ATE445620T1 - Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte - Google Patents

Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte

Info

Publication number
ATE445620T1
ATE445620T1 AT07801417T AT07801417T ATE445620T1 AT E445620 T1 ATE445620 T1 AT E445620T1 AT 07801417 T AT07801417 T AT 07801417T AT 07801417 T AT07801417 T AT 07801417T AT E445620 T1 ATE445620 T1 AT E445620T1
Authority
AT
Austria
Prior art keywords
asenapine
intermediate products
products used
production process
production
Prior art date
Application number
AT07801417T
Other languages
English (en)
Inventor
Gerardus Kemperman
Timothy Stuk
Van Der Linden
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv filed Critical Organon Nv
Application granted granted Critical
Publication of ATE445620T1 publication Critical patent/ATE445620T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07801417T 2006-07-05 2007-07-03 Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte ATE445620T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06116660 2006-07-05
PCT/EP2007/005876 WO2008003460A1 (en) 2006-07-05 2007-07-03 Process for the preparation of asenapine and intermediate products used in said process.

Publications (1)

Publication Number Publication Date
ATE445620T1 true ATE445620T1 (de) 2009-10-15

Family

ID=37685865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07801417T ATE445620T1 (de) 2006-07-05 2007-07-03 Herstellungsverfahren für asenapin und in diesem verfahren verwendete zwischenprodukte

Country Status (18)

Country Link
EP (1) EP2044076B1 (de)
JP (1) JP2010503611A (de)
CN (1) CN101484456B (de)
AR (1) AR061811A1 (de)
AT (1) ATE445620T1 (de)
CA (1) CA2655670A1 (de)
CY (1) CY1109707T1 (de)
DE (1) DE602007002826D1 (de)
DK (1) DK2044076T3 (de)
ES (1) ES2333488T3 (de)
HK (1) HK1127044A1 (de)
MX (1) MX2008016490A (de)
PL (1) PL2044076T3 (de)
PT (1) PT2044076E (de)
SI (1) SI2044076T1 (de)
TW (1) TW200817414A (de)
WO (1) WO2008003460A1 (de)
ZA (1) ZA200810859B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7875729B2 (en) * 2007-01-05 2011-01-25 Synthon Bv Process for making asenapine
US7964739B2 (en) * 2008-01-04 2011-06-21 N.V. Organon Process for the preparation of asenapine and intermediate products used in said process
CN102596172A (zh) 2009-06-24 2012-07-18 Msd欧斯股份有限公司 含有阿塞那平的注射剂和使用其的治疗方法
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
CN102229613B (zh) * 2011-04-27 2013-08-07 上海华升生物科技有限公司 阿森纳平的合成工艺
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524921A1 (de) * 2011-05-17 2012-11-21 Sandoz AG Neue kristalline Salze von Asenapin
EP2524919A1 (de) * 2011-05-17 2012-11-21 Sandoz AG Neue kristalline Salze von Asenapin mit organischen Di-Säuren und Tri-Säuren
CN102952144A (zh) * 2011-08-29 2013-03-06 上海华拓医药科技发展股份有限公司 阿森纳平马来酸盐的晶型、制备方法及其药物组合物
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
EP2572703A1 (de) 2011-09-21 2013-03-27 Hexal AG Komprimierte orale Dosierform für Asenapinmaleat
GB201121128D0 (en) * 2011-12-08 2012-01-18 Dow Corning Treatment of filler with silane
GB201121124D0 (en) * 2011-12-08 2012-01-18 Dow Corning Hydrolysable silanes
CN103183680A (zh) * 2011-12-27 2013-07-03 上海华拓医药科技发展股份有限公司 阿森那平的制备方法
WO2013190481A1 (en) * 2012-06-21 2013-12-27 Alembic Pharmaceuticals Limited Process for preparing asenapine and salts of intermediates thereof
CN103772402A (zh) * 2014-01-07 2014-05-07 万特制药(海南)有限公司 一种新的阿塞那平马来酸盐粗品精制方法
CN104974167B (zh) * 2014-04-02 2019-01-04 洋浦慧谷医药有限公司 阿塞那平的制备方法以及用于制备阿塞那平的中间体
US10056563B2 (en) 2016-04-08 2018-08-21 Samsung Electronics Co., Ltd. Synthetic method of fused heteroaromatic compound and fused heteroaromatic compound, and intermediate thereof
KR20180051260A (ko) 2016-11-08 2018-05-16 삼성전자주식회사 축합 헤테로방향족 화합물의 합성 방법, 축합 헤테로방향족 화합물 및 그 중간체 및 합성 방법
RU2764443C2 (ru) 2016-12-20 2022-01-17 Лтс Ломанн Терапи-Систем Аг Трансдермальная терапевтическая система, содержащая азенапин и полисилоксан или полиизобутилен
RU2762896C2 (ru) 2016-12-20 2021-12-23 Лтс Ломанн Терапи-Систем Аг Трансдермальная терапевтическая система, содержащая азенапин
WO2019002204A1 (en) 2017-06-26 2019-01-03 Lts Lohmann Therapie-Systeme Ag TRANSDERMAL THERAPEUTIC SYSTEM CONTAINING ASENAPINE AND SILICONE-TYPE ACRYLIC HYBRID POLYMER
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
CN110183457A (zh) * 2019-06-27 2019-08-30 浙江天顺药业有限公司 一种阿塞那平及其制备方法
CN110606852B (zh) 2019-08-13 2021-02-05 浙江奥翔药业股份有限公司 制备阿塞那平的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
RU2397164C2 (ru) * 2005-04-07 2010-08-20 Н.В. Органон ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ПОЛУЧЕНИЯ ТРАНС-5-ХЛОР-2-МЕТИЛ-2,3,3f,12b-ТЕТРАГИДРО-1Н-ДИБЕНЗ[2,3:6,7]-ОКСЕПИНО[4,5-c]ПИРРОЛА

Also Published As

Publication number Publication date
CY1109707T1 (el) 2014-04-09
EP2044076B1 (de) 2009-10-14
MX2008016490A (es) 2009-01-22
WO2008003460A1 (en) 2008-01-10
ES2333488T3 (es) 2010-02-22
AR061811A1 (es) 2008-09-24
ZA200810859B (en) 2009-09-30
CN101484456B (zh) 2011-09-07
DE602007002826D1 (de) 2009-11-26
CN101484456A (zh) 2009-07-15
DK2044076T3 (da) 2010-02-01
HK1127044A1 (en) 2009-09-18
CA2655670A1 (en) 2008-01-10
SI2044076T1 (sl) 2010-01-29
TW200817414A (en) 2008-04-16
JP2010503611A (ja) 2010-02-04
PT2044076E (pt) 2010-01-20
PL2044076T3 (pl) 2010-03-31
EP2044076A1 (de) 2009-04-08

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