CN103153316B - 组合药物递送方法和设备 - Google Patents
组合药物递送方法和设备 Download PDFInfo
- Publication number
- CN103153316B CN103153316B CN201180048624.5A CN201180048624A CN103153316B CN 103153316 B CN103153316 B CN 103153316B CN 201180048624 A CN201180048624 A CN 201180048624A CN 103153316 B CN103153316 B CN 103153316B
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- CN
- China
- Prior art keywords
- therapeutic agent
- reservoir
- release
- chamber
- rate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
- A61F2250/0068—Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
Abstract
Description
化合物 | MW | 温度C | 扩散系数(cm^2/s) |
BSA | 69,000 | 20 | 6.1E-07 |
BSA | 69,000 | 37 | 9.1E-07 |
兰尼单抗 | 48,000 | 20 | 6.9E-07 |
兰尼单抗 | 48,000 | 37 | 1.0E-06 |
贝伐单抗 | 149,000 | 20 | 4.7E-07 |
贝伐单抗 | 149,000 | 37 | 7.1E-07 |
扩散系数(cm2/s) | 5.0E-06 |
溶解度(ug/mL) | 25000 |
储器容积(ml) | 0.0250 |
PA/FL(RRI,mm) | 0.02 |
半衰期(hr) | 3 |
速度常数,k(1/天) | 5.545 |
玻璃体体积(ml) | 4.5 |
扩散系数(cm2/s) | 5.0E-06 |
载量(mg/mL) | 300.0 |
溶解度(mg/mL) | 25.00 |
储器容积(ml) | 0.025 |
半衰期(hr) | 3 |
速度常数,k(1/day) | 5.545 |
玻璃体体积(ml) | 4.5 |
扩散系数(cm2/s) | 1.0E-06 |
初始载量(ug/mL) | 10000 |
储器容积(ml) | 0.125 |
PA/TL(mm) | 改变的 |
半衰期(天数) | 9 |
速度常数,k(1/天) | 0.077 |
玻璃体体积(ml) | 4.5 |
注射的体积(mL) | 0.05 |
时间步长(天数) | 0.1 |
再次填充之间的时间(天数) | 180 |
再次填充的效率 | 100% |
容积(uL) | 装置 | RRI(mm) | SS(ug/天)2 |
33 | 1 | 0.015 | 0.35 |
33 | 2 | 0.018 | 0.16 |
16 | 1 | 0.018 | 0.05 |
16 | 2 | 0.022 | 0.06 |
平均值 | 0.018 | ||
%CV | 16% |
装置 | RRI(mm) | SS(ug/天)2 |
1 | 0.029 | 26.0 |
2 | 0.027 | 8.5 |
5 | 0.018 | 3.7 |
30 | 0.013 | 0.1 |
31 | 0.013 | 0.1 |
32 | 0.015 | 0.7 |
33 | 0.022 | 30.5 |
平均值 | 0.020 | |
%CV | 34% |
Claims (14)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37116810P | 2010-08-05 | 2010-08-05 | |
US61/371,168 | 2010-08-05 | ||
PCT/US2011/046817 WO2012019139A1 (en) | 2010-08-05 | 2011-08-05 | Combined drug delivery methods and apparatus |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103153316A CN103153316A (zh) | 2013-06-12 |
CN103153316B true CN103153316B (zh) | 2015-08-19 |
Family
ID=45559845
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201180048624.5A Active CN103153316B (zh) | 2010-08-05 | 2011-08-05 | 组合药物递送方法和设备 |
Country Status (7)
Country | Link |
---|---|
US (2) | US10617557B2 (zh) |
EP (1) | EP2600876B1 (zh) |
JP (1) | JP6111194B2 (zh) |
CN (1) | CN103153316B (zh) |
AU (1) | AU2011285548B2 (zh) |
CA (1) | CA2807537C (zh) |
WO (1) | WO2012019139A1 (zh) |
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WO2012019139A1 (en) * | 2010-08-05 | 2012-02-09 | Forsight Vision4, Inc. | Combined drug delivery methods and apparatus |
EP3861969A1 (en) | 2010-08-05 | 2021-08-11 | ForSight Vision4, Inc. | Injector apparatus for drug delivery |
CA2818612C (en) | 2010-11-19 | 2020-12-29 | Forsight Vision4, Inc. | Therapeutic agent formulations for implanted devices |
EP4249059A3 (en) | 2011-06-28 | 2023-11-29 | ForSight Vision4, Inc. | An apparatus for collecting a sample of fluid from a reservoir chamber of a therapeutic device for the eye |
SI2755600T1 (sl) | 2011-09-16 | 2021-08-31 | Forsight Vision4, Inc. | Naprava za izmenjavo tekočine |
US10010448B2 (en) | 2012-02-03 | 2018-07-03 | Forsight Vision4, Inc. | Insertion and removal methods and apparatus for therapeutic devices |
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EP4302736A3 (en) | 2013-03-28 | 2024-04-03 | ForSight Vision4, Inc. | Ophthalmic implant for delivering therapeutic substances |
CN111374821B (zh) * | 2014-06-19 | 2022-05-03 | 加州理工学院 | 用于输送药物或排除废物的小分子运输设备 |
US10258503B2 (en) | 2014-07-15 | 2019-04-16 | Forsight Vision4, Inc. | Ocular implant delivery device and method |
MY182793A (en) | 2014-08-08 | 2021-02-05 | Forsight Vision4 Inc | Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof |
US10507101B2 (en) | 2014-10-13 | 2019-12-17 | W. L. Gore & Associates, Inc. | Valved conduit |
US10500091B2 (en) | 2014-11-10 | 2019-12-10 | Forsight Vision4, Inc. | Expandable drug delivery devices and methods of use |
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AR106018A1 (es) | 2015-08-26 | 2017-12-06 | Achillion Pharmaceuticals Inc | Compuestos de arilo, heteroarilo y heterocíclicos para el tratamiento de trastornos médicos |
EP3340982B1 (en) | 2015-08-26 | 2021-12-15 | Achillion Pharmaceuticals, Inc. | Compounds for treatment of immune and inflammatory disorders |
US11013403B2 (en) | 2015-09-29 | 2021-05-25 | The Regents Of The University Of California | Methods of diagnosing diseases of mucosal surfaces |
CN108430405B (zh) | 2015-11-20 | 2021-04-13 | 弗赛特影像4股份有限公司 | 用于缓释药物递送装置的多孔结构 |
US11617680B2 (en) | 2016-04-05 | 2023-04-04 | Forsight Vision4, Inc. | Implantable ocular drug delivery devices |
AU2017290593A1 (en) | 2016-06-27 | 2019-01-03 | Achillion Pharmaceuticals, Inc. | Quinazoline and indole compounds to treat medical disorders |
US11523940B2 (en) | 2017-03-17 | 2022-12-13 | W. L. Gore & Associates, Inc. | Delivery aids for glaucoma shunts |
JP7284948B2 (ja) * | 2017-06-14 | 2023-06-01 | バーテックス ファーマシューティカルズ インコーポレイテッド | 療法薬を送達するためのデバイスおよび方法 |
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JP6111194B2 (ja) | 2017-04-05 |
EP2600876B1 (en) | 2015-04-29 |
AU2011285548B2 (en) | 2014-02-06 |
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WO2012019139A9 (en) | 2013-03-28 |
WO2012019139A1 (en) | 2012-02-09 |
CA2807537A1 (en) | 2012-02-09 |
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US20200405537A1 (en) | 2020-12-31 |
EP2600876A1 (en) | 2013-06-12 |
AU2011285548A1 (en) | 2013-03-07 |
CN103153316A (zh) | 2013-06-12 |
CA2807537C (en) | 2018-09-18 |
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