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US3902495A - Flow control system - Google Patents

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US3902495A
US3902495A US43716574A US3902495A US 3902495 A US3902495 A US 3902495A US 43716574 A US43716574 A US 43716574A US 3902495 A US3902495 A US 3902495A
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fluid
chamber
pressure
flow
means
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Steven N Weiss
Alan Broadwin
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Cooper Cos Inc
Cavitron Corp
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Cavitron Corp
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/0058Suction-irrigation systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/0023Suction drainage systems
    • A61M1/0031Suction control
    • A61M1/0033Suction control by changing the size of a vent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/02Enemata; Irrigators
    • A61M3/0233Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • A61M3/02Enemata; Irrigators
    • A61M3/0233Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs
    • A61M3/0241Enemata; Irrigators characterised by liquid supply means, e.g. from pressurised reservoirs the liquid being supplied by gravity

Abstract

A fluidic control system for use in irrigation and aspiration of the anterior chamber of the eye during ultrasonic emulsification of a cataract therein. The system comprises a handpiece with an (ultrasonically vibrated) hollow tip, the hollow tip being connected to the fluid withdrawal or aspirating portion, while an annular passage around the tip is used to introduce fluid for irrigation purposes. The aspirating portion comprises a withdrawal hose attached to the output manifold of the handpiece in fluid communication with the hollow tip, a constant flow pump attached to the other end of the withdrawal hose, and a vacuum relief valve connected to the withdrawal hose intermediate the pump and the handpiece. The irrigation portion comprises a fluid supply bottle at a predetermined height above the eye, and administration set attached to the bottle, and an inflow hose attached to the intake manifold of the handpiece and in fluid communication with the annular passage. All the aforementioned components are in fluid communication with the anterior chamber of the eye during removal of a cataract by insertion of the handpiece tip into the eye chamber.

Description

United States Patent [1 1 Weiss et al. Sept. 2, 1975 1 FLOW CONTROL SYSTEM [57] ABSTRACT [75] Inventors: Steven N. Weiss, New York; Alan A fluidic control system for use in irrigation and aspi- [73] Assignee: Cavitron Corporation, New York,

[22] Filed: Jan. 28, 1974 [21] Appl. No.: 437,165

[52] US. Cl. 128/276; 128/24 A [51] Int. Cl. A61M U110 [58] Field of Search 128/276, 24 A, 303.1, 305; 137/ 102 [5 6] References Cited UNITED STATES PATENTS 3,693,613 9/1972 Kelman 128/24 A 3,732,858 5/1973 Banko 128/305 X 3,736,938 6/1973 Evvard et al..... 128/24 A X 3,776,238 12/1973 Peyman et a1. 128/305 3,809,093 5/1974 Abraham 128/305 3,812,855 5/1974 Banko 128/276 3,815,604 6/1974 OMalley et al. 128/276 3,818,913 6/1974 Wallach 128/305 Broadwin, Brooklyn, both of NY.

Sperber ration of the anterior chamber of the eye during ultrasonic emulsification of a cataract therein. The system comprises a handpiece with an (ultrasonically vibrated) hollow tip, the hollow tip being connected to the fluid withdrawal or aspirating portion, while an annular passage around the tip is used to introduce fluid for irrigation purposes. The aspirating portion comprises a withdrawal hose attached to the output manifold of the handpiece in fluid communication with the hollow tip, a constant flow pump attached to the other ehd of the withdrawal hose, and a vacuum relief valve connected to the withdrawal hose intermediate the pump and the handpiece. The irrigation portion comchamber of the eye during removal of a cataract by insertion of the handpiece tip into the eye chamber.

12 Claims, 2 Drawing Figures FLOW CONTROL SYSTEM BACKGROUND OF THE INVENTION This application relates to an improvement in the control of fluid flow in a surgical device. More particularly this invention relates to an improvement in the fluid flow systems for a surgical device useful in cataract removal such as that shown by U.S. Pat. No. 3,589,363 issued June 29, 1971 to A. Banko and C. D. Kelman for a Material Removal Apparatus and Method Employing High Frequency Vibrations. The aforesaid patent describes an instrument for breaking apart and removing unwanted tissue and material especially a cataract located in the anterior chamber of the eye by ultrasonically fragmenting the cataract while simultaneously introducing fluid into the eye chamber, and withdrawing the fluid and fragmented cataract particles. Briefly the device described includes a handpiece having an operative tip vibrating in the ultrasonic range which is also hollow and is in turn surrounded by a tubular sleeve. In operation the tip of the handpiece including the surrounding tubular sleeve are inserted into the anterior chamber of the eye. Treatment fluid is introduced through the hollow sleeve at a constant low pressure. This introduction of fluid which is called irrigation is to provide a replacement for fluid withdrawn or lost from the eye chamber. The withdrawl of fluid and suspended material from the anterior chamber is specifically called aspiration and ideally there is no change in fluid content or anterior chamber pressure as a result of irrigation-aspiration. This of course is impossible to achieve since aspiration is intended to remove solids which until broken up sometimes tend to occlude or block the fluid withdrawal openings of the handpiece.

This problem with control of fluid content and pressure within the anterior chamber of the eye during irrigation-aspiration is discussed in detail in U.S. Pat. No. 3,693,613 issued Sept. 26, 1972 to Charles Kelman for a Surgical Handpiece and Flow Control System for Use Therewith, and commonly assigned herewith.

A handpiece described in the aforesaid U.S. Pat. as well as the instrumentation described in U.S. Pat. No. 3,589,363 provides a tool tip insertable in the anterior chamber of the eye with an annular nozzle for supply of fluid for irrigation, a hollow tool tip which is vibrated at about 40,000 cps to provide the energy to break up the cataract and allow fluid withdrawal for aspirating the reduced particles and fluid. When the handpiece is inserted into the eye, it is extremely important to maintain the fluid pressure of the chamber within a certain range and to prevent rapid fluctuations of the pressure and fluid content of the chamber. A collapse of the anterior chamber for lack of sufficient pressure could result in damage to soft tissues of the eye as well as possible damage of the eye posterior capsule itself from contact of the tissues with the vibrating tool tip. This problem of maintaining the proper pressure is a particularly difficult and sensitive one and is one of the problems which the apparatus shown in the aforesaid U.S. Pat. No. 3.693.613 was designed to solve. The system shown therein while satisfactory is quite obviously a rather complex apparatus which requires in terms of control, close and competent operation personnel. Thus as part of the operation to remove a cataract from the anterior chamber of the eye the handpiece is inserted into the chamber through a small incision and the fluid flow adjusted to the desired level principally by the height at which the irrigation fluid source is supported to provide a gravity flow into the eye, and the speed of a constant flow positive displacement pump in the piping from the eye to withdraw the aspirating stream. The surgeon then moves the cataract lens into the anterior chamber, applies the ultrasonic vibration to the tip of the handpiece in contact with the lens and proceeds to break up the lens.

As part of the application of the tip to the lens the opening in the tip through which aspiration proceeds is periodically occluded by lens material. During such occlusion, fluid is prevented from entering the hollow tip, although the constant flow pump continues to operate. The pump operation thus starts drawing a vacuum in the conduit between the handpiece tip and the pump. At the same time, the pressure from the gravity feed of irrigation fluid into the eye remains constant and increases fluid pressure in the anterior chamber of they eye, expanding it somewhat. However once the opening into the handpiece tip is uncapped by fragmentation of the occlusion, the high vacuum existing in the aspirating system tends to quickly withdraw fluid from the anterior chamber. This may rapidly decompress the anterior chamber and draw the enclosing tissues towards the handpiece tip. Besides the danger represented by the ultrasonic vibrations of the handpiece tip on contact with these tissues, the rapid decompression itself may be injurious to the tissues. The apparatus shown by the aforesaid U.S. Pat. No. 3,693,613 of course is designed to eliminate such pertubrations to the eye by monitoring and controlling flow. It would be advantageous to have a system which is not only failsafe by means of being simple rather than complex, but is also more easily regulated and controlled by normal operative personnel rather than trained technicians.

SUMMARY OF THE INVENTION Accordingly we have invented a fluidic flow system for use in the irrigation and aspiration ofa small elastic pressure responsive chamber. The system comprises: a fluid source under substantially constant pressure; fluid inflow means connected to the fluid source for limiting flow of the fluid from the source into the chamber thereby providing irrigation fluid at a predetermined limited flow rate and pressure into the chamber; fluid withdrawal means in fluid communication with the chamber for aspirating fluid from the chamber at a rate to eliminate transient pressure shocks to the chamber; a constant flow pump connected to the other end of the fluid withdrawal means, with the pump acting to draw fluid from the chamber through the withdrawal means; and the withdrawal means including a pressure differential relief valve intermediate the chamber and the pump, the relief valve responsively opening at a predetermined pressure differential which in combination with the parameters of the fluid withdrawal means limits the occurrence of pressure transients communicated to the chamber, whereby flow resistivity of the withdrawal means between the chamber and the valve attenuates the pressure changes transmitted to the chamber when the valve opens in response to the predetermined pressure differential between atmosphere and the pressure in the withdrawal means reaching the predetermined differential pressure. Preferably where the enclosed volume is the anterior chamber of the eye, the relief valve opens to atmosphere in response to a pressure differential of from 10 mm of mercury (Hg) to I mm Hg; the pressure of the fluid source is in the range of from to I00 mm Hg; the flow resistivity of the inflow means is from 0.042 to 18.5 mm Hg per ml per min; the flow resistivity of the fluid withdrawal means is from 0.35 to 21.5 mm Hg per ml per min; and the constant flow volume of the pump is from 5 to 50 ml per min. More particularly the preferred pressure, flow and flow resistivity ranges of the system according to the present invention comprise the following: a fluid source exerting a constant pressure of from 30 to 60 mm Hg; the inflow means having a flow resistivity of from 0.5 to 2.5 mm Hg. ml per min between the fluid source at one end and to the operative volume of the anterior chamber of an eye at the other end; the fluid withdrawal means having a flow resistivity of from 1.33 to 3.0 mm Hg. per ml per min. from the operative volume of the anterior chamber of the eye and to the atmosphere; the constant volume pump having a flow rate of from to ml per min; and the relief valve connected to the flow withdrawal means intermediate the pump and the eye chamber responsively opening the atmosphere at a pressure differential of between about 30 and 50 mm Hg.

It is therefore an object of this invention to provide a fluidic control system for use in irrigating and aspirating a small enclosed elastic volumetric space.

Another object of the present invention is to provide an effective flow control system for irrigating and aspirating the anterior chamber of the eye.

Yet another object of the present invention is to provide a flow control system for effectively limiting the transient pressure and flow changes as felt by the anterior chamber of the eye during irrigation and aspiration thereof.

Other objects and advantages of the system according to the present invention will be apparent from the brief description of the drawings and the preferred embodiment which follows.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 of the drawings is a diagram of the fluidic flow control system of the present invention; and

FIG. 2 of the drawings is an electrical circuit analog of the flow control system of FIG. 1.

DESCRIPTION OF THE PREFERRED EMBODIMENT In the US. Pat. No. 3,589,363 described hereinbefore and which is incorporated herein by reference. apparatus and method for the removal of material by employing high frequency vibration is shown and described. Briefly the aforesaid patent describes an instrument for breaking apart and removing unwanted material such as for surgically removing a cataract from the eye. The apparatus includes a handpiece having an operative tip vibrating at a frequency in the ultrasonic range (preferably about 40.000 cps) with an amplitude controllable up to several thousandths of an inch. The operative tip is itself hollow and is in turn surrounded by a tubular sleeve forming an annular passage. The inflow fluid for irrigating the anterior chamber of the eye is introduced into the chamber through the annular passage and the broken up material. small particles and fluid in the eye, is withdrawn at the same time through the hollow tip to aspirate the chamber.

Referring now to FIG. 1 of the drawings wherein a simplified diagram of a handpiece 12 is shown with an operative tip 14 having a hollow withdrawal means 16, and an annular passage 18 surrounding the tip 14 for introducing fluid into an anterior chamber 20 of an eye undergoing cataract surgery. For a more detailed description of the handpiece 12 described above. reference is made to the handpieces shown in the aforesaid US. Pat. Nos. 3.589.363 and 3.693.613 commonly assigned to the assignee herein.

Irrigation fluid is introduced into the handpiece 12 via an inflow hose 22 which is connected at one end to the handpiece and at the other end to an administration set 23. that is a hose connected to an irrigation fluid supply bottle 24 suspended by an appropriate bracket (not shown) a fixed height I: over the level of the hand piece and eye. The fixed height h at which the fluid supply bottle is suspended acts to apply a fixed fluid pressure to fluid entering the hose 22 from the bottle to the eye. The selected height is such as to apply a pressure of from about l0 mm Hg to about I00 mm Hg to fluid entering the administration set and thereby furnish a fluid source having a constant preselected pressure level in relation to the handpiece.

More preferably the height at which the supply bottle is suspended is such as to apply a pressure head of from 30 mm Hg to 60 mm Hg. According to the present invention, this is the sole means for supplying the pressure head which forces the flow of fluid from the bottle through the administration set 23, the inflow hose 22 and the annular passage of the handpiece into the anterior chamber of the eye.

For purposes of this invention the pressure which is internally applied to the eye is of prime importance. For instance. as described in US Pat. No. 3.693.613. it is very important that pressure of the anterior chamber of the eye be maintained within a certain range of values to prevent damage thereto. A collapse of the anterior chamber due to reduced pressure could result in either the iris. the endothelium layer of the cornea. or the posterior capsule as well as other soft tissue. coming in contact with the operating tip of the handpiece. This problem of maintaining the proper pressure is a particularly difficult and sensitive one in the case of an operative site such as the anterior chamber, which is considerably smaller in volume than the volume of fluid necessary for continuous irrigation and aspirationv The anterior chamber of the eye is. of course, in the same pressure related system as the apparatus of this invention. In a cataract operation, pressure transients are periodically being induced at the tip of the handpiece due to the presence of a particle or part of the cataract. This initially prevents entry of aspirating fluid into the tip with resulting buildup of suction in the tip. and then sudden clearance of the occlusion blocking the handpiece tip. The apparatus shown in the US. Pat. No. 3.693.613 is designed to reduce and overcome this problem and as such is effective though expensive and complicated.

Basically the present invention provides an irrigation system which limits the fluid pressure to which the anterior chamber of the eye is subject by limiting the height at which the irrigation fluid supply is maintained in reference to the eye, and by further limiting the flow rate into the eye utilizing specified inflow means having a specified resistivity to flow. as well as relating the irrigation system to the fluid withdrawal or aspiration system. That portion of the fluidic system comprising the fluid withdrawal means, the constant flow pump and the differential pressure relief valve act in combination to limit fluid flow from the eye, and more importantly prevent sudden pressure changes or pressure transients from occuring by increasing the time period over which the pressure changes occur and by limiting the maximum pressure drop to which theeye would be exposed. This is accomplished by controlling the constant flow rate of the pump; by setting a predetermined limit to the pressure differential, the relief valve will open to atmosphere; and by controlling the flow resistivity of the fluid piping as herein described.

Referring back to FIG. 1 of the drawing the operative tip 14 of the handpiece is hollow and has an internal fluid withdrawal passage 30 constituting part of the fluid withdrawal system of the present invention utilized in aspirating the operative site of the eye. A fluid withdrawal pipe 32 is connected to the handpiece at one end and is in fluid communication with the fluid withdrawal passage. The other end of the fluid withdrawal pipe is connected to a constant flow pump 34 preferably a constant displacement, variable speed, peristaltic pump. The peristaltic feature acts to avoid any contact of the operating parts with the withdrawn fluid suspension. Intermediate the pump 34 and the handpiece, a relief valve 36 is connected by a T joint 38 to the fluid withdrawal pipe and is set to open to atmosphere should the pressure differential in the fluid withdrawal pipe exceed a predetermined pressure, which pressure may be from 30 mm Hg to 50 mm Hg. Preferably the pressure differential at which the relief valve opens is a pressure of about 40 mm Hg. Constant flow capacity of the pump is preferably a flow of from about ml per min to ml per minute. Flow resistivity of the fluid withdrawal means at these preferred conditions is from about l.33 mm Hg to about 3.0 mm Hg. Flow resistivity in the fluid inflow system is on the order of from about 0.5 to about 2.5 mm Hg per ml per min.

We have therefore described an effective, economical system for irrigating and aspirating the anterior chamber of the eye during an operation involving the insertion of a handpiece through a small incision in the eye and during which parts of the eye such as a cataract are reduced by the action of an ultrasonically vibrating tip. With reference to further understanding the operation of our invention reference is now made to FIG. 2 of the drawing which shows the electrical analog circuit which led to the fluidic control system of this invention. it must be further understood that each part of our invention functions in relation to a moderately uncontrollable set of conditions imposed by the needs of the operative site, i.e., anterior chamber of human eye and the size of the operative incision. The conditions in the anterior chamber of the eye are analogized by two electrical elements which are a resistive element 44 to account for flow resistivity through the incision, and a capacitor 45 to correspond to elasticity of the eye chamber, both elements being in parallel and connected to ground at one end and at the other end to the inflow irrigation system and the fluid withdrawal system. The fluid inflow system is analogized by a constant voltage source 46 corresponding to the fluid supply bottle set at a specified height to provide a constant pressure head; administration set resistance 47 corresponding to the flow resistivity thereof; an inflow resistance 48 corresponding to flow resistivity of the inflow hosing, and a resistance 50 corresponding to the flow resistivity of the fluid inflow manifold of the handpiece. For the fluid withdrawal system a pipe resistance 52 corresponds to the resistivity imposed in the fluid withdrawal piping, and of the handpiece by outflow manifold resistance 54.

The relief valve is analogized by a diode 56 and a zener diode 58 back to back in series at one end to the fluid withdrawal pipe and at the other end to ground (or atmosphere). The constant flow pump is analogized by inserting a hypothetical electrical current element 60 acting as a constant current source. In terms of the electrical analogues of the fluid parameters, resistance (R) is equivalent to flow resistance in pressure terms; voltage (V) is equivalent to a pressure source in mm Hg; and current amperes (I) is equivalent to flow in ml per min. Utilizing the above analogy we have been able to-conceive and build our invention and relate various known conditions in determining the operative parameters which are described hereinbefore.

The system is able to accomplish the irrigationaspiration of the anterior chamber of the eye, while at the same time reducing transients introduced by occlusions of the fluid withdrawal or aspirating system. It can by seen be by our invention, we have provided a simplified though quite effective fluidic control system for use in conjunction with the operative system described herein and in the aforesaid U.S. Pat. No. 3,589,363 and which provides the safeguards, effectiveness, ease of use, and operative usefullness desired by the system shown in U.S. Pat. No. 3,693,613.

Our invention may be employed with certain modifications and variations. For instance, the irrigation portion of our system may be employed without the aspiration system. In this mode of employment flow of fluid into the eye is as previously described while flow of fluid out of the anterior chamber of the eye is through the opening or incision made therein for the insertion of the handpiece tip. A modification of the irrigation system is shown in the drawings in solid line, where a pressure means for relief of undue pressure head is employed. The pressure means comprises a pressure relief valve 39 connected to the inflow hose 22 by a tube 40. The pressure relief valve 39 is selected to prevent undue pressure from being applied through the irrigation system to the eye chamber. The analogous components shown in FIG. 2 of the drawings to such a pressure relief means incorporated in the irrigation system comprise a diode 64 connected to the circuit between resistors 48 and 50 and a zener diode 62 connected back to back with the diode 64. The zener diode anode is connected to ground (atmosphere). By this variation we are able to further limit the pressure which can be communicated to the eye chamber through the irrigation system.

Having thus described our preferred embodiment and wishing to cover those aspects of our invention which would be apparent to those skilled in the art, from the invention herein but without departing from either the spirit or scope thereof, we claim:

1. A fluidic flow system for use in irrigationaspiration of a small elastic pressure responsive chamber, said system compising a fluid source at a pressure of from about 10 to mm Hg, fluid inflow means connected to said fluid source and in fluid communication with said chamber for (introducing) conducting from said source into said chamber, thereby providing irrigation, said fluid inflow means having a flow resistivity of from about 0.42 to 18.5 mm. Hg. per ml per min, fluid withdrawal means in fluid communication with said chamber for aspirating fluid from said chamber, said fluid withdrawal means having a flow resistivity of from about 0.35 to 21.5 mm Hg. per ml per min., thereby aspirating said chamber at a rate to limit rapid pressure changes in said chamber, constant flow pump means connected to said fluid withdrawal means at a point remote from said chamber, said pump means having a flow rate of from about to 50 ml per min. and acting to draw fluid from said chamber into said fluid withdrawal means, and

pressure responsive valve means connected to said fluid withdrawal means intermediate said chamber and said pump means, said pressure responsive valve means opening said fluid withdrawal means to atmosphere at a predetermined pressure differential of between about and 100 min Hg. to thereby limit vacuum buildup in said fluid withdrawal means, said flow resistivities, flow rates and pressure differential act in combination to prevent excessive pressure and pressure transients in said chamber.

2. The fluidic flow system according to claim 1 wherein said chamber is the anterior chamber of the eye.

3. The fluid flow system according to claim 2 wherein said fluid supply pressure is about 45 mm Hg, the pressure response means opens at a pressure differential of about 40 mm Hg, said pump has a flow rate of about ml per min, the flow resistivity of said inflow means between said fluid source and said chamber opening is about 1.06 mm Hg per ml per min. and said fluid withdrawal means flow resistivity between said chamber and said pump is about 1.57 mm Hg per ml per min.

4. The fluidic flow system according to claim 1 wherein said fluid source pressure is in the range of from about to 60 mm Hg, said fluid inflow means has a flow resistivity of from about 0.5 to 2.5 mm Hg per ml per min. between said fluid source and said chamber, said fluid withdrawal means has a flow resistivity of from about 1.33 to 3.0 mm Hg per ml per min. between said chamber and said pump, said constant flow pump has a flow rate of from about 20 to 30 ml per min. and said pressure response means opens at a differential pressure between about 30 and 50 mm Hg.

5. The fluidic flow system according to claim 2 which additionally comprises a handpiece having an inflow manifold therethrough connected said fluid inflow means,

a hollow tip mounted on the distal portion of said handpiece, said hollow tip being in fluid communication with said fluid withdrawal means, and capable of being inserted into the chamber of the eye,

a fluid passage mounted adjacent said tip on said handpiece, said fluid passage being in fluid communication with said handpiece inflow manifold, said passage having an opening which is in fluid communication with the anterior chamber of the eye when the tip is inserted in the eye.

6. The fluidic flow system according to claim 5 wherein said hollow tip is ultrasonically vibrated.

7. The fluid flow system according to claim 6 wherein said fluid source is a fluid supply bottle supported at a 5 predetermined height about the level of the eye, thereby establishing a constant pressure, and said fluid inflow means comprises an administration set between said supply bottle and a fluid hose connected to said handpiece fluid inflow manifold.

10 8. The fluidic flow system according to claim 1 wherein said chamber is the anterior chamber of the eye, said eye chamber being characterized by being a small elastic pressure responsive volume, said system being further characterized by said fluid source applying a limited pressure of about mm Hg applied thereto to limit pressure imposed within the chamber of the eye,

9. A method of providing irrigationaspiration to a small elastic pressure responsive chamber, said method comprising,

supplying fluid to a chamber at a pressure of from about 30 to 60 mm Hg and a flow resistivity to said chamber of from about 0.5 to 2.5 mm Hg. per ml per min. pumping fluid from the chamber at a limited rate (into) through a flow withdrawal means at a flow rate of from about 5 to ml per min. subject to a flow resistivity of from about 0.35 to 21.5 mm Hg. per ml per min. responsively opening said flow withdrawal means to ambiant pressure in response to a per determined pressure differential of between about 10 and 100 mm Hg. between pressure on said withdrawal means and pressure. slowing fluid flow from the chamber in order to prevent pressure transmient from occuring between said flow withdrawal means and the chamber immediately after said opening. 10. The method of claim 9 wherein said step of pumping fluid from the chamber comprises applying a flow resistivity in the flow withdrawal means of from about 1.33 to 3.0 mm Hgs per ml per min. at a constant pumping rate of from about 20 to 30 ml per min. while simultaneously limiting 45 the pressure differential between about 30 and 50 mm Hg. 11. The method of claim 9 including the step of supplying fluid to the anterior chamber of the eye.

12. A method of providing irrigation-aspiration to the 50 anterior chamber of the eye, said method comprising, supplying fluid to said chamber at a pressure of about 45 mm Hg. and a flow resistivity to said chamber of 1 mm Hg. per ml per min. pumping fluid from the chamber at a limited rate through a flow withdrawal means at a flow rate of about 25 ml per min.

subject to a flow resistivity of about 1.6 mm Hg. per ml per min.

responsively opening said flow withdrawal means to ambiant pressure in response to a predetermined pressure differential of about 40 mm Hg. between pressure on said withdrawal means and ambi nt pressure.

Claims (12)

1. A fluidic flow system for use in irrigation-aspiration of a small elastic pressure responsive chamber, said system compising a fluid source at a pressure of from about 10 to 100 mm Hg, fluid inflow means connected to said fluid source and in fluid communication with said chamber for (introducing) conducting from said source into said chamber, thereby providing irrigation, said fluid inflow means having a flow resistivity of from about 0.42 to 18.5 mm. Hg. per ml per min, fluid withdrawal means in fluid communication with said chamber for aspirating fluid from said chamber, said fluid withdrawal means having a flow resistivity of from about 0.35 to 21.5 mm Hg. per ml per min., thereby aspirating said chamber at a rate to limit rapid pressure changes in said chamber, constant flow pump means connected to said fluid withdrawal means at a point remote from said chamber, said pump means having a flow rate of from about 5 to 50 ml per min. and acting to draw fluid from said chamber into said fluid withdrawal means, and pressure responsive valve means connected to said fluid withdrawal means intermediate said chamber and said pump means, said pressure responsivE valve means opening said fluid withdrawal means to atmosphere at a predetermined pressure differential of between about 10 and 100 min Hg. to thereby limit vacuum buildup in said fluid withdrawal means, said flow resistivities, flow rates and pressure differential act in combination to prevent excessive pressure and pressure transients in said chamber.
2. The fluidic flow system according to claim 1 wherein said chamber is the anterior chamber of the eye.
3. The fluid flow system according to claim 2 wherein said fluid supply pressure is about 45 mm Hg, the pressure response means opens at a pressure differential of about 40 mm Hg, said pump has a flow rate of about 25 ml per min, the flow resistivity of said inflow means between said fluid source and said chamber opening is about 1.06 mm Hg per ml per min. and said fluid withdrawal means flow resistivity between said chamber and said pump is about 1.57 mm Hg per ml per min.
4. The fluidic flow system according to claim 1 wherein said fluid source pressure is in the range of from about 30 to 60 mm Hg, said fluid inflow means has a flow resistivity of from about 0.5 to 2.5 mm Hg per ml per min. between said fluid source and said chamber, said fluid withdrawal means has a flow resistivity of from about 1.33 to 3.0 mm Hg per ml per min. between said chamber and said pump, said constant flow pump has a flow rate of from about 20 to 30 ml per min. and said pressure response means opens at a differential pressure between about 30 and 50 mm Hg.
5. The fluidic flow system according to claim 2 which additionally comprises a handpiece having an inflow manifold therethrough connected said fluid inflow means, a hollow tip mounted on the distal portion of said handpiece, said hollow tip being in fluid communication with said fluid withdrawal means, and capable of being inserted into the chamber of the eye, a fluid passage mounted adjacent said tip on said handpiece, said fluid passage being in fluid communication with said handpiece inflow manifold, said passage having an opening which is in fluid communication with the anterior chamber of the eye when the tip is inserted in the eye.
6. The fluidic flow system according to claim 5 wherein said hollow tip is ultrasonically vibrated.
7. The fluid flow system according to claim 6 wherein said fluid source is a fluid supply bottle supported at a predetermined height about the level of the eye, thereby establishing a constant pressure, and said fluid inflow means comprises an administration set between said supply bottle and a fluid hose connected to said handpiece fluid inflow manifold.
8. The fluidic flow system according to claim 1 wherein said chamber is the anterior chamber of the eye, said eye chamber being characterized by being a small elastic pressure responsive volume, said system being further characterized by said fluid source applying a limited pressure of about 45 mm Hg applied thereto to limit pressure imposed within the chamber of the eye,
9. A method of providing irrigationaspiration to a small elastic pressure responsive chamber, said method comprising, supplying fluid to a chamber at a pressure of from about 30 to 60 mm Hg and a flow resistivity to said chamber of from about 0.5 to 2.5 mm Hg. per ml per min. pumping fluid from the chamber at a limited rate (into) through a flow withdrawal means at a flow rate of from about 5 to 50 ml per min. subject to a flow resistivity of from about 0.35 to 21.5 mm Hg. per ml per min. responsively opening said flow withdrawal means to ambiant pressure in response to a per determined pressure differential of between about 10 and 100 mm Hg. between pressure on said withdrawal means and pressure. slowing fluid flow from the chamber in order to prevent pressure transmient from occUring between said flow withdrawal means and the chamber immediately after said opening.
10. The method of claim 9 wherein said step of pumping fluid from the chamber comprises applying a flow resistivity in the flow withdrawal means of from about 1.33 to 3.0 mm Hgs per ml per min. at a constant pumping rate of from about 20 to 30 ml per min. while simultaneously limiting the pressure differential between about 30 and 50 mm Hg.
11. The method of claim 9 including the step of supplying fluid to the anterior chamber of the eye.
12. A method of providing irrigation-aspiration to the anterior chamber of the eye, said method comprising, supplying fluid to said chamber at a pressure of about 45 mm Hg. and a flow resistivity to said chamber of 1 mm Hg. per ml per min. pumping fluid from the chamber at a limited rate through a flow withdrawal means at a flow rate of about 25 ml per min. subject to a flow resistivity of about 1.6 mm Hg. per ml per min. responsively opening said flow withdrawal means to ambiant pressure in response to a predetermined pressure differential of about 40 mm Hg. between pressure on said withdrawal means and ambiant pressure.
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Cited By (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4011870A (en) * 1976-03-05 1977-03-15 Michael Goldstein Needle instrument
US4014333A (en) * 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4033349A (en) * 1976-04-13 1977-07-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Corneal seal device
US4041947A (en) * 1974-01-28 1977-08-16 Cavitron Corporation Flow control system
US4056855A (en) * 1976-04-07 1977-11-08 Charles Kelman Intraocular lens and method of implanting same
US4136700A (en) * 1975-03-05 1979-01-30 Cavitron Corporation Neurosonic aspirator
FR2401656A1 (en) * 1977-08-31 1979-03-30 Nasa ophthalmic Method for treating an eye with glaucoma
FR2474857A1 (en) * 1980-02-06 1981-08-07 Boutmy Ets Multipurpose surgical probe - has fluid inlet pipes and pipes for withdrawal of waste fluid from operating site
US4314560A (en) * 1979-11-28 1982-02-09 Helfgott Maxwell A Powered handpiece for endophthalmic surgery
US4363326A (en) * 1980-12-22 1982-12-14 Advanced Diagnostic Research Corporation Ultrasonic apparatus for needle insertion
US4493694A (en) * 1980-10-17 1985-01-15 Cooper Lasersonics, Inc. Surgical pre-aspirator
US4504264A (en) * 1982-09-24 1985-03-12 Kelman Charles D Apparatus for and method of removal of material using ultrasonic vibraton
US4516398A (en) * 1980-10-08 1985-05-14 Cooper Lasersonics, Inc. Method of use of an ultrasonic surgical pre-aspirator having a orifice by-pass
US4650461A (en) * 1985-06-10 1987-03-17 Woods Randall L Extracapasular cortex irrigation and extraction
US4670006A (en) * 1984-10-16 1987-06-02 Sinnett Kevin B Fluid and air infusion device
US4689040A (en) * 1985-04-29 1987-08-25 Thompson Robert J Tip for a phacoemulsification needle
US4750902A (en) * 1985-08-28 1988-06-14 Sonomed Technology, Inc. Endoscopic ultrasonic aspirators
US4750488A (en) * 1986-05-19 1988-06-14 Sonomed Technology, Inc. Vibration apparatus preferably for endoscopic ultrasonic aspirator
US4832685A (en) * 1985-06-05 1989-05-23 Coopervision, Inc. Fluid flow control system and connecting fitting therefor
US4921477A (en) * 1987-10-14 1990-05-01 The Cooper Companies, Inc. Surgical irrigation and aspiration system with dampening device
US4921476A (en) * 1980-10-08 1990-05-01 Cavitron, Inc. Method for preventing clogging of a surgical aspirator
US4922902A (en) * 1986-05-19 1990-05-08 Valleylab, Inc. Method for removing cellular material with endoscopic ultrasonic aspirator
US4924851A (en) * 1988-01-05 1990-05-15 Societe Dite Sinergy S.A. Surgical apparatus
US4935005A (en) * 1985-06-05 1990-06-19 Nestle, S.A. Opthalmic fluid flow control system
US5084012A (en) * 1991-03-22 1992-01-28 Kelman Charles D Apparatus and method for irrigation and aspiration of interior regions of the human eye
US5160317A (en) * 1991-01-03 1992-11-03 Costin John A Computer controlled smart phacoemulsification method and apparatus
US5185002A (en) * 1991-06-28 1993-02-09 Alcon Surgical, Inc. Transducer apparatus having water hammer dampening means
US5197947A (en) * 1991-10-24 1993-03-30 University Of New Mexico Powered clysis and clyser
US5279547A (en) * 1991-01-03 1994-01-18 Alcon Surgical Inc. Computer controlled smart phacoemulsification method and apparatus
US5318570A (en) * 1989-01-31 1994-06-07 Advanced Osseous Technologies, Inc. Ultrasonic tool
US5324297A (en) * 1989-01-31 1994-06-28 Advanced Osseous Technologies, Inc. Ultrasonic tool connector
US5328456A (en) * 1990-11-13 1994-07-12 Nidek Co., Ltd. Irrigation and aspiration apparatus
US5370602A (en) * 1992-09-04 1994-12-06 American Cyanamid Company Phacoemulsification probe circuit with pulse width Modulating drive
US5382251A (en) * 1989-01-31 1995-01-17 Biomet, Inc. Plug pulling method
US5417654A (en) * 1994-02-02 1995-05-23 Alcon Laboratories, Inc. Elongated curved cavitation-generating tip for disintegrating tissue
US5476448A (en) * 1994-10-19 1995-12-19 Urich; Alex Apparatus for suppressing a vacuum surge in eye surgery
US5562612A (en) * 1995-02-02 1996-10-08 Charles D. Kelman Apparatus and method for reverse flow irrigation and aspiration of interior regions of the human eye
US5685841A (en) * 1995-08-14 1997-11-11 Mackool; Richard J. Support for fluid infusion tube for use during eye surgery
US5722945A (en) * 1990-07-17 1998-03-03 Aziz Yehia Anis Removal of tissue
US5827292A (en) * 1990-07-17 1998-10-27 Anis; Aziz Yehia Removal of tissue
US5921999A (en) * 1997-06-03 1999-07-13 Dileo; Frank System and method employing a pie-zoelectric crystal and transverse oscillation to perform a capsulotomy
US5941887A (en) * 1996-09-03 1999-08-24 Bausch & Lomb Surgical, Inc. Sleeve for a surgical instrument
US5984904A (en) * 1996-08-22 1999-11-16 Bausch & Lomb Surgical, Inc. Sleeve for a surgical instrument
US6013048A (en) * 1997-11-07 2000-01-11 Mentor Corporation Ultrasonic assisted liposuction system
US6203516B1 (en) 1996-08-29 2001-03-20 Bausch & Lomb Surgical, Inc. Phacoemulsification device and method for using dual loop frequency and power control
US6283937B1 (en) * 1998-06-30 2001-09-04 Nidek Co. Ltd. Irrigation/aspiration apparatus
WO2001070152A1 (en) * 2000-03-23 2001-09-27 Graham David Barrett An aspiration flow modulation device
US6352519B1 (en) 1990-07-17 2002-03-05 Aziz Yehia Anis Removal of tissue
US6599271B1 (en) 1999-04-13 2003-07-29 Syntec, Inc. Ophthalmic flow converter
US20040000187A1 (en) * 2002-06-28 2004-01-01 Mitsuyuki Kobayashi Evaporative emission leak detection system with brushless motor
US6702761B1 (en) 2000-03-06 2004-03-09 Fonar Corporation Vibration assisted needle device
US20050209561A1 (en) * 2004-03-22 2005-09-22 Raphael Gordon Method of detecting surgical events
US20050209560A1 (en) * 2004-03-22 2005-09-22 Alcon, Inc. Method of controlling a surgical system based on a rate of change of an operating parameter
US20050228425A1 (en) * 2004-03-22 2005-10-13 Alcon, Inc. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20050267504A1 (en) * 2004-03-22 2005-12-01 Alcon, Inc. Method of controlling a surgical system based on irrigation flow
US20050277869A1 (en) * 2004-03-22 2005-12-15 Alcon, Inc. Method of operating an ultrasound handpiece
US20060036180A1 (en) * 2004-08-12 2006-02-16 Mikhail Boukhny Ultrasonic handpiece
US20060041220A1 (en) * 2004-08-12 2006-02-23 Alcon, Inc. Ultrasound handpiece
US20060058811A1 (en) * 2002-06-21 2006-03-16 Makoto Kishimoto Decompression-compensating instrument for ocular surgery, instrument for ocular surgery provided with same and method of ocular surgery
US20060078448A1 (en) * 2004-10-11 2006-04-13 Holden Hugo R Phacoemulsification machine with post-occlusion surge control system and related method
US20060224163A1 (en) * 2005-03-30 2006-10-05 Sutton Thomas B Phaco aspiration flow restrictor with bypass tube
US20080172076A1 (en) * 2006-11-01 2008-07-17 Alcon, Inc. Ultrasound apparatus and method of use
US20080281253A1 (en) * 2007-05-10 2008-11-13 Injev Valentine P Method of Operating an Ultrasound Handpiece
US20080319374A1 (en) * 2007-06-19 2008-12-25 Jaime Zacharias Post-occlusion chamber collapse canceling system for a surgical apparatus and method of use
US20090163852A1 (en) * 2007-12-20 2009-06-25 Cull Laurence J Surgical System Having Means for Isolating Vacuum Pump
US20090163863A1 (en) * 2007-12-20 2009-06-25 Mark Ian Lutwyche Surgical System Having Means for Stopping Vacuum Pump
US20100036256A1 (en) * 2008-08-08 2010-02-11 Mikhail Boukhny Offset ultrasonic hand piece
US20100094321A1 (en) * 2008-10-10 2010-04-15 Takayuki Akahoshi Ultrasound Handpiece
US20100324581A1 (en) * 2006-12-08 2010-12-23 Alcon, Inc. Torsional Ultrasound Hand Piece That Eliminates Chatter
US20110071415A1 (en) * 2009-03-13 2011-03-24 Atrium Medical Corporation Pleural drainage system and method of use
US20110137232A1 (en) * 2009-12-09 2011-06-09 Alcon Research, Ltd. Thermal Management Algorithm For Phacoemulsification System
US8246579B2 (en) 2007-12-20 2012-08-21 Bausch & Lomb Incorporated Surgical system having means for pressurizing venting valve
US8277830B2 (en) 2009-01-29 2012-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
US8414605B2 (en) 2011-07-08 2013-04-09 Alcon Research, Ltd. Vacuum level control of power for phacoemulsification hand piece
US8486052B2 (en) 2001-06-12 2013-07-16 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
US8623040B2 (en) 2009-07-01 2014-01-07 Alcon Research, Ltd. Phacoemulsification hook tip
USD698019S1 (en) 2013-03-05 2014-01-21 Alcon Research, Ltd. Ophthalmic surgical cassette
US8784357B2 (en) 2010-09-15 2014-07-22 Alcon Research, Ltd. Phacoemulsification hand piece with two independent transducers
US20140221909A1 (en) * 2013-01-14 2014-08-07 R. Ashley Burrow Surgical Aspiration and Irrigation
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8992493B2 (en) 2009-03-13 2015-03-31 Atrium Medical Corporation Chest drainage systems and methods
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9549850B2 (en) 2013-04-26 2017-01-24 Novartis Ag Partial venting system for occlusion surge mitigation
US9561321B2 (en) 2011-12-08 2017-02-07 Alcon Research, Ltd. Selectively moveable valve elements for aspiration and irrigation circuits
US9883968B2 (en) 2011-09-16 2018-02-06 Forsight Vision4, Inc. Fluid exchange apparatus and methods
US9931268B2 (en) 2014-09-12 2018-04-03 Kci Licensing, Inc. Reduced pressure treatment system having blockage clearing and dual-zone pressure protection capabilities

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5897524A (en) 1997-03-24 1999-04-27 Wortrich; Theodore S. Compact cassette for ophthalmic surgery
US6561999B1 (en) 2000-09-29 2003-05-13 Alcon Universal Ltd. Surgical cassette and consumables for combined ophthalmic surgical procedure
US7713237B2 (en) 2005-09-28 2010-05-11 Alcon, Inc. Surgical cassette for intraocular pressure control
US7326183B2 (en) 2005-09-28 2008-02-05 Alcon, Inc. Intraocular pressure control
US9119699B2 (en) 2012-10-22 2015-09-01 Alcon Research, Ltd. Pressure control in phacoemulsification system
US9119701B2 (en) 2012-10-22 2015-09-01 Alcon Research, Ltd. Pressure control in phacoemulsification system

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3693613A (en) * 1970-12-09 1972-09-26 Cavitron Corp Surgical handpiece and flow control system for use therewith
US3732858A (en) * 1968-09-16 1973-05-15 Surgical Design Corp Apparatus for removing blood clots, cataracts and other objects from the eye
US3736938A (en) * 1971-11-15 1973-06-05 Nasa Ophthalmic method and apparatus
US3776238A (en) * 1971-08-24 1973-12-04 Univ California Ophthalmic instrument
US3809093A (en) * 1972-04-14 1974-05-07 S Abraham Surgical tool
US3812855A (en) * 1971-12-15 1974-05-28 Surgical Design Corp System for controlling fluid and suction pressure
US3815604A (en) * 1972-06-19 1974-06-11 Malley C O Apparatus for intraocular surgery
US3818913A (en) * 1972-08-30 1974-06-25 M Wallach Surgical apparatus for removal of tissue

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732858A (en) * 1968-09-16 1973-05-15 Surgical Design Corp Apparatus for removing blood clots, cataracts and other objects from the eye
US3693613A (en) * 1970-12-09 1972-09-26 Cavitron Corp Surgical handpiece and flow control system for use therewith
US3776238A (en) * 1971-08-24 1973-12-04 Univ California Ophthalmic instrument
US3736938A (en) * 1971-11-15 1973-06-05 Nasa Ophthalmic method and apparatus
US3812855A (en) * 1971-12-15 1974-05-28 Surgical Design Corp System for controlling fluid and suction pressure
US3809093A (en) * 1972-04-14 1974-05-07 S Abraham Surgical tool
US3815604A (en) * 1972-06-19 1974-06-11 Malley C O Apparatus for intraocular surgery
US3818913A (en) * 1972-08-30 1974-06-25 M Wallach Surgical apparatus for removal of tissue

Cited By (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4041947A (en) * 1974-01-28 1977-08-16 Cavitron Corporation Flow control system
US4136700A (en) * 1975-03-05 1979-01-30 Cavitron Corporation Neurosonic aspirator
US4014333A (en) * 1975-09-22 1977-03-29 Mcintyre David J Instrument for aspirating and irrigating during ophthalmic surgery
US4011870A (en) * 1976-03-05 1977-03-15 Michael Goldstein Needle instrument
US4056855A (en) * 1976-04-07 1977-11-08 Charles Kelman Intraocular lens and method of implanting same
US4033349A (en) * 1976-04-13 1977-07-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Corneal seal device
FR2401656A1 (en) * 1977-08-31 1979-03-30 Nasa ophthalmic Method for treating an eye with glaucoma
US4184491A (en) * 1977-08-31 1980-01-22 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Intra-ocular pressure normalization technique and equipment
US4314560A (en) * 1979-11-28 1982-02-09 Helfgott Maxwell A Powered handpiece for endophthalmic surgery
FR2474857A1 (en) * 1980-02-06 1981-08-07 Boutmy Ets Multipurpose surgical probe - has fluid inlet pipes and pipes for withdrawal of waste fluid from operating site
US4516398A (en) * 1980-10-08 1985-05-14 Cooper Lasersonics, Inc. Method of use of an ultrasonic surgical pre-aspirator having a orifice by-pass
US4921476A (en) * 1980-10-08 1990-05-01 Cavitron, Inc. Method for preventing clogging of a surgical aspirator
US4493694A (en) * 1980-10-17 1985-01-15 Cooper Lasersonics, Inc. Surgical pre-aspirator
US4363326A (en) * 1980-12-22 1982-12-14 Advanced Diagnostic Research Corporation Ultrasonic apparatus for needle insertion
US4504264A (en) * 1982-09-24 1985-03-12 Kelman Charles D Apparatus for and method of removal of material using ultrasonic vibraton
US4670006A (en) * 1984-10-16 1987-06-02 Sinnett Kevin B Fluid and air infusion device
US4689040A (en) * 1985-04-29 1987-08-25 Thompson Robert J Tip for a phacoemulsification needle
US4832685A (en) * 1985-06-05 1989-05-23 Coopervision, Inc. Fluid flow control system and connecting fitting therefor
US4935005A (en) * 1985-06-05 1990-06-19 Nestle, S.A. Opthalmic fluid flow control system
US4650461A (en) * 1985-06-10 1987-03-17 Woods Randall L Extracapasular cortex irrigation and extraction
US4750902A (en) * 1985-08-28 1988-06-14 Sonomed Technology, Inc. Endoscopic ultrasonic aspirators
US5334183A (en) * 1985-08-28 1994-08-02 Valleylab, Inc. Endoscopic electrosurgical apparatus
US4750488A (en) * 1986-05-19 1988-06-14 Sonomed Technology, Inc. Vibration apparatus preferably for endoscopic ultrasonic aspirator
US4922902A (en) * 1986-05-19 1990-05-08 Valleylab, Inc. Method for removing cellular material with endoscopic ultrasonic aspirator
US4921477A (en) * 1987-10-14 1990-05-01 The Cooper Companies, Inc. Surgical irrigation and aspiration system with dampening device
US4924851A (en) * 1988-01-05 1990-05-15 Societe Dite Sinergy S.A. Surgical apparatus
US5318570A (en) * 1989-01-31 1994-06-07 Advanced Osseous Technologies, Inc. Ultrasonic tool
US5324297A (en) * 1989-01-31 1994-06-28 Advanced Osseous Technologies, Inc. Ultrasonic tool connector
US5382251A (en) * 1989-01-31 1995-01-17 Biomet, Inc. Plug pulling method
US6352519B1 (en) 1990-07-17 2002-03-05 Aziz Yehia Anis Removal of tissue
US5722945A (en) * 1990-07-17 1998-03-03 Aziz Yehia Anis Removal of tissue
US5827292A (en) * 1990-07-17 1998-10-27 Anis; Aziz Yehia Removal of tissue
US5328456A (en) * 1990-11-13 1994-07-12 Nidek Co., Ltd. Irrigation and aspiration apparatus
US5279547A (en) * 1991-01-03 1994-01-18 Alcon Surgical Inc. Computer controlled smart phacoemulsification method and apparatus
US5160317A (en) * 1991-01-03 1992-11-03 Costin John A Computer controlled smart phacoemulsification method and apparatus
US5520633A (en) * 1991-01-03 1996-05-28 Costin; John A. Computer controlled smart phacoemulsification method and apparatus
US5084012A (en) * 1991-03-22 1992-01-28 Kelman Charles D Apparatus and method for irrigation and aspiration of interior regions of the human eye
WO1992016246A1 (en) * 1991-03-22 1992-10-01 Kelman Charles D Apparatus, method for eye irrigation and aspiration
US5185002A (en) * 1991-06-28 1993-02-09 Alcon Surgical, Inc. Transducer apparatus having water hammer dampening means
US5197947A (en) * 1991-10-24 1993-03-30 University Of New Mexico Powered clysis and clyser
US5370602A (en) * 1992-09-04 1994-12-06 American Cyanamid Company Phacoemulsification probe circuit with pulse width Modulating drive
US5417654A (en) * 1994-02-02 1995-05-23 Alcon Laboratories, Inc. Elongated curved cavitation-generating tip for disintegrating tissue
US5476448A (en) * 1994-10-19 1995-12-19 Urich; Alex Apparatus for suppressing a vacuum surge in eye surgery
US5562612A (en) * 1995-02-02 1996-10-08 Charles D. Kelman Apparatus and method for reverse flow irrigation and aspiration of interior regions of the human eye
US5685841A (en) * 1995-08-14 1997-11-11 Mackool; Richard J. Support for fluid infusion tube for use during eye surgery
US5984904A (en) * 1996-08-22 1999-11-16 Bausch & Lomb Surgical, Inc. Sleeve for a surgical instrument
US6203516B1 (en) 1996-08-29 2001-03-20 Bausch & Lomb Surgical, Inc. Phacoemulsification device and method for using dual loop frequency and power control
US5941887A (en) * 1996-09-03 1999-08-24 Bausch & Lomb Surgical, Inc. Sleeve for a surgical instrument
US5921999A (en) * 1997-06-03 1999-07-13 Dileo; Frank System and method employing a pie-zoelectric crystal and transverse oscillation to perform a capsulotomy
US6013048A (en) * 1997-11-07 2000-01-11 Mentor Corporation Ultrasonic assisted liposuction system
US6283937B1 (en) * 1998-06-30 2001-09-04 Nidek Co. Ltd. Irrigation/aspiration apparatus
US6599271B1 (en) 1999-04-13 2003-07-29 Syntec, Inc. Ophthalmic flow converter
US6702761B1 (en) 2000-03-06 2004-03-09 Fonar Corporation Vibration assisted needle device
US7008383B1 (en) 2000-03-06 2006-03-07 Fonar Corporation Method of conducting a needle biopsy procedure
US20030078591A1 (en) * 2000-03-23 2003-04-24 Barrett Graham David Aspiration flow modulation device
US7357779B2 (en) 2000-03-23 2008-04-15 Graham David Barrett Aspiration flow modulation device
WO2001070152A1 (en) * 2000-03-23 2001-09-27 Graham David Barrett An aspiration flow modulation device
US9522082B2 (en) 2001-06-12 2016-12-20 The Johns Hopkins University Reservoir device for intraocular drug delivery
US8486052B2 (en) 2001-06-12 2013-07-16 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US9180046B2 (en) 2001-06-12 2015-11-10 The Johns Hopkins University School Of Medicine Reservoir device for intraocular drug delivery
US7303566B2 (en) * 2002-06-21 2007-12-04 Makoto Kishimoto Decompression-compensating instrument for ocular surgery, instrument for ocular surgery provided with the same and method of ocular surgery
US20060058811A1 (en) * 2002-06-21 2006-03-16 Makoto Kishimoto Decompression-compensating instrument for ocular surgery, instrument for ocular surgery provided with same and method of ocular surgery
US20040000187A1 (en) * 2002-06-28 2004-01-01 Mitsuyuki Kobayashi Evaporative emission leak detection system with brushless motor
US8523812B2 (en) 2004-03-22 2013-09-03 Alcon Research, Ltd. Method of controlling a surgical system based on a rate of change of an operating parameter
US9282989B2 (en) 2004-03-22 2016-03-15 Novartis Ag Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20100130914A1 (en) * 2004-03-22 2010-05-27 Alcon, Inc. Method Of Controlling A Surgical System Based On Irrigation Flow
US20050277869A1 (en) * 2004-03-22 2005-12-15 Alcon, Inc. Method of operating an ultrasound handpiece
US20050267504A1 (en) * 2004-03-22 2005-12-01 Alcon, Inc. Method of controlling a surgical system based on irrigation flow
US20050261715A1 (en) * 2004-03-22 2005-11-24 Alcon, Inc. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20050261628A1 (en) * 2004-03-22 2005-11-24 Alcon, Inc. Method of controlling a surgical system based on a rate of change of an operating parameter
US20050228425A1 (en) * 2004-03-22 2005-10-13 Alcon, Inc. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US8974412B2 (en) 2004-03-22 2015-03-10 Novartis Ag Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20050209560A1 (en) * 2004-03-22 2005-09-22 Alcon, Inc. Method of controlling a surgical system based on a rate of change of an operating parameter
US8430838B2 (en) 2004-03-22 2013-04-30 Novartis Ag Method of controlling a surgical system based on irrigation flow
US7727193B2 (en) 2004-03-22 2010-06-01 Alcon, Inc. Method of controlling a surgical system based on a rate of change of an operating parameter
US8403851B2 (en) 2004-03-22 2013-03-26 Novartis Ag Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20050209561A1 (en) * 2004-03-22 2005-09-22 Raphael Gordon Method of detecting surgical events
US7625388B2 (en) 2004-03-22 2009-12-01 Alcon, Inc. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US20090306583A1 (en) * 2004-03-22 2009-12-10 Mikhail Boukhny Method of Operating An Ultrasound Handpiece
US8257307B2 (en) 2004-03-22 2012-09-04 Alcon Research, Ltd. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US8172786B2 (en) 2004-03-22 2012-05-08 Alcon Research, Ltd. Method of operating an ultrasound handpiece
US7645255B2 (en) 2004-03-22 2010-01-12 Alcon, Inc. Method of controlling a surgical system based on irrigation flow
US8048020B2 (en) 2004-03-22 2011-11-01 Alcon, Inc. Method of controlling a surgical system based on irrigation flow
US20100036406A1 (en) * 2004-03-22 2010-02-11 Alcon, Inc. Method of Controlling a Surgical System Based on a Load on the Cutting Tip of a Handpiece
US7811255B2 (en) 2004-03-22 2010-10-12 Alcon, Inc. Method of controlling a surgical system based on a rate of change of an operating parameter
US7758538B2 (en) 2004-03-22 2010-07-20 Alcon, Inc. Method of controlling a surgical system based on irrigation flow
US7713202B2 (en) 2004-03-22 2010-05-11 Alcon, Inc. Method of controlling a surgical system based on a load on the cutting tip of a handpiece
US7572242B2 (en) 2004-03-22 2009-08-11 Alcon, Inc. Method of operating an ultrasound handpiece
US20110015563A1 (en) * 2004-03-22 2011-01-20 Alcon, Inc. Method Of Controlling A Surgical System Based On A Rate Of Change Of An Operating Parameter
US8771301B2 (en) 2004-08-12 2014-07-08 Alcon Research, Ltd. Ultrasonic handpiece
US8814894B2 (en) 2004-08-12 2014-08-26 Novartis Ag Ultrasound handpiece
US7645256B2 (en) 2004-08-12 2010-01-12 Alcon, Inc. Ultrasound handpiece
US20060036180A1 (en) * 2004-08-12 2006-02-16 Mikhail Boukhny Ultrasonic handpiece
US20060041220A1 (en) * 2004-08-12 2006-02-23 Alcon, Inc. Ultrasound handpiece
US7651490B2 (en) 2004-08-12 2010-01-26 Alcon, Inc. Ultrasonic handpiece
US20100004585A1 (en) * 2004-08-12 2010-01-07 Mikhail Boukhny Ultrasonic Handpiece
US20060078448A1 (en) * 2004-10-11 2006-04-13 Holden Hugo R Phacoemulsification machine with post-occlusion surge control system and related method
US20060224163A1 (en) * 2005-03-30 2006-10-05 Sutton Thomas B Phaco aspiration flow restrictor with bypass tube
US8241242B2 (en) 2005-03-30 2012-08-14 Abbott Medical Optics Inc. Phacoaspiration flow restrictor with bypass tube
US20080172076A1 (en) * 2006-11-01 2008-07-17 Alcon, Inc. Ultrasound apparatus and method of use
US20100324581A1 (en) * 2006-12-08 2010-12-23 Alcon, Inc. Torsional Ultrasound Hand Piece That Eliminates Chatter
US8579929B2 (en) 2006-12-08 2013-11-12 Alcon Research, Ltd. Torsional ultrasound hand piece that eliminates chatter
US8303530B2 (en) 2007-05-10 2012-11-06 Novartis Ag Method of operating an ultrasound handpiece
US20080281253A1 (en) * 2007-05-10 2008-11-13 Injev Valentine P Method of Operating an Ultrasound Handpiece
US8721594B2 (en) 2007-06-19 2014-05-13 Alcon Research, Ltd. Post-occlusion chamber collapse canceling system for a surgical apparatus and method of use
US20080319374A1 (en) * 2007-06-19 2008-12-25 Jaime Zacharias Post-occlusion chamber collapse canceling system for a surgical apparatus and method of use
US8579851B2 (en) 2007-12-20 2013-11-12 Bausch & Lomb Incorporated Surgical system having means for isolating vacuum pump
US8246579B2 (en) 2007-12-20 2012-08-21 Bausch & Lomb Incorporated Surgical system having means for pressurizing venting valve
US8034018B2 (en) 2007-12-20 2011-10-11 Bausch & Lomb Incorporated Surgical system having means for stopping vacuum pump
US20090163852A1 (en) * 2007-12-20 2009-06-25 Cull Laurence J Surgical System Having Means for Isolating Vacuum Pump
CN101932348B (en) 2007-12-20 2013-08-28 博士伦公司 Surgical system having means for pressurizing venting valve
US20090163863A1 (en) * 2007-12-20 2009-06-25 Mark Ian Lutwyche Surgical System Having Means for Stopping Vacuum Pump
US20100036256A1 (en) * 2008-08-08 2010-02-11 Mikhail Boukhny Offset ultrasonic hand piece
US20100094321A1 (en) * 2008-10-10 2010-04-15 Takayuki Akahoshi Ultrasound Handpiece
US8399006B2 (en) 2009-01-29 2013-03-19 Forsight Vision4, Inc. Posterior segment drug delivery
US9417238B2 (en) 2009-01-29 2016-08-16 Forsight Vision4, Inc. Posterior segment drug delivery
US9066779B2 (en) 2009-01-29 2015-06-30 Forsight Vision4, Inc. Implantable therapeutic device
US8277830B2 (en) 2009-01-29 2012-10-02 Forsight Vision4, Inc. Posterior segment drug delivery
US9851351B2 (en) 2009-01-29 2017-12-26 Forsight Vision4, Inc. Posterior segment drug delivery
US8298578B2 (en) 2009-01-29 2012-10-30 Forsight Vision4, Inc. Posterior segment drug delivery
US8808727B2 (en) 2009-01-29 2014-08-19 Forsight Vision4, Inc. Posterior segment drug delivery
US8795712B2 (en) 2009-01-29 2014-08-05 Forsight Vision4, Inc. Posterior segment drug delivery
US8992493B2 (en) 2009-03-13 2015-03-31 Atrium Medical Corporation Chest drainage systems and methods
US20110071415A1 (en) * 2009-03-13 2011-03-24 Atrium Medical Corporation Pleural drainage system and method of use
US9814807B2 (en) 2009-03-13 2017-11-14 Atrium Medical Corporation Chest drainage systems and methods
US8882678B2 (en) 2009-03-13 2014-11-11 Atrium Medical Corporation Pleural drainage system and method of use
US9314599B2 (en) 2009-03-13 2016-04-19 Atrium Medical Corporation Pleural drainage system and method of use
US8623040B2 (en) 2009-07-01 2014-01-07 Alcon Research, Ltd. Phacoemulsification hook tip
US9233021B2 (en) 2009-07-01 2016-01-12 Alcon Research, Ltd. Phacoemulsification hook tip
US8070711B2 (en) 2009-12-09 2011-12-06 Alcon Research, Ltd. Thermal management algorithm for phacoemulsification system
US20110137232A1 (en) * 2009-12-09 2011-06-09 Alcon Research, Ltd. Thermal Management Algorithm For Phacoemulsification System
US8623395B2 (en) 2010-01-29 2014-01-07 Forsight Vision4, Inc. Implantable therapeutic device
WO2011112291A1 (en) * 2010-03-12 2011-09-15 Atrium Medical Corporation Chest drainage systems and methods
US9492315B2 (en) 2010-08-05 2016-11-15 Forsight Vision4, Inc. Implantable therapeutic device
US9861521B2 (en) 2010-08-05 2018-01-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US9033911B2 (en) 2010-08-05 2015-05-19 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8905963B2 (en) 2010-08-05 2014-12-09 Forsight Vision4, Inc. Injector apparatus and method for drug delivery
US8784357B2 (en) 2010-09-15 2014-07-22 Alcon Research, Ltd. Phacoemulsification hand piece with two independent transducers
US8414605B2 (en) 2011-07-08 2013-04-09 Alcon Research, Ltd. Vacuum level control of power for phacoemulsification hand piece
US9883968B2 (en) 2011-09-16 2018-02-06 Forsight Vision4, Inc. Fluid exchange apparatus and methods
US9561321B2 (en) 2011-12-08 2017-02-07 Alcon Research, Ltd. Selectively moveable valve elements for aspiration and irrigation circuits
US9480782B2 (en) * 2013-01-14 2016-11-01 R. Ashley Burrow Surgical aspiration and irrigation
US20140221909A1 (en) * 2013-01-14 2014-08-07 R. Ashley Burrow Surgical Aspiration and Irrigation
USD698019S1 (en) 2013-03-05 2014-01-21 Alcon Research, Ltd. Ophthalmic surgical cassette
US9526654B2 (en) 2013-03-28 2016-12-27 Forsight Vision4, Inc. Ophthalmic implant for delivering therapeutic substances
US9549850B2 (en) 2013-04-26 2017-01-24 Novartis Ag Partial venting system for occlusion surge mitigation
US9474756B2 (en) 2014-08-08 2016-10-25 Forsight Vision4, Inc. Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9895369B2 (en) 2014-08-08 2018-02-20 Forsight Vision4, Inc Stable and soluble formulations of receptor tyrosine kinase inhibitors, and methods of preparation thereof
US9931268B2 (en) 2014-09-12 2018-04-03 Kci Licensing, Inc. Reduced pressure treatment system having blockage clearing and dual-zone pressure protection capabilities

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