US3692027A - Implanted medication dispensing device and method - Google Patents

Implanted medication dispensing device and method Download PDF

Info

Publication number
US3692027A
US3692027A US3692027DA US3692027A US 3692027 A US3692027 A US 3692027A US 3692027D A US3692027D A US 3692027DA US 3692027 A US3692027 A US 3692027A
Authority
US
Grant status
Grant
Patent type
Prior art keywords
body
means
device
power source
dispensing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
Inventor
Everett H Ellinwood Jr
Original Assignee
Everett H Ellinwood Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Grant date

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142Pressure infusion, e.g. using pumps
    • A61M5/14244Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body
    • A61M5/14276Pressure infusion, e.g. using pumps adapted to be carried by the patient, e.g. portable on the body specially adapted for implantation

Abstract

A self-micro-powered implanted device contains a store of medicine in powdered, liquid or other dispensable form and which is gradually discharged incrementally over a substantially long period of time.

Description

United States Patent Ellinwood, Jr.

[54] IMPLANTED MEDICATION DISPENSING DEVICE AND METHOD [72] Inventor: Everett H. Ellinwood, Jr., 3519 Tornbridge Way, Durham, N.C. 27707 [22] Filed: April 23, 1971 [21] Appl. No.: 136,789

[52] US. Cl ..128/260 [151 3,692,027 51 Sept. 19, 1972 [56] References Cited UNITED STATES PATENTS 3,118,439 l/ 1964 Perrenoud ..128/260 X 3,315,660 4/1967 Abella ..128/260 X 3,485,235 12/1969 Felson ..128/260 X 3,527,220 9/1970 Summers. 128/260 Primary Examiner-Charles F. Rosenbaum Attorney--B. B. Olive A nself-micro-powered implanted device contains a store of medicine in powdered, liquid or other dispensable form and which is gradually discharged in- [51] Int. Cl. ..A6lm 7/00 [57] ABSTRACT [58] Field of Search 128/2 P, 1,260, 261, 214 E, 128/214 F crementally over a substantially long period of time.

11 Claims, 8 Drawing Figures PATENTED 19 I97? 3. 692,027

sum 1 or 2 INVENTOR. Everett H. Ellinwood, Jr.

ATTORNEY BACKGROUND OF THE INVENTION 1. Field of the Invention:

This invention pertains to dispensing medicine internally and more specifically to dispensing a premeasured dosage at specific intervals over a long period of time. t

2. Description of the Prior Art:

Dosages of medicine have conventionally been dispensed in capsules which release the medication either immediately or on a delayed basis normally measured at the most in terms of a number of minutes or relatively few hours. It has been proposed to have orally administered capsules which can be caused to disintegrate by externally applied heat or other forms of radiation designed to penetrate the body and break down the capsule housing. There has further been proposed a device (US. Patent No. 3,527,220) suited to be implanted and designed to discharge successively, by pumping units of liquid medication with the operating power for the device being supplied by an external rotating magnetic fieldand whose timing depends on an external source. It has also been proposed to provide a multi-unit capsule designed to release one strength medication at one time and another strength medication at another time.

Representative prior art is found in US. Pat. Nos. 2,921,584, 3,118,439, 3,313,289, 3,315,660, 3,447,161, 3,485,235 and 3,527,220.

A review of all the known prior art reveals that there has not been available a device operative on and timed by its own micropower source, suitable to being entirely implanted and adapted to dispensing premeasured dosages of a given medication, liquid, powdered or otherwise, to a patient at specific intervals, which might be 12 hours, 6 hours or even 6 days, over a long period of time measured in terms of l to 2 years. In particular, there is no device presently known which can be implanted in narcotic addicts and/or psychiatric patients which can be used to administer medication internally on a predetermined long term schedule. Long term treatment of the addict with narcotic antagonistmedication is a means of blocking the effects of subsequent self-injected narcotic drugs. In a similar vein, long term administration of an anti-psychotic medication to certain psychiatric patients would be of marked benefit in rendering them more adaptable to themselves and society.

SUMMARY OF THE INVENTION The present invention resides around the concept of implanting a container within which there is mounted a battery powered, microsource of power, a store of premeasured dosages of a given medication and a mechanism operated and timed by the power source and designed to eject the dosages at specific intervals over a long period of time.

DESCRIPTION OF THE DRAWINGS FIG. 1 is a side elevation view of the device with one cover side section removed.

FIG. 2 is an enlarged fragmentary partial section view taken substantially along line 2-2 of FIG. 1.

FIG. 3 is a fragmentary section view taken substantiallyalong line 3-3 of FIG. 2.

FIG. 4 is an enlarged fragmentary partial section view, similar to FIG. 2, of a second embodiment.

FIG. 5 is a fragmentary section view taken substantially along line 5--5 of FIG. 4.

FIG. 6 is an enlarged fragmentary partial section view of a third embodiment.

FIG. 7 is a fragmentary partial section view of the pump component shown in FIG. 6.

FIG. 8 is a fragmentary partial section view of the bladder component of FIG. 6.

DESCRIPTION OF THE PREFERRED EMBODIMENTS The device of the invention includes a case 10 having two side sections 11 and 12 secured by a suitable threaded connection 13. The outer surface of case 10 provides an essentially solid surface with the exception of an aperture 14 through which the individual dosages are ejected at specific intervals. Case 10 can be thought of as essentially resembling the case of an ordinary pocket watch and in one embodiment is 6 centimeters in diameter by 1.4 centimeters thick. The surface should be smooth.

Since case 10 is designed to be implanted, the choice of material of which case 10 is made is somewhat critical. Such 'materialshould be of minimum weight, nonallergenic, non-reactive to body fluids and adapted to mass fabrication. Stainless steel is one such material though plastics and other materials may be employed.

Within case 10 there is mounted a suitable battery powered micro power and timing source 24 which is preferably a so-called accutron movement made by the Bulova Watch Company of Flushing, NY. A movement of this kind is relatively light in weight and can be obtained designed to turn one revolution per day so as to drive a drive shaft 20 and a drive wheel 21 at one revolution per day and for a period of time up to and approximately two years according tobattery life. At this speed output shaft 20 can be made to produce approximately 0.42 ounce/inch of torque and with a very nominal increase in speed at this loading. Such a power and timing source is considered a micro power and timing source. The invention recognizes the unique capability of the Accutron movement to serve as a micropower and timing source outside its conventional use for watches and clocks. The invention also recognizes that pistons, cocking mechanisms and the like within the realm of watchmaking technology can be practically applied in a medicine dispensing device.

A circular wheel member 25 has an outer peripheral face 26 in which there are formed a plurality of cavities 27 in which the individual dosages C are contained. In one example, 72 such cavities are formed in wheel 25 and each such cavity contains one capsule C of the desired medication. Each cavity has an associated piston member 31 which when moved radially outward in a timed sequence ejects its respective capsule C through aperture 14. Thus, for a 72 cavity wheel member 25 there are 72 piston members 31.

Drive wheel 21 mounts on its periphery an indexing pin 28 which is positioned perpendicular to the plane of wheel 21. As drive wheel 21 rotates at one revolution per day it causes indexing pin 28 to rotate at the same speed and to drive a link 29 which in turn is connected to oscillate a piston pusher member 30. Piston pusher member 30 thus moves back and forth once a day in the embodiment being described. As piston pusher 30 moves forward it is adapted to engage a selected piston member 31 each of which has a compression spring 32, a pusher head 33 and a piston 34 which bears against the capsule C. Each compression spring 32 tends to always retain its particular associated piston member 31 moved radially inwardly. Indexing of wheel member 25 is effected by means of indexing pin 28 successively engaging each one of a plurality of peripherally spaced indexing tabs 35 formed internally of wheel 25 as shown in the drawings. Wheel 25 is supported on a precision pin 36 mounted in suitable bearings 37 and 38. A washer 39 provides support for piston pusher 30 which is guided by a guide pin 40 internally secured to case side section 12. To prevent the entry of moisture internally of case an O-ring seal 41 is suitably adhered to case 10 around the aperture 14.

Here it should be noted that since body fluids may contact O-ring 41 and may also contact the interior of each individual capsule-cavity and piston member 31 that the same criteria applying to case 10 applies to the choice of materials selected. That is, none of the materials employed in wheel member 25, piston member 31 or O-ring 41 should be allergenic or reactive with any body fluid which might make contact with the same. Those skilled in the art will however recognize a wide choice of materials.

In one embodiment the device is implanted in the patients abdominal intraperitoneal cavity, a cavity that has a glistening moistened surface but does not maintain fluid levels except in pathological conditions. The device is sutured by suture threads secured to anchoring stays 15. The device of the invention then dispenses medication into this cavity for absorption through the intraperitoneal surface. The device is intended as a general application for any feasible medication; however, there are specific applications for which it is being developed. One such application is to implant the device into the abdomen of narcotic addicts with a sufficient number of dosages of a narcotic antagonist, to be dispensed over a long period of time. The narcotic antagonist dispensed actively, blocks the euphoriant effect of any subsequent use of narcotics. A psychotic medication can also be administered to psychiatric patients. This means that from the viewpoint of the patient, the doctor, and society, that the patient obtains the required daily dosage of a given drug without having to rely on his own willpower and initiative.

In the embodiment of the medication dispensing device used as an example, an Accutron movement or battery powered micro power plant is used to provide the timing mechanism as well as a source of power and the movement is geared to drive the output At FIGS. shaft clockwise, one revolution per day. In the more general application, any micro power and timing mechanism could be used. However, by using extreme care in reducing weight and friction in all of the moving parts of the device the Accutron movement in the present state of the art is preferred and can provide sufficient torque as well as long term continuous operation.

In use, the device is assembled with each dosage cell or cavity of wheel member 25 being loaded with a capsule C of the active medication and is suitably implanted. Each capsule C with the medication inside is successively ejected by means of its associated respective piston member 31 into the body cavity and subsequently dissolves as wheel member 25 gradually indexes around. In the embodiment of the example, the piston member 31 is designed to have a stroke of approximately 0.50 centimeters and each indexing tab 28 a movement of approximately 5 degrees and for each rotation of drive wheel 21 indexing pin 28 will contact a particular indexing tab 35 over approximately 30 of movement of wheel 21. This motion is thus repeated once a day and one capsule C is thus ejected each day. At the end of the battery life of the Accutron movement, the device may be removed, a new battery installed, wheel 25 reloaded and the device reassembled and reimplanted. It may also be noted that while capsules C are shown on FIGS. 2 and 3, each cavity 27 could be loaded with a liquid, powdered or granular medication and sealed with a fracturable seal as depicted in FIGS. 4 and 5 and later explained.

FIGS. 4 and 5 illustrate a second embodiment in which the case is formed by a stationary circular medication storage wheel member 50 and a base plate 51 having a suitable threaded connection 52. The same micro power and timing source 24 is employed to drive a similar output shaft 20, drive wheel 21 and indexing pin 28. Spaced indexing tabs 55, similar to tabs 35 of FIGS. 1 and 3, are provided on an internal peripheral surface of wheel member 50. In this embodiment, wheel member 50 remains stationary and is provided on an outer peripheral surface with plural cavities 56, e.g. 72 in number, each of which is shown loaded with a dosage of granular or powered medication M. Each cavity 56 is sealed by a rupturable film seal 57 of suitable thinness and strength that is ruptured when the particular dosage is ejected. A piston 60 is located in each cavity 56 and is formed integral with a piston rod 61 and a pusher head 63. A compression spring 62 forces piston 60 in a radially inward direction.

Each respective pusher head 63 is successively engaged by a piston pusher 65 which is guided by a guide pin 66 and a bearing pin 67. Piston pusher 65 mounts a vertical locking pin 68 which successively slides in and out of each corresponding indexing slot 69 as each respective pusher head 63 is engaged. Piston pusher 65 is in turn linked to indexing pin 28 by means of a link and a pin 71.

The micro power and timing source 24 indexes itself in a slow rotative movement around the bearing pin 67 by means of indexing pin 28 going in and out of successive indexing slots 69. That is, as wheel 21 rotates, indexing pin 28 rotates and causes power source 24 as well as all of the linkage shown mounted above power source 24 to index by the angular difference between slot locations. Ball bearings 49 support the power source 24 and bearing pin 67 provides low friction surfaces. Furthermore, as indexing pin 28 leaves a particular indexing slot 69, piston pusher 65 is moved to engage a respective pusher head 63 and to cause locking pin 68 to enter and lock itself in an opposite indexing slot 69 (now effectively a locking slot). As piston pusher 65 continues to move under the influence of indexing pin 28, which is always in slow constant rotation, the respective piston 60 pushes on the respective dosage M and ruptures the seal 57 which allows the dosage M to dump internally of the body in which the device is implanted.

In a third embodiment shown in FIGS. 6, 7 and 8, the medication is in liquid form and is stored in a bladder 80 having a flexible discharge line or tube 81 converted to a micro powered and timed pump-valve unit 82 which discharges through a flexible line or tube 83. Lines 81 and 83 should preferably be flexible and may be in the nature of rubber tubing. The bladder and pump-valve unit 82 may be sutured by means of suture stays 84, 85 and line 83 is placed where desired in the body.

Bladder 80 includes a self-sealing port preferably having two self-sealing membranes 90, 91 and an internal filling cavity 92 with. a one-way valve generally represented at 93. The outer .case of bladder 80 is preferably of hard rubber except at the port and a hard rubber striker plate 95 is provided internally to prevent inadvertent puncturing and also toprevent entry of the syringe needle beyond the filling cavity 92. In use, bladder 80 is filledwith the desired liquid medication by syringe injection into the cavity 92 such that the one-way valve 93 opens and allows the liquid medication to fill the interior of bladder 80. Once the syringe has been withdrawn it can be seen that bladder 80 is effectively filled with a pressurized liquid medication yet the patient, e.g. an addict, cannot withdraw the medicine himself as he normally would be tempted to do.

A suitable pressure reducing valve 100 controls the flow to line 81 and to the pump unit 82 having a pair of spring-loaded one-way ball valves 101,102; valve 101 controlling entry and valve 102 controlling discharge of liquids from cylinder 103. A piston 105 has a piston rod 106, loaded by spring 109, that is connected to and cocked by a cocking pin 107 mounted on a constantly driven wheel 108 driven by the same type micro power and timing source 24 previously mentioned, e. g. an Accutron movement, fixed to a base 111 threadably secured to a cover 112.

In the third embodiment of FIGS. 6, 7 and 8, it will be understood that bladder 80 is refilled when depletedllowever, the pump-valve unit 82 operates continuously and is limited only by the battery life of the power source 24. Thus, increments of liquid can be dispensed on some predetermined time schedule according to the particular design of cocking mechanism and subject to maintaining bladder 80 filled can be dispensed over a relatively long period of time. Tube pinching devices or other devices for controlling flow through lines 81 and 83 could be. operated by a micro power source and used instead of thepump-valve unit 82. Furthermore, the patient, e.g. the addict or psychiatric patient, such as a schizophrenic patient, is

are often negligent inmeeting medical appointments and taking their regular medication. Considering the scope of the problem, it can be seen that the present invention opens. up an entirelynew method of treating and dispensing medication. Examples of medication deemed suited to the invention include cyclazocine in powder and liquid form for addicts, stelazine in powder form for psychiatric patients and methadone and naloxone in liquid form for addicts.

In the first and second embodiments illustrated by FIGS. l-8, it will of course be appreciated that in order to save time during reimplantation procedures the wheel medication storage members 25 and50. can be prefilled and held in inventory as spares. During reimplantation, the full spare storage member-can then be substituted for theempty storage member and used with the other parts of the device being reimplanted. Thus, both battery replacement and medication replacement become relatively inexpensive and easy to will reveal themselves where it is necessary to have an unattended micro size and micro powered timing and dispensingapparatus. Thus, such broaderapplications are contemplated by the invention.

It is contemplated thatthe sealing means shown in the drawings may require modification for some applications where the device is in a high moisture or high fluid environment. Thus,.the piston mechanism may require a form of sealing in such applications.

It should. also be noted that the term bodyand .animal body. asused in the claims. are intended to includeanimal, human and other. living bodies..Further, the term body" is intended to encompassanyenvironmental body, whether livingor otherwise adapted to receiving a self, micro powered and timeddevice for incremental dispensing of substances into such body.

What is claimed is:

.1. A device adapted to be positioned internally of a selected body for dispensing-materials therein, comprising:

a. a storage memberadapted tobe positionedwithin the selected bodyand to store a quantity of the materialto be dispensed;

b. a micro size power source secured within said body proximate said storage member. and having an output member capable of. being driven by said source over .a predeterminedperiod in terms of at least several daysand at a substantially precise rate; and

c. dispensing means powered and timed by said micro power. source and adapted to discharge from said storage member .and into said body on a predetermined time schedule successive increments of said material.

2. Adeviceas claimed in claim 1 wherein said body is that of an animal including human, said material is a liquid, saidstorage member constitutes a bladder and said dispensing means constitutes pump and valve means powered and timed by said source and havingan inlet connected to said bladder and an outlet whereby said liquid may be withdrawn from said bladder and discharged from said outlet in increments.

3. A device as claimed in claim 1, wherein said body is that of an animal including human, said material is a medication, said storage member provides a plurality of cavities each having a predetermined unit of said medication, and said dispensing means includes a piston operator for each such cavity and linkage means operated by said power source whereby each respective such piston operator is activated in turn and effects successive discharge of each respective said unit from said storage member.

4. A device as claimed in claim 3 wherein said storage member is circular and is rotatively indexed by said power source to effect discharge of said units.

5. A device as claimed in claim 3 wherein said storage member is circular and fixed relative to said power source and said power source rotatively indexes itself to effect discharge of said units.

6. A device as claimed in claim 1 including a case providing an internal void and having an aperture in the wall thereof and wherein said micro power source and dispensing means are mounted within said case and dispensing of said material is through said aperture.

7. An implantable device for dispensing a medication material within an animal body, said device comprising in combination:

a. a case adapted to be implanted in the body and providing an internal void;

a micro power source secured within said void and having an output member capable of being driven by said source over a predetermined period in terms of at least several days and at a substantially precise rate;

. holder means mounted within said void and loosely mounting premeasured units of said material in a circular configuration; and

. ejection means powered by said output member in timed relation with said holder means and operative upon each successive said unit of material whereby each said unit is successively discharged from said holder means internally of said body.

8. A device as claimed in claim 7 wherein said case includes an aperture in the wall thereof, said holder means rotates and is driven by said output member to bring each successive unit to a position opposite said aperture and said ejection means operates upon each said unit successively upon reaching such position.

9. An implantable device for dispensing liquid drugs into an animal body, including human, comprising:

a. a bladder adapted to be implanted in the body and to be filled by external injection;

b. a metering means having an inlet connected to said bladder and an outlet adapted to discharge into said body said metering means being adapted in one mode to withdraw and discharge predetermined uniform units of said material and in another mode to block flow of said material;

. a micro power source connected to said metering means and adapted to power and time said metering means in said modes whereby said units may be discharged at spaced time intervals and over a substantially long period of time; and

d. a case adapted to be implanted and mounting both said metering means and micro power source.

10. A device as claimed in claim 9 wherein said meit?ass ssesazsearigsargsa body, comprising the steps:

a. implanting within the body a container having a substantially large supply of the drug to be dispensed;

b. with said container implanting a micro power source and dispensing means operated and timed by said micro power source for drawing off and discharging successive uniform units of said drug in said body; and 0. allowing said source and dispensing means to operate on said supply over a substantially long period of time until said supply is exhausted.

t t a II! t:

Claims (11)

1. A device adapted to be positioned internally of a selected body for dispensing materials therein, comprising: a. a storage member adapted to be positioned within the selected body and to store a quantity of the material to be dispensed; b. a micro size power source secured within said body proximate said storage member and having an output member capable of being driven by said source over a predetermined period in terms of at least several days and at a substantially precise rate; and c. dispensing means powered and timed by said micro power source and adapted to discharge from said storage member and into said body on a predetermined time schedule successive increments of said material.
2. A device as claimed in claim 1 wherein said body is that of an animal including human, said material is a liquid, said storage member constitutes a bladder and said dispensing means constituteS pump and valve means powered and timed by said source and having an inlet connected to said bladder and an outlet whereby said liquid may be withdrawn from said bladder and discharged from said outlet in increments.
3. A device as claimed in claim 1, wherein said body is that of an animal including human, said material is a medication, said storage member provides a plurality of cavities each having a predetermined unit of said medication, and said dispensing means includes a piston operator for each such cavity and linkage means operated by said power source whereby each respective such piston operator is activated in turn and effects successive discharge of each respective said unit from said storage member.
4. A device as claimed in claim 3 wherein said storage member is circular and is rotatively indexed by said power source to effect discharge of said units.
5. A device as claimed in claim 3 wherein said storage member is circular and fixed relative to said power source and said power source rotatively indexes itself to effect discharge of said units.
6. A device as claimed in claim 1 including a case providing an internal void and having an aperture in the wall thereof and wherein said micro power source and dispensing means are mounted within said case and dispensing of said material is through said aperture.
7. An implantable device for dispensing a medication material within an animal body, said device comprising in combination: a. a case adapted to be implanted in the body and providing an internal void; b. a micro power source secured within said void and having an output member capable of being driven by said source over a predetermined period in terms of at least several days and at a substantially precise rate; c. holder means mounted within said void and loosely mounting premeasured units of said material in a circular configuration; and d. ejection means powered by said output member in timed relation with said holder means and operative upon each successive said unit of material whereby each said unit is successively discharged from said holder means internally of said body.
8. A device as claimed in claim 7 wherein said case includes an aperture in the wall thereof, said holder means rotates and is driven by said output member to bring each successive unit to a position opposite said aperture and said ejection means operates upon each said unit successively upon reaching such position.
9. An implantable device for dispensing liquid drugs into an animal body, including human, comprising: a. a bladder adapted to be implanted in the body and to be filled by external injection; b. a metering means having an inlet connected to said bladder and an outlet adapted to discharge into said body said metering means being adapted in one mode to withdraw and discharge predetermined uniform units of said material and in another mode to block flow of said material; c. a micro power source connected to said metering means and adapted to power and time said metering means in said modes whereby said units may be discharged at spaced time intervals and over a substantially long period of time; and d. a case adapted to be implanted and mounting both said metering means and micro power source.
10. A device as claimed in claim 9 wherein said metering means constitutes a pumping device.
11. The method of dispensing a drug in a body, comprising the steps: a. implanting within the body a container having a substantially large supply of the drug to be dispensed; b. with said container implanting a micro power source and dispensing means operated and timed by said micro power source for drawing off and discharging successive uniform units of said drug in said body; and c. allowing said source and dispensing means to operate on said supply over a substantially long period of time until said supply is exhausted.
US3692027A 1971-04-23 1971-04-23 Implanted medication dispensing device and method Expired - Lifetime US3692027A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13678971 true 1971-04-23 1971-04-23

Publications (1)

Publication Number Publication Date
US3692027A true US3692027A (en) 1972-09-19

Family

ID=22474370

Family Applications (1)

Application Number Title Priority Date Filing Date
US3692027A Expired - Lifetime US3692027A (en) 1971-04-23 1971-04-23 Implanted medication dispensing device and method

Country Status (1)

Country Link
US (1) US3692027A (en)

Cited By (118)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US3996933A (en) * 1972-10-02 1976-12-14 Morton Gutnick Intrauterine contraceptive devices and processes
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4013074A (en) * 1974-06-21 1977-03-22 Siposs George G Implantable medication-dispensing device
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
WO1980001755A1 (en) * 1979-02-28 1980-09-04 Andros Inc Implantable infusion device
WO1983002063A1 (en) * 1981-12-07 1983-06-23 Univ Johns Hopkins Refillable medication infusion apparatus
DE3247232A1 (en) * 1979-04-27 1984-07-05 Univ Johns Hopkins Infusion system for drug supply
US4604090A (en) * 1983-11-22 1986-08-05 Consolidated Controls Corporation Compact implantable medication infusion device
US4668231A (en) * 1984-02-15 1987-05-26 Cordis Corporation Implantable hand-operable dispensers for fluid medicaments
US4871351A (en) * 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
WO1994021314A1 (en) * 1993-03-17 1994-09-29 Corporation De L'ecole Polytechnique Implantable medication dispensing device
WO1996007440A2 (en) * 1994-09-02 1996-03-14 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Methods and apparatus for the delivery of solid drug compositions
US5690682A (en) * 1996-06-17 1997-11-25 Pharmatarget, Inc. Device and method for treatment of cardiac arrhythmia
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
WO1999002208A1 (en) * 1997-07-11 1999-01-21 Pets 'n People Ltd. Apparatus and methods for dispensing pet care substances
US6283943B1 (en) * 1999-02-19 2001-09-04 Minimed Inc. Negative pressure pump
US6361522B1 (en) 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US20020072784A1 (en) * 2000-10-10 2002-06-13 Sheppard Norman F. Microchip reservoir devices using wireless transmission of power and data
DE10063612A1 (en) * 2000-12-20 2002-07-04 Fraunhofer Ges Forschung Active material controlled delivery microsystem, used as an implant, e.g. cardiac catheter or stent, has reservoir with thin, flexible, impermeable support with permeable microducts or microcracks, electrode pairs and electroporous layer
US6464671B1 (en) * 1999-04-28 2002-10-15 Sten-Olof Elver Medical system
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US6485462B1 (en) 1997-08-27 2002-11-26 Science Incorporated Fluid delivery device with heat activated energy source
US20030018362A1 (en) * 2001-06-15 2003-01-23 Chris Fellows Ablation stent for treating atrial fibrillation
US6527762B1 (en) 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US6551838B2 (en) 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US20030158584A1 (en) * 2002-02-19 2003-08-21 Cates Adam W Chronically-implanted device for sensing and therapy
US20040002739A1 (en) * 2002-06-28 2004-01-01 Cates Adam W. Method and apparatus for delivering pre-shock defibrillation therapy
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US20040034332A1 (en) * 1999-11-17 2004-02-19 Uhland Scott A. Implantable drug delivery device
US6730072B2 (en) 2000-05-30 2004-05-04 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US20040106914A1 (en) * 2002-09-23 2004-06-03 Coppeta Jonathan R. Micro-reservoir osmotic release systems and microtube array device
US20040121486A1 (en) * 2002-08-16 2004-06-24 Uhland Scott A. Controlled release device and method using electrothermal ablation
US20040220553A1 (en) * 2001-04-10 2004-11-04 Medtronic, Inc. Implantable therapeutic substance delivery device
US20040248320A1 (en) * 1999-12-10 2004-12-09 Santini John T. Medical device with array of electrode-containing reservoirs
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US20050096587A1 (en) * 2003-11-03 2005-05-05 Santini John T.Jr. Medical device for sensing glucose
US20050143715A1 (en) * 2001-05-31 2005-06-30 Cima Michael J. Device for controlled reservoir opening with reinforced reservoir caps
US6976982B2 (en) 2001-01-09 2005-12-20 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
DE102004026615A1 (en) * 2004-06-01 2005-12-29 Siemens Ag Apparatus and method for releasing a guided inside the body of a patient the therapeutic agent
US20060024358A1 (en) * 2004-07-30 2006-02-02 Santini John T Jr Multi-reservoir device for transdermal drug delivery and sensing
US20060034943A1 (en) * 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
US20060057737A1 (en) * 2004-09-01 2006-03-16 Santini John T Jr Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US7072711B2 (en) 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US20060147371A1 (en) * 2003-10-31 2006-07-06 Tuszynski Jack A Water-soluble compound
US7082970B2 (en) 2001-09-24 2006-08-01 Bartholomew Julie R Apparatus and method for custom cosmetic dispensing
US20070027394A1 (en) * 2005-07-29 2007-02-01 Ujhelyi Michael R Method and apparatus to control conduction through the heart to treat cardiac conditions
US20070043777A1 (en) * 2000-03-09 2007-02-22 Yuri Basin Systems and methods for manipulating and managing computer archive files
US20070055296A1 (en) * 1999-07-19 2007-03-08 Endoart Sa Flow control method and device
US20070093875A1 (en) * 2005-10-24 2007-04-26 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US20070233019A1 (en) * 2005-11-02 2007-10-04 Potencia Medical Ag Implantable infusion devices and methods
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US7340303B2 (en) 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
US7369890B2 (en) 2000-11-02 2008-05-06 Cardiac Pacemakers, Inc. Technique for discriminating between coordinated and uncoordinated cardiac rhythms
US20090012503A1 (en) * 2004-11-10 2009-01-08 Hironao Kawano Body-Insertable Apparatus
US7567841B2 (en) 2004-08-20 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
DE102008010876A1 (en) 2008-02-23 2009-09-03 Universität Leipzig Microsystem for controlled active substance release in e.g. therapy of neurological defects, has integrated electronics controlling electroactive polymers and conductive paths for contacting polymers provided on carrier substrate
US20090220563A1 (en) * 2008-02-29 2009-09-03 Pharmaco-Kinesis Corporation Artificial tooth medicating apparatus for controlling, regulating, sensing, and releasing medical agents into the body
US20090259182A1 (en) * 2007-09-28 2009-10-15 Calibra Medical, Inc. wearable low profile infusion device
US7621905B2 (en) 1997-12-30 2009-11-24 Remon Medical Technologies Ltd. Devices for intrabody delivery of molecules and systems and methods utilizing same
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
US7641619B2 (en) 2000-10-16 2010-01-05 Remon Medical Technologies, Ltd. Barometric pressure correction based on remote sources of information
US20100016927A1 (en) * 2005-05-16 2010-01-21 Anthony Caparso Transvascular reshaping lead system
US7742815B2 (en) 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US20100234827A1 (en) * 2009-03-13 2010-09-16 Sigg Daniel C Method of treating heart failure
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
US20100318175A1 (en) * 2007-12-31 2010-12-16 C.R. Bard, Inc. Vascular graft prosthesis with selective flow reduction
EP2263719A3 (en) * 2003-01-22 2011-03-09 Codman & Shurtleff, Inc. Multireservoir implantable drug delivery pumps
US7931582B2 (en) 2000-02-11 2011-04-26 Obtech Medical Ag Controlled impotence treatment
US7955268B2 (en) 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20110184358A1 (en) * 2010-01-27 2011-07-28 Weiner Alan L Pulsatile peri-corneal drug delivery device
US8017137B2 (en) 2004-07-19 2011-09-13 Bartholomew Julie R Customized retail point of sale dispensing methods
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US20110224636A1 (en) * 2010-03-15 2011-09-15 Keisic Hollis S Urinary bag system
US8034026B2 (en) * 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US8096938B2 (en) 1999-08-12 2012-01-17 Obtech Medical Ag Controlled anal incontinence disease treatment
US8096939B2 (en) 2000-02-10 2012-01-17 Obtech Medical Ag Urinary incontinence treatment with wireless energy supply
US8126558B2 (en) 2000-02-14 2012-02-28 Obtech Medical Ag Controlled penile prosthesis
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8271093B2 (en) 2004-09-17 2012-09-18 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements using a backend computing system
US8290594B2 (en) 2000-02-11 2012-10-16 Obtech Medical Ag Impotence treatment apparatus with energy transforming means
US8287444B2 (en) 2000-02-10 2012-10-16 Obtech Medical Ag Mechanical impotence treatment apparatus
US8313423B2 (en) 2000-02-14 2012-11-20 Peter Forsell Hydraulic anal incontinence treatment
US8369960B2 (en) 2008-02-12 2013-02-05 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
US8509894B2 (en) 2008-10-10 2013-08-13 Milux Holding Sa Heart help device, system, and method
US8545384B2 (en) 1999-08-12 2013-10-01 Obtech Medical Ag Anal incontinence disease treatment with controlled wireless energy supply
US8556796B2 (en) 2000-02-10 2013-10-15 Obtech Medical Ag Controlled urinary incontinence treatment
US8573263B2 (en) 2001-09-24 2013-11-05 Cosmetic Technologies, Llc Apparatus and method for custom cosmetic dispensing
US8591423B2 (en) 2008-10-10 2013-11-26 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
US8600510B2 (en) 2008-10-10 2013-12-03 Milux Holding Sa Apparatus, system and operation method for the treatment of female sexual dysfunction
US8632470B2 (en) 2008-11-19 2014-01-21 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
US8636809B2 (en) 2008-01-29 2014-01-28 Milux Holding Sa Device for treating obesity
US8678997B2 (en) 2000-02-14 2014-03-25 Obtech Medical Ag Male impotence prosthesis apparatus with wireless energy supply
US8696745B2 (en) 2008-10-10 2014-04-15 Kirk Promotion Ltd. Heart help device, system, and method
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8725260B2 (en) 2008-02-11 2014-05-13 Cardiac Pacemakers, Inc Methods of monitoring hemodynamic status for rhythm discrimination within the heart
US8734318B2 (en) 2000-02-11 2014-05-27 Obtech Medical Ag Mechanical anal incontinence
US8761717B1 (en) 2012-08-07 2014-06-24 Brian K. Buchheit Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate
US8764627B2 (en) 2000-02-14 2014-07-01 Obtech Medical Ag Penile prosthesis
US20140221963A1 (en) * 2011-08-25 2014-08-07 Edy E. Soffer Use of eating detection to control the release of biologically active agents
US8874215B2 (en) 2008-10-10 2014-10-28 Peter Forsell System, an apparatus, and a method for treating a sexual dysfunctional female patient
US8929990B2 (en) 2005-04-11 2015-01-06 Cardiac Pacemakers, Inc. Transvascular neural stimulation device and method for treating hypertension
US8961448B2 (en) 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
US9173996B2 (en) 2001-05-18 2015-11-03 Deka Products Limited Partnership Infusion set for a fluid pump
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US9949812B2 (en) 2009-07-17 2018-04-24 Peter Forsell Vaginal operation method for the treatment of anal incontinence in women

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3118439A (en) * 1957-04-09 1964-01-21 Perrenoud Jean-Pierre Diagnostic and medicating capsule and the method of use
US3315660A (en) * 1963-08-08 1967-04-25 Carlos A Abella Capsule for insertion in the digestive track
US3485235A (en) * 1967-12-04 1969-12-23 Ronald Felson Capsule for the study and treatment of the digestive tract
US3527220A (en) * 1968-06-28 1970-09-08 Fairchild Hiller Corp Implantable drug administrator

Cited By (212)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996933A (en) * 1972-10-02 1976-12-14 Morton Gutnick Intrauterine contraceptive devices and processes
US4102998A (en) * 1972-10-02 1978-07-25 Morton Gutnick Process for the prevention of venereal disease
US3797492A (en) * 1972-12-27 1974-03-19 Alza Corp Device for dispensing product with directional guidance member
US4146029A (en) * 1974-04-23 1979-03-27 Ellinwood Jr Everett H Self-powered implanted programmable medication system and method
US3923060A (en) * 1974-04-23 1975-12-02 Jr Everett H Ellinwood Apparatus and method for implanted self-powered medication dispensing having timing and evaluator means
US4003379A (en) * 1974-04-23 1977-01-18 Ellinwood Jr Everett H Apparatus and method for implanted self-powered medication dispensing
US4013074A (en) * 1974-06-21 1977-03-22 Siposs George G Implantable medication-dispensing device
WO1980001755A1 (en) * 1979-02-28 1980-09-04 Andros Inc Implantable infusion device
US4265241A (en) * 1979-02-28 1981-05-05 Andros Incorporated Implantable infusion device
DE3247232A1 (en) * 1979-04-27 1984-07-05 Univ Johns Hopkins Infusion system for drug supply
WO1983002063A1 (en) * 1981-12-07 1983-06-23 Univ Johns Hopkins Refillable medication infusion apparatus
US4604090A (en) * 1983-11-22 1986-08-05 Consolidated Controls Corporation Compact implantable medication infusion device
US4668231A (en) * 1984-02-15 1987-05-26 Cordis Corporation Implantable hand-operable dispensers for fluid medicaments
US4871351A (en) * 1984-09-28 1989-10-03 Vladimir Feingold Implantable medication infusion system
WO1994021314A1 (en) * 1993-03-17 1994-09-29 Corporation De L'ecole Polytechnique Implantable medication dispensing device
US5366454A (en) * 1993-03-17 1994-11-22 La Corporation De L'ecole Polytechnique Implantable medication dispensing device
WO1996007440A2 (en) * 1994-09-02 1996-03-14 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A. Methods and apparatus for the delivery of solid drug compositions
WO1996007440A3 (en) * 1994-09-02 1996-05-23 Scras Methods and apparatus for the delivery of solid drug compositions
US5660846A (en) * 1994-09-02 1997-08-26 Societe De Conseils De Recherches Et D'applications Scientifiques Methods and apparatus for the delivery of solid drug compositions
US6306420B1 (en) 1994-09-02 2001-10-23 Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. Methods and apparatus for the delivery of solid drug compositions
US6142972A (en) * 1994-09-02 2000-11-07 Delab Method and apparatus for the delivery of elongate solid drug compositions
US5837276A (en) * 1994-09-02 1998-11-17 Delab Apparatus for the delivery of elongate solid drug compositions
EP0953362A3 (en) * 1994-09-02 2000-03-08 Delab Methods and apparatus for the delivery of solid drug compositions
EP0953362A2 (en) * 1994-09-02 1999-11-03 Delab Methods and apparatus for the delivery of solid drug compositions
US5690682A (en) * 1996-06-17 1997-11-25 Pharmatarget, Inc. Device and method for treatment of cardiac arrhythmia
US6123861A (en) * 1996-07-02 2000-09-26 Massachusetts Institute Of Technology Fabrication of microchip drug delivery devices
US7901397B2 (en) 1996-07-02 2011-03-08 Massachusetts Institute Of Technology Method for operating microchip reservoir device
US5797898A (en) * 1996-07-02 1998-08-25 Massachusetts Institute Of Technology Microchip drug delivery devices
US7892221B2 (en) 1996-07-02 2011-02-22 Massachusetts Institute Of Technology Method of controlled drug delivery from implant device
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US20080051766A1 (en) * 1996-07-02 2008-02-28 Massachusetts Institute Of Technology Method for Operating Microchip Reservoir Device
US6349232B1 (en) 1997-07-11 2002-02-19 Pets 'n People Ltd. Apparatus and method for dispensing pet care substances
US20020065479A1 (en) * 1997-07-11 2002-05-30 Pets 'n People Ltd. Apparatus and methods for dispensing pet care substances
WO1999002208A1 (en) * 1997-07-11 1999-01-21 Pets 'n People Ltd. Apparatus and methods for dispensing pet care substances
US6485462B1 (en) 1997-08-27 2002-11-26 Science Incorporated Fluid delivery device with heat activated energy source
US7621905B2 (en) 1997-12-30 2009-11-24 Remon Medical Technologies Ltd. Devices for intrabody delivery of molecules and systems and methods utilizing same
US7948148B2 (en) 1997-12-30 2011-05-24 Remon Medical Technologies Ltd. Piezoelectric transducer
US6283943B1 (en) * 1999-02-19 2001-09-04 Minimed Inc. Negative pressure pump
US6464671B1 (en) * 1999-04-28 2002-10-15 Sten-Olof Elver Medical system
US20110144670A1 (en) * 1999-07-19 2011-06-16 Allergan, Inc. Flow control method and device
US20110130702A1 (en) * 1999-07-19 2011-06-02 Allergan Medical S.A. Flow control method and device
US8079974B2 (en) * 1999-07-19 2011-12-20 Allergan, Inc. Flow control method and device
US20110130701A1 (en) * 1999-07-19 2011-06-02 Allergan Medical S.A. Flow control method and device
US8506517B2 (en) 1999-07-19 2013-08-13 Allergan, Inc. Flow control method and device
US8932247B2 (en) 1999-07-19 2015-01-13 Apollo Endosurgery, Inc. Flow control method and device
US20070055296A1 (en) * 1999-07-19 2007-03-08 Endoart Sa Flow control method and device
US8545384B2 (en) 1999-08-12 2013-10-01 Obtech Medical Ag Anal incontinence disease treatment with controlled wireless energy supply
US8096938B2 (en) 1999-08-12 2012-01-17 Obtech Medical Ag Controlled anal incontinence disease treatment
US6527762B1 (en) 1999-08-18 2003-03-04 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US7473248B2 (en) 1999-08-18 2009-01-06 Microchips, Inc. Thermally-activated reservoir devices
US6669683B2 (en) 1999-08-18 2003-12-30 Microchips, Inc. Thermally-activated microchip chemical delivery devices
US20040143236A1 (en) * 1999-08-18 2004-07-22 Santini John T. Thermally-activated reservoir devices
US6361522B1 (en) 1999-10-21 2002-03-26 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US7201733B2 (en) 1999-10-21 2007-04-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US20020099328A1 (en) * 1999-10-21 2002-07-25 Cardiac Pacemakers, Inc. Drug delivery system for implantable cardiac device
US7052488B2 (en) 1999-11-17 2006-05-30 Boston Scientific Scimed, Inc. Implantable drug delivery device
US20040034332A1 (en) * 1999-11-17 2004-02-19 Uhland Scott A. Implantable drug delivery device
US20040248320A1 (en) * 1999-12-10 2004-12-09 Santini John T. Medical device with array of electrode-containing reservoirs
US20060189963A1 (en) * 1999-12-10 2006-08-24 Massachusetts Institute Of Technology Multi-reservoir device for controlled drug delivery
US7070592B2 (en) 1999-12-10 2006-07-04 Massachusetts Institute Of Technology Medical device with array of electrode-containing reservoirs
US8096939B2 (en) 2000-02-10 2012-01-17 Obtech Medical Ag Urinary incontinence treatment with wireless energy supply
US8556796B2 (en) 2000-02-10 2013-10-15 Obtech Medical Ag Controlled urinary incontinence treatment
US8602966B2 (en) 2000-02-10 2013-12-10 Obtech Medical, AG Mechanical impotence treatment apparatus
US8287444B2 (en) 2000-02-10 2012-10-16 Obtech Medical Ag Mechanical impotence treatment apparatus
US9655724B2 (en) 2000-02-11 2017-05-23 Peter Forsell Controlled impotence treatment
US8734318B2 (en) 2000-02-11 2014-05-27 Obtech Medical Ag Mechanical anal incontinence
US8290594B2 (en) 2000-02-11 2012-10-16 Obtech Medical Ag Impotence treatment apparatus with energy transforming means
US7931582B2 (en) 2000-02-11 2011-04-26 Obtech Medical Ag Controlled impotence treatment
US8678997B2 (en) 2000-02-14 2014-03-25 Obtech Medical Ag Male impotence prosthesis apparatus with wireless energy supply
US8313423B2 (en) 2000-02-14 2012-11-20 Peter Forsell Hydraulic anal incontinence treatment
US8764627B2 (en) 2000-02-14 2014-07-01 Obtech Medical Ag Penile prosthesis
US8126558B2 (en) 2000-02-14 2012-02-28 Obtech Medical Ag Controlled penile prosthesis
US7410616B2 (en) 2000-03-02 2008-08-12 Microchips, Inc. Device for the controlled exposure of reservoir-based sensors
US7648677B2 (en) 2000-03-02 2010-01-19 Microchips, Inc. Method for operating a reservoir-based sensor device
US7445766B2 (en) 2000-03-02 2008-11-04 Microchips, Inc. Medical device and method for diagnostic sensing
US20050124979A1 (en) * 2000-03-02 2005-06-09 Santini John T.Jr. Device for release of chemical molecules using pressure-generated rupture of reservoirs
US7614135B2 (en) 2000-03-02 2009-11-10 Microchips, Inc. Method for making reservoir-based sensor device
US20070299385A1 (en) * 2000-03-02 2007-12-27 Microchips, Inc. Device for the controlled exposure of reservoir-based sensors
US6551838B2 (en) 2000-03-02 2003-04-22 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US6849463B2 (en) 2000-03-02 2005-02-01 Microchips, Inc. Microfabricated devices for the storage and selective exposure of chemicals and devices
US20070043777A1 (en) * 2000-03-09 2007-02-22 Yuri Basin Systems and methods for manipulating and managing computer archive files
US6730072B2 (en) 2000-05-30 2004-05-04 Massachusetts Institute Of Technology Methods and devices for sealing microchip reservoir devices
US7226442B2 (en) 2000-10-10 2007-06-05 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US20080083041A1 (en) * 2000-10-10 2008-04-03 Microchips, Inc. Pre-Clinical Animal Testing Method
US20080221555A1 (en) * 2000-10-10 2008-09-11 Microchips, Inc. Method for wirelessly monitoring implanted medical device
US8403907B2 (en) 2000-10-10 2013-03-26 Microchips, Inc. Method for wirelessly monitoring implanted medical device
US20080172043A1 (en) * 2000-10-10 2008-07-17 Microchips, Inc. Microchip reservoir devices using wireless transmission of power and data
US20020072784A1 (en) * 2000-10-10 2002-06-13 Sheppard Norman F. Microchip reservoir devices using wireless transmission of power and data
US7641619B2 (en) 2000-10-16 2010-01-05 Remon Medical Technologies, Ltd. Barometric pressure correction based on remote sources of information
US7369890B2 (en) 2000-11-02 2008-05-06 Cardiac Pacemakers, Inc. Technique for discriminating between coordinated and uncoordinated cardiac rhythms
US7425210B2 (en) 2000-12-18 2008-09-16 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
DE10063612C2 (en) * 2000-12-20 2002-11-07 Fraunhofer Ges Forschung Microsystem for control of drug release from a drug reservoir and implant Microsystems
DE10063612A1 (en) * 2000-12-20 2002-07-04 Fraunhofer Ges Forschung Active material controlled delivery microsystem, used as an implant, e.g. cardiac catheter or stent, has reservoir with thin, flexible, impermeable support with permeable microducts or microcracks, electrode pairs and electroporous layer
US7582080B2 (en) 2001-01-09 2009-09-01 Microchips, Inc. Implantable, tissue conforming drug delivery device
US7776024B2 (en) 2001-01-09 2010-08-17 Microchips, Inc. Method of actuating implanted medical device
US20060178655A1 (en) * 2001-01-09 2006-08-10 Santini John T Jr Implantable, tissue conforming drug delivery device
US20080071252A1 (en) * 2001-01-09 2008-03-20 Microchips, Inc. Method of actuating implanted medical device
US6976982B2 (en) 2001-01-09 2005-12-20 Microchips, Inc. Flexible microchip devices for ophthalmic and other applications
US7879019B2 (en) 2001-01-09 2011-02-01 Microchips, Inc. Method of opening reservoir of containment device
US20040220553A1 (en) * 2001-04-10 2004-11-04 Medtronic, Inc. Implantable therapeutic substance delivery device
US7758568B2 (en) * 2001-04-10 2010-07-20 Medtronic, Inc. Implantable therapeutic substance delivery device
US7563255B2 (en) 2001-05-03 2009-07-21 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US20030069560A1 (en) * 2001-05-03 2003-04-10 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
WO2002089767A1 (en) * 2001-05-03 2002-11-14 Massachusetts Eye And Ear Infirmary Implantable drug delivery device and use thereof
US9173996B2 (en) 2001-05-18 2015-11-03 Deka Products Limited Partnership Infusion set for a fluid pump
US8034026B2 (en) * 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
US20050143715A1 (en) * 2001-05-31 2005-06-30 Cima Michael J. Device for controlled reservoir opening with reinforced reservoir caps
US20030018362A1 (en) * 2001-06-15 2003-01-23 Chris Fellows Ablation stent for treating atrial fibrillation
US7493162B2 (en) 2001-06-15 2009-02-17 Cardiac Pacemakers, Inc. Pulmonary vein stent for treating atrial fibrillation
US20030069606A1 (en) * 2001-06-15 2003-04-10 Girouard Steven D. Pulmonary vein stent for treating atrial fibrillation
US7209783B2 (en) 2001-06-15 2007-04-24 Cardiac Pacemakers, Inc. Ablation stent for treating atrial fibrillation
US8141596B2 (en) 2001-09-24 2012-03-27 Cosmetic Technologies Llc Apparatus and method for custom cosmetic dispensing
US7082970B2 (en) 2001-09-24 2006-08-01 Bartholomew Julie R Apparatus and method for custom cosmetic dispensing
US7475710B2 (en) 2001-09-24 2009-01-13 Bartholomew Julie R Apparatus and method for custom cosmetic dispensing
US8573263B2 (en) 2001-09-24 2013-11-05 Cosmetic Technologies, Llc Apparatus and method for custom cosmetic dispensing
US7340303B2 (en) 2001-09-25 2008-03-04 Cardiac Pacemakers, Inc. Evoked response sensing for ischemia detection
US7236821B2 (en) 2002-02-19 2007-06-26 Cardiac Pacemakers, Inc. Chronically-implanted device for sensing and therapy
US20030158584A1 (en) * 2002-02-19 2003-08-21 Cates Adam W Chronically-implanted device for sensing and therapy
US20040002739A1 (en) * 2002-06-28 2004-01-01 Cates Adam W. Method and apparatus for delivering pre-shock defibrillation therapy
US7089055B2 (en) 2002-06-28 2006-08-08 Cardiac Pacemakers, Inc. Method and apparatus for delivering pre-shock defibrillation therapy
US7455667B2 (en) 2002-08-16 2008-11-25 Microchips, Inc. Controlled release device and method using electrothermal ablation
US7910151B2 (en) 2002-08-16 2011-03-22 Microchips, Inc. Method for making device for controlled reservoir opening by electrothermal ablation
US20040121486A1 (en) * 2002-08-16 2004-06-24 Uhland Scott A. Controlled release device and method using electrothermal ablation
US20060100608A1 (en) * 2002-08-16 2006-05-11 Uhland Scott A Controlled release device and method using electrothermal ablation
US7510551B2 (en) 2002-08-16 2009-03-31 Microchips, Inc. Controlled release device and method using electrothermal ablation
US20080168921A1 (en) * 2002-08-16 2008-07-17 Uhland Scott A Method for making device for controlled reservoir opening by electrothermal ablation
US7534241B2 (en) 2002-09-23 2009-05-19 Microchips, Inc. Micro-reservoir osmotic release systems and microtube array device
US20040106914A1 (en) * 2002-09-23 2004-06-03 Coppeta Jonathan R. Micro-reservoir osmotic release systems and microtube array device
US8275456B2 (en) 2002-11-12 2012-09-25 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7072711B2 (en) 2002-11-12 2006-07-04 Cardiac Pacemakers, Inc. Implantable device for delivering cardiac drug therapy
US7627373B2 (en) 2002-11-30 2009-12-01 Cardiac Pacemakers, Inc. Method and apparatus for cell and electrical therapy of living tissue
EP2263719A3 (en) * 2003-01-22 2011-03-09 Codman & Shurtleff, Inc. Multireservoir implantable drug delivery pumps
US20050055014A1 (en) * 2003-08-04 2005-03-10 Coppeta Jonathan R. Methods for accelerated release of material from a reservoir device
US8016783B2 (en) 2003-08-21 2011-09-13 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US7320675B2 (en) 2003-08-21 2008-01-22 Cardiac Pacemakers, Inc. Method and apparatus for modulating cellular metabolism during post-ischemia or heart failure
US20060034943A1 (en) * 2003-10-31 2006-02-16 Technology Innovations Llc Process for treating a biological organism
US20060147371A1 (en) * 2003-10-31 2006-07-06 Tuszynski Jack A Water-soluble compound
US20050096587A1 (en) * 2003-11-03 2005-05-05 Santini John T.Jr. Medical device for sensing glucose
US8095197B2 (en) 2003-11-03 2012-01-10 Microchips, Inc. Medical device for sensing glucose
US7840263B2 (en) 2004-02-27 2010-11-23 Cardiac Pacemakers, Inc. Method and apparatus for device controlled gene expression
DE102004026615A1 (en) * 2004-06-01 2005-12-29 Siemens Ag Apparatus and method for releasing a guided inside the body of a patient the therapeutic agent
US7764995B2 (en) 2004-06-07 2010-07-27 Cardiac Pacemakers, Inc. Method and apparatus to modulate cellular regeneration post myocardial infarct
US8017137B2 (en) 2004-07-19 2011-09-13 Bartholomew Julie R Customized retail point of sale dispensing methods
US20090234214A1 (en) * 2004-07-30 2009-09-17 Microchips, Inc. Multi-reservoir device and method for transdermal sensing
US20060024358A1 (en) * 2004-07-30 2006-02-02 Santini John T Jr Multi-reservoir device for transdermal drug delivery and sensing
US7537590B2 (en) 2004-07-30 2009-05-26 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
US7567841B2 (en) 2004-08-20 2009-07-28 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
US8805492B2 (en) 2004-08-20 2014-08-12 Cardiac Pacemakers, Inc. Method and apparatus for delivering combined electrical and drug therapies
US7604628B2 (en) 2004-09-01 2009-10-20 Microchips, Inc. Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US20060057737A1 (en) * 2004-09-01 2006-03-16 Santini John T Jr Multi-cap reservoir devices for controlled release or exposure of reservoir contents
US8403915B2 (en) 2004-09-01 2013-03-26 Microchips, Inc. Multi-opening reservoir devices for controlled release or exposure of reservoir contents
US8271093B2 (en) 2004-09-17 2012-09-18 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements using a backend computing system
US8852099B2 (en) 2004-09-17 2014-10-07 Cardiac Pacemakers, Inc. Systems and methods for deriving relative physiologic measurements
US8100889B2 (en) * 2004-11-10 2012-01-24 Olympus Corporation Body-insertable apparatus
US20090012503A1 (en) * 2004-11-10 2009-01-08 Hironao Kawano Body-Insertable Apparatus
US7813808B1 (en) 2004-11-24 2010-10-12 Remon Medical Technologies Ltd Implanted sensor system with optimized operational and sensing parameters
US8060219B2 (en) 2004-12-20 2011-11-15 Cardiac Pacemakers, Inc. Epicardial patch including isolated extracellular matrix with pacing electrodes
US7981065B2 (en) 2004-12-20 2011-07-19 Cardiac Pacemakers, Inc. Lead electrode incorporating extracellular matrix
US20080076975A1 (en) * 2005-01-25 2008-03-27 Microchips, Inc. Method and implantable device with reservoir array for pre-clinical in vivo testing
US8929990B2 (en) 2005-04-11 2015-01-06 Cardiac Pacemakers, Inc. Transvascular neural stimulation device and method for treating hypertension
US7979141B2 (en) 2005-05-16 2011-07-12 Cardiac Pacemakers, Inc. Transvascular reshaping lead system
US20100016927A1 (en) * 2005-05-16 2010-01-21 Anthony Caparso Transvascular reshaping lead system
US8892197B2 (en) 2005-07-29 2014-11-18 Medtronic, Inc. Method and apparatus to control conduction through the heart to treat cardiac conditions
US20070027394A1 (en) * 2005-07-29 2007-02-01 Ujhelyi Michael R Method and apparatus to control conduction through the heart to treat cardiac conditions
US7742815B2 (en) 2005-09-09 2010-06-22 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US7949394B2 (en) 2005-09-09 2011-05-24 Cardiac Pacemakers, Inc. Using implanted sensors for feedback control of implanted medical devices
US8660648B2 (en) 2005-10-24 2014-02-25 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US20070093875A1 (en) * 2005-10-24 2007-04-26 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US8126561B2 (en) 2005-10-24 2012-02-28 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US8634921B2 (en) 2005-10-24 2014-01-21 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US20170119961A1 (en) * 2005-11-02 2017-05-04 Peter Forsell Implantable infusion devices and methods
US9504785B2 (en) * 2005-11-02 2016-11-29 Peter Forsell Implantable infusion devices and methods
US20070233019A1 (en) * 2005-11-02 2007-10-04 Potencia Medical Ag Implantable infusion devices and methods
US7955268B2 (en) 2006-07-21 2011-06-07 Cardiac Pacemakers, Inc. Multiple sensor deployment
US20090259182A1 (en) * 2007-09-28 2009-10-15 Calibra Medical, Inc. wearable low profile infusion device
US20100318175A1 (en) * 2007-12-31 2010-12-16 C.R. Bard, Inc. Vascular graft prosthesis with selective flow reduction
US8961448B2 (en) 2008-01-28 2015-02-24 Peter Forsell Implantable drainage device
US9694165B2 (en) * 2008-01-28 2017-07-04 Peter Mats Forsell Implantable drainage device
US20150157836A1 (en) * 2008-01-28 2015-06-11 Peter Mats Forsell Implantable drainage device
US8636809B2 (en) 2008-01-29 2014-01-28 Milux Holding Sa Device for treating obesity
US9060771B2 (en) 2008-01-29 2015-06-23 Peter Forsell Method and instrument for treating obesity
US8725260B2 (en) 2008-02-11 2014-05-13 Cardiac Pacemakers, Inc Methods of monitoring hemodynamic status for rhythm discrimination within the heart
US8369960B2 (en) 2008-02-12 2013-02-05 Cardiac Pacemakers, Inc. Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices
DE102008010876A1 (en) 2008-02-23 2009-09-03 Universität Leipzig Microsystem for controlled active substance release in e.g. therapy of neurological defects, has integrated electronics controlling electroactive polymers and conductive paths for contacting polymers provided on carrier substrate
US20090220563A1 (en) * 2008-02-29 2009-09-03 Pharmaco-Kinesis Corporation Artificial tooth medicating apparatus for controlling, regulating, sensing, and releasing medical agents into the body
US8202090B2 (en) * 2008-02-29 2012-06-19 Pharmaco-Kinesis Corporation Artificial tooth medicating apparatus for controlling, regulating, sensing, and releasing medical agents into the body
US8262616B2 (en) 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US8600510B2 (en) 2008-10-10 2013-12-03 Milux Holding Sa Apparatus, system and operation method for the treatment of female sexual dysfunction
US8591423B2 (en) 2008-10-10 2013-11-26 Cardiac Pacemakers, Inc. Systems and methods for determining cardiac output using pulmonary artery pressure measurements
US9526649B2 (en) 2008-10-10 2016-12-27 Peter Forsell Method and instrument for treating obesity
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8696745B2 (en) 2008-10-10 2014-04-15 Kirk Promotion Ltd. Heart help device, system, and method
US8874215B2 (en) 2008-10-10 2014-10-28 Peter Forsell System, an apparatus, and a method for treating a sexual dysfunctional female patient
US8509894B2 (en) 2008-10-10 2013-08-13 Milux Holding Sa Heart help device, system, and method
US8016789B2 (en) 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US9370656B2 (en) 2008-10-10 2016-06-21 Peter Forsell System, an apparatus, and a method for treating a sexual dysfunctional female patient
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8708376B2 (en) 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US9072907B2 (en) 2008-10-10 2015-07-07 Peter Forsell Heart help device, system, and method
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US8632470B2 (en) 2008-11-19 2014-01-21 Cardiac Pacemakers, Inc. Assessment of pulmonary vascular resistance via pulmonary artery pressure
US20100234827A1 (en) * 2009-03-13 2010-09-16 Sigg Daniel C Method of treating heart failure
US9949812B2 (en) 2009-07-17 2018-04-24 Peter Forsell Vaginal operation method for the treatment of anal incontinence in women
US20110184358A1 (en) * 2010-01-27 2011-07-28 Weiner Alan L Pulsatile peri-corneal drug delivery device
US8469934B2 (en) * 2010-01-27 2013-06-25 Alcon Research, Ltd. Pulsatile peri-corneal drug delivery device
US20110224636A1 (en) * 2010-03-15 2011-09-15 Keisic Hollis S Urinary bag system
US20140221963A1 (en) * 2011-08-25 2014-08-07 Edy E. Soffer Use of eating detection to control the release of biologically active agents
US8761717B1 (en) 2012-08-07 2014-06-24 Brian K. Buchheit Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate
US8954030B1 (en) 2012-08-07 2015-02-10 Brian K. Buchheit Safety feature to disable an electronic device when a wireless implantable medical device (IMD) is proximate

Similar Documents

Publication Publication Date Title
US3384080A (en) Portable spring powered infusion device having escapement means controlling speed ofinfusion
US5707361A (en) Implantable infusion system with a neutral pressure medication container
US4561856A (en) Infusion pump
US4548607A (en) Implantable manually actuated medication dispensing system
US5466218A (en) Method of cleaning an implanted medication infusion pump with discharge side port
US7144384B2 (en) Dispenser components and methods for patient infusion device
US4692147A (en) Drug administration device
US6669669B2 (en) Laminated patient infusion device
US5360410A (en) Safety syringe for mixing two-component medicaments
US4209014A (en) Dispensing device for medicaments
US4973304A (en) Device for sustained release of active substance
US5785688A (en) Fluid delivery apparatus and method
US4437859A (en) Hydraulic syringe drive
US8465455B2 (en) Cartridge insertion assembly
US4146029A (en) Self-powered implanted programmable medication system and method
US5304165A (en) Syringe-filling medication dispenser
US4813951A (en) Self-actuated implantable pump
US4351335A (en) Injection device and method
US5722957A (en) Implantable infusion pump
US4267836A (en) Injection device and method
US7311693B2 (en) Drug delivery device and method
US5374256A (en) Fluid container for use with a fluid delivery apparatus
US6629954B1 (en) Drug delivery pump with isolated hydraulic metering
US8114064B2 (en) Infusion device with piston pump
US4522622A (en) Multiple fluid pulse dispenser