AR110740A1 - Compuestos bicíclicos como inhibidores alostéricos de shp2 - Google Patents
Compuestos bicíclicos como inhibidores alostéricos de shp2Info
- Publication number
- AR110740A1 AR110740A1 ARP180100059A ARP180100059A AR110740A1 AR 110740 A1 AR110740 A1 AR 110740A1 AR P180100059 A ARP180100059 A AR P180100059A AR P180100059 A ARP180100059 A AR P180100059A AR 110740 A1 AR110740 A1 AR 110740A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- nr5s
- cycloalkyl
- heterocycle
- nr5r6
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762449530P | 2017-01-23 | 2017-01-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR110740A1 true AR110740A1 (es) | 2019-05-02 |
Family
ID=61054566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP180100059A AR110740A1 (es) | 2017-01-23 | 2018-01-09 | Compuestos bicíclicos como inhibidores alostéricos de shp2 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11739093B2 (OSRAM) |
| EP (1) | EP3571199A1 (OSRAM) |
| JP (2) | JP7240319B2 (OSRAM) |
| KR (1) | KR102665763B1 (OSRAM) |
| CN (2) | CN117327075A (OSRAM) |
| AR (1) | AR110740A1 (OSRAM) |
| AU (2) | AU2018210770B2 (OSRAM) |
| BR (1) | BR112019015075A2 (OSRAM) |
| CA (1) | CA3051206A1 (OSRAM) |
| IL (2) | IL296456A (OSRAM) |
| MX (2) | MX2019008695A (OSRAM) |
| SG (1) | SG11201906209SA (OSRAM) |
| TW (1) | TWI820013B (OSRAM) |
| WO (1) | WO2018136265A1 (OSRAM) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| JP7044375B2 (ja) | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
| RU2744988C2 (ru) | 2016-06-14 | 2021-03-17 | Новартис Аг | Соединения и композиции для подавления активности shp2 |
| PE20190624A1 (es) | 2016-07-12 | 2019-04-26 | Revolution Medicines Inc | 3-metil pirazinas 2,5-disustituidas y 3-metil pirazinas 2,5,6-trisustituidas como inhibidores alostericos de shp2 |
| WO2018057884A1 (en) | 2016-09-22 | 2018-03-29 | Relay Therapeutics, Inc. | Shp2 phosphatase inhibitors and methods of use thereof |
| TWI848901B (zh) | 2016-10-24 | 2024-07-21 | 美商傳達治療有限公司 | Shp2磷酸酶抑制劑及其使用方法 |
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| US11591336B2 (en) | 2017-05-26 | 2023-02-28 | D. E. Shaw Research, Llc | Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors |
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| TW202313041A (zh) | 2021-06-09 | 2023-04-01 | 瑞士商諾華公司 | 包含達拉菲尼、曲美替尼和shp2抑制劑之三重藥物組合 |
| TW202317100A (zh) | 2021-06-23 | 2023-05-01 | 瑞士商諾華公司 | 包含ｋｒａｓ ｇ１２ｃ抑制劑的藥物組合及其用於治療癌症之用途 |
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| CN112368272B (zh) | 2018-03-21 | 2023-04-21 | 苏州浦合医药科技有限公司 | Shp2抑制剂及其用途 |
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| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのｋｒａｓｇ１２ｃ阻害剤及び１種以上の薬学的に活性な追加の薬剤を含む併用療法 |
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-
2018
- 2018-01-09 CN CN202311080113.2A patent/CN117327075A/zh active Pending
- 2018-01-09 JP JP2019539774A patent/JP7240319B2/ja active Active
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- 2018-01-09 WO PCT/US2018/013023 patent/WO2018136265A1/en not_active Ceased
- 2018-01-09 SG SG11201906209SA patent/SG11201906209SA/en unknown
- 2018-01-09 BR BR112019015075-7A patent/BR112019015075A2/pt not_active Application Discontinuation
- 2018-01-09 EP EP18701883.3A patent/EP3571199A1/en active Pending
- 2018-01-09 MX MX2019008695A patent/MX2019008695A/es unknown
- 2018-01-09 CA CA3051206A patent/CA3051206A1/en active Pending
- 2018-01-09 IL IL296456A patent/IL296456A/en unknown
- 2018-01-09 KR KR1020197024604A patent/KR102665763B1/ko active Active
- 2018-01-09 AU AU2018210770A patent/AU2018210770B2/en not_active Ceased
- 2018-01-09 CN CN201880018606.4A patent/CN110446709B/zh active Active
- 2018-01-09 TW TW107100769A patent/TWI820013B/zh not_active IP Right Cessation
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2019
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2022
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2023
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| IL268030A (en) | 2019-09-26 |
| KR20190111079A (ko) | 2019-10-01 |
| CA3051206A1 (en) | 2018-07-26 |
| AU2022204275A1 (en) | 2022-07-07 |
| JP2020506178A (ja) | 2020-02-27 |
| US12365688B2 (en) | 2025-07-22 |
| JP2023018095A (ja) | 2023-02-07 |
| IL268030B2 (en) | 2023-02-01 |
| IL296456A (en) | 2022-11-01 |
| MX2023004037A (es) | 2023-04-27 |
| RU2019126456A (ru) | 2021-02-24 |
| CN117327075A (zh) | 2024-01-02 |
| AU2018210770A1 (en) | 2019-08-15 |
| TWI820013B (zh) | 2023-11-01 |
| SG11201906209SA (en) | 2019-08-27 |
| US11739093B2 (en) | 2023-08-29 |
| TW201827435A (zh) | 2018-08-01 |
| AU2018210770B2 (en) | 2022-03-24 |
| WO2018136265A1 (en) | 2018-07-26 |
| IL268030B (en) | 2022-10-01 |
| KR102665763B1 (ko) | 2024-05-10 |
| RU2019126456A3 (OSRAM) | 2021-02-26 |
| US20200017511A1 (en) | 2020-01-16 |
| CN110446709B (zh) | 2023-09-12 |
| US20240199616A1 (en) | 2024-06-20 |
| CN110446709A (zh) | 2019-11-12 |
| BR112019015075A2 (pt) | 2020-03-10 |
| JP7240319B2 (ja) | 2023-03-15 |
| MX2019008695A (es) | 2019-09-11 |
| EP3571199A1 (en) | 2019-11-27 |
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