BRPI0615029A2 - processos e intermediários - Google Patents

processos e intermediários

Info

Publication number
BRPI0615029A2
BRPI0615029A2 BRPI0615029-2A BRPI0615029A BRPI0615029A2 BR PI0615029 A2 BRPI0615029 A2 BR PI0615029A2 BR PI0615029 A BRPI0615029 A BR PI0615029A BR PI0615029 A2 BRPI0615029 A2 BR PI0615029A2
Authority
BR
Brazil
Prior art keywords
processes
intermediaries
protease inhibitors
useful
compounds
Prior art date
Application number
BRPI0615029-2A
Other languages
English (en)
Inventor
Gerald J Tanoury
Minzhang Chen
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BRPI0615029A2 publication Critical patent/BRPI0615029A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link

Abstract

PROCESSOS E INTERMEDIáRIOS. A invenção se refere a compostos e processos úteis para o preparo de inibidores de protease, particularmente inibidores de protease d serina. Os inibidores de protease são úteis para o tratamento de infecçóes pelo HCV.
BRPI0615029-2A 2005-08-19 2006-08-18 processos e intermediários BRPI0615029A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70996405P 2005-08-19 2005-08-19
US81004206P 2006-06-01 2006-06-01
PCT/US2006/032481 WO2007022459A2 (en) 2005-08-19 2006-08-18 Processes and intermediates

Publications (1)

Publication Number Publication Date
BRPI0615029A2 true BRPI0615029A2 (pt) 2009-06-16

Family

ID=37708299

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0615029-2A BRPI0615029A2 (pt) 2005-08-19 2006-08-18 processos e intermediários

Country Status (25)

Country Link
US (3) US7776887B2 (pt)
EP (4) EP2194043B1 (pt)
JP (1) JP5203203B2 (pt)
KR (4) KR20130038947A (pt)
CN (2) CN101291909B (pt)
AR (1) AR058025A1 (pt)
AT (1) ATE463480T1 (pt)
AU (1) AU2006279357B2 (pt)
BR (1) BRPI0615029A2 (pt)
CA (1) CA2619659A1 (pt)
CY (2) CY1110214T1 (pt)
DE (1) DE602006013492D1 (pt)
DK (2) DK2194043T3 (pt)
ES (2) ES2449268T3 (pt)
HK (2) HK1122801A1 (pt)
IL (2) IL189585A (pt)
NZ (3) NZ604087A (pt)
PL (3) PL385229A1 (pt)
PT (2) PT1934179E (pt)
RU (2) RU2446171C2 (pt)
SG (1) SG2014013338A (pt)
SI (2) SI1934179T1 (pt)
TW (2) TW201245149A (pt)
WO (1) WO2007022459A2 (pt)
ZA (1) ZA200801791B (pt)

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WO2007022459A2 (en) 2007-02-22
CY1110214T1 (el) 2015-01-14
DE602006013492D1 (de) 2010-05-20
NZ566049A (en) 2011-07-29
RU2446171C2 (ru) 2012-03-27
WO2007022459A3 (en) 2008-02-28
TWI391376B (zh) 2013-04-01
CY1114916T1 (el) 2016-12-14
PL2194043T3 (pl) 2014-07-31
JP2009504780A (ja) 2009-02-05
EP2194043A2 (en) 2010-06-09
ATE463480T1 (de) 2010-04-15
PL385229A1 (pl) 2008-09-29
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US20140107318A1 (en) 2014-04-17
IL228770A0 (en) 2013-12-31
RU2011148615A (ru) 2013-06-10
SI2194043T1 (sl) 2014-04-30
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