PT2044076E - Processo de preparação de asenapina e de produtos intermediários utilizados no referido processo - Google Patents
Processo de preparação de asenapina e de produtos intermediários utilizados no referido processo Download PDFInfo
- Publication number
- PT2044076E PT2044076E PT07801417T PT07801417T PT2044076E PT 2044076 E PT2044076 E PT 2044076E PT 07801417 T PT07801417 T PT 07801417T PT 07801417 T PT07801417 T PT 07801417T PT 2044076 E PT2044076 E PT 2044076E
- Authority
- PT
- Portugal
- Prior art keywords
- asenapine
- preparation
- intermediate products
- products used
- products
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/24—Halogenated derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/017—Esters of hydroxy compounds having the esterified hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06116660 | 2006-07-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2044076E true PT2044076E (pt) | 2010-01-20 |
Family
ID=37685865
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07801417T PT2044076E (pt) | 2006-07-05 | 2007-07-03 | Processo de preparação de asenapina e de produtos intermediários utilizados no referido processo |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP2044076B1 (pt) |
JP (1) | JP2010503611A (pt) |
CN (1) | CN101484456B (pt) |
AR (1) | AR061811A1 (pt) |
AT (1) | ATE445620T1 (pt) |
CA (1) | CA2655670A1 (pt) |
CY (1) | CY1109707T1 (pt) |
DE (1) | DE602007002826D1 (pt) |
DK (1) | DK2044076T3 (pt) |
ES (1) | ES2333488T3 (pt) |
HK (1) | HK1127044A1 (pt) |
MX (1) | MX2008016490A (pt) |
PL (1) | PL2044076T3 (pt) |
PT (1) | PT2044076E (pt) |
SI (1) | SI2044076T1 (pt) |
TW (1) | TW200817414A (pt) |
WO (1) | WO2008003460A1 (pt) |
ZA (1) | ZA200810859B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7875729B2 (en) * | 2007-01-05 | 2011-01-25 | Synthon Bv | Process for making asenapine |
JP2011508751A (ja) * | 2008-01-04 | 2011-03-17 | ナームローゼ・フエンノートチヤツプ・オルガノン | アセナピンの調製方法および前記方法において使用される中間生成物 |
AU2010264670A1 (en) * | 2009-06-24 | 2012-01-19 | Merck Sharp & Dohme B.V. | Injectable formulations containing asenapine and method of treatment using same |
WO2012123325A1 (en) | 2011-03-11 | 2012-09-20 | Medichem S.A. | NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID |
CN102229613B (zh) * | 2011-04-27 | 2013-08-07 | 上海华升生物科技有限公司 | 阿森纳平的合成工艺 |
ITMI20110734A1 (it) * | 2011-05-02 | 2012-11-03 | Olon Spa | Sali cristallini di asenapina |
EP2524919A1 (en) * | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids |
EP2524921A1 (en) * | 2011-05-17 | 2012-11-21 | Sandoz AG | Novel Crystalline Salts of Asenapine |
CN102952144A (zh) * | 2011-08-29 | 2013-03-06 | 上海华拓医药科技发展股份有限公司 | 阿森纳平马来酸盐的晶型、制备方法及其药物组合物 |
EP2572703A1 (en) | 2011-09-21 | 2013-03-27 | Hexal AG | Compressed oral dosage form for asenapine maleate |
WO2013041604A1 (en) | 2011-09-21 | 2013-03-28 | Sandoz Ag | Crystal form of asenapine maleate |
GB201121124D0 (en) * | 2011-12-08 | 2012-01-18 | Dow Corning | Hydrolysable silanes |
GB201121128D0 (en) * | 2011-12-08 | 2012-01-18 | Dow Corning | Treatment of filler with silane |
CN103183680A (zh) * | 2011-12-27 | 2013-07-03 | 上海华拓医药科技发展股份有限公司 | 阿森那平的制备方法 |
WO2013190481A1 (en) * | 2012-06-21 | 2013-12-27 | Alembic Pharmaceuticals Limited | Process for preparing asenapine and salts of intermediates thereof |
CN103772402A (zh) * | 2014-01-07 | 2014-05-07 | 万特制药(海南)有限公司 | 一种新的阿塞那平马来酸盐粗品精制方法 |
CN104974167B (zh) * | 2014-04-02 | 2019-01-04 | 洋浦慧谷医药有限公司 | 阿塞那平的制备方法以及用于制备阿塞那平的中间体 |
US10056563B2 (en) | 2016-04-08 | 2018-08-21 | Samsung Electronics Co., Ltd. | Synthetic method of fused heteroaromatic compound and fused heteroaromatic compound, and intermediate thereof |
KR20180051260A (ko) | 2016-11-08 | 2018-05-16 | 삼성전자주식회사 | 축합 헤테로방향족 화합물의 합성 방법, 축합 헤테로방향족 화합물 및 그 중간체 및 합성 방법 |
CN110087641B (zh) | 2016-12-20 | 2024-03-12 | 罗曼治疗系统股份公司 | 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗系统 |
MX2019007391A (es) | 2016-12-20 | 2019-08-16 | Lts Lohmann Therapie Systeme Ag | Sistema terapeutico transdermico que contiene asenapina. |
CN110799180A (zh) | 2017-06-26 | 2020-02-14 | 罗曼治疗系统股份公司 | 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗系统 |
WO2019243452A1 (en) | 2018-06-20 | 2019-12-26 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic system containing asenapine |
CN110183457A (zh) * | 2019-06-27 | 2019-08-30 | 浙江天顺药业有限公司 | 一种阿塞那平及其制备方法 |
CN110606852B (zh) * | 2019-08-13 | 2021-02-05 | 浙江奥翔药业股份有限公司 | 制备阿塞那平的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7605526A (nl) * | 1976-05-24 | 1977-11-28 | Akzo Nv | Nieuwe tetracyclische derivaten. |
RS51341B (en) * | 2005-04-07 | 2011-02-28 | N.V. Organon | INTERMEDIATE COMPOUNDS FOR THE TRANS-5-CHLOR-2-METHYL-2,3A, 12B-TETRAHYDRO-1H-DIBENZE [2,3; 6,7] OXEPINO [4,5-C] Pyrrole |
-
2007
- 2007-06-27 TW TW096123323A patent/TW200817414A/zh unknown
- 2007-07-03 CN CN2007800254650A patent/CN101484456B/zh not_active Expired - Fee Related
- 2007-07-03 DK DK07801417.2T patent/DK2044076T3/da active
- 2007-07-03 CA CA002655670A patent/CA2655670A1/en not_active Abandoned
- 2007-07-03 MX MX2008016490A patent/MX2008016490A/es active IP Right Grant
- 2007-07-03 SI SI200730116T patent/SI2044076T1/sl unknown
- 2007-07-03 PT PT07801417T patent/PT2044076E/pt unknown
- 2007-07-03 DE DE602007002826T patent/DE602007002826D1/de active Active
- 2007-07-03 PL PL07801417T patent/PL2044076T3/pl unknown
- 2007-07-03 EP EP07801417A patent/EP2044076B1/en active Active
- 2007-07-03 ES ES07801417T patent/ES2333488T3/es active Active
- 2007-07-03 JP JP2009517030A patent/JP2010503611A/ja not_active Withdrawn
- 2007-07-03 AT AT07801417T patent/ATE445620T1/de active
- 2007-07-03 WO PCT/EP2007/005876 patent/WO2008003460A1/en active Application Filing
- 2007-07-04 AR ARP070102980A patent/AR061811A1/es unknown
-
2008
- 2008-12-23 ZA ZA200810859A patent/ZA200810859B/xx unknown
-
2009
- 2009-07-14 HK HK09106284.3A patent/HK1127044A1/xx not_active IP Right Cessation
-
2010
- 2010-01-05 CY CY20101100007T patent/CY1109707T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
CY1109707T1 (el) | 2014-04-09 |
JP2010503611A (ja) | 2010-02-04 |
PL2044076T3 (pl) | 2010-03-31 |
HK1127044A1 (en) | 2009-09-18 |
WO2008003460A1 (en) | 2008-01-10 |
TW200817414A (en) | 2008-04-16 |
DE602007002826D1 (de) | 2009-11-26 |
EP2044076B1 (en) | 2009-10-14 |
ATE445620T1 (de) | 2009-10-15 |
EP2044076A1 (en) | 2009-04-08 |
CN101484456B (zh) | 2011-09-07 |
ES2333488T3 (es) | 2010-02-22 |
ZA200810859B (en) | 2009-09-30 |
AR061811A1 (es) | 2008-09-24 |
MX2008016490A (es) | 2009-01-22 |
CA2655670A1 (en) | 2008-01-10 |
SI2044076T1 (sl) | 2010-01-29 |
DK2044076T3 (da) | 2010-02-01 |
CN101484456A (zh) | 2009-07-15 |
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