of oligonucleotides for therapeutics, diagnostics and research reagents |
| DK0610396T3 (da) | 1991-10-23 | 2001-01-29 | Baylor College Medicine | Fingeraftryksidentifikation af bakteriestammer med anvendelse af repetitiv DNA-sekvensamplifikation |
| FR2683827B1 (fr) * | 1991-11-15 | 1994-03-04 | Institut Nal Sante Recherc Medic | Procede de determination de la quantite d'un fragment d'adn d'interet par une methode d'amplification enzymatique. |
| TW393513B (en) * | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| AU3222793A (en) * | 1991-11-26 | 1993-06-28 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) * | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| US6235887B1 (en) * | 1991-11-26 | 2001-05-22 | Isis Pharmaceuticals, Inc. | Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines |
| IL103935A0 (en) * | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| JPH07504749A (ja) | 1992-03-13 | 1995-05-25 | サーモマイクロスコープス コーポレーション | 走査型プローブ電子顕微鏡 |
| US5981176A (en) * | 1992-06-17 | 1999-11-09 | City Of Hope | Method of detecting and discriminating between nucleic acid sequences |
| US6303297B1 (en) | 1992-07-17 | 2001-10-16 | Incyte Pharmaceuticals, Inc. | Database for storage and analysis of full-length sequences |
| FR2694754B1 (fr) | 1992-08-12 | 1994-09-16 | Bio Merieux | Fragments d'ADN de mycobactéries, amorces d'amplification, sondes d'hybridation, réactifs et procédé de détection de détection de mycobactéries. |
| CA2123580C (en) | 1992-09-16 | 2005-04-26 | James B. Dale | Antigen of hybrid m protein and carrier for group a streptococcal vaccine |
| EP0672187A4 (en) * | 1992-10-08 | 1999-11-17 | Univ California | PCR ASSAYS FOR DETERMINING THE PRESENCE AND CONCENTRATION OF A TARGET. |
| US6436635B1 (en) * | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US5503980A (en) * | 1992-11-06 | 1996-04-02 | Trustees Of Boston University | Positional sequencing by hybridization |
| US6372424B1 (en) * | 1995-08-30 | 2002-04-16 | Third Wave Technologies, Inc | Rapid detection and identification of pathogens |
| US5547835A (en) * | 1993-01-07 | 1996-08-20 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| US6194144B1 (en) * | 1993-01-07 | 2001-02-27 | Sequenom, Inc. | DNA sequencing by mass spectrometry |
| FR2701961B1 (fr) | 1993-02-24 | 1995-04-21 | Bio Merieux | Procédé de destabilisation d'une structure secondaire intracaténaire d'un polynucléotide simple brin, et de capture dudit nucléotide. |
| US6074823A (en) * | 1993-03-19 | 2000-06-13 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| ATE220114T1 (de) * | 1993-03-19 | 2002-07-15 | Sequenom Inc | Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease |
| US5639606A (en) | 1993-04-06 | 1997-06-17 | The University Of Rochester | Method for quantitative measurement of gene expression using multiplex competitive reverse transcriptase-polymerase chain reaction |
| US6323041B1 (en) * | 1993-06-11 | 2001-11-27 | Pfizer Inc. | Screening novel human phosphodiesterase IV isozymes for compounds which modify their enzymatic activity |
| JPH0775585A (ja) | 1993-06-14 | 1995-03-20 | Immuno Japan:Kk | Ｃ型肝炎ウイルス関連オリゴヌクレオチドならびにｃ型肝炎 ウイルス遺伝子型判定方法 |
| US5830853A (en) | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
| US6001584A (en) | 1993-07-19 | 1999-12-14 | The Regents Of The University Of California | Oncoprotein protein kinase |
| AU7551594A (en) | 1993-07-29 | 1995-02-28 | MURASHIGE, Kate H. | Method for recognition of the nucleotide sequence of a purified dna segment |
| GB9315847D0 (en) * | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US5527675A (en) * | 1993-08-20 | 1996-06-18 | Millipore Corporation | Method for degradation and sequencing of polymers which sequentially eliminate terminal residues |
| US6376178B1 (en) * | 1993-09-03 | 2002-04-23 | Duke University | Method of nucleic acid sequencing |
| WO1995006752A1 (en) | 1993-09-03 | 1995-03-09 | Duke University | A method of nucleic acid sequencing |
| US5484909A (en) * | 1993-09-10 | 1996-01-16 | Amoco Corporation | Nucleic acid probes for the detection of bacteria of the genera Pediococcus and Lactobacillus and methods for the detection of the bacterial agents causing spoilage of beer |
| US5502177A (en) | 1993-09-17 | 1996-03-26 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| WO1995011996A1 (en) | 1993-10-27 | 1995-05-04 | Cornell Research Foundation, Inc. | Detection assay for listeria and erwinia microorganisms |
| US5504327A (en) * | 1993-11-04 | 1996-04-02 | Hv Ops, Inc. (H-Nu) | Electrospray ionization source and method for mass spectrometric analysis |
| DE4338119A1 (de) | 1993-11-08 | 1995-05-11 | Bayer Ag | Spezifische Gensonden und Verfahren zum quantitativen Nachweis von methicillinresistenten Staphylococcen |
| NL9301957A (nl) | 1993-11-11 | 1995-06-01 | U Gene Research Bv | Werkwijze voor het identificeren van micro-organismen, en daarvoor bruikbare hulpmiddelen. |
| US5928905A (en) | 1995-04-18 | 1999-07-27 | Glaxo Group Limited | End-complementary polymerase reaction |
| JP3396942B2 (ja) | 1994-02-21 | 2003-04-14 | 三菱化学株式会社 | 芳香族ポリカーボネートの製造方法 |
| US5849492A (en) | 1994-02-28 | 1998-12-15 | Phylogenetix Laboratories, Inc. | Method for rapid identification of prokaryotic and eukaryotic organisms |
| US5608217A (en) * | 1994-03-10 | 1997-03-04 | Bruker-Franzen Analytik Gmbh | Electrospraying method for mass spectrometric analysis |
| DE4444229C2 (de) * | 1994-03-10 | 1996-07-25 | Bruker Franzen Analytik Gmbh | Verfahren und Vorrichtungen zur Elektrosprüh-Ionisierung für speichernde Massenspektometer |
| US5976798A (en) | 1994-03-30 | 1999-11-02 | Mitokor | Methods for detecting mitochondrial mutations diagnostic for Alzheimer's disease and methods for determining heteroplasmy of mitochondrial nucleic acid |
| WO1995031997A1 (en) | 1994-05-20 | 1995-11-30 | UNITED STATES OF AMERICA, represented by THE SECRETARY OF THE ARMY | Model for testing immunogenicity of peptides |
| US5814442A (en) | 1994-06-10 | 1998-09-29 | Georgetown University | Internally controlled virion nucleic acid amplification reaction for quantitation of virion and virion nucleic acid |
| DE4421901A1 (de) * | 1994-06-23 | 1996-01-04 | Bayer Ag | Ein DNA-Schnelltest zum Nachweis von chinolonresistenten Staphylococcus aureus Erregern in klinischem Probenmaterial |
| US5541405A (en) | 1994-07-27 | 1996-07-30 | Parker-Hannifin Corporation | Method and device for continuous pattern sensing using fiber optics |
| GB9417211D0 (en) | 1994-08-25 | 1994-10-12 | Solicitor For The Affairs Of H | Nucleotide sequencing method |
| US6001564A (en) | 1994-09-12 | 1999-12-14 | Infectio Diagnostic, Inc. | Species specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US20020055101A1 (en) | 1995-09-11 | 2002-05-09 | Michel G. Bergeron | Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| CA2118048C (en) * | 1994-09-30 | 2003-04-08 | James W. Schumm | Multiplex amplification of short tandem repeat loci |
| US5753489A (en) * | 1994-11-10 | 1998-05-19 | Immuno Ag | Method for producing viruses and vaccines in serum-free culture |
| US5654141A (en) | 1994-11-18 | 1997-08-05 | Thomas Jefferson University | Amplification based detection of bacterial infection |
| KR100399813B1 (ko) | 1994-12-14 | 2004-06-09 | 가부시키가이샤 니콘 | 노광장치 |
| US5763169A (en) | 1995-01-13 | 1998-06-09 | Chiron Diagnostics Corporation | Nucleic acid probes for the detection and identification of fungi |
| US6180339B1 (en) | 1995-01-13 | 2001-01-30 | Bayer Corporation | Nucleic acid probes for the detection and identification of fungi |
| US5707802A (en) | 1995-01-13 | 1998-01-13 | Ciba Corning Diagnostics Corp. | Nucleic acid probes for the detection and identification of fungi |
| US5702895A (en) | 1995-01-19 | 1997-12-30 | Wakunaga Seiyaku Kabushiki Kaisha | Method and kit for detecting methicillin-resistant Staphylococcus aureus |
| US5484808A (en) * | 1995-02-09 | 1996-01-16 | Eli Lilly And Company | Methods of inhibiting cell-cell adhesion |
| GB9504598D0 (en) * | 1995-03-03 | 1995-04-26 | Imp Cancer Res Tech | Method of nucleic acid analysis |
| US6428955B1 (en) * | 1995-03-17 | 2002-08-06 | Sequenom, Inc. | DNA diagnostics based on mass spectrometry |
| AU5544696A (en) | 1995-04-11 | 1996-10-30 | Trustees Of Boston University | Solid phase sequencing of biopolymers |
| US5932220A (en) | 1995-05-08 | 1999-08-03 | Board Of Regents University Of Texas System | Diagnostic tests for a new spirochete, Borrelia lonestari sp. nov. |
| US5625184A (en) * | 1995-05-19 | 1997-04-29 | Perseptive Biosystems, Inc. | Time-of-flight mass spectrometry analysis of biomolecules |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| US5630653A (en) * | 1995-06-02 | 1997-05-20 | Polka; John G. | Wheel cover mounting bracket |
| EP0837933A4 (en) | 1995-06-07 | 2003-05-21 | Commw Scient Ind Res Org | OPTIMIZED MINIZYMES AND MINIRIBOZYMES AND THE USE THEREOF |
| US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| US6218529B1 (en) * | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
| US6146854A (en) | 1995-08-31 | 2000-11-14 | Sequenom, Inc. | Filtration processes, kits and devices for isolating plasmids |
| US5994066A (en) * | 1995-09-11 | 1999-11-30 | Infectio Diagnostic, Inc. | Species-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial pathogens and associated antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories |
| US5869242A (en) * | 1995-09-18 | 1999-02-09 | Myriad Genetics, Inc. | Mass spectrometry to assess DNA sequence polymorphisms |
| US5727202A (en) | 1995-10-18 | 1998-03-10 | Palm Computing, Inc. | Method and apparatus for synchronizing information on two different computer systems |
| US5972693A (en) | 1995-10-24 | 1999-10-26 | Curagen Corporation | Apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5871697A (en) * | 1995-10-24 | 1999-02-16 | Curagen Corporation | Method and apparatus for identifying, classifying, or quantifying DNA sequences in a sample without sequencing |
| US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
| US6312893B1 (en) * | 1996-01-23 | 2001-11-06 | Qiagen Genomics, Inc. | Methods and compositions for determining the sequence of nucleic acid molecules |
| GB9602028D0 (en) | 1996-02-01 | 1996-04-03 | Amersham Int Plc | Nucleoside analogues |
| US6852487B1 (en) * | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| AU2069597A (en) * | 1996-03-04 | 1997-09-22 | Genetrace Systems, Inc. | Methods of screening nucleic acids using mass spectrometry |
| AU2217597A (en) | 1996-03-18 | 1997-10-22 | Sequenom, Inc. | Dna sequencing by mass spectrometry |
| US6737235B1 (en) | 1996-03-20 | 2004-05-18 | Bio Merieux | Nucleic acid isolation |
| JP3365198B2 (ja) | 1996-03-21 | 2003-01-08 | ミノルタ株式会社 | 画像形成装置 |
| US5745751A (en) | 1996-04-12 | 1998-04-28 | Nelson; Robert W. | Civil site information system |
| US6214555B1 (en) * | 1996-05-01 | 2001-04-10 | Visible Genetics Inc. | Method compositions and kit for detection |
| US5928906A (en) * | 1996-05-09 | 1999-07-27 | Sequenom, Inc. | Process for direct sequencing during template amplification |
| CA2257866A1 (en) | 1996-06-10 | 1997-12-18 | University Of Utah Research Foundation | Rapid, accurate identification of dna sequence variants by electrospray mass spectrometry |
| WO1998003684A1 (en) | 1996-07-19 | 1998-01-29 | Hybridon, Inc. | Method for sequencing nucleic acids using matrix-assisted laser desorption ionization time-of-flight mass spectrometry |
| US6563025B1 (en) | 1996-07-26 | 2003-05-13 | Board Of Trustees Of The University Of Illinois | Nucleotide sequences encoding anthranilate synthase |
| US5831046A (en) * | 1996-08-05 | 1998-11-03 | Prolinx, Incorporated | Boronic acid-contaning nucleic acid monomers |
| DE19633436A1 (de) * | 1996-08-20 | 1998-02-26 | Boehringer Mannheim Gmbh | Verfahren zum Nachweis von Nukleinsäuren unter Ermittlung der Masse |
| US5777324A (en) * | 1996-09-19 | 1998-07-07 | Sequenom, Inc. | Method and apparatus for maldi analysis |
| WO1998012355A1 (en) | 1996-09-19 | 1998-03-26 | Genetrace Systems | Methods of preparing nucleic acids for mass spectrometric analysis |
| US5965363A (en) * | 1996-09-19 | 1999-10-12 | Genetrace Systems Inc. | Methods of preparing nucleic acids for mass spectrometric analysis |
| US6361940B1 (en) * | 1996-09-24 | 2002-03-26 | Qiagen Genomics, Inc. | Compositions and methods for enhancing hybridization and priming specificity |
| US5864137A (en) * | 1996-10-01 | 1999-01-26 | Genetrace Systems, Inc. | Mass spectrometer |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| GB9620769D0 (en) | 1996-10-04 | 1996-11-20 | Brax Genomics Ltd | Nucleic acid sequencing |
| US6110710A (en) | 1996-10-15 | 2000-08-29 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Sequence modification of oligonucleotide primers to manipulate non-templated nucleotide addition |
| CA2702219C (en) | 1996-11-06 | 2013-01-08 | Sequenom, Inc. | High density immobilization of nucleic acids |
| US7285422B1 (en) | 1997-01-23 | 2007-10-23 | Sequenom, Inc. | Systems and methods for preparing and analyzing low volume analyte array elements |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| US5900481A (en) * | 1996-11-06 | 1999-05-04 | Sequenom, Inc. | Bead linkers for immobilizing nucleic acids to solid supports |
| US6024925A (en) * | 1997-01-23 | 2000-02-15 | Sequenom, Inc. | Systems and methods for preparing low volume analyte array elements |
| US6140053A (en) * | 1996-11-06 | 2000-10-31 | Sequenom, Inc. | DNA sequencing by mass spectrometry via exonuclease degradation |
| EP1164203B1 (en) * | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA Diagnostics based on mass spectrometry |
| WO1998021066A1 (de) | 1996-11-12 | 1998-05-22 | Hp-Chemie Pelzer Research And Development Ltd. | Wiederverwertbares teppichbodenformteil |
| US6060246A (en) | 1996-11-15 | 2000-05-09 | Avi Biopharma, Inc. | Reagent and method for isolation and detection of selected nucleic acid sequences |
| US6187842B1 (en) * | 1996-11-28 | 2001-02-13 | New Japan Chemical Co., Ltd. | Sugar compounds, gelling agents, gelling agent compositions processes for the preparation of them, and gel compositions |
| US5822824A (en) | 1996-12-03 | 1998-10-20 | Dion; William D. | Mountable washing device |
| DE69735445T2 (de) | 1996-12-10 | 2006-08-10 | Sequenom, Inc., San Diego | Abspaltbare, nicht-flüchtige moleküle zur massenmarkierung |
| US5981190A (en) | 1997-01-08 | 1999-11-09 | Ontogeny, Inc. | Analysis of gene expression, methods and reagents therefor |
| US6046005A (en) * | 1997-01-15 | 2000-04-04 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group |
| CA2441655A1 (en) | 1997-01-15 | 1998-07-23 | Xzillion Gmbh & Co Kg | Mass label linked hybridisation probes |
| US5876936A (en) * | 1997-01-15 | 1999-03-02 | Incyte Pharmaceuticals, Inc. | Nucleic acid sequencing with solid phase capturable terminators |
| WO1998035057A1 (en) | 1997-02-06 | 1998-08-13 | The National University Of Singapore | Diagnosis of plasmodium infection by analysis of extrachromosomal genetic material |
| US5858062A (en) * | 1997-02-10 | 1999-01-12 | Litton Systems, Inc. | Oxygen concentrator |
| US6727061B2 (en) * | 1997-02-20 | 2004-04-27 | Cabtec, Inc. | Methods for identifying species or Shigella and E. coli using operon sequence analysis |
| US5828062A (en) | 1997-03-03 | 1998-10-27 | Waters Investments Limited | Ionization electrospray apparatus for mass spectrometry |
| US6553317B1 (en) | 1997-03-05 | 2003-04-22 | Incyte Pharmaceuticals, Inc. | Relational database and system for storing information relating to biomolecular sequences and reagents |
| DE19710166C1 (de) | 1997-03-12 | 1998-12-10 | Bruker Franzen Analytik Gmbh | Zwei-Schritt-Verfahren der DNA-Amplifikation für MALDI-TOF-Messungen |
| WO1998040520A1 (en) | 1997-03-14 | 1998-09-17 | Hybridon, Inc. | Method for sequencing of modified nucleic acids using electrospray ionization-fourier transform mass spectrometry |
| US5849497A (en) | 1997-04-03 | 1998-12-15 | The Research Foundation Of State University Of New York | Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker |
| US6018713A (en) | 1997-04-09 | 2000-01-25 | Coli; Robert D. | Integrated system and method for ordering and cumulative results reporting of medical tests |
| DE19717085C2 (de) | 1997-04-23 | 1999-06-17 | Bruker Daltonik Gmbh | Verfahren und Geräte für extrem schnelle DNA-Vervielfachung durch Polymerase-Kettenreaktionen (PCR) |
| US20010039263A1 (en) | 1997-05-02 | 2001-11-08 | Max-Delbruck-Centrum Fur Molekulare Medizin | Chimeric oligonucleotides and the use thereof |
| US6054278A (en) * | 1997-05-05 | 2000-04-25 | The Perkin-Elmer Corporation | Ribosomal RNA gene polymorphism based microorganism identification |
| EP0985148A4 (en) | 1997-05-28 | 2004-03-10 | Inst Medical W & E Hall | DIAGNOSIS OF NUCLEIC ACIDS BY MASS SPECTROMETRY, MASS SEPARATION AND BASE-SPECIFIC CLEAVING |
| US6159681A (en) | 1997-05-28 | 2000-12-12 | Syntrix Biochip, Inc. | Light-mediated method and apparatus for the regional analysis of biologic material |
| AU7804098A (en) | 1997-05-30 | 1998-12-30 | Genetrace Systems, Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| US6061686A (en) | 1997-06-26 | 2000-05-09 | Digital Equipment Corporation | Updating a copy of a remote document stored in a local computer system |
| DE69814629T2 (de) | 1997-07-22 | 2004-03-25 | Qiagen Genomics, Inc., Bothell | Verfahren und verbindungen zur analysierung von nukleinsaeuren durch massenspektrometrie |
| DE19732086C2 (de) | 1997-07-25 | 2002-11-21 | Univ Leipzig | Verfahren zur quantitativen Bestimmung von Eubakterien |
| US6207370B1 (en) | 1997-09-02 | 2001-03-27 | Sequenom, Inc. | Diagnostics based on mass spectrometric detection of translated target polypeptides |
| GB9719044D0 (en) | 1997-09-08 | 1997-11-12 | Inst Of Ophthalmology | Assay |
| US6090558A (en) * | 1997-09-19 | 2000-07-18 | Genetrace Systems, Inc. | DNA typing by mass spectrometry with polymorphic DNA repeat markers |
| US6063031A (en) | 1997-10-14 | 2000-05-16 | Assurance Medical, Inc. | Diagnosis and treatment of tissue with instruments |
| US6111096A (en) | 1997-10-31 | 2000-08-29 | Bbi Bioseq, Inc. | Nucleic acid isolation and purification |
| JP3423597B2 (ja) | 1997-11-05 | 2003-07-07 | 三井農林株式会社 | 細菌の同定方法 |
| US6007992A (en) | 1997-11-10 | 1999-12-28 | Gilead Sciences, Inc. | Pyrimidine derivatives for labeled binding partners |
| US6028183A (en) | 1997-11-07 | 2000-02-22 | Gilead Sciences, Inc. | Pyrimidine derivatives and oligonucleotides containing same |
| CA2312052A1 (en) | 1997-12-05 | 1999-06-17 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Method for identifying nucleic acids by means of matrix-assisted laser desorption/ionisation mass spectrometry |
| US6914137B2 (en) | 1997-12-06 | 2005-07-05 | Dna Research Innovations Limited | Isolation of nucleic acids |
| US6268131B1 (en) * | 1997-12-15 | 2001-07-31 | Sequenom, Inc. | Mass spectrometric methods for sequencing nucleic acids |
| US6458533B1 (en) * | 1997-12-19 | 2002-10-01 | High Throughput Genomics, Inc. | High throughput assay system for monitoring ESTs |
| US20030096232A1 (en) | 1997-12-19 | 2003-05-22 | Kris Richard M. | High throughput assay system |
| GB9815166D0 (en) * | 1998-07-13 | 1998-09-09 | Brax Genomics Ltd | Compounds for mass spectrometry |
| JP3793342B2 (ja) | 1997-12-26 | 2006-07-05 | ソニーケミカル株式会社 | アクリル系エマルジョン、及び粘着テープ |
| DE19802905C2 (de) | 1998-01-27 | 2001-11-08 | Bruker Daltonik Gmbh | Verfahren zur bevorzugten Herstellung nur eines Stranges selektierten Genmaterials für massenspektrometrische Messungen |
| US6428956B1 (en) | 1998-03-02 | 2002-08-06 | Isis Pharmaceuticals, Inc. | Mass spectrometric methods for biomolecular screening |
| CA2322202C (en) * | 1998-03-10 | 2010-11-30 | Large Scale Proteomics Corporation | Detection and characterization of microorganisms |
| US6268146B1 (en) * | 1998-03-13 | 2001-07-31 | Promega Corporation | Analytical methods and materials for nucleic acid detection |
| US6270974B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Exogenous nucleic acid detection |
| US6270973B1 (en) * | 1998-03-13 | 2001-08-07 | Promega Corporation | Multiplex method for nucleic acid detection |
| US6277578B1 (en) * | 1998-03-13 | 2001-08-21 | Promega Corporation | Deploymerization method for nucleic acid detection of an amplified nucleic acid target |
| US6391551B1 (en) * | 1998-03-13 | 2002-05-21 | Promega Corporation | Detection of nucleic acid hybrids |
| US6235480B1 (en) * | 1998-03-13 | 2001-05-22 | Promega Corporation | Detection of nucleic acid hybrids |
| US6312902B1 (en) * | 1998-03-13 | 2001-11-06 | Promega Corporation | Nucleic acid detection |
| US6261769B1 (en) | 1998-03-31 | 2001-07-17 | The United States Of America As Represented By The Secretary Of Agriculture | Intergenic spacer target sequence for detecting and distinguishing Chlamydial species or strains |
| US20030228597A1 (en) | 1998-04-13 | 2003-12-11 | Cowsert Lex M. | Identification of genetic targets for modulation by oligonucleotides and generation of oligonucleotides for gene modulation |
| US7321828B2 (en) * | 1998-04-13 | 2008-01-22 | Isis Pharmaceuticals, Inc. | System of components for preparing oligonucleotides |
| US6223186B1 (en) | 1998-05-04 | 2001-04-24 | Incyte Pharmaceuticals, Inc. | System and method for a precompiled database for biomolecular sequence information |
| US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
| DE19822108A1 (de) | 1998-05-12 | 2000-02-03 | Schering Ag | Verfahren zur Detektion von Mikroorganismen in Produkten, insbesondere in Arzneimitteln und Kosmetika |
| US6221587B1 (en) | 1998-05-12 | 2001-04-24 | Isis Pharmceuticals, Inc. | Identification of molecular interaction sites in RNA for novel drug discovery |
| DE19922161A1 (de) | 1998-05-18 | 1999-12-09 | Fraunhofer Ges Forschung | Anti-Haft-Beschichtung und Verfahren zu ihrer Herstellung |
| US6468743B1 (en) | 1998-05-18 | 2002-10-22 | Conagra Grocery Products Company | PCR techniques for detecting microbial contaminants in foodstuffs |
| DE19824280B4 (de) | 1998-05-29 | 2004-08-19 | Bruker Daltonik Gmbh | Mutationsanalyse mittels Massenspektrometrie |
| US6104028A (en) * | 1998-05-29 | 2000-08-15 | Genetrace Systems Inc. | Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry |
| GB2339905A (en) | 1998-06-24 | 2000-02-09 | Bruker Daltonik Gmbh | Use of mass-specrometry for detection of mutations |
| ATE440963T1 (de) | 1998-07-02 | 2009-09-15 | Gen Probe Inc | Molekulare fackeln |
| US6218118B1 (en) * | 1998-07-09 | 2001-04-17 | Agilent Technologies, Inc. | Method and mixture reagents for analyzing the nucleotide sequence of nucleic acids by mass spectrometry |
| US6074831A (en) | 1998-07-09 | 2000-06-13 | Agilent Technologies, Inc. | Partitioning of polymorphic DNAs |
| US6432651B1 (en) * | 1998-07-10 | 2002-08-13 | Cetek Corporation | Method to detect and analyze tight-binding ligands in complex biological samples using capillary electrophoresis and mass spectrometry |
| US6605433B1 (en) | 1998-08-20 | 2003-08-12 | The Johns Hopkins University | Mitochondrial dosimeter |
| US6146144A (en) * | 1998-09-29 | 2000-11-14 | Fowler; Ernest R. | Rug hooking kit and method for handicapped |
| US6610492B1 (en) | 1998-10-01 | 2003-08-26 | Variagenics, Inc. | Base-modified nucleotides and cleavage of polynucleotides incorporating them |
| US6238927B1 (en) * | 1998-10-05 | 2001-05-29 | Mosaic Technologies, Incorporated | Reverse displacement assay for detection of nucleic acid sequences |
| IT1303330B1 (it) | 1998-11-05 | 2000-11-06 | Ilpea Ind Spa | Guarnizione per frogoriferi con controporta sagomata. |
| DE19852167C2 (de) | 1998-11-12 | 2000-12-14 | Bruker Saxonia Analytik Gmbh | Einfache SNP-Analyse mittels Massenspektrometrie |
| AU766693B2 (en) | 1998-11-24 | 2003-10-23 | Emory University | Transgenic circulating endothelial cells |
| US6994962B1 (en) * | 1998-12-09 | 2006-02-07 | Massachusetts Institute Of Technology | Methods of identifying point mutations in a genome |
| DE19859723A1 (de) | 1998-12-23 | 2000-06-29 | Henkel Kgaa | Mittel zum Färben von keratinhaltigen Fasern |
| US6503718B2 (en) | 1999-01-10 | 2003-01-07 | Exact Sciences Corporation | Methods for detecting mutations using primer extension for detecting disease |
| US6638714B1 (en) | 1999-02-03 | 2003-10-28 | Ortho-Clinical Diagnostics, Inc. | Oligonucleotide primers for efficient detection of hepatitis C virus (HCV) and methods of use thereof |
| US6153389A (en) * | 1999-02-22 | 2000-11-28 | Haarer; Brian K. | DNA additives as a mechanism for unambiguously marking biological samples |
| EP1035219A1 (en) | 1999-02-25 | 2000-09-13 | Universiteit Gent | Gastric helicobacter 16 S rDNA sequences from cattle and pigs and their use for detection and typing of Helicobacter strains |
| DE19910592A1 (de) * | 1999-03-10 | 2000-09-14 | Volkswagen Ag | Rückhaltevorrichtung |
| US6436640B1 (en) * | 1999-03-18 | 2002-08-20 | Exiqon A/S | Use of LNA in mass spectrometry |
| US6613509B1 (en) * | 1999-03-22 | 2003-09-02 | Regents Of The University Of California | Determination of base (nucleotide) composition in DNA oligomers by mass spectrometry |
| WO2000063362A1 (en) | 1999-04-21 | 2000-10-26 | Annovis, Inc. | Magnetic dna extraction kit for plants |
| US6140067A (en) | 1999-04-30 | 2000-10-31 | Mitokor | Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus |
| US6649351B2 (en) * | 1999-04-30 | 2003-11-18 | Aclara Biosciences, Inc. | Methods for detecting a plurality of analytes by mass spectrometry |
| ATE386139T1 (de) | 1999-05-03 | 2008-03-15 | Gen Probe Inc | Verfahren, basierend auf einer polynukleotidmatrix, zur identifizierung von mikroorganismen |
| US20020086289A1 (en) | 1999-06-15 | 2002-07-04 | Don Straus | Genomic profiling: a rapid method for testing a complex biological sample for the presence of many types of organisms |
| CN1367829A (zh) | 1999-06-30 | 2002-09-04 | 科里克萨有限公司 | 用于肺癌治疗和诊断的组合物和方法 |
| EP1198597A1 (de) | 1999-07-22 | 2002-04-24 | Artus Gesellschaft Für Molekularbiologische Diagnostik und Entwicklung MbH. | Verfahren zum speziesspezifischen nachweis von organismen |
| US6723505B1 (en) | 1999-08-13 | 2004-04-20 | Nye Colifast As | Method for identification of the indicators of contamination in liquid samples |
| US6266144B1 (en) | 1999-08-26 | 2001-07-24 | Taiwan Semiconductor Manufacturing Company | Stepper and scanner new exposure sequence with intra-field correction |
| DE19943374A1 (de) * | 1999-09-10 | 2001-03-29 | Max Planck Gesellschaft | Verfahren zum Anbinden von Nukleinsäuren an eine Festphase |
| US7005274B1 (en) | 1999-09-15 | 2006-02-28 | Migenix Corp. | Methods and compositions for diagnosing and treating arthritic disorders and regulating bone mass |
| WO2001023608A2 (en) | 1999-09-27 | 2001-04-05 | Merck Sharp & Dohme De Espana, S.A.E. | Hybridization probes which specifically detect strains of the genera microbispora, microtetraspora, nonomuria and planobispora |
| EP1246935B1 (en) | 1999-09-28 | 2013-08-14 | Geneohm Sciences Canada Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| US6296188B1 (en) * | 1999-10-01 | 2001-10-02 | Perfect Plastic Printing Corporation | Transparent/translucent financial transaction card including an infrared light filter |
| WO2001027857A2 (en) | 1999-10-13 | 2001-04-19 | Sequenom, Inc. | Methods for generating databases and databases for identifying polymorphic genetic markers |
| US6787302B2 (en) | 1999-10-25 | 2004-09-07 | Genprime, Inc. | Method and apparatus for prokaryotic and eukaryotic cell quantitation |
| EP1228244A4 (en) | 1999-11-04 | 2005-02-09 | California Inst Of Techn | METHODS AND DEVICES FOR ANALYZING POLYNUCLEOTIDE SEQUENCES |
| US6286146B1 (en) | 1999-11-15 | 2001-09-11 | Debra Rocker | Method of wearing weighted training vest while listening to audio equipment |
| US6856914B1 (en) * | 1999-11-19 | 2005-02-15 | The University Of British Columbia | Method, apparatus, media and signals for identifying associated cell signaling proteins |
| IL149846A0 (en) | 1999-11-29 | 2002-11-10 | Aventis Pharma Sa | Method for obtaining nucleic acids from an evironment sample, resulting nucleic acids and use in synthesis of novel compounds |
| US6608190B1 (en) * | 1999-12-16 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors |
| US6936414B2 (en) | 1999-12-22 | 2005-08-30 | Abbott Laboratories | Nucleic acid isolation method and kit |
| WO2001049882A2 (en) * | 1999-12-29 | 2001-07-12 | Keygene N.V. | METHOD FOR GENERATING OLIGONUCLEOTIDES, IN PARTICULAR FOR THE DETECTION OF AMPLIFIED RESTRICTION FRAGMENTS OBTAINED USING AFLP$m(3) |
| SE0000061D0 (sv) | 2000-01-10 | 2000-01-10 | Bjoern Herrmann | A method for detection of pathogenic organisms |
| EP1276901A2 (en) * | 2000-01-13 | 2003-01-22 | Amsterdam Support Diagnostics B.V. | A universal nucleic acid amplification system for nucleic acids in a sample |
| US20010034250A1 (en) | 2000-01-24 | 2001-10-25 | Sanjay Chadha | Hand-held personal computing device with microdisplay |
| CA2298181C (en) | 2000-02-02 | 2006-09-19 | Dayan Burke Goodnough | Non-targeted complex sample analysis |
| US20020009727A1 (en) | 2000-02-02 | 2002-01-24 | Schultz Gary A. | Detection of single nucleotide polymorphisms |
| US6453244B1 (en) | 2000-02-10 | 2002-09-17 | Stanford University | Detection of polymorphisms by denaturing high-performance liquid chromatography |
| EP1266338A2 (en) | 2000-02-14 | 2002-12-18 | First Opinion Corporation | Automated diagnostic system and method |
| US6393367B1 (en) | 2000-02-19 | 2002-05-21 | Proteometrics, Llc | Method for evaluating the quality of comparisons between experimental and theoretical mass data |
| DE10015797B4 (de) | 2000-03-26 | 2006-02-02 | Bruker Daltonik Gmbh | Multiplex-Analyse von DNA-Gemischen mittels photolytisch ablesbarer DNA-Chips |
| DE10015262A1 (de) | 2000-03-28 | 2001-10-04 | Basf Ag | Papierstreichmassen, enthaltend Bindemittel mit Makromonomeren |
| US6713258B2 (en) | 2000-03-29 | 2004-03-30 | Center For The Application Of Molecular Biology To International Agriculture (Cambia) | Methods for genotyping by hybridization analysis |
| AU2001253310A1 (en) | 2000-04-10 | 2001-10-23 | Matthew Ashby | Methods for the survey and genetic analysis of populations |
| US6475736B1 (en) * | 2000-05-23 | 2002-11-05 | Variagenics, Inc. | Methods for genetic analysis of DNA using biased amplification of polymorphic sites |
| US6716634B1 (en) * | 2000-05-31 | 2004-04-06 | Agilent Technologies, Inc. | Increasing ionization efficiency in mass spectrometry |
| US6507837B1 (en) | 2000-06-08 | 2003-01-14 | Hyperphrase Technologies, Llc | Tiered and content based database searching |
| US20020177552A1 (en) | 2000-06-09 | 2002-11-28 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| AU2001268468A1 (en) * | 2000-06-13 | 2001-12-24 | The Trustees Of Boston University | Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing |
| EP1170379A1 (en) * | 2000-06-30 | 2002-01-09 | Centre National de Genotypage | Sample generation for genotyping by mass spectrometry |
| FR2811321A1 (fr) | 2000-07-04 | 2002-01-11 | Bio Merieux | Amplificateur d'une region ribonucleique cible d'un arn ribosomal 16s ou adn pour un tel arn d'une espece eubacterienne et detection de telles especes |
| US6504021B2 (en) * | 2000-07-05 | 2003-01-07 | Edge Biosystems, Inc. | Ion exchange method for DNA purification |
| US20040072239A1 (en) | 2000-07-06 | 2004-04-15 | Patricia Renaud | Method for controlling the microbiological quality of an aqueous medium and kit therefor |
| US6783939B2 (en) | 2000-07-07 | 2004-08-31 | Alphavax, Inc. | Alphavirus vectors and virosomes with modified HIV genes for use in vaccines |
| WO2002010186A1 (en) | 2000-07-27 | 2002-02-07 | California Institute Of Technology | A rapid, quantitative method for the mass spectrometric analysis of nucleic acids for gene expression and genotyping |
| AUPQ909000A0 (en) | 2000-07-28 | 2000-08-24 | University Of Sydney, The | A method of detecting microorganisms |
| US20030190635A1 (en) | 2002-02-20 | 2003-10-09 | Mcswiggen James A. | RNA interference mediated treatment of Alzheimer's disease using short interfering RNA |
| GB0021286D0 (en) | 2000-08-30 | 2000-10-18 | Gemini Genomics Ab | Identification of drug metabolic capacity |
| US20040005555A1 (en) * | 2000-08-31 | 2004-01-08 | Rothman Richard E. | Molecular diagnosis of bactermia |
| US6813615B1 (en) | 2000-09-06 | 2004-11-02 | Cellomics, Inc. | Method and system for interpreting and validating experimental data with automated reasoning |
| US7349808B1 (en) * | 2000-09-06 | 2008-03-25 | Egenomics, Inc. | System and method for tracking and controlling infections |
| US20020120408A1 (en) | 2000-09-06 | 2002-08-29 | Kreiswirth Barry N. | System and method for tracking and controlling infections |
| WO2002021108A2 (en) | 2000-09-08 | 2002-03-14 | Large Scale Proteomics Corporation | Method for detecting molecules or chemical reactions by determining variation of conductance |
| SE0003286D0 (sv) | 2000-09-15 | 2000-09-15 | Ulf Gyllensten | Method and kit for human identification |
| CN1582333B (zh) | 2000-09-25 | 2010-06-16 | 波利门科学生物免疫研究有限公司 | 活疫苗及生产方法 |
| WO2002028901A2 (en) | 2000-10-05 | 2002-04-11 | Millennium Pharmaceuticals, Inc. | Seven-transmembrane (7tm) receptors and uses thereof |
| US6996472B2 (en) | 2000-10-10 | 2006-02-07 | The United States Of America As Represented By The Department Of Health And Human Services | Drift compensation method for fingerprint spectra |
| CA2423552A1 (en) | 2000-10-13 | 2002-04-18 | Irm Llc | High throughput processing system and method of using |
| ATE380883T1 (de) | 2000-10-24 | 2007-12-15 | Univ Leland Stanford Junior | Direkte multiplex charakterisierung von genomischer dna |
| US6906316B2 (en) | 2000-10-27 | 2005-06-14 | Fuji Electric Co., Ltd. | Semiconductor device module |
| US6682889B1 (en) * | 2000-11-08 | 2004-01-27 | Becton, Dickinson And Company | Amplification and detection of organisms of the Chlamydiaceae family |
| WO2002050307A1 (fr) | 2000-12-12 | 2002-06-27 | Chugai Seiyaku Kabushiki Kaisha | Procede de detection de polymorphisme dans l'adn au moyen d'une spectroscopie de masse |
| US6800289B2 (en) | 2000-12-21 | 2004-10-05 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence | Strain of the western equine encephalitis virus |
| US6586584B2 (en) | 2001-01-29 | 2003-07-01 | Becton, Dickinson And Company | Sequences and methods for detection of Hepatitis C virus |
| DE10108453B4 (de) | 2001-02-22 | 2005-10-20 | Bruker Daltonik Gmbh | Massenspektrometrische Mutationsanalyse mit photolytisch spaltbaren Primern |
| EP1404868A2 (en) | 2001-02-28 | 2004-04-07 | Chondrogene Inc. | Compositions and methods relating to osteoarthritis |
| CA2478020C (en) | 2001-03-01 | 2006-12-19 | The Johns Hopkins University | Quantitative assay for the simultaneous detection and speciation of bacterial infections |
| US7226739B2 (en) * | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| US20040121313A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in organs for transplantation |
| US20040121310A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in forensic studies |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| US7718354B2 (en) | 2001-03-02 | 2010-05-18 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| AU2003298030B2 (en) | 2001-03-02 | 2009-12-10 | Ibis Biosciences, Inc. | Methods for rapid identification of pathogens in humans and animals |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US20040038206A1 (en) * | 2001-03-14 | 2004-02-26 | Jia Zhang | Method for high throughput assay of genetic analysis |
| US20030104410A1 (en) | 2001-03-16 | 2003-06-05 | Affymetrix, Inc. | Human microarray |
| ATE335754T1 (de) | 2001-03-19 | 2006-09-15 | Harvard College | Entwicklung neuer molekularer funktionen |
| CN1316034C (zh) | 2001-03-28 | 2007-05-16 | 科学与工业研究会 | 用于野生生物鉴定的通用引物 |
| US7630836B2 (en) | 2001-05-30 | 2009-12-08 | The Kitasato Institute | Polynucleotides |
| CA2348042A1 (en) | 2001-06-04 | 2002-12-04 | Ann Huletsky | Sequences for detection and identification of methicillin-resistant staphylococcus aureus |
| US20020187477A1 (en) * | 2001-06-06 | 2002-12-12 | Hong Xue | Method for detecting single nucleotide polymorphisms (SNPs) and point mutations |
| AU2002316966B2 (en) | 2001-06-06 | 2007-05-17 | Dsm Ip Assets B.V. | Improved isoprenoid production |
| GB0113908D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Designing degenerate PCR primers |
| GB0113907D0 (en) | 2001-06-07 | 2001-08-01 | Univ London | Virus detection using degenerate PCR primers |
| US20020187490A1 (en) | 2001-06-07 | 2002-12-12 | Michigan State University | Microbial identification chip based on DNA-DNA hybridization |
| US8073627B2 (en) | 2001-06-26 | 2011-12-06 | Ibis Biosciences, Inc. | System for indentification of pathogens |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| DE10132147B4 (de) | 2001-07-03 | 2004-04-15 | Universität Leipzig | Verfahren zur schnellen quantitativen Bestimmung von Eu-Bakterien |
| GB0117054D0 (en) | 2001-07-12 | 2001-09-05 | Plant Bioscience Ltd | Methods and means for modification of plant characteristics |
| DE60210621T2 (de) | 2001-07-19 | 2007-03-08 | Infectio Diagnostic (I.D.I.) Inc., Sainte-Foy | Universelle methode und zusammensetzung zur schnellen lysierung von zellen zur freisetzung von nukleinsäuren und ihre detektion |
| US20040191769A1 (en) | 2001-07-24 | 2004-09-30 | Transgenomic, Inc. | Methods, compositions, and kits for mutation detection in mitochondrial DNA |
| WO2003012074A2 (en) | 2001-07-30 | 2003-02-13 | Den Kgl. Veterinær- Og Landbohøjskole | Bacterial strains belonging to lactobacillus species and their use in food and feed industry |
| US7115385B2 (en) | 2001-08-02 | 2006-10-03 | North Carolina State University | Media and methods for cultivation of microorganisms |
| AT411174B (de) | 2001-08-09 | 2003-10-27 | Lambda Labor Fuer Molekularbio | Verfahren und chip zur analyse von nukleinsäuren |
| US20030039976A1 (en) * | 2001-08-14 | 2003-02-27 | Haff Lawrence A. | Methods for base counting |
| US20040175715A1 (en) | 2001-08-21 | 2004-09-09 | Burgoyne Leigh A. | Method and device for simultaneously molecularly cloning and polylocus profiling of genomes or genomes mixtures |
| US7105296B2 (en) | 2001-08-29 | 2006-09-12 | E. I. Du Pont De Nemours And Company | Genes encoding Baeyer-Villiger monooxygenases |
| US7049286B2 (en) | 2001-08-30 | 2006-05-23 | Diatos, S.A. | Insulin conjugates and methods of use thereof |
| CA2459347C (en) | 2001-09-04 | 2012-10-09 | Exiqon A/S | Locked nucleic acid (lna) compositions and uses thereof |
| US20040101809A1 (en) | 2001-09-21 | 2004-05-27 | Weiss Ervin I | Device, method and materials for mobilizing substances into dentinal tubules in root canal treatment |
| DE10150121B4 (de) | 2001-10-11 | 2005-12-01 | Bernhard-Nocht-Institut für Tropenmedizin | Echtzeitdetektion von DNA-Amplifikationsprodukten |
| US6977148B2 (en) | 2001-10-15 | 2005-12-20 | Qiagen Gmbh | Multiple displacement amplification |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| DE10152821B4 (de) | 2001-10-25 | 2006-11-16 | Bruker Daltonik Gmbh | Massenspektren ohne elektronisches Rauschen |
| US20040029129A1 (en) * | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| EP1308506A1 (en) | 2001-11-06 | 2003-05-07 | Eidgenössische Technische Hochschule Zürich | Mixtures of Propionibacterium jensenii and Lactobacillus sp. with antimicrobial activities for use as a natural preservation system |
| NZ578982A (en) | 2001-11-13 | 2011-03-31 | Univ Pennsylvania | A method of detecting and/or identifying adeno-associated virus (AAV) sequences and isolating novel sequences identified thereby |
| EP1453484B1 (en) * | 2001-11-15 | 2009-12-23 | Whatman, Inc. | Methods and materials for detecting genetic material |
| US20040023209A1 (en) * | 2001-11-28 | 2004-02-05 | Jon Jonasson | Method for identifying microorganisms based on sequencing gene fragments |
| JP3692067B2 (ja) | 2001-11-30 | 2005-09-07 | 株式会社東芝 | 銅のｃｍｐ用研磨スラリーおよびそれを用いた半導体装置の製造方法 |
| US20030148284A1 (en) * | 2001-12-17 | 2003-08-07 | Vision Todd J. | Solid phase detection of nucleic acid molecules |
| TW509116U (en) | 2001-12-18 | 2002-11-01 | Ind Tech Res Inst | Device for clipping and tightening spindle of honing and milling machine |
| US20030175709A1 (en) | 2001-12-20 | 2003-09-18 | Murphy George L. | Method and system for depleting rRNA populations |
| US7468185B2 (en) | 2001-12-21 | 2008-12-23 | Pfizer Inc. | Vaccine for periodontal disease |
| KR100444230B1 (ko) | 2001-12-27 | 2004-08-16 | 삼성전기주식회사 | 내환원성 유전체 자기 조성물 |
| AU2002358353A1 (en) | 2001-12-28 | 2003-07-30 | Keygene N.V. | Discrimination and detection of target nucleotide sequences using mass spectrometry |
| EP1333101B1 (en) | 2002-02-01 | 2007-03-28 | Bruker Daltonik GmbH | Mutation analysis by PCR and Mass spectrometry |
| CN1202204C (zh) | 2002-02-27 | 2005-05-18 | 财团法人工业技术研究院 | 红光有机电激发光化合物及用其制成的组件和装置 |
| KR100600988B1 (ko) | 2002-03-13 | 2006-07-13 | 주식회사 엘지생명과학 | Ｄｎａ 면역화에서 인플루엔자 ｎｐ 유전자 ｄｎａ를 함께투여하여 면역반응을 증가시키는 방법 |
| US7024370B2 (en) * | 2002-03-26 | 2006-04-04 | P) Cis, Inc. | Methods and apparatus for early detection of health-related events in a population |
| US6897027B2 (en) | 2002-03-27 | 2005-05-24 | Decode Genetics Ehf. | Method for desalting nucleic acids |
| WO2003100035A2 (en) | 2002-04-01 | 2003-12-04 | Isis Pharmaceuticals, Inc. | Method for rapid detection and identification of viral bioagents |
| AU2003224897A1 (en) | 2002-04-09 | 2003-10-27 | Kenneth L. Beattie | Oligonucleotide probes for genosensor chips |
| JP2004000200A (ja) | 2002-04-19 | 2004-01-08 | Menicon Co Ltd | 微生物の検出方法 |
| FR2838740A1 (fr) | 2002-04-22 | 2003-10-24 | Centre Nat Rech Scient | Oligonucleotides issus des sequences codant pour la composante de surface des proteines d'enveloppe des ptlv et leurs utilisations |
| GB0209812D0 (en) | 2002-04-30 | 2002-06-05 | Renovo Ltd | Genetic testing |
| DE10222632B4 (de) | 2002-05-17 | 2006-03-09 | Con Cipio Gmbh | Mikrosatellitenmarker für genetische Analysen und zur Unterscheidung von Rosen |
| US6906319B2 (en) | 2002-05-17 | 2005-06-14 | Micromass Uk Limited | Mass spectrometer |
| EP1365031A1 (en) | 2002-05-21 | 2003-11-26 | MTM Laboratories AG | Method for detection of somatic mutations using mass spectometry |
| WO2003099840A1 (en) * | 2002-05-24 | 2003-12-04 | Isis Pharmaceuticals, Inc. | Oligonucleotides having modified nucleoside units |
| US20030220844A1 (en) * | 2002-05-24 | 2003-11-27 | Marnellos Georgios E. | Method and system for purchasing genetic data |
| AU2003240150B2 (en) | 2002-05-29 | 2008-10-30 | Aresa Biodetection Aps | Reporter system for plants |
| GB0212666D0 (en) | 2002-05-31 | 2002-07-10 | Secr Defence | Immunogenic sequences |
| AU2003238930A1 (en) | 2002-06-07 | 2003-12-22 | Incyte Corporation | Enzymes |
| AU2003245488A1 (en) | 2002-06-13 | 2003-12-31 | Regulome Corporation | Functional sites |
| KR100484144B1 (ko) * | 2002-06-20 | 2005-04-18 | 삼성전자주식회사 | 원격 관리 서버 및 원격 관리 방법 |
| EP1539944A4 (en) | 2002-07-01 | 2005-12-28 | Univ Wayne State | METHODS AND COMPOSITIONS FOR THE IDENTIFICATION OF ANTIBIOTICS WHICH DO NOT RESPOND TO ANTIBIOTIC RESISTANCE |
| AU2003254093A1 (en) | 2002-07-19 | 2004-02-09 | Isis Pharmaceuticals, Inc. | Methods for mass spectrometry analysis utilizing an integrated microfluidics sample platform |
| US6916483B2 (en) * | 2002-07-22 | 2005-07-12 | Biodynamics, Llc | Bioabsorbable plugs containing drugs |
| GB0217434D0 (en) | 2002-07-27 | 2002-09-04 | Royal Vetinary College | Biological material |
| US20040022764A1 (en) * | 2002-07-31 | 2004-02-05 | Hanan Polansky | Inhibition of microcompetition with a foreign polynucleotide as treatment of chronic disease |
| US7172868B2 (en) | 2002-08-01 | 2007-02-06 | The Regents Of The University Of California | Nucleotide sequences specific to Francisella tularensis and methods for the detection of Francisella tularensis |
| US20040038385A1 (en) * | 2002-08-26 | 2004-02-26 | Langlois Richard G. | System for autonomous monitoring of bioagents |
| WO2004022721A2 (en) * | 2002-09-06 | 2004-03-18 | The Trustees Of Boston University | Quantification of gene expression |
| US20040110138A1 (en) | 2002-11-01 | 2004-06-10 | University Of Ottawa | Method for the detection of multiple genetic targets |
| EP1560932A2 (en) | 2002-11-12 | 2005-08-10 | Genolife | One step real-time rt pcr kits for the universal detection of organisms in industrial products |
| US7250496B2 (en) | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| WO2004070001A2 (en) | 2002-11-15 | 2004-08-19 | Gen-Probe Incorporated | Assay and compositions for detection of bacillus anthracis nucleic acid |
| US6680476B1 (en) * | 2002-11-22 | 2004-01-20 | Agilent Technologies, Inc. | Summed time-of-flight mass spectrometry utilizing thresholding to reduce noise |
| JP2006516193A (ja) | 2002-12-06 | 2006-06-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ヒトおよび動物における病原体の迅速な同定方法 |
| JP2004201679A (ja) | 2002-12-10 | 2004-07-22 | Kao Corp | Ｐｃｒ法によるフゾバクテリウム・ニュークレタム菌の検出用プライマー及びその検出方法 |
| US20040117354A1 (en) | 2002-12-16 | 2004-06-17 | Azzaro Steven Hector | Process for tagging and measuring quality |
| US20040122857A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in forensic studies thereby |
| US20040122598A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in food products and cosmetics thereby |
| US20040121329A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in blood, bodily fluids, and bodily tissues thereby |
| US20040121312A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of the absence of bioagents |
| US20040121340A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent associated with host versus graft and graft versus host rejections thereby |
| US20040121315A1 (en) | 2002-12-18 | 2004-06-24 | Ecker David J. | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent in containers thereby |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| JP2004201641A (ja) | 2002-12-26 | 2004-07-22 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | 真菌検出方法 |
| US20040170981A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Real-time polymerase chain reaction using large target amplicons |
| US20040170954A1 (en) | 2003-02-10 | 2004-09-02 | Mckenney Keith | Pathogen inactivation assay |
| US20040185438A1 (en) | 2003-03-10 | 2004-09-23 | Ecker David J. | Methods of detection and notification of bioagent contamination |
| US20050065813A1 (en) * | 2003-03-11 | 2005-03-24 | Mishelevich David J. | Online medical evaluation system |
| US8046171B2 (en) | 2003-04-18 | 2011-10-25 | Ibis Biosciences, Inc. | Methods and apparatus for genetic evaluation |
| CA2523490A1 (en) | 2003-04-25 | 2004-11-11 | Sequenom, Inc. | Fragmentation-based methods and systems for de novo sequencing |
| US8057993B2 (en) | 2003-04-26 | 2011-11-15 | Ibis Biosciences, Inc. | Methods for identification of coronaviruses |
| WO2005009202A2 (en) | 2003-05-12 | 2005-02-03 | Isis Pharmaceuticals, Inc. | Automatic identification of bioagents |
| US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| EP1644520B1 (en) | 2003-07-03 | 2007-09-19 | Danmarks og Gronlands Geologiske Undersogelse | Method for selective detection of a target nucleic acid |
| AU2003257013A1 (en) * | 2003-07-29 | 2005-03-07 | Sigma Aldrich Co. | Methods and compositions for amplification of dna |
| JP4304292B2 (ja) * | 2003-07-30 | 2009-07-29 | 日本電気株式会社 | 移動通信システム、移動通信端末及びそれに用いるパワーコントロール方法並びにそのプログラム |
| KR100632429B1 (ko) | 2003-08-01 | 2006-10-09 | 프로테온 주식회사 | 프라이머 특이성 유무에 의한 멀티플렉스 역전사 중합효소연쇄반응을 이용한 재조합 독감 바이러스의 스크리닝 방법 |
| US20060240412A1 (en) | 2003-09-11 | 2006-10-26 | Hall Thomas A | Compositions for use in identification of adenoviruses |
| US20120122096A1 (en) | 2003-09-11 | 2012-05-17 | Rangarajan Sampath | Compositions for use in identification of bacteria |
| US20050142584A1 (en) | 2003-10-01 | 2005-06-30 | Willson Richard C. | Microbial identification based on the overall composition of characteristic oligonucleotides |
| WO2005036369A2 (en) | 2003-10-09 | 2005-04-21 | Isis Pharmaceuticals, Inc. | Database for microbial investigations |
| FR2861743B1 (fr) | 2003-11-04 | 2007-10-19 | Univ Aix Marseille Ii | Identification moleculaire des bacteries du genre corynebacterium |
| JP3861871B2 (ja) | 2003-11-26 | 2006-12-27 | サンケン電気株式会社 | スイッチング電源装置 |
| WO2005062770A2 (en) | 2003-12-19 | 2005-07-14 | Novakoff James L | Method for conducting pharmacogenomics-based studies |
| EP2251441B1 (en) | 2004-02-10 | 2013-05-08 | F. Hoffmann-La Roche AG | Detection of parvovirus B19 |
| US7666592B2 (en) * | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| JP2007525978A (ja) | 2004-02-18 | 2007-09-13 | アイシス ファーマシューティカルズ インコーポレイテッド | 細菌の同定で用いられる組成物 |
| US8119336B2 (en) | 2004-03-03 | 2012-02-21 | Ibis Biosciences, Inc. | Compositions for use in identification of alphaviruses |
| US7312036B2 (en) * | 2004-03-22 | 2007-12-25 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of viral hemorrhagic fever viruses |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| WO2006135400A2 (en) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Methods for rapid identification of recombinant organisms |
| US7627437B2 (en) | 2005-01-14 | 2009-12-01 | Idaho Research Foundation | Categorization of microbial communities |
| DE102005008583B4 (de) | 2005-02-24 | 2007-10-25 | Johannes-Gutenberg-Universität Mainz | Verfahren zur Typisierung eines Individuums mittels short tandem repeat (STR)-Loci der genomischen DNA |
| CA2600184A1 (en) | 2005-03-03 | 2006-09-08 | Isis Pharmaceuticals, Inc. | Compositions for use in identification of adventitious viruses |
| DE602006017365D1 (de) | 2005-04-13 | 2010-11-18 | Ibis Biosciences Inc | Zusammensetzungen für die identifizierung von adenoviren |
| JP5081144B2 (ja) | 2005-04-21 | 2012-11-21 | アイビス バイオサイエンシズ インコーポレイティッド | 細菌の同定に用いる組成物 |
| JP2009502137A (ja) | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| US20070026435A1 (en) | 2005-07-28 | 2007-02-01 | Polysciences, Inc. | Hydroxysilane functionalized magnetic particles and nucleic acid separation method |
| WO2008104002A2 (en) | 2007-02-23 | 2008-08-28 | Ibis Biosciences, Inc. | Methods for rapid forensic dna analysis |
| WO2008118809A1 (en) | 2007-03-23 | 2008-10-02 | Ibis Biosciences, Inc. | Compositions for use in identification of mixed populations of bioagents |
| JP5067239B2 (ja) | 2008-03-28 | 2012-11-07 | 富士通株式会社 | ケーブルマネージメント装置および電子機器装置 |
-
2001
- 2001-03-02 US US09/798,007 patent/US20030027135A1/en not_active Abandoned
-
2002
- 2002-03-04 WO PCT/US2002/006763 patent/WO2002070664A2/en active Application Filing
- 2002-03-04 EP EP02709785A patent/EP1364064B1/en not_active Expired - Lifetime
- 2002-03-04 EP EP10179791A patent/EP2311992B1/en not_active Expired - Lifetime
- 2002-03-04 RU RU2003129269/13A patent/RU2003129269A/ru not_active Application Discontinuation
- 2002-03-04 NZ NZ527857A patent/NZ527857A/en not_active IP Right Cessation
- 2002-03-04 MX MXPA03007927A patent/MXPA03007927A/es active IP Right Grant
- 2002-03-04 CA CA2439655A patent/CA2439655C/en not_active Expired - Fee Related
- 2002-03-04 MX MX2014010221A patent/MX349763B/es unknown
- 2002-03-04 ES ES10179789.2T patent/ES2448770T3/es not_active Expired - Lifetime
- 2002-03-04 ES ES10179795.9T patent/ES2451003T3/es not_active Expired - Lifetime
- 2002-03-04 EP EP10179795.9A patent/EP2322649B1/en not_active Expired - Lifetime
- 2002-03-04 CN CN028091221A patent/CN1505685B/zh not_active Expired - Fee Related
- 2002-03-04 IL IL15766102A patent/IL157661A0/xx unknown
- 2002-03-04 CA CA2853831A patent/CA2853831C/en not_active Expired - Fee Related
- 2002-03-04 AU AU2002244250A patent/AU2002244250B2/en not_active Ceased
- 2002-03-04 CN CN201210348178.6A patent/CN102912036B/zh not_active Expired - Fee Related
- 2002-03-04 JP JP2002570692A patent/JP2005504508A/ja not_active Withdrawn
- 2002-03-04 ES ES02709785T patent/ES2394731T3/es not_active Expired - Lifetime
- 2002-03-04 EP EP10179789.2A patent/EP2333118B1/en not_active Expired - Lifetime
- 2002-05-24 US US10/156,608 patent/US7108974B2/en not_active Expired - Lifetime
- 2002-12-13 US US10/318,881 patent/US20030175695A1/en not_active Abandoned
- 2002-12-13 US US10/319,290 patent/US20030175696A1/en not_active Abandoned
- 2002-12-13 US US10/319,342 patent/US20030175697A1/en not_active Abandoned
- 2002-12-18 US US10/326,047 patent/US20030190605A1/en not_active Abandoned
-
2003
- 2003-05-06 US US10/430,253 patent/US20040110169A1/en not_active Abandoned
- 2003-05-09 US US10/435,307 patent/US20040202997A1/en not_active Abandoned
- 2003-08-29 IL IL157661A patent/IL157661A/en not_active IP Right Cessation
- 2003-09-01 ZA ZA200306810A patent/ZA200306810B/en unknown
-
2005
- 2005-09-21 US US11/233,630 patent/US8017322B2/en not_active Expired - Fee Related
-
2006
- 2006-01-13 US US11/331,987 patent/US8017358B2/en not_active Expired - Fee Related
- 2006-01-13 US US11/331,978 patent/US7741036B2/en not_active Expired - Fee Related
-
2007
- 2007-10-30 US US11/929,707 patent/US8017743B2/en not_active Expired - Fee Related
- 2007-10-30 US US11/930,017 patent/US8265878B2/en not_active Expired - Fee Related
-
2009
- 2009-10-26 JP JP2009245976A patent/JP5121803B2/ja not_active Expired - Fee Related
-
2010
- 2010-03-10 AU AU2010200893A patent/AU2010200893B2/en not_active Ceased
-
2015
- 2015-05-17 IL IL238855A patent/IL238855A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5605798A (en) * | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
Non-Patent Citations (2)
| Title |
|---|
| Hurst et al., Rapid Communications in Mass Spectrometry, 1996, Vol. 10, 377-382. * |
| Johnson et al., Journal of Microbiological Methods, 2000, 40, 241-254. * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7956175B2 (en) | 2003-09-11 | 2011-06-07 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
| US8013142B2 (en) | 2003-09-11 | 2011-09-06 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
| CN112861170A (zh) * | 2020-08-03 | 2021-05-28 | 德能森智能科技（成都）有限公司 | 一种保护隐私的智慧园区管理系统 |
| CN112861170B (zh) * | 2020-08-03 | 2023-03-31 | 德能森智能科技（成都）有限公司 | 一种保护隐私的智慧园区管理系统 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2002244250B2 (en) | Method for rapid detection and identification of bioagents | |
| US8298760B2 (en) | Secondary structure defining database and methods for determining identity and geographic origin of an unknown bioagent thereby | |
| AU2002244250A1 (en) | Method for rapid detection and identification of bioagents | |
| US20040253619A1 (en) | Methods for rapid detection and identification of bacterial bioagents | |
| US20040121309A1 (en) | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues | |
| US20040121310A1 (en) | Methods for rapid detection and identification of bioagents in forensic studies | |
| US20040121312A1 (en) | Methods for rapid detection and identification of the absence of bioagents | |
| US20030228571A1 (en) | Method for rapid detection and identification of viral bioagents |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| PC | Assignment registered |
Owner name: IBIS BIOSCIENCES, INC. Free format text: FORMER OWNER WAS: ISIS PHARMACEUTICALS, INC. |
|
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |