ATE463480T1 - Verfahren und zwischenprodukte - Google Patents

Verfahren und zwischenprodukte

Info

Publication number
ATE463480T1
ATE463480T1 AT06813568T AT06813568T ATE463480T1 AT E463480 T1 ATE463480 T1 AT E463480T1 AT 06813568 T AT06813568 T AT 06813568T AT 06813568 T AT06813568 T AT 06813568T AT E463480 T1 ATE463480 T1 AT E463480T1
Authority
AT
Austria
Prior art keywords
intermediate products
products
Prior art date
Application number
AT06813568T
Other languages
English (en)
Inventor
Gerald Tanoury
Minzhang Chen
John Cochran
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Application granted granted Critical
Publication of ATE463480T1 publication Critical patent/ATE463480T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT06813568T 2005-08-19 2006-08-18 Verfahren und zwischenprodukte ATE463480T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70996405P 2005-08-19 2005-08-19
US81004206P 2006-06-01 2006-06-01
PCT/US2006/032481 WO2007022459A2 (en) 2005-08-19 2006-08-18 Processes and intermediates

Publications (1)

Publication Number Publication Date
ATE463480T1 true ATE463480T1 (de) 2010-04-15

Family

ID=37708299

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06813568T ATE463480T1 (de) 2005-08-19 2006-08-18 Verfahren und zwischenprodukte

Country Status (24)

Country Link
US (3) US7776887B2 (de)
EP (4) EP2364970A1 (de)
JP (1) JP5203203B2 (de)
KR (4) KR20130110236A (de)
CN (2) CN102382170A (de)
AR (1) AR058025A1 (de)
AT (1) ATE463480T1 (de)
AU (1) AU2006279357B2 (de)
BR (1) BRPI0615029A2 (de)
CA (1) CA2619659A1 (de)
CY (2) CY1110214T1 (de)
DE (1) DE602006013492D1 (de)
DK (2) DK1934179T3 (de)
ES (2) ES2344156T3 (de)
IL (2) IL189585A (de)
NZ (3) NZ604087A (de)
PL (3) PL1934179T4 (de)
PT (2) PT1934179E (de)
RU (2) RU2446171C2 (de)
SG (1) SG2014013338A (de)
SI (2) SI2194043T1 (de)
TW (2) TW201245149A (de)
WO (1) WO2007022459A2 (de)
ZA (1) ZA200801791B (de)

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EP2134717A2 (de) * 2007-02-27 2009-12-23 Vertex Pharmceuticals Incorporated Serinprotease-hemmer
MX2009009182A (es) * 2007-02-27 2009-09-04 Vertex Pharma Co-cristales y composiciones farmaceuticas que los comprenden.
NZ583699A (en) * 2007-08-30 2012-04-27 Vertex Pharma Co-crystals of vx-950 (telaprevir) other components and pharmaceutical compositions comprising the same
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CN103450066B (zh) * 2012-05-30 2017-03-15 博瑞生物医药（苏州）股份有限公司 特拉匹韦中间体的制备方法
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CN103342656B (zh) * 2013-07-04 2015-04-08 苏州永健生物医药有限公司 特拉匹韦中间体的合成方法
CN103435532B (zh) * 2013-09-02 2015-07-08 苏州永健生物医药有限公司 波普瑞韦中间体的合成方法
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JP2016539931A (ja) * 2013-10-23 2016-12-22 株式会社カネカ テトラペプチド化合物及びその製造方法
CN103664739B (zh) * 2013-12-10 2016-04-27 湖南科源生物制品有限公司 一种特拉匹韦中间体的制备方法
WO2016057931A1 (en) 2014-10-10 2016-04-14 The Research Foundation For The State University Of New York Trifluoromethoxylation of arenes via intramolecular trifluoromethoxy group migration
CN105646329A (zh) * 2014-11-28 2016-06-08 重庆圣华曦药业股份有限公司 一种制备特拉匹韦中间体的方法
CN105111129A (zh) * 2015-08-24 2015-12-02 上海合全药业股份有限公司 (1S,3aR,6aS)-八氢环戊烯并[C]吡咯-1-羧酸叔丁酯草酸盐的制备方法
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JP7584418B2 (ja) 2018-12-04 2024-11-15 ブリストル－マイヤーズ スクイブ カンパニー 多重反応同位体分子種反応モニタリングによる、サンプル内検量線を用いた分析方法
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EP1934179A2 (de) 2008-06-25
AU2006279357B2 (en) 2012-05-31
PT1934179E (pt) 2010-07-12
IL189585A (en) 2013-10-31
HK1145022A1 (en) 2011-03-25
KR20140069370A (ko) 2014-06-09
IL228770A0 (en) 2013-12-31
JP2009504780A (ja) 2009-02-05
TW201245149A (en) 2012-11-16
CN101291909A (zh) 2008-10-22
CA2619659A1 (en) 2007-02-22
EP2194043A3 (de) 2010-11-24
CN101291909B (zh) 2012-09-05
BRPI0615029A2 (pt) 2009-06-16
SI2194043T1 (sl) 2014-04-30
AR058025A1 (es) 2008-01-23
US8637457B2 (en) 2014-01-28
TW200800889A (en) 2008-01-01
CN102382170A (zh) 2012-03-21
EP2364970A1 (de) 2011-09-14
KR101474405B1 (ko) 2014-12-23
KR20080047396A (ko) 2008-05-28
PT2194043E (pt) 2014-03-04
RU2011148615A (ru) 2013-06-10
DK2194043T3 (da) 2014-01-20
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CY1110214T1 (el) 2015-01-14
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AU2006279357A1 (en) 2007-02-22
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RU2446171C2 (ru) 2012-03-27
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EP1934179B1 (de) 2010-04-07
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CY1114916T1 (el) 2016-12-14
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