CY1114916T1 - Μεθοδοι - Google Patents
ΜεθοδοιInfo
- Publication number
- CY1114916T1 CY1114916T1 CY20141100149T CY141100149T CY1114916T1 CY 1114916 T1 CY1114916 T1 CY 1114916T1 CY 20141100149 T CY20141100149 T CY 20141100149T CY 141100149 T CY141100149 T CY 141100149T CY 1114916 T1 CY1114916 T1 CY 1114916T1
- Authority
- CY
- Cyprus
- Prior art keywords
- protease inhibitors
- methods
- useful
- compounds
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
Abstract
Η εφεύρεση αφορά σε ενώσεις και μεθόδους χρήσιμες για την παρασκευή αναστολέων πρωτεάσης, ιδιαιτέρως αναστολέων πρωτεάσης σερίνης. Οι αναστολείς πρωτεάσης είναι χρήσιμοι για την θεραπεία μολύνσεων HCV.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70996405P | 2005-08-19 | 2005-08-19 | |
US81004206P | 2006-06-01 | 2006-06-01 | |
EP10155058.0A EP2194043B1 (en) | 2005-08-19 | 2006-08-18 | Processes |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1114916T1 true CY1114916T1 (el) | 2016-12-14 |
Family
ID=37708299
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100613T CY1110214T1 (el) | 2005-08-19 | 2010-07-05 | Μεθοδοι και ενδιαμεσα |
CY20141100149T CY1114916T1 (el) | 2005-08-19 | 2014-02-25 | Μεθοδοι |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100613T CY1110214T1 (el) | 2005-08-19 | 2010-07-05 | Μεθοδοι και ενδιαμεσα |
Country Status (25)
Country | Link |
---|---|
US (3) | US7776887B2 (el) |
EP (4) | EP2194043B1 (el) |
JP (1) | JP5203203B2 (el) |
KR (4) | KR20130038947A (el) |
CN (2) | CN101291909B (el) |
AR (1) | AR058025A1 (el) |
AT (1) | ATE463480T1 (el) |
AU (1) | AU2006279357B2 (el) |
BR (1) | BRPI0615029A2 (el) |
CA (1) | CA2619659A1 (el) |
CY (2) | CY1110214T1 (el) |
DE (1) | DE602006013492D1 (el) |
DK (2) | DK2194043T3 (el) |
ES (2) | ES2449268T3 (el) |
HK (2) | HK1122801A1 (el) |
IL (2) | IL189585A (el) |
NZ (3) | NZ604087A (el) |
PL (3) | PL385229A1 (el) |
PT (2) | PT1934179E (el) |
RU (2) | RU2446171C2 (el) |
SG (1) | SG2014013338A (el) |
SI (2) | SI1934179T1 (el) |
TW (2) | TW201245149A (el) |
WO (1) | WO2007022459A2 (el) |
ZA (1) | ZA200801791B (el) |
Families Citing this family (69)
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SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
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CA2617679A1 (en) * | 2005-08-02 | 2007-02-08 | Steve Lyons | Inhibitors of serine proteases |
ATE463480T1 (de) | 2005-08-19 | 2010-04-15 | Vertex Pharma | Verfahren und zwischenprodukte |
US8399615B2 (en) * | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US7964624B1 (en) * | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
CA2646123A1 (en) | 2006-03-16 | 2007-09-27 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for preparing steric compounds |
AU2007227544B2 (en) | 2006-03-16 | 2012-11-01 | Vertex Pharmaceuticals Incorporated | Deuterated hepatitis C protease inhibitors |
WO2008076316A2 (en) * | 2006-12-15 | 2008-06-26 | Schering Corporation | Bisulfite purification of an alpha-keto amide |
TW200846343A (en) * | 2007-02-27 | 2008-12-01 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
JP2010519329A (ja) * | 2007-02-27 | 2010-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | セリンプロテアーゼ阻害剤 |
US8492546B2 (en) * | 2007-08-30 | 2013-07-23 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
US8431733B2 (en) * | 2008-03-12 | 2013-04-30 | Virobay, Inc. | Process for the preparation of (3S)-3-amino-N-cyclopropyl-2-hydroxyalkanamide derivatives |
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CN103108865A (zh) | 2010-06-03 | 2013-05-15 | 弗特克斯药品有限公司 | 方法和中间体 |
CN102167680B (zh) * | 2011-03-23 | 2014-07-02 | 合亚医药科技(上海)有限公司 | 八氢环戊基并[c]吡咯羧酸衍生物的制备方法 |
WO2012158513A1 (en) | 2011-05-13 | 2012-11-22 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
CN103748059A (zh) * | 2011-05-13 | 2014-04-23 | 弗特克斯药品有限公司 | 制备蛋白酶抑制剂的方法 |
JP2013010738A (ja) * | 2011-05-31 | 2013-01-17 | Sumitomo Chemical Co Ltd | エステル化合物の製造方法 |
JP5677645B2 (ja) | 2011-10-21 | 2015-02-25 | アッヴィ・インコーポレイテッド | 少なくとも2種の直接作用型抗ウイルス剤、およびリバビリンを含むがインターフェロンを含まない、hcvを治療するための方法 |
CN104436197A (zh) | 2011-10-21 | 2015-03-25 | 艾伯维公司 | 至少两种直接作用抗病毒剂的组合产品 |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
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CN103183632A (zh) * | 2011-12-29 | 2013-07-03 | 山东方明药业集团股份有限公司 | 一种3-氮杂双环辛烷盐酸盐的提纯方法 |
ITMI20120192A1 (it) | 2012-02-13 | 2013-08-14 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
ITMI20120359A1 (it) | 2012-03-07 | 2013-09-08 | Dipharma Francis Srl | Procedimento per la preparazione di intermedi utili nella preparazione di un inibitore delle proteasi virali |
ITMI20121668A1 (it) * | 2012-10-05 | 2014-04-06 | Dipharma Francis Srl | Sintesi di un intermedio di un composto antivirale |
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