ATE359762T1 - Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation - Google Patents

Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation

Info

Publication number
ATE359762T1
ATE359762T1 AT02707424T AT02707424T ATE359762T1 AT E359762 T1 ATE359762 T1 AT E359762T1 AT 02707424 T AT02707424 T AT 02707424T AT 02707424 T AT02707424 T AT 02707424T AT E359762 T1 ATE359762 T1 AT E359762T1
Authority
AT
Austria
Prior art keywords
ophthalmological
applications
microchip devices
eye
drug
Prior art date
Application number
AT02707424T
Other languages
English (en)
Inventor
John T Santini Jr
Michael J Cima
Robert S Langer
Dennis Ausiello
Norman F Sheppard Jr
Stephen J Herman
Original Assignee
Microchips Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microchips Inc filed Critical Microchips Inc
Application granted granted Critical
Publication of ATE359762T1 publication Critical patent/ATE359762T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • A61K9/0051Ocular inserts or implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0048Eye, e.g. artificial tears
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Medicinal compositions released by microdevices, e.g. microelectromechanical systems [MEMS], microdevices comprising chips or microdevices on silicon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • HELECTRICITY
    • H10SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10WGENERIC PACKAGES, INTERCONNECTIONS, CONNECTORS OR OTHER CONSTRUCTIONAL DETAILS OF DEVICES COVERED BY CLASS H10
    • H10W72/00Interconnections or connectors in packages
    • H10W72/01Manufacture or treatment
    • H10W72/0198Manufacture or treatment batch processes

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Prostheses (AREA)
  • Medicinal Preparation (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT02707424T 2001-01-09 2002-01-09 Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation ATE359762T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26072501P 2001-01-09 2001-01-09

Publications (1)

Publication Number Publication Date
ATE359762T1 true ATE359762T1 (de) 2007-05-15

Family

ID=22990347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02707424T ATE359762T1 (de) 2001-01-09 2002-01-09 Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation

Country Status (8)

Country Link
US (5) US6976982B2 (de)
EP (1) EP1372602B1 (de)
JP (3) JP4657577B2 (de)
AT (1) ATE359762T1 (de)
AU (1) AU2002241834B2 (de)
CA (1) CA2432438C (de)
DE (1) DE60219607T2 (de)
WO (1) WO2002055058A2 (de)

Families Citing this family (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070590B1 (en) * 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
DE60018582T2 (de) * 1999-08-18 2006-01-19 Microchips, Inc., Bedford Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
JP2003516343A (ja) * 1999-12-10 2003-05-13 マサチューセッツ インスティテュート オブ テクノロジー 分子を送達するマイクロチップ素子およびその製作方法
US6551838B2 (en) * 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
EP1339312B1 (de) * 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
EP1372602B1 (de) 2001-01-09 2007-04-18 Microchips, Inc. Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
WO2002096389A1 (en) * 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
AU2002326304A1 (en) * 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
DE60239868D1 (de) 2001-06-12 2011-06-09 Univ Johns Hopkins Med Reservoirvorrichtung für die intraokulare arzneimittelabgabe
AU2001263694A1 (en) * 2001-06-13 2002-12-23 Sis Ag Surgical Instrument Systems Devices and methods for determining an inner pressure of the eye
US6827250B2 (en) * 2001-06-28 2004-12-07 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US7556621B2 (en) * 2001-06-29 2009-07-07 The Board Of Trustees Of The Leland Stanford Junior University Optically controlled microfluidic chip
DE10133870A1 (de) * 2001-07-12 2003-02-06 Chris P Lohmann Ophthalmisches Mittel, Verwendung von EGF zur Behandlung von Dry Eye-Syndrom und Insert zur Verabreichung von EGF am Auge
US20030078487A1 (en) * 2001-08-09 2003-04-24 Jeffries Robert E. Ocular pressure measuring device
GB0127989D0 (en) * 2001-11-22 2002-01-16 Glaxo Group Ltd Medicament dispensing system
BR0308482A (pt) * 2002-03-11 2005-02-22 Alcon Inc Sistema de administração de droga implantável
KR100725973B1 (ko) * 2002-08-16 2007-06-11 마이크로칩스 인코포레이티드 전열적 제거를 이용한 제어 방출 장치 및 방법
WO2004022033A1 (en) * 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US7534241B2 (en) * 2002-09-23 2009-05-19 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
AU2003284018A1 (en) * 2002-10-04 2004-05-04 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
WO2004033036A2 (en) * 2002-10-04 2004-04-22 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
WO2004062480A2 (en) * 2003-01-09 2004-07-29 The Regents Of The University Of California Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration
US20060167435A1 (en) * 2003-02-18 2006-07-27 Adamis Anthony P Transscleral drug delivery device and related methods
WO2004096176A2 (en) * 2003-04-25 2004-11-11 Boston Scientific Scimed Inc. Solid drug formulation and device for storage and controlled delivery thereof
CA2524029A1 (en) * 2003-04-30 2004-11-18 Insulet Corporation Rf medical device
US20040220531A1 (en) * 2003-05-01 2004-11-04 Bui Tuan S. System and method operating microreservoirs delivering medication in coordination with a pump delivering diluent
WO2005010240A2 (en) * 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
WO2005016558A2 (en) * 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
US7169405B2 (en) * 2003-08-06 2007-01-30 Warsaw Orthopedic, Inc. Methods and devices for the treatment of intervertebral discs
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US8095197B2 (en) * 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
EP1765455A2 (de) * 2004-06-01 2007-03-28 Microchips, Inc. Vorrichtungen und verfahren zur messung und verstärkung des wirkstoff- oder analyttransports zu/von einem medizinischen implantat
EP2650907B1 (de) 2004-06-04 2024-10-23 The Board Of Trustees Of The University Of Illinois Verfahren und Einrichtungen zum Herstellen und Zusammenbauen von druckbaren Halbleiterelementen
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
JP4874970B2 (ja) * 2004-06-07 2012-02-15 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング センサ付き整形外科用インプラント
US7729761B2 (en) 2004-07-14 2010-06-01 Cardiac Pacemakers, Inc. Method and apparatus for controlled gene or protein delivery
US20070036835A1 (en) * 2004-07-19 2007-02-15 Microchips, Inc. Hermetically Sealed Devices for Controlled Release or Exposure of Reservoir Contents
US7537590B2 (en) * 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US7621906B2 (en) * 2004-08-25 2009-11-24 Cardiac Pacemakers, Inc. Method and apparatus to deliver drug and pacing therapy for treatment of cardiac disorders
ATE424928T1 (de) * 2004-09-01 2009-03-15 Microchips Inc Behältervorrichtungen mit mehreren verschlüssen zur gesteuerten abgabe oder exponierung des behälterinhalts
US7156049B2 (en) * 2004-09-10 2007-01-02 The United States Of America As Represented By The Secretary Of The Army Release mechanism to interact with biota, in particular fauna that may outgrow available habitat
US8931896B2 (en) 2004-11-02 2015-01-13 E-Vision Smart Optics Inc. Eyewear including a docking station
US9801709B2 (en) 2004-11-02 2017-10-31 E-Vision Smart Optics, Inc. Electro-active intraocular lenses
US8778022B2 (en) 2004-11-02 2014-07-15 E-Vision Smart Optics Inc. Electro-active intraocular lenses
ATE408432T1 (de) * 2004-11-02 2008-10-15 Sydney Biotech Pty Ltd Extraokulare vorrichtung
EP1861333B1 (de) 2004-11-04 2018-12-26 Microchips Biotech, Inc. Druck- und kaltschweissdichtverfahren und -vorrichtungen
US8388553B2 (en) 2004-11-04 2013-03-05 Smith & Nephew, Inc. Cycle and load measurement device
US7413846B2 (en) 2004-11-15 2008-08-19 Microchips, Inc. Fabrication methods and structures for micro-reservoir devices
DE102004055220B4 (de) 2004-11-16 2018-03-29 Implandata Ophthalmic Products Gmbh Vorrichtung zur Intraokulardruckmessung
EP1843783B1 (de) 2005-01-25 2012-05-30 MicroCHIPS, Inc. Steuerung der wirkstofffreisetzung mittels transienter modifizierung lokaler mikroumgebungen
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
WO2006108054A2 (en) * 2005-04-05 2006-10-12 The Ohio State University Diffusion delivery system and methods of fabrication
CN103637840A (zh) 2005-08-23 2014-03-19 史密夫和内修有限公司 遥测矫形植入物
US8168584B2 (en) 2005-10-08 2012-05-01 Potentia Pharmaceuticals, Inc. Methods of treating age-related macular degeneration by compstatin and analogs thereof
US20090203985A1 (en) * 2005-10-14 2009-08-13 Ehrecke Timothy J Pressure Monitor
US20070088442A1 (en) * 2005-10-14 2007-04-19 Microchips, Inc. Passive wear-indicating sensor for implantable prosthetic device
DE602007012417D1 (de) 2006-03-14 2011-03-24 Univ Southern California Mems-Vorrichtung zur Wirkstofffreisetzung
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8642060B2 (en) * 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for osteal growth
US8642059B2 (en) 2006-04-24 2014-02-04 Warsaw Orthopedic, Inc. Controlled release systems and methods for intervertebral discs
US7879027B2 (en) * 2006-04-24 2011-02-01 Warsaw Orthopedic, Inc. Controlled release devices for fusion of osteal structures
US7771414B2 (en) * 2006-04-24 2010-08-10 Warsaw Orthopedic, Inc. Controlled release devices for therapeutic treatments of spinal discs
US7981096B2 (en) * 2006-05-12 2011-07-19 David Castillejos Optic nerve head implant and medication delivery system
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
JP2009542359A (ja) 2006-06-29 2009-12-03 ボストン サイエンティフィック リミテッド 選択的被覆部を備えた医療装置
EP2043728A2 (de) * 2006-07-11 2009-04-08 Microchips, Inc. Mehrkammerpumpenvorrichtung für dialyse, biosensing oder verabreichung von substanzen
EP2056708B1 (de) * 2006-08-29 2014-07-16 California Institute of Technology Mikrofabrizierter implantierbarer funkdrucksensor zur verwendung in biomedizinischen anwendungen sowie druckmessungs- und sensorenimplantationsverfahren
WO2008029372A2 (en) * 2006-09-08 2008-03-13 Koninklijke Philips Electronics N.V. Device for the controlled release of a predefined quantity of a substance
WO2008033711A2 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
US7666179B2 (en) * 2006-10-10 2010-02-23 Boston Scientific Scimed, Inc. Medical devices having porous regions for controlled therapeutic agent exposure or delivery
US8923961B2 (en) 2006-10-18 2014-12-30 The Cleveland Clinic Foundation Electrode assembly for delivering a therapeutic agent into ocular tissue
EP2101975A2 (de) 2006-11-03 2009-09-23 Trustees of Tufts College Biopolymersensor und herstellungsverfahren dafür
US20100046902A1 (en) * 2006-11-03 2010-02-25 Trustees Of Tufts College Biopolymer photonic crystals and method of manufacturing the same
EP2650112B1 (de) 2006-11-03 2016-08-24 Trustees Of Tufts College Biopolymer-lichtwellenleiter und herstellungsverfahren dafür
WO2008127403A2 (en) * 2006-11-03 2008-10-23 Trustees Of Tufts College Biopolymer optofluidic device and method of manufacturing the same
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
CA2672602C (en) * 2006-12-18 2014-05-20 Electronic Dietary Foods Inc. Device for delivery of a substance
DE102007003341B4 (de) * 2007-01-17 2018-01-04 Eyesense Ag Okularsensor und Messsystem zum Nachweis eines Analyten in einer Augenflüssigkeit
AR064985A1 (es) 2007-01-22 2009-05-06 E Vision Llc Lente electroactivo flexible
UY30883A1 (es) * 2007-01-31 2008-05-31 Alcon Res Tapones punctales y metodos de liberacion de agentes terapeuticos
WO2008097525A2 (en) 2007-02-05 2008-08-14 Potentia Pharmaceuticals, Inc. Local complement inhibition for treatment of complement-mediated disorders
AU2008218240B2 (en) * 2007-02-23 2014-01-30 E-Vision Smart Optics, Inc. Ophthalmic dynamic aperture
US9445720B2 (en) 2007-02-23 2016-09-20 Smith & Nephew, Inc. Processing sensed accelerometer data for determination of bone healing
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
EP2471457A1 (de) 2007-06-07 2012-07-04 Microchips, Inc. Elektrochemische Biosensoren und Anordnungen
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2187988B1 (de) 2007-07-19 2013-08-21 Boston Scientific Limited Endoprothese mit nicht verschmutzender oberfläche
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
EP2185103B1 (de) 2007-08-03 2014-02-12 Boston Scientific Scimed, Inc. Überzug für ein medizinprodukt mit vergrösserter oberfläche
US8570187B2 (en) 2007-09-06 2013-10-29 Smith & Nephew, Inc. System and method for communicating with a telemetric implant
WO2009042114A2 (en) 2007-09-21 2009-04-02 The Johns Hopkins University Phenazine derivatives and uses thereof
EP2052700A1 (de) 2007-09-26 2009-04-29 Microchips, Inc. Arzneimittelverabreichungsvorrichtung und Verfahren zur Verwendung mit Prothesenimplantaten.
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
WO2009061823A1 (en) 2007-11-05 2009-05-14 Trustees Of Tufts College Fabrication of silk fibroin photonic structures by nanocontact imprinting
US8180446B2 (en) 2007-12-05 2012-05-15 The Invention Science Fund I, Llc Method and system for cyclical neural modulation based on activity state
US8233976B2 (en) 2007-12-05 2012-07-31 The Invention Science Fund I, Llc System for transdermal chemical modulation of neural activity
US8165669B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc System for magnetic modulation of neural conduction
US8195287B2 (en) 2007-12-05 2012-06-05 The Invention Science Fund I, Llc Method for electrical modulation of neural conduction
US8170658B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc System for electrical modulation of neural conduction
US8989858B2 (en) 2007-12-05 2015-03-24 The Invention Science Fund I, Llc Implant system for chemical modulation of neural activity
US8170659B2 (en) 2007-12-05 2012-05-01 The Invention Science Fund I, Llc Method for thermal modulation of neural activity
US8165668B2 (en) 2007-12-05 2012-04-24 The Invention Science Fund I, Llc Method for magnetic modulation of neural conduction
ES2425769T5 (es) 2007-12-20 2017-07-28 University Of Southern California Aparato para la administración de agentes terapéuticos
US8521273B2 (en) 2008-01-29 2013-08-27 Gilbert H. KLIMAN Drug delivery devices, kits and methods therefor
CN101981821B (zh) * 2008-02-01 2015-06-03 史密夫和内修有限公司 用于与植入物通信的系统及方法
WO2009109966A1 (en) * 2008-03-04 2009-09-11 Elan Ziv Vaginal carrier for the controlled release of substances
BRPI0908992A2 (pt) 2008-03-18 2015-11-24 Pixeloptics Inc dispositivo ótico eletro-ativo avançado
US20090259176A1 (en) * 2008-04-09 2009-10-15 Los Gatos Research, Inc. Transdermal patch system
EP2271380B1 (de) 2008-04-22 2013-03-20 Boston Scientific Scimed, Inc. Medizinprodukte mit einer beschichtung aus anorganischem material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
CN102202708B (zh) 2008-05-08 2015-01-21 迷你泵有限责任公司 药物输送泵及其制造方法
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
WO2009137780A2 (en) 2008-05-08 2009-11-12 Replenish Pumps, Llc Implantable pumps and cannulas therefor
US9095404B2 (en) 2008-05-12 2015-08-04 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
WO2009140246A2 (en) * 2008-05-12 2009-11-19 University Of Utah Research Foundation Intraocular drug delivery device and associated methods
US8449603B2 (en) 2008-06-18 2013-05-28 Boston Scientific Scimed, Inc. Endoprosthesis coating
EP2307054A4 (de) * 2008-06-18 2013-02-06 Tufts College Essbare holografische seidenprodukte
US20100061976A1 (en) * 2008-07-24 2010-03-11 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Method for treating or preventing osteoporosis by reducing follicle stimulating hormone to cyclic physiological levels in a mammalian subject
EP2349440B1 (de) 2008-10-07 2019-08-21 Mc10, Inc. Katheterballon mit dehnbarer integrierter schaltung und sensoranordnung
US8389862B2 (en) 2008-10-07 2013-03-05 Mc10, Inc. Extremely stretchable electronics
US8097926B2 (en) 2008-10-07 2012-01-17 Mc10, Inc. Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy
US8372726B2 (en) 2008-10-07 2013-02-12 Mc10, Inc. Methods and applications of non-planar imaging arrays
US8886334B2 (en) 2008-10-07 2014-11-11 Mc10, Inc. Systems, methods, and devices using stretchable or flexible electronics for medical applications
WO2010045487A1 (en) * 2008-10-15 2010-04-22 Palmetto Biomedical, Inc. Device and method for delivery of therapeutic agents via internal implants
US9642658B2 (en) 2008-10-15 2017-05-09 Orthoclip Llc Device and method for delivery of therapeutic agents via internal implants
TWI361169B (en) * 2008-10-20 2012-04-01 Nat Chip Implementation Ct Nat Applied Res Lab Biosensor package structure with micro-fluidic channel
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
WO2010078063A1 (en) * 2009-01-02 2010-07-08 Alcon Research, Ltd. In-situ refillable ophthalmic implant
US8685093B2 (en) 2009-01-23 2014-04-01 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8126736B2 (en) 2009-01-23 2012-02-28 Warsaw Orthopedic, Inc. Methods and systems for diagnosing, treating, or tracking spinal disorders
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
CN104887389B (zh) 2009-01-29 2017-06-23 弗赛特影像4股份有限公司 后段给药
US8747886B2 (en) 2009-02-12 2014-06-10 Tufts University Nanoimprinting of silk fibroin structures for biomedical and biophotonic applications
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
AU2010226326B2 (en) 2009-03-20 2015-11-26 Incube Labs, Llc Solid drug delivery apparatus, formulations and methods of use
US8287937B2 (en) 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
US12478503B2 (en) 2009-05-18 2025-11-25 Glaukos Corporation Implants with controlled drug delivery features and methods of using same
CA2762536C (en) 2009-05-18 2019-05-21 Dose Medical Corporation Drug eluting ocular implant
AU2010307268B2 (en) 2009-07-20 2015-05-14 Tufts University/Trustees Of Tufts College All-protein implantable, resorbable reflectors
JP5758388B2 (ja) 2009-08-18 2015-08-05 ミニパンプス, エルエルシー 適応制御を有する電解質薬物送達ポンプ
EP2474054A4 (de) 2009-08-31 2013-03-13 Tufts University Trustees Of Tufts College Seidentransistorvorrichtungen
US10092691B2 (en) 2009-09-02 2018-10-09 Becton, Dickinson And Company Flexible and conformal patch pump
US20110054445A1 (en) * 2009-09-02 2011-03-03 Board Of Regents, The University Of Texas System Devices and Methods for Treatment of Eye Disease
US8257295B2 (en) 2009-09-21 2012-09-04 Alcon Research, Ltd. Intraocular pressure sensor with external pressure compensation
US8545431B2 (en) * 2009-09-21 2013-10-01 Alcon Research, Ltd. Lumen clearing valve for glaucoma drainage device
US8419673B2 (en) 2009-09-21 2013-04-16 Alcon Research, Ltd. Glaucoma drainage device with pump
US8721580B2 (en) * 2009-09-21 2014-05-13 Alcon Research, Ltd. Power saving glaucoma drainage device
WO2011041727A1 (en) 2009-10-01 2011-04-07 Mc10, Inc. Protective cases with integrated electronics
EP2485765A2 (de) * 2009-10-09 2012-08-15 Board Of Regents The University Of Texas System Fotokinetisches verfahren zur vorrichtung zur freisetzung eines augenarzneimittels
EP2496936B1 (de) 2009-10-16 2018-02-21 Microchips Biotech, Inc. Mehrkanal-potentiostat für eine biosensoranordnung und verwendungsverfahren
EP2490617A1 (de) * 2009-10-22 2012-08-29 On Demand Therapeutics, Inc. Visuelle anzeige von rissbildung bei einem wirkstoffreservoir
EP2513953B1 (de) 2009-12-16 2017-10-18 The Board of Trustees of the University of Illionis Elektrophysiologie unter verwendung konformer elektronischer vorrichtungen
US10441185B2 (en) 2009-12-16 2019-10-15 The Board Of Trustees Of The University Of Illinois Flexible and stretchable electronic systems for epidermal electronics
US9936574B2 (en) 2009-12-16 2018-04-03 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
US8696740B2 (en) 2010-01-05 2014-04-15 The Johns Hopkins University Implantable pressure-actuated drug delivery systems and methods of manufacture and use
US8469934B2 (en) * 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
WO2013022801A1 (en) 2011-08-05 2013-02-14 Forsight Vision4, Inc. Small molecule delivery with implantable therapeutic device
US8911426B2 (en) 2010-02-08 2014-12-16 On Demand Therapeutics, Inc. Low-permeability, laser-activated drug delivery device
WO2011112931A1 (en) * 2010-03-12 2011-09-15 The Board Of Trustees Of The University Of Illinois Waterproof stretchable optoelectronics
JP5751728B2 (ja) 2010-03-17 2015-07-22 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ 生体吸収性基板上の埋め込み型バイオメディカルデバイス
US20110248671A1 (en) * 2010-04-08 2011-10-13 Alcon Research, Ltd. Power System Implantable in Eye
CA2799350A1 (en) * 2010-05-14 2011-11-17 The Cleveland Clinic Foundation Electrode assembly for delivering a therapeutic agent into ocular tissue
US8397578B2 (en) 2010-06-03 2013-03-19 Medtronic, Inc. Capacitive pressure sensor assembly
US9737657B2 (en) 2010-06-03 2017-08-22 Medtronic, Inc. Implantable medical pump with pressure sensor
WO2011153538A2 (en) * 2010-06-04 2011-12-08 The Regents Of The University Of Michigan Implantable device and surgical implantation technique
WO2011156095A2 (en) 2010-06-10 2011-12-15 The Regents Of The University Of California Textile-based printable electrodes for electrochemical sensing
US8895597B2 (en) 2010-06-17 2014-11-25 Violette Renard Recinos Combination of local temozolomide with local BCNU
WO2012012017A1 (en) * 2010-07-20 2012-01-26 Alcon Research, Ltd. Closed loop glaucoma drug delivery system
CA2807554C (en) 2010-08-05 2021-10-26 Forsight Vision4 Inc. Implantable therapeutic device
AU2011285548B2 (en) 2010-08-05 2014-02-06 Forsight Vision4, Inc. Combined drug delivery methods and apparatus
WO2012019136A2 (en) 2010-08-05 2012-02-09 Forsight Vision 4, Inc. Injector apparatus and method for drug delivery
US9289584B2 (en) * 2010-09-13 2016-03-22 The University Of British Columbia Remotely controlled drug delivery systems
KR101766763B1 (ko) * 2010-10-27 2017-08-09 이리듐 메디칼 테크놀로지 컴퍼니 리미티드 플렉시블 인조 망막 장치들
CA2818612C (en) 2010-11-19 2020-12-29 Forsight Vision4, Inc. Therapeutic agent formulations for implanted devices
US8679093B2 (en) 2010-11-23 2014-03-25 Microchips, Inc. Multi-dose drug delivery device and method
EP2654715B1 (de) 2010-11-24 2017-01-25 Dose Medical Corporation Arzneimittelfreisetzendes augenimplantat
RU2598057C2 (ru) * 2011-02-04 2016-09-20 ТАРИС Биомедикал ЛЛК Имплантируемое устройство для контролируемого высвобождения лекарственного средства с низкой растворимостью
BR112013027057A2 (pt) 2011-04-21 2020-08-11 Trustees Of Tufts College composições e métodos para a estabilização de agentes ativos
US9765934B2 (en) 2011-05-16 2017-09-19 The Board Of Trustees Of The University Of Illinois Thermally managed LED arrays assembled by printing
KR102000302B1 (ko) 2011-05-27 2019-07-15 엠씨10, 인크 전자, 광학, 및/또는 기계 장치 및 시스템, 그리고 이를 제조하기 위한 방법
US8934965B2 (en) 2011-06-03 2015-01-13 The Board Of Trustees Of The University Of Illinois Conformable actively multiplexed high-density surface electrode array for brain interfacing
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
EP4249059B1 (de) 2011-06-28 2025-07-30 ForSight Vision4, Inc. Vorrichtung zum sammeln einer flüssigkeitsprobe aus einer reservoirkammer einer therapeutischen vorrichtung für das auge
WO2013011511A1 (en) 2011-07-18 2013-01-24 Mor Research Applications Ltd. A device for adjusting the intraocular pressure
JP6117788B2 (ja) 2011-08-25 2017-04-19 マイクロチップス バイオテック,インコーポレイテッド 空間効率的な封じ込めデバイスおよびこれを作成する方法
US10427153B2 (en) 2011-08-25 2019-10-01 Microchips Biotech, Inc. Systems and methods for sealing a plurality of reservoirs of a microchip element with a sealing grid
EP4643921A3 (de) 2011-09-16 2026-01-07 ForSight Vision4, Inc. Flüssigkeitsaustauschvorrichtung
US8585631B2 (en) 2011-10-18 2013-11-19 Alcon Research, Ltd. Active bimodal valve system for real-time IOP control
CN104472023B (zh) 2011-12-01 2018-03-27 伊利诺伊大学评议会 经设计以经历可编程转变的瞬态器件
US8753305B2 (en) 2011-12-06 2014-06-17 Alcon Research, Ltd. Bubble-driven IOP control system
US8840578B2 (en) 2011-12-09 2014-09-23 Alcon Research, Ltd. Multilayer membrane actuators
US8579848B2 (en) 2011-12-09 2013-11-12 Alcon Research, Ltd. Active drainage systems with pressure-driven valves and electronically-driven pump
US8603024B2 (en) 2011-12-12 2013-12-10 Alcon Research, Ltd. Glaucoma drainage devices including vario-stable valves and associated systems and methods
WO2013090197A1 (en) 2011-12-12 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
WO2013090231A1 (en) 2011-12-13 2013-06-20 Alcon Research, Ltd. Active drainage systems with dual-input pressure-driven valves
US9339187B2 (en) 2011-12-15 2016-05-17 Alcon Research, Ltd. External pressure measurement system and method for an intraocular implant
US9095267B2 (en) 2011-12-22 2015-08-04 Modular Bionics Inc. Neural interface device and insertion tools
US20150005595A1 (en) 2011-12-30 2015-01-01 Kibur Medical, Inc. Implantable devices and methods for evaluation of active agents
JP2015511322A (ja) 2012-01-06 2015-04-16 エイチピーオー アセッツ エルエルシー アイウェアドッキングステーションおよび電子モジュール
FR2986156B1 (fr) * 2012-01-30 2014-07-04 Rhenovia Pharma Dispositif transdermique pour l'administration controlee a un patient d'au moins un principe actif
US10010448B2 (en) 2012-02-03 2018-07-03 Forsight Vision4, Inc. Insertion and removal methods and apparatus for therapeutic devices
US9155653B2 (en) 2012-02-14 2015-10-13 Alcon Research, Ltd. Pressure-driven membrane valve for pressure control system
US8986240B2 (en) 2012-02-14 2015-03-24 Alcon Research, Ltd. Corrugated membrane actuators
BR112014020186A8 (pt) 2012-02-22 2017-07-11 Duchesnay Inc Formulação de doxilamina e piridoxina e/ou seus metabólitos ou sais
SG193127A1 (en) * 2012-02-29 2013-09-30 Johnson & Johnson Vision Care Punctal plug with energized containment array
US8998838B2 (en) 2012-03-29 2015-04-07 Alcon Research, Ltd. Adjustable valve for IOP control with reed valve
CN105283122B (zh) 2012-03-30 2020-02-18 伊利诺伊大学评议会 可共形于表面的可安装于附肢的电子器件
WO2013170069A1 (en) 2012-05-09 2013-11-14 Massachusetts Institute Of Technology Medicament, method, and drug delivery device for treatment of ovarian cancer
US9820692B2 (en) 2012-05-10 2017-11-21 The Regents Of The University Of California Wearable electrochemical sensors
US9211374B2 (en) 2012-05-25 2015-12-15 Robert F. Wallace Therapeutic implantable device
CA2875146C (en) 2012-05-30 2022-03-22 The Regents Of The University Of California Bioactive agent delivery devices and methods of making and using the same
US8652085B2 (en) 2012-07-02 2014-02-18 Alcon Research, Ltd. Reduction of gas escape in membrane actuators
US9910008B2 (en) 2012-07-06 2018-03-06 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US9810688B2 (en) 2013-03-15 2017-11-07 Robert Bosch Gmbh Smart glass slide for microarrays
US9874538B2 (en) 2012-07-06 2018-01-23 Robert Bosch Gmbh Methods for generating pH/ionic concentration gradient near electrode surfaces for modulating biomolecular interactions
US10310294B2 (en) * 2012-07-24 2019-06-04 Johnson & Johnson Vision Care, Inc. Thinned and flexible semiconductor elements on three dimensional surfaces
EP2879761A4 (de) 2012-08-06 2016-03-02 Baylor College Medicine Spendervorrichtung für therapeutika und herstellungsverfahren dafür
US9171794B2 (en) 2012-10-09 2015-10-27 Mc10, Inc. Embedding thin chips in polymer
ES2780674T3 (es) 2012-11-15 2020-08-26 Apellis Pharmaceuticals Inc Análogos de compstatina de acción prolongada y composiciones y métodos relacionados
US9295389B2 (en) 2012-12-17 2016-03-29 Novartis Ag Systems and methods for priming an intraocular pressure sensor in an intraocular implant
US9572712B2 (en) 2012-12-17 2017-02-21 Novartis Ag Osmotically actuated fluidic valve
US9528633B2 (en) 2012-12-17 2016-12-27 Novartis Ag MEMS check valve
SG11201504886SA (en) 2012-12-21 2015-07-30 Microchips Biotech Inc Implantable medical device for minimally-invasive insertion
US10561605B2 (en) 2013-01-22 2020-02-18 Robert F. Wallace Electrospun therapeutic carrier and implant
JP6387357B2 (ja) 2013-02-28 2018-09-05 マイクロチップス バイオテック,インコーポレイテッド 低侵襲挿入のための植え込み型医療デバイス
EP2968113B8 (de) 2013-03-14 2020-10-28 Forsight Vision4, Inc. Systeme zur verzögerten intraokularen abgabe schwerlöslicher verbindungen aus einem implantat mit einem portabgabesystem
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
WO2014152391A1 (en) 2013-03-15 2014-09-25 Apellis Pharmaceuticals, Inc. Cell-penetrating compstatin analogs and uses thereof
WO2014160884A1 (en) 2013-03-28 2014-10-02 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
EP3024466B1 (de) 2013-07-22 2018-04-04 Duchesnay Inc. Zusammensetzung zur behandlung von übelkeit und erbrechen
US9226851B2 (en) 2013-08-24 2016-01-05 Novartis Ag MEMS check valve chip and methods
US9289324B2 (en) 2013-08-26 2016-03-22 Novartis Ag Externally adjustable passive drainage device
US9283115B2 (en) 2013-08-26 2016-03-15 Novartis Ag Passive to active staged drainage device
US8742623B1 (en) 2013-09-16 2014-06-03 Google Inc. Device with dual power sources
US10092735B2 (en) 2013-10-09 2018-10-09 Matthew Q. Shaw Therapeutic delivery device
EP3105572B1 (de) 2014-02-13 2019-04-10 Robert Bosch GmbH Kapazitive luftblasenerkennung
US9603742B2 (en) 2014-03-13 2017-03-28 Novartis Ag Remote magnetic driven flow system
US9681983B2 (en) 2014-03-13 2017-06-20 Novartis Ag Debris clearance system for an ocular implant
RU2677538C2 (ru) * 2014-04-25 2019-01-17 Джонсон Энд Джонсон Вижн Кэа, Инк. Способ и офтальмологическое устройство с системой высвобождения активного агента
US20150342875A1 (en) 2014-05-29 2015-12-03 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
ES2992100T3 (es) 2014-07-15 2024-12-09 Forsight Vision4 Inc Dispositivo de administración de implante ocular
MX2017001818A (es) 2014-08-08 2017-05-30 Forsight Vision4 Inc Formulaciones estables y solubles de inhibidores de receptor de quinasa tirosina y metodos de preparacion de los mismos.
SG11201703726XA (en) 2014-11-10 2017-06-29 Forsight Vision4 Inc Expandable drug delivery devices and method of use
US10722160B2 (en) 2014-12-03 2020-07-28 The Regents Of The University Of California Non-invasive and wearable chemical sensors and biosensors
JP2018505200A (ja) 2015-02-11 2018-02-22 ザ・ジョンズ・ホプキンス・ユニバーシティー 腫瘍を治療するためのアクリフラビンの局所送達形態
US9655777B2 (en) 2015-04-07 2017-05-23 Novartis Ag System and method for diagphragm pumping using heating element
WO2016171529A1 (ko) 2015-04-24 2016-10-27 포항공과대학교 산학협력단 스마트 콘택트 렌즈 및 스마트 안경
EP3304430A4 (de) 2015-06-01 2019-03-06 The Board of Trustees of the University of Illionis Miniaturisierte elektronische systeme mit drahtlosstrom- und nahfeldkommunikationfähigkeiten
KR20180034342A (ko) 2015-06-01 2018-04-04 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 대안적인 자외선 감지방법
US10674914B1 (en) 2015-06-24 2020-06-09 Modular Bionics Inc. Wireless neural interface system
US11867660B2 (en) 2015-07-06 2024-01-09 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surface
US10379080B2 (en) 2015-07-06 2019-08-13 Robert Bosch Gmbh Electronic control of the pH of a solution close to an electrode surfaces
US10011549B2 (en) 2015-07-06 2018-07-03 Robert Bosch Gmbh Electrochemically active agents for pH modulation in biological buffers
US10967122B2 (en) 2015-08-07 2021-04-06 Massachusetts Institute Of Technology Subcutaneous drug delivery device with manual activation and deactivation of drug release
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
FI3359555T3 (fi) 2015-10-07 2024-03-20 Apellis Pharmaceuticals Inc Annostusohjeet
US10835126B1 (en) * 2015-11-06 2020-11-17 Verily Life Sciences Llc Implantable micro-spectrophotometer
US10925543B2 (en) 2015-11-11 2021-02-23 The Board Of Trustees Of The University Of Illinois Bioresorbable silicon electronics for transient implants
CN113069681B (zh) 2015-11-20 2022-12-23 弗赛特影像4股份有限公司 制造用于缓释药物递送的治疗装置的方法
CN109195556B (zh) 2016-04-05 2021-03-26 弗赛特影像4股份有限公司 可植入眼睛药物递送装置
JP7003110B2 (ja) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション 生体吸収性眼球薬物送達デバイス
US10086192B2 (en) 2016-07-07 2018-10-02 Modular Bionics Inc. Neural interface insertion and retraction tools
AU2017298024B2 (en) * 2016-07-21 2021-06-03 Patrick, James Finlay Transmission of energy and data using a collimated beam
US10406336B2 (en) * 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
US10620151B2 (en) 2016-08-30 2020-04-14 Analog Devices Global Electrochemical sensor, and a method of forming an electrochemical sensor
US12188893B2 (en) 2016-08-30 2025-01-07 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
US11268927B2 (en) 2016-08-30 2022-03-08 Analog Devices International Unlimited Company Electrochemical sensor, and a method of forming an electrochemical sensor
EP3532093A1 (de) 2016-09-19 2019-09-04 Vaxess Technologies, Inc. Impfstoffformulierungen mit erhöhter stabilität
WO2018089688A1 (en) 2016-11-09 2018-05-17 Jinjun Shi Restoration of tumor suppression using mrna-based delivery system
US12109032B1 (en) 2017-03-11 2024-10-08 Biolinq Incorporated Methods for achieving an isolated electrical interface between an anterior surface of a microneedle structure and a posterior surface of a support structure
US11040107B2 (en) 2017-04-07 2021-06-22 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
US11045142B1 (en) 2017-04-29 2021-06-29 Biolinq, Inc. Heterogeneous integration of silicon-fabricated solid microneedle sensors and CMOS circuitry
US10604843B2 (en) * 2017-05-10 2020-03-31 Xerox Corporation High registration particles-transferring system
CN108968976B (zh) 2017-05-31 2022-09-13 心脏起搏器股份公司 具有化学传感器的植入式医疗设备
SG10201913998YA (en) 2017-07-25 2020-03-30 Taris Biomedical Llc Methods of treating tumor metastasis
WO2019023093A1 (en) 2017-07-26 2019-01-31 Cardiac Pacemakers, Inc. SYSTEMS AND METHODS FOR POSTURE DISAMBIGULATION
CN109381195B (zh) 2017-08-10 2023-01-10 心脏起搏器股份公司 包括电解质传感器融合的系统和方法
CN109419515B (zh) 2017-08-23 2023-03-24 心脏起搏器股份公司 具有分级激活的可植入化学传感器
CA3073719A1 (en) * 2017-08-24 2019-02-28 The Regents Of The University Of Michigan Precision bio-chemotronic system
BR112020010053A2 (pt) 2017-11-21 2020-11-03 Forsight Vision4, Inc. aparelho para troca de fluido para sistema de liberação de porta expansível e métodos de uso do mesmo
CN109864746B (zh) 2017-12-01 2023-09-29 心脏起搏器股份公司 用于医学装置的多模式分析物传感器
CN109864747B (zh) 2017-12-05 2023-08-25 心脏起搏器股份公司 多模式分析物传感器光电子接口
US11065439B1 (en) 2017-12-11 2021-07-20 Modular Bionics Inc. Conforming modular neural interface system
WO2019118938A1 (en) 2017-12-15 2019-06-20 Apellis Pharmaceuticals, Inc. Dosing regimens and related compositions and methods
US11022579B2 (en) 2018-02-05 2021-06-01 Analog Devices International Unlimited Company Retaining cap
CA3093231A1 (en) 2018-03-07 2019-09-12 Soovu Labs, Inc. Systems and methods for improved pain relief from stimulation of thermal fibers
US11672697B2 (en) 2018-06-19 2023-06-13 Twenty Twenty Therapeutics Llc Eye-mountable therapeutic devices, and associated systems and methods
DE102019126959A1 (de) * 2019-10-08 2021-04-08 Implandata Ophthalmic Products Gmbh Anordnung zur in vivo Veränderung eines Augeninnendrucks
DK4048152T3 (da) 2020-07-29 2024-03-11 Biolinq Incorporated System til kontinuerlig analytovervågning med mikronålsindretning
US12551145B2 (en) 2020-10-29 2026-02-17 Cardiac Pacemakers, Inc. Integrated thermo-photonic chemical sensor
KR20240005085A (ko) 2021-05-08 2024-01-11 바이오링크 인코포레이티드 미세 바늘 어레이 기반 지속 분석물 모니터링 장치의 고장 감지
USD1033637S1 (en) 2022-01-24 2024-07-02 Forsight Vision4, Inc. Fluid exchange device
US20230255481A1 (en) * 2022-02-02 2023-08-17 Twenty Twenty Therapeutics Llc Electronic Pressure Sensor for Eye with Optical Interface
JP2026504447A (ja) 2023-02-02 2026-02-05 バイオリンク インコーポレイテッド マイクロニードルベースの持続分析物モニタリングシステムの改善されたセンサ感度のための方法
DE102023123792A1 (de) * 2023-09-05 2025-03-06 Implandata Ophthalmic Products Gmbh Wirkstoffabgebendes Implantat
US12274640B1 (en) * 2024-11-08 2025-04-15 Michael Reynard Implant for electrolysis of aqueous humor

Family Cites Families (180)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3692027A (en) 1971-04-23 1972-09-19 Everett H Ellinwood Jr Implanted medication dispensing device and method
US4003379A (en) 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4089734A (en) 1974-09-16 1978-05-16 Raytheon Company Integrated circuit fusing technique
US3952741A (en) * 1975-01-09 1976-04-27 Bend Research Inc. Controlled release delivery system by an osmotic bursting mechanism
DE2806609C2 (de) * 1978-02-16 1980-03-13 Anton Dr. 4400 Muenster Haerle Osteosynthesehilfsmittel
US4209894A (en) * 1978-04-27 1980-07-01 Texas Instruments Incorporated Fusible-link semiconductor memory
US4200098A (en) * 1978-10-23 1980-04-29 Alza Corporation Osmotic system with distribution zone for dispensing beneficial agent
US4345981A (en) 1978-11-24 1982-08-24 Diamond Shamrock Corporation Anodically polarized surface for biofouling and scale control
US4360019A (en) 1979-02-28 1982-11-23 Andros Incorporated Implantable infusion device
US4731051A (en) * 1979-04-27 1988-03-15 The Johns Hopkins University Programmable control means for providing safe and controlled medication infusion
JPS57163309A (en) 1981-04-01 1982-10-07 Olympus Optical Co Ltd Capsule apparatus for medical use
US4888176A (en) * 1984-05-21 1989-12-19 Massachusetts Institute Of Technology Controlled drug delivery high molecular weight polyanhydrides
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4585652A (en) 1984-11-19 1986-04-29 Regents Of The University Of Minnesota Electrochemical controlled release drug delivery system
US4585625A (en) * 1985-09-04 1986-04-29 Fmc Corporation Catalytic thermal oxidation of methyl isocyanate in waste gases
GB2189702B (en) * 1986-04-30 1989-10-18 Alza Corp Dosage form with improved delivery capability
CH670381A5 (de) * 1986-05-05 1989-06-15 Sulzer Ag
US4865813A (en) 1986-07-07 1989-09-12 Leon Luis P Disposable analytical device
US5042975A (en) 1986-07-25 1991-08-27 Rutgers, The State University Of New Jersey Iontotherapeutic device and process and iontotherapeutic unit dose
US4731049A (en) 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
EP0347579B1 (de) 1988-06-01 1994-03-30 Daimler-Benz Aerospace Aktiengesellschaft Vorrichtung mit Träger besonderer Struktur zur Aufnahme, Untersuchung und Behandlung von Proben
US5252294A (en) 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
US5200051A (en) 1988-11-14 1993-04-06 I-Stat Corporation Wholly microfabricated biosensors and process for the manufacture and use thereof
JPH0786551B2 (ja) 1988-12-26 1995-09-20 株式会社東芝 補機冷却海水系取水設備
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5229131A (en) 1990-02-05 1993-07-20 University Of Michigan Pulsatile drug delivery system
US5170801A (en) 1990-10-02 1992-12-15 Glaxo Inc. Medical capsule device actuated by radio-frequency (rf) signal
US5167625A (en) 1990-10-09 1992-12-01 Sarcos Group Multiple vesicle implantable drug delivery system
US5196002A (en) * 1990-10-09 1993-03-23 University Of Utah Research Foundation Implantable drug delivery system with piston acutation
US5493177A (en) 1990-12-03 1996-02-20 The Regents Of The University Of California Sealed micromachined vacuum and gas filled devices
US5391164A (en) 1991-05-03 1995-02-21 Giampapa; Vincent C. Subcutaneous implantable multiple-agent delivery system
US5279607A (en) 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
AU2563292A (en) 1991-08-26 1993-03-16 Rutgers, The State University Of New Jersey Iontotherapeutic device and process
US5533995A (en) * 1991-11-13 1996-07-09 Elan Corporation, Plc Passive transdermal device with controlled drug delivery
US5193539A (en) 1991-12-18 1993-03-16 Alfred E. Mann Foundation For Scientific Research Implantable microstimulator
JPH05212122A (ja) * 1992-02-07 1993-08-24 Olympus Optical Co Ltd 薬剤放出装置
US5262127A (en) 1992-02-12 1993-11-16 The Regents Of The University Of Michigan Solid state chemical micro-reservoirs
US5429822A (en) 1992-03-13 1995-07-04 Cambridge Scientific, Inc. Biodegradable bursting release system
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
US5304293A (en) 1992-05-11 1994-04-19 Teknekron Sensor Development Corporation Microsensors for gaseous and vaporous species
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5433718A (en) * 1992-08-20 1995-07-18 Brinker; Mark Antibiotic eluding intramedullary nail apparatus
US6124259A (en) 1993-01-28 2000-09-26 Celtrix Pharmaceuticals, Inc. Method for treating ophthalmic disorders with IGFBP
US5380272A (en) 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
US5707643A (en) 1993-02-26 1998-01-13 Santen Pharmaceutical Co., Ltd. Biodegradable scleral plug
US5368588A (en) 1993-02-26 1994-11-29 Bettinger; David S. Parenteral fluid medication reservoir pump
US5366454A (en) 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5427585A (en) 1993-03-29 1995-06-27 Bettinger; David S. On-demand iontophoretic system
US5474527A (en) 1993-03-29 1995-12-12 Bettinger; David S. Positive displacement transdermal system
US5538902A (en) * 1993-06-29 1996-07-23 Sanyo Electric Co., Ltd. Method of fabricating a photovoltaic device having a three-dimensional shape
JPH0799332A (ja) * 1993-06-29 1995-04-11 Sanyo Electric Co Ltd 3次元形状光起電力素子の製造方法
US5368704A (en) 1993-08-06 1994-11-29 Teknekron Corporation Micro-electrochemical valves and method
JP3461368B2 (ja) * 1993-09-16 2003-10-27 オリンパス光学工業株式会社 可撓性薄膜基板を有する電子デバイスの製造方法
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5443505A (en) 1993-11-15 1995-08-22 Oculex Pharmaceuticals, Inc. Biocompatible ocular implants
FR2715568B1 (fr) 1994-01-28 1996-04-12 Joseph Virassamy Utilisation de poudre de nacre pour prothèse et implants de prothèse conçus pour cela.
US6129685A (en) 1994-02-09 2000-10-10 The University Of Iowa Research Foundation Stereotactic hypothalamic obesity probe
US5798042A (en) 1994-03-07 1998-08-25 Regents Of The University Of California Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters
JPH07254727A (ja) * 1994-03-16 1995-10-03 Olympus Optical Co Ltd 半導体装置及びその製造方法
US5971931A (en) 1994-03-29 1999-10-26 Raff; Gilbert Lewis Biologic micromonitoring methods and systems
US5947893A (en) * 1994-04-27 1999-09-07 Board Of Regents, The University Of Texas System Method of making a porous prothesis with biodegradable coatings
US5837276A (en) 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
DE4432324A1 (de) 1994-09-13 1996-03-14 Vwb Elektronik Techn Gmbh Vorrichtung f}r eine Einrichtung zur drahtlosen Informationsabfrage und Verfahren zur Herstellung der Vorrichtung
US6063116A (en) 1994-10-26 2000-05-16 Medarex, Inc. Modulation of cell proliferation and wound healing
US5585069A (en) 1994-11-10 1996-12-17 David Sarnoff Research Center, Inc. Partitioned microelectronic and fluidic device array for clinical diagnostics and chemical synthesis
US5591217A (en) 1995-01-04 1997-01-07 Plexus, Inc. Implantable stimulator with replenishable, high value capacitive power source and method therefor
JPH08270552A (ja) * 1995-03-30 1996-10-15 Toyota Autom Loom Works Ltd 可変容量圧縮機
US5733814A (en) * 1995-04-03 1998-03-31 Aptek Industries, Inc. Flexible electronic card and method
US5504026A (en) 1995-04-14 1996-04-02 Analog Devices, Inc. Methods for planarization and encapsulation of micromechanical devices in semiconductor processes
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US5992769A (en) 1995-06-09 1999-11-30 The Regents Of The University Of Michigan Microchannel system for fluid delivery
US5713954A (en) 1995-06-13 1998-02-03 Abiomed R&D, Inc. Extra cardiac ventricular assist device
SE9502258D0 (sv) 1995-06-21 1995-06-21 Pharmacia Biotech Ab Method for the manufacture of a membrane-containing microstructure
US5662689A (en) 1995-09-08 1997-09-02 Medtronic, Inc. Method and apparatus for alleviating cardioversion shock pain
JPH09151138A (ja) * 1995-11-29 1997-06-10 Toray Ind Inc 薬剤徐放性積層体
US6261584B1 (en) * 1996-02-02 2001-07-17 Alza Corporation Sustained delivery of an active agent using an implantable system
WO1997029802A2 (en) 1996-02-20 1997-08-21 Advanced Bionics Corporation Improved implantable microstimulator and systems employing the same
DE19610293C1 (de) * 1996-03-15 1997-07-31 Fraunhofer Ges Forschung Vorrichtung zur gekapselten Aufnahme eines Materials
US5743274A (en) 1996-03-18 1998-04-28 Peyman; Gholam A. Macular bandage for use in the treatment of subretinal neovascular members
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
GB9615159D0 (en) * 1996-07-19 1996-09-04 Boc Group Plc Treatment of liquid
WO1998032595A1 (en) * 1997-01-24 1998-07-30 California Institute Of Technology Flexible skin incorporating mems technology
US5782799A (en) 1997-02-07 1998-07-21 Sarcos, Inc. Method for automatic dosing of drugs
US6056734A (en) 1997-02-07 2000-05-02 Sarcos Lc Method for automatic dosing of drugs
DE19716683C1 (de) 1997-04-21 1998-06-04 Fraunhofer Ges Forschung Vorrichtung zur getrennten, gekapselten Aufnahme einer Mehrzahl gleicher oder unterschiedlicher Stoffe
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
IL121286A0 (en) * 1997-07-11 1998-01-04 Pets N People Ltd Apparatus and methods for dispensing pet care substances
US5949187A (en) 1997-07-29 1999-09-07 Motorola, Inc. Organic electroluminescent device with plural microcavities
US5961492A (en) 1997-08-27 1999-10-05 Science Incorporated Fluid delivery device with temperature controlled energy source
US5842787A (en) 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6585763B1 (en) 1997-10-14 2003-07-01 Vascusense, Inc. Implantable therapeutic device and method
FR2769640B1 (fr) * 1997-10-15 1999-12-17 Sgs Thomson Microelectronics Amelioration de la resistance mecanique d'une tranche de silicium monocristallin
US6081736A (en) 1997-10-20 2000-06-27 Alfred E. Mann Foundation Implantable enzyme-based monitoring systems adapted for long term use
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6163720A (en) * 1997-12-18 2000-12-19 Alza Corporation Layered rate controlling membranes for use in an electrotransport device
US6140740A (en) 1997-12-30 2000-10-31 Remon Medical Technologies, Ltd. Piezoelectric transducer
US6001090A (en) 1998-02-09 1999-12-14 Lenhart; Douglas Thermal pharmaceutical delivery system
US6757560B1 (en) 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
US6319241B1 (en) 1998-04-30 2001-11-20 Medtronic, Inc. Techniques for positioning therapy delivery elements within a spinal cord or a brain
US6161047A (en) 1998-04-30 2000-12-12 Medtronic Inc. Apparatus and method for expanding a stimulation lead body in situ
US6047214A (en) 1998-06-09 2000-04-04 North Carolina State University System and method for powering, controlling, and communicating with multiple inductively-powered devices
US6243608B1 (en) 1998-06-12 2001-06-05 Intermedics Inc. Implantable device with optical telemetry
US6941171B2 (en) 1998-07-06 2005-09-06 Advanced Bionics Corporation Implantable stimulator methods for treatment of incontinence and pain
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
US6201980B1 (en) 1998-10-05 2001-03-13 The Regents Of The University Of California Implantable medical sensor system
DE19855421C2 (de) * 1998-11-02 2001-09-20 Alcove Surfaces Gmbh Implantat
US6232150B1 (en) 1998-12-03 2001-05-15 The Regents Of The University Of Michigan Process for making microstructures and microstructures made thereby
US6289237B1 (en) 1998-12-22 2001-09-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Apparatus for energizing a remote station and related method
WO2000040089A1 (en) 1999-01-05 2000-07-13 Massachusetts Eye And Ear Infirmary Targeted transscleral controlled release drug delivery to the retina and choroid
US6171850B1 (en) 1999-03-08 2001-01-09 Caliper Technologies Corp. Integrated devices and systems for performing temperature controlled reactions and analyses
US6178349B1 (en) 1999-04-15 2001-01-23 Medtronic, Inc. Drug delivery neural stimulation device for treatment of cardiovascular disorders
US6923784B2 (en) 1999-04-30 2005-08-02 Medtronic, Inc. Therapeutic treatment of disorders based on timing information
US6348050B1 (en) * 1999-04-30 2002-02-19 Medtronic, Inc. Infusion systems for creating microenvironments in a living body
US6096656A (en) 1999-06-24 2000-08-01 Sandia Corporation Formation of microchannels from low-temperature plasma-deposited silicon oxynitride
US6587719B1 (en) 1999-07-01 2003-07-01 Cyberonics, Inc. Treatment of obesity by bilateral vagus nerve stimulation
US6804558B2 (en) 1999-07-07 2004-10-12 Medtronic, Inc. System and method of communicating between an implantable medical device and a remote computer system or health care provider
US6334859B1 (en) 1999-07-26 2002-01-01 Zuli Holdings Ltd. Subcutaneous apparatus and subcutaneous method for treating bodily tissues with electricity or medicaments
DE60018582T2 (de) 1999-08-18 2006-01-19 Microchips, Inc., Bedford Thermisch aktivierbarer microchip als abgabevorrichtung für chemikalien
US6442434B1 (en) 1999-10-19 2002-08-27 Abiomed, Inc. Methods and apparatus for providing a sufficiently stable power to a load in an energy transfer system
US6738661B1 (en) * 1999-10-22 2004-05-18 Biosynergetics, Inc. Apparatus and methods for the controllable modification of compound concentration in a tube
JP2003513755A (ja) * 1999-11-17 2003-04-15 マイクロチップス・インコーポレーテッド キャリア流体内への分子の送達のための微細加工されたデバイス
WO2001037926A1 (en) 1999-11-22 2001-05-31 Abiomed, Inc. Apparatus for transferring energy across a boundary
JP2003516343A (ja) 1999-12-10 2003-05-13 マサチューセッツ インスティテュート オブ テクノロジー 分子を送達するマイクロチップ素子およびその製作方法
US6328699B1 (en) 2000-01-11 2001-12-11 Cedars-Sinai Medical Center Permanently implantable system and method for detecting, diagnosing and treating congestive heart failure
US6384353B1 (en) 2000-02-01 2002-05-07 Motorola, Inc. Micro-electromechanical system device
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
WO2001059447A1 (en) 2000-02-11 2001-08-16 Yale University Planar patch clamp electrodes
US6551838B2 (en) 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US6673068B1 (en) * 2000-04-12 2004-01-06 Afx, Inc. Electrode arrangement for use in a medical instrument
AU2001265128A1 (en) 2000-05-30 2001-12-11 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
WO2002013785A2 (en) 2000-08-14 2002-02-21 Pharmacia Corporation Drug delivery system with burst electrode
ATE404140T1 (de) * 2000-08-30 2008-08-15 Univ Johns Hopkins Vorrichtung zur intraokularen wirkstoffverabreichung
EP1339312B1 (de) 2000-10-10 2006-01-04 Microchips, Inc. Mikrochip-reservoir-vorrichtungen mit drahtloser übertragung von energie und daten
US6773429B2 (en) * 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
WO2002034327A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Method and apparatus to minimize the effects of a cardiac insult
EP1339451B1 (de) 2000-10-26 2009-09-30 Medtronic, Inc. Vorrichtung zur minimierung der wirkungen eines herzinsults
WO2002045791A2 (en) 2000-10-26 2002-06-13 Medtronic, Inc. Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions
DE10061057A1 (de) 2000-12-08 2002-06-13 Pharmed Holding Gmbh Chip-Systeme zur kontrollierten Emission chemosensorisch wirkender Stoffe
DE10063612C2 (de) 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Mikrosystem zur Kontrolle der Wirkstoffabgabe aus einem Wirkstoffreservoir sowie Implantat mit Mikrosystem
WO2002056863A2 (en) * 2000-12-29 2002-07-25 Bausch & Lomb Incorporated Sustained release drug delivery devices
US6666821B2 (en) 2001-01-08 2003-12-23 Medtronic, Inc. Sensor system
EP1372602B1 (de) * 2001-01-09 2007-04-18 Microchips, Inc. Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
WO2002056940A2 (en) 2001-01-22 2002-07-25 Integrated Sensing Systems, Inc. Sensing catheter system and method of fabrication
US6571125B2 (en) 2001-02-12 2003-05-27 Medtronic, Inc. Drug delivery device
US7181287B2 (en) 2001-02-13 2007-02-20 Second Sight Medical Products, Inc. Implantable drug delivery device
US7338522B2 (en) 2001-02-13 2008-03-04 Second Sight Medical Products, Inc. Implantable retinal electrode array configuration for minimal retinal damage and method of reducing retinal stress
US6726678B1 (en) * 2001-02-22 2004-04-27 Isurgical, Llc Implantable reservoir and system for delivery of a therapeutic agent
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20020144548A1 (en) 2001-04-06 2002-10-10 Cohn Michael B. High precision accelerometer
WO2002089767A1 (en) 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6733485B1 (en) 2001-05-25 2004-05-11 Advanced Bionics Corporation Microstimulator-based electrochemotherapy methods and systems
EP1395335A1 (de) 2001-05-29 2004-03-10 Medtronic, Inc. Neuromodulation mit geschlossenem regelkreis zur verhinderung und behandlung von herzzuständen
WO2002096389A1 (en) 2001-05-30 2002-12-05 Microchips, Inc. Conformal coated microchip reservoir devices
AU2002326304A1 (en) 2001-05-31 2002-12-16 Massachusetts Institute Of Technology Microchip devices with improved reservoir opening
US6827250B2 (en) 2001-06-28 2004-12-07 Microchips, Inc. Methods for hermetically sealing microchip reservoir devices
US6663615B1 (en) 2001-09-04 2003-12-16 The Ohio State University Dual stage microvalve and method of use
US7025760B2 (en) 2001-09-07 2006-04-11 Medtronic Minimed, Inc. Method and system for non-vascular sensor implantation
GB0123804D0 (en) 2001-10-04 2001-11-21 Osseobiotek Ltd Implant
WO2003048665A1 (en) 2001-12-03 2003-06-12 Massachusetts Institute Of Technology Microscale lyophilization and drying methods for the stabilization of molecules
US6893885B2 (en) 2002-01-18 2005-05-17 The Regents Of The University Of Michigan Method for electrically and mechanically connecting microstructures using solder
BR0308482A (pt) * 2002-03-11 2005-02-22 Alcon Inc Sistema de administração de droga implantável
EP1358859A1 (de) 2002-04-29 2003-11-05 Politecnico Di Milano Knochenprothesen mit mehrlagiger Oberfläche
GB0213774D0 (en) 2002-06-15 2002-07-24 Osseobiotek Ltd Prosthesis
US20060246103A1 (en) * 2002-07-22 2006-11-02 Ralph James D Implantable devices for the delivery of therapeutic agents to an orthopaedic surgical site
US6916483B2 (en) * 2002-07-22 2005-07-12 Biodynamics, Llc Bioabsorbable plugs containing drugs
US7824699B2 (en) * 2002-07-22 2010-11-02 Biodynamics Llc Implantable prosthetic devices containing timed release therapeutic agents
KR100725973B1 (ko) * 2002-08-16 2007-06-11 마이크로칩스 인코포레이티드 전열적 제거를 이용한 제어 방출 장치 및 방법
WO2004022033A1 (en) 2002-09-04 2004-03-18 Microchips, Inc. Method and device for the controlled delivery of parathyroid hormone
US7534241B2 (en) 2002-09-23 2009-05-19 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
AU2003284018A1 (en) 2002-10-04 2004-05-04 Microchips, Inc. Medical device for neural stimulation and controlled drug delivery
WO2004033036A2 (en) 2002-10-04 2004-04-22 Microchips, Inc. Medical device for controlled drug delivery and cardiac monitoring and/or stimulation
US9445901B2 (en) * 2003-03-12 2016-09-20 Deger C. Tunc Prosthesis with sustained release analgesic
WO2004096176A2 (en) 2003-04-25 2004-11-11 Boston Scientific Scimed Inc. Solid drug formulation and device for storage and controlled delivery thereof
WO2005010240A2 (en) 2003-07-17 2005-02-03 Microchips, Inc. Low temperature methods for hermetically sealing reservoir devices
WO2005016558A2 (en) 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
US7632234B2 (en) 2003-08-29 2009-12-15 Medtronic, Inc. Implantable biosensor devices for monitoring cardiac marker molecules
KR20140134338A (ko) 2003-09-11 2014-11-21 테라노스, 인코포레이티드 피분석물의 모니터링 및 약물 전달을 위한 의료 기기

Also Published As

Publication number Publication date
WO2002055058A3 (en) 2003-10-16
JP2004517858A (ja) 2004-06-17
CA2432438A1 (en) 2002-07-18
US20080071252A1 (en) 2008-03-20
AU2002241834B2 (en) 2006-11-09
US20080221557A1 (en) 2008-09-11
WO2002055058A2 (en) 2002-07-18
US20020099359A1 (en) 2002-07-25
US20060178655A1 (en) 2006-08-10
DE60219607D1 (de) 2007-05-31
US7776024B2 (en) 2010-08-17
US6976982B2 (en) 2005-12-20
JP4354521B2 (ja) 2009-10-28
JP2010099483A (ja) 2010-05-06
US8308707B2 (en) 2012-11-13
EP1372602B1 (de) 2007-04-18
DE60219607T2 (de) 2007-12-27
JP2009142661A (ja) 2009-07-02
US7582080B2 (en) 2009-09-01
EP1372602A2 (de) 2004-01-02
US20110172587A1 (en) 2011-07-14
CA2432438C (en) 2011-04-26
US7879019B2 (en) 2011-02-01
JP4657577B2 (ja) 2011-03-23

Similar Documents

Publication Publication Date Title
ATE359762T1 (de) Flexible mikrochip-vorrichtungen zur ophthalmologischen und anderen applikation
AU2003297848A8 (en) High viscosity liquid controlled delivery system and medical or surgical device
WO2006002366A3 (en) Biodegradable ocular devices, methods and systems
ATE439887T1 (de) System zur freisetzung eines heilmittels
DE59610355D1 (de) Medizinisches implantat
ATE358505T1 (de) Beschichtete endovaskuläre vorrichtung
DK1660034T3 (da) Fremstilling af langtidsafgivende medikamentindretninger af polyurethanbaserede polymerer
WO2004067044A3 (en) Light-activated adhesive composite, system, and methods
WO2003039622A3 (en) Novel iontophoretic drug delivery systems
ATE554806T1 (de) Vorrichtung zur abgabe therapeutischer mittel mit einer trennenden schutzschicht
WO2003040986A3 (en) Patient directed therapy management
ATE241394T1 (de) Beigeordnetes polymersystem zur verwendung mit einer medizinischen vorrichtung
WO2007001624A3 (en) Medical and dental implant devices for controlled drug delivery
DE69113470D1 (de) Intraokulares und intraorbitales Implantat zur kontrollierten Zuführung von Arzneimitteln.
WO2006023130A3 (en) Biodegradable controlled release bioactive agent delivery device
WO2005048850A3 (en) Systems and methods relating to associating a medical implant with a delivery device
WO2002072172A3 (en) Apparatus and methods for capture of medical agents
ATE555779T1 (de) Biologisch abbaubares augenimplantat
AU2003261350A8 (en) Separable medical devices comprising a holding material
DE69636507D1 (de) Blutbehälter, sowie Instrument und Gerät zur Abgabe von Blut
WO2003051452A8 (en) Drug implant injection device
EP1426066A4 (de) Gerüstprodukt für die konstruktion von menschlichem knochengewebe, verfahren zu seiner herstellung und anwendungsgebiete
DK1779877T3 (da) Bæremateriale for medicinske implantater
WO2006094113A3 (en) Mask container
WO2005065643A3 (en) Sutureless ophthalmic drug delivery system and method

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties