AR095601A1 - Diazilhidrazinas que contienen boro - Google Patents
Diazilhidrazinas que contienen boroInfo
- Publication number
- AR095601A1 AR095601A1 ARP140101226A ARP140101226A AR095601A1 AR 095601 A1 AR095601 A1 AR 095601A1 AR P140101226 A ARP140101226 A AR P140101226A AR P140101226 A ARP140101226 A AR P140101226A AR 095601 A1 AR095601 A1 AR 095601A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- optionally substituted
- alkyl
- hydrogen
- hydroxy
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N55/00—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
- A01N55/08—Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/69—Boron compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
Abstract
Es útil para aplicaciones tales como la terapia génica, el tratamiento de enfermedades, la producción a gran escala de proteínas y anticuerpos, los ensayos de cribado basados en células, la genómica funcional, la proteómica, la metabolómica y la regulación de los rasgos en organismos transgénicos, donde el control de gen los niveles de expresión es deseable. Reivindicación 1: Un compuesto que tiene la fórmula (1), donde: R¹ y R² se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, alquilo opcionalmente sustituido y haloalquilo; o R¹ y R² tomados en conjunto con el átomo de carbono al cual están unidos forman un cicloalquilo de 4 a 8 miembros; R³ se selecciona del grupo que consiste de hidrógeno, alquilo opcionalmente sustituido, haloalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, arilo opcionalmente sustituido y heteroarilo opcionalmente sustituido; R⁴ se selecciona del grupo que consiste de los restos del grupo de fórmulas (2); X¹ se selecciona del grupo que consiste de -O- y -N(R⁸ᵃ)-; Y¹ es -(CR⁹ᵃR⁹ᵇ)ₘ-; Z¹ se selecciona del grupo que consiste de -O- y -N(R⁸ᵇ)- o Z¹ está ausente; R⁶ᵃ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵃ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵃ y R⁷ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁷ᵃ y R⁷ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵃ y R⁸ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵃ y R⁹ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; m es 1, 2, 3 ó 4; X² se selecciona del grupo que consiste de -O- y -N(R⁸ᶜ)-; Y² es -(CR⁹ᶜR⁹ᵈ)ₙ-; Z² se selecciona del grupo que consiste de -O- y -N(R⁸ᵈ)- o Z² está ausente; R⁶ᵇ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵇ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᶜ y R⁷ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᶜ y R⁸ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᶜ y R⁹ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; n es 1, 2, 3 ó 4; X se selecciona del grupo que consiste de -O- y -N(R⁸ᵉ)-; R⁶ᶜ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᶜ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵉ y R⁷ᶠ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵉ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁶ᵈ se selecciona del grupo que consiste de hidroxi, alquilo y alcoxi; o R⁶ᵈ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁶ᶠ se selecciona del grupo que consiste de hidrógeno, alquilo, amino e hidroxi; X⁵ se selecciona del grupo que consiste de -O- y -N(R⁸ᵏ)-; R⁷ᵍ y R⁷ʰ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᵏ se selecciona del grupo que consiste de hidrógeno y alquilo; X⁶ se selecciona del grupo que consiste de -O- y -N(R⁸ˡ)-; X⁷ se selecciona del grupo que consiste de -O- y -N(R⁸ⁿ)-; R⁸ˡ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁸ᵐ se selecciona del grupo que consiste de hidrógeno y alquilo; R⁸ⁿ se selecciona del grupo que consiste de hidrógeno y alquilo; R¹⁰ᵃ se selecciona del grupo que consiste de hidrógeno y -(CR¹¹ᵃR¹¹ᵇ)ₒ-B(R¹²ᵃ)(R¹²ᵇ); y R¹⁰ᵇ, R¹⁰ᶜ, y R¹⁰ᵈ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alquilo opcionalmente sustituido, haloalquilo, alcoxialquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, heteroalquilo, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᵇ se selecciona del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, -N(H)CHO, -N(H)CN, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, heteroalquilo, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o -N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᶜ y R¹⁰ᵈ tomados en conjunto con dos átomos de carbono adyacentes forman un grupo cicloalquilo opcionalmente sustituido fusionado, heterociclo opcionalmente sustituido o heteroarilo opcionalmente sustituido; R¹¹ᵃ y R¹¹ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R¹²ᵃ y R¹²ᵇ se seleccionan del grupo que consiste de hidroxi y alcoxi; o R¹²ᵃ y R¹²ᵇ tomados en conjunto forman una unión -O(CR¹³ᵃR¹³ᵇ)ₚO-; o -B(R¹²ᵃ)(R¹²ᵇ) forma un aducto de flúor; R¹³ᵃ y R¹³ᵇ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo C₁₋₄; o es 0, 1, 2, 3, 4 ó 5; p es 2, 3 ó 4; R⁵ es un resto R⁴-3, R⁴-4, R⁴-8, R⁴-9 o R⁴-10 del grupo de fórmulas (2); o R⁵ se selecciona del grupo que consiste de los compuestos del grupo de fórmulas (3); X³ se selecciona del grupo que consiste de -O- y -N(R⁸ᶠ)-; Y³ es -(CR⁹ᵉR⁹ᶠ)q-; Z³ se selecciona del grupo que consiste de -O- y -N(R⁸ᵍ)- o Z³ está ausente; R⁶ᵉ se selecciona del grupo que consiste de hidroxi y alquilo; o R⁶ᵉ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ⁱ y R⁷ʲ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ᶠ y R⁸ᵍ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵉ y R⁹ᶠ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; q es 1, 2, 3 ó 4; X⁴ se selecciona del grupo que consiste de -O- y -N(R⁸ʰ)-; Y⁴ es -(CR⁹ᵍR⁹ʰ)ʳ-; Z⁴ se selecciona del grupo que consiste de -O- y -N(R⁸ⁱ)- o Z⁴ está ausente; R⁶ᵍ se selecciona del grupo que consiste de hidroxi y alquilo; o R⁶ᵍ forma un aducto de hidroxi ácido o un aducto de amino ácido; R⁷ᵏ y R⁷ˡ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, alcoxi y alquiltio; R⁸ʰ y R⁸ⁱ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; R⁹ᵍ y R⁹ʰ se seleccionan -cada uno en forma independiente- del grupo que consiste de hidrógeno y alquilo; r es 1, 2, 3 ó 4; R¹⁰ᵉ se selecciona del grupo que consiste de hidrógeno y -(CR¹¹ᶜR¹¹ᵈ)ₛ-B(R¹²ᶜ)(R¹²ᵈ); y R¹⁰ᶠ, R¹⁰ᵍ, y R¹⁰ʰ se seleccionan -de manera independiente- del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alquilo opcionalmente sustituido, haloalquilo, hidroxialquilo, arilalquilo, cicloalquilo opcionalmente sustituido, alquenilo opcionalmente sustituido, alquinilo opcionalmente sustituido, arilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, heterociclo opcionalmente sustituido, alcoxi, ariloxi, arilalquiloxi, alquiltio, carboxamido, sulfonamido, -COR¹⁶, -SO₂R¹⁷, -N(R¹⁸)COR¹⁹, -N(R¹⁸)SO₂R²⁰ o -N(R¹⁸)C=N(R²¹)-amino; o R¹⁰ᶠ se selecciona del grupo que consiste de hidrógeno, halo, nitro, ciano, hidroxi, amino, -N(H)CHO, -N(H)CN, alqu
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201361792412P | 2013-03-15 | 2013-03-15 |
Publications (1)
Publication Number | Publication Date |
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AR095601A1 true AR095601A1 (es) | 2015-10-28 |
Family
ID=51529908
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP140101226A AR095601A1 (es) | 2013-03-15 | 2014-03-17 | Diazilhidrazinas que contienen boro |
Country Status (21)
Country | Link |
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US (4) | US9127024B2 (es) |
EP (1) | EP2970106B1 (es) |
JP (1) | JP6379173B2 (es) |
KR (1) | KR20150129034A (es) |
CN (1) | CN105283439B (es) |
AR (1) | AR095601A1 (es) |
AU (2) | AU2014227571B2 (es) |
BR (1) | BR112015022994A2 (es) |
CA (1) | CA2904436C (es) |
DK (1) | DK2970106T3 (es) |
ES (1) | ES2683329T3 (es) |
HK (1) | HK1220441A1 (es) |
IL (1) | IL241119B (es) |
MX (1) | MX361717B (es) |
NZ (1) | NZ712167A (es) |
PH (1) | PH12015502099A1 (es) |
RU (1) | RU2637946C2 (es) |
SG (1) | SG11201506875YA (es) |
TW (1) | TWI636986B (es) |
WO (1) | WO2014144380A1 (es) |
ZA (1) | ZA201506985B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101386799B1 (ko) | 2009-10-06 | 2014-04-21 | 리전츠 오브 더 유니버스티 오브 미네소타 | 생분해성 색전술용 미소구체 |
PL2603514T3 (pl) | 2010-08-10 | 2019-04-30 | Rempex Pharmaceuticals Inc | Cykliczne pochodne estrowe kwasu boronowego oraz ich zastosowania terapeutyczne |
US10070649B2 (en) | 2013-01-30 | 2018-09-11 | Agrofresh Inc. | Volatile applications against pathogens |
US11039617B2 (en) | 2013-01-30 | 2021-06-22 | Agrofresh Inc. | Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness |
KR20150129034A (ko) * | 2013-03-15 | 2015-11-18 | 인트렉손 코포레이션 | 붕소-함유 디아실하이드라진류 |
KR20170007448A (ko) | 2014-05-19 | 2017-01-18 | 렘펙스 파머수티클스 인코퍼레이티드 | 보론산 유도체 및 그의 치료적 용도 |
CN107406373B (zh) * | 2014-09-17 | 2020-04-28 | 英特瑞克斯顿股份有限公司 | 含硼的二酰基肼化合物 |
WO2016081297A1 (en) | 2014-11-18 | 2016-05-26 | Rempex Pharmaceuticals, Inc. | Cyclic boronic acid ester derivatives and therapeutic uses thereof |
WO2016149393A1 (en) | 2015-03-17 | 2016-09-22 | Rempex Pharmaceuticals, Inc. | Boronic acid derivatives and therapeutic uses thereof |
CN105675559B (zh) * | 2016-01-14 | 2018-01-30 | 中国科学院理化技术研究所 | 一种利用碳点作为荧光探针检测多巴胺的方法 |
WO2017155879A1 (en) | 2016-03-07 | 2017-09-14 | Agrofresh Inc. | Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops |
US10182979B2 (en) | 2016-03-22 | 2019-01-22 | Regents Of The University Of Minnesota | Biodegradable microspheres |
EP3443001A4 (en) | 2016-04-11 | 2020-04-29 | Obsidian Therapeutics, Inc. | REGULATED BIOCIRCUIT SYSTEMS |
MY196909A (en) | 2016-06-30 | 2023-05-09 | Qpex Biopharma Inc | Boronic acid derivatives and therapeutic uses thereof |
MX2019002918A (es) * | 2016-09-16 | 2019-07-18 | Dyax Corp | Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activacion por contacto. |
CN113620981A (zh) * | 2016-10-05 | 2021-11-09 | 结核病药物开发全球联盟公司 | 用于治疗分枝杆菌感染的杂芳基三氟硼酸盐化合物 |
CN109119689B (zh) * | 2017-06-26 | 2020-11-20 | 比亚迪股份有限公司 | 非水电解液以及锂离子电池 |
AU2018338855B2 (en) | 2017-09-29 | 2022-04-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
US11286270B2 (en) | 2017-10-11 | 2022-03-29 | Qpex Biopharma, Inc. | Boronic acid derivatives and synthesis thereof |
CN112592364A (zh) * | 2020-12-22 | 2021-04-02 | 江西同和药业股份有限公司 | 一种克立硼罗中间、制备方法体及其在制备克立硼罗中的应用 |
Family Cites Families (113)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4631211A (en) | 1985-03-25 | 1986-12-23 | Scripps Clinic & Research Foundation | Means for sequential solid phase organic synthesis and methods using the same |
US5424333A (en) | 1985-10-21 | 1995-06-13 | Rohm And Haas Company | Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines |
US5354762A (en) | 1986-07-14 | 1994-10-11 | Rohm And Haas Company | Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines |
US4985461A (en) | 1985-10-21 | 1991-01-15 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
DK483586A (da) * | 1985-10-21 | 1987-04-22 | Rohm & Haas | Insecticide n'-substituerede-n,n'-diacylhydraziner |
US5117057A (en) | 1985-10-21 | 1992-05-26 | Rohm And Haas Company | Insecticidal N' substituted-N-N'-disubstituted-hydrazines |
US4814349A (en) | 1985-12-09 | 1989-03-21 | American Cyanamid Company | Insecticidal substituted and unsubstituted benzoic acid 1-alkyl, 2 alkyl and 2-cycloalkylhydrazides |
EP0228564B1 (en) | 1985-12-09 | 1992-01-29 | American Cyanamid Company | Novel insecticidal diacylhydrazine compounds |
CA1338289C (en) | 1986-01-22 | 1996-04-30 | Raymond August Murphy | Insecticidal n'-substituted-n-alkylcarbonyl- n'-acylhydrazines |
CA1295618C (en) | 1986-02-28 | 1992-02-11 | Adam Chi-Tung Hsu | Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines |
US4859609A (en) | 1986-04-30 | 1989-08-22 | Genentech, Inc. | Novel receptors for efficient determination of ligands and their antagonists or agonists |
CA1281716C (en) | 1986-05-01 | 1991-03-19 | Raymond August Murphy | Insecticidal n-substituted-n'-substituted-n,n'- diacylhydrazines |
US5225443A (en) | 1986-05-01 | 1993-07-06 | Rohm And Haas Company | Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines |
ES2037709T3 (es) | 1986-07-14 | 1996-07-16 | Rohm & Haas | Derivados heterociclicos de seis miembros de n,n'-diacilhidrazinas n'-sustituidas. |
US5071773A (en) | 1986-10-24 | 1991-12-10 | The Salk Institute For Biological Studies | Hormone receptor-related bioassays |
EP0286746B1 (en) | 1987-04-15 | 1991-02-27 | Rohm And Haas Company | Insecticidal n-(optionally substituted) - n'-substituted-n,n'-disubstituted- hydrazines |
US4906280A (en) | 1987-10-14 | 1990-03-06 | Pennwalt Corporation | Tertiary butylhydrazides as plant growth regulators |
US4981784A (en) | 1987-12-02 | 1991-01-01 | The Salk Institute For Biological Studies | Retinoic acid receptor method |
US5171671A (en) | 1987-12-02 | 1992-12-15 | The Salk Institute For Biological Studies | Retinoic acid receptor composition |
US5429952A (en) | 1988-02-02 | 1995-07-04 | Biocode, Inc. | Marking of products to establish identity and source |
US5110986A (en) | 1988-04-26 | 1992-05-05 | Rohm And Haas Company | Synthesis of n-t-alkyl-1,2-diacylhydrazines |
US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
WO1989012690A1 (en) | 1988-06-13 | 1989-12-28 | American Biogentic Sciences, Inc. | Method for the production of monoclonal antibodies utilizing a germfree animal |
MY107431A (en) | 1988-06-15 | 1995-12-30 | Rohm & Haas | Insecticidal n''''substituted-n-alkylcarbonyl-n''''-acylhydra zines and n''''substituted-n-acyl-n''''-alkylcarbonylhydrazines. |
ZA894508B (en) | 1988-06-16 | 1990-03-28 | Rohm & Haas | Pharmaceutical compounds |
JPH02207066A (ja) | 1989-02-07 | 1990-08-16 | Ishihara Sangyo Kaisha Ltd | ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤 |
US4950666A (en) | 1989-03-30 | 1990-08-21 | Fmc Corporation | Difluoroalkane and difluoroalkenylalkane pesticides |
US4954655A (en) | 1989-03-31 | 1990-09-04 | Rohm And Haas Company | Preparation of alkylhydrazines |
EP0395581A1 (de) | 1989-04-27 | 1990-10-31 | Ciba-Geigy Ag | N-Sulfenyl- und N-sulfinyl-N,N'-diacylhydrazide |
NZ228936A (en) | 1989-05-01 | 1992-04-28 | Rohm & Haas | Method for treating insect infestation in rice plants comprising applying diacylhydrazine derivatives |
JPH03141245A (ja) | 1989-10-24 | 1991-06-17 | Ishihara Sangyo Kaisha Ltd | ヒドラジン系化合物、それらの製造方法及びそれらを含有する有害動物防除剤 |
JPH03145447A (ja) | 1989-10-31 | 1991-06-20 | Nissan Chem Ind Ltd | ジベンゾイルヒドラジン化合物および殺虫剤 |
US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
ATE196310T1 (de) | 1990-02-09 | 2000-09-15 | Salk Inst For Biological Studi | Retinoid-rezeptor-zusammensetzungen und verfahren |
AU7492291A (en) | 1990-02-26 | 1991-09-18 | Board Of Trustees Of The Leland Stanford Junior University | Identification and expression of insect steroid receptor dna sequences |
US5688691A (en) | 1990-03-22 | 1997-11-18 | The Salk Institute For Biological Studies | Insect retinoid-like receptor compositions and methods |
AU655417B2 (en) | 1990-03-22 | 1994-12-22 | Salk Institute For Biological Studies, The | Insect retinoid receptor compositions and methods |
US7119077B1 (en) | 1990-03-22 | 2006-10-10 | The Salk Institute For Biological Studies | Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor |
US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
CA2043775A1 (en) | 1990-06-14 | 1991-12-15 | Dat P. Le | Dibenzoylakylcyanohydrazines |
JPH0539252A (ja) | 1990-08-01 | 1993-02-19 | Nippon Kayaku Co Ltd | N,N’−ジベンゾイル−tert−ブチルヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
JP2885902B2 (ja) | 1990-08-01 | 1999-04-26 | 日本化薬株式会社 | N’―tert―ブチル―N―ハロゲノメチルスルフェニル―N,N’―ジベンゾイルヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
JP3068846B2 (ja) | 1990-08-01 | 2000-07-24 | 日本化薬株式会社 | 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
US5075471A (en) | 1990-10-09 | 1991-12-24 | Rohm And Haas Company | Insecticidal ferrocenoyl acylhydrazines |
JP3087854B2 (ja) | 1991-01-09 | 2000-09-11 | 日本化薬株式会社 | 新規ヒドラジン誘導体及びそれを有効成分とする殺虫組成物 |
IL100643A (en) | 1991-01-25 | 1996-10-31 | Nippon Kayaku Kk | History of hydrazine and pesticides containing these histories as an active ingredient |
US5668175A (en) | 1991-08-23 | 1997-09-16 | The Salk Institute For Biological Studies | Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids |
AU2516092A (en) | 1991-08-23 | 1993-03-16 | Ligand Pharmaceuticals, Inc. | Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones |
AU2579692A (en) | 1991-09-17 | 1993-04-27 | Salk Institute For Biological Studies, The | Receptor of the thyroid/steroid hormone receptor superfamily |
EP0619842A1 (en) | 1991-12-06 | 1994-10-19 | The Salk Institute For Biological Studies | Multimeric forms of members of the steroid/thyroid superfamily of receptors |
US6013836A (en) | 1992-02-28 | 2000-01-11 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-disubstitutedhydrazines |
US5530028A (en) | 1992-11-23 | 1996-06-25 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
US5344958A (en) | 1992-11-23 | 1994-09-06 | Rohm And Haas Company | Insecticidal N'-substituted-N,N'-diacylhydrazines |
JPH06172342A (ja) | 1992-12-07 | 1994-06-21 | Nippon Kayaku Co Ltd | 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
JP3298954B2 (ja) | 1992-12-16 | 2002-07-08 | 三共株式会社 | 新規n,n’−ジベンゾイルヒドラジン誘導体及び殺虫組成物 |
PT705279E (pt) | 1993-05-27 | 2003-07-31 | Selectide Corp | Bibliotecas em fase solida codificadas, segregadas topologicamente |
US5358966A (en) | 1993-06-08 | 1994-10-25 | Rohm And Haas Company | Turfgrass insecticides |
EP0639559B1 (en) | 1993-08-19 | 1997-10-15 | Rohm And Haas Company | Preparation of 1,2-diacyl-2-(t-alkyl)hydrazines |
FR2714830B1 (fr) | 1994-01-10 | 1996-03-22 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
FR2715847B1 (fr) | 1994-02-08 | 1996-04-12 | Rhone Poulenc Rorer Sa | Composition contenant des acides nucléiques, préparation et utilisations. |
US5482962A (en) * | 1994-07-22 | 1996-01-09 | Rohm And Haas Company | Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines |
FR2727679B1 (fr) | 1994-12-05 | 1997-01-03 | Rhone Poulenc Rorer Sa | Nouveaux agents de transfection et leurs applications pharmaceutiques |
WO1996021457A1 (en) | 1995-01-13 | 1996-07-18 | The Salk Institute For Biological Studies | Allosteric control of nuclear hormone receptors |
FR2730637B1 (fr) | 1995-02-17 | 1997-03-28 | Rhone Poulenc Rorer Sa | Composition pharmaceutique contenant des acides nucleiques, et ses utilisations |
JP3600298B2 (ja) | 1995-02-27 | 2004-12-15 | 日本化薬株式会社 | 新規ヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
JPH08231529A (ja) | 1995-02-27 | 1996-09-10 | Nippon Kayaku Co Ltd | ヒドラジン誘導体およびそれを有効成分とする殺虫組成物 |
CA2213340C (en) | 1995-03-03 | 2011-07-26 | Novartis Ag | Control of gene expression in plants by receptor mediated transactivation in the presence of a chemical ligand |
AU711391B2 (en) | 1995-05-26 | 1999-10-14 | Syngenta Limited | A gene switch comprising an ecdysone receptor |
JPH09100262A (ja) | 1995-06-06 | 1997-04-15 | Rohm & Haas Co | N,N’−ジアシル−N’−t−アルキルヒドラジン化合物の製造方法 |
CA2200423C (en) | 1996-03-26 | 2006-12-19 | Sietse Mosselman | Novel estrogen receptor |
CA2251466A1 (en) | 1996-04-05 | 1997-10-16 | The Salk Institute For Biological Studies | Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6723531B2 (en) * | 1996-04-05 | 2004-04-20 | The Salk Institute For Biological Studies | Method for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6025483A (en) | 1996-06-05 | 2000-02-15 | The Regents Of The University Of California | Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same |
US5919667A (en) | 1996-06-20 | 1999-07-06 | The Salk Institute For Biological Studies | Modular assembly retroviral vectors and uses thereof |
US5948406A (en) | 1996-08-12 | 1999-09-07 | Rohm And Haas Company | Immunogens, antibodies formed therefrom, and coating antigens useful in a diacylhydrazine immunoassay method |
US6300488B1 (en) | 1997-07-10 | 2001-10-09 | The Salk Institute For Biological Studies | Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression |
AU738494B2 (en) | 1997-07-10 | 2001-09-20 | Salk Institute For Biological Studies, The | Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression |
DE19837620A1 (de) | 1997-08-22 | 1999-02-25 | Novartis Ag | Organische Verbindungen |
CA2300376A1 (en) | 1997-08-26 | 1999-03-04 | Ariad Gene Therapeutics, Inc. | Fusion proteins comprising a dimerization, trimerization or tetramerization domain and an additional heterologous transcription activation, transcription repression, dna binding or ligand binding domain |
US6756491B2 (en) | 1998-01-09 | 2004-06-29 | The Salk Institute For Biological Studies | Steroid-activated nuclear receptors and uses therefor |
AUPP135698A0 (en) | 1998-01-15 | 1998-02-05 | Commonwealth Scientific And Industrial Research Organisation | Insectical modalities |
US6333318B1 (en) * | 1998-05-14 | 2001-12-25 | The Salk Institute For Biological Studies | Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto |
US6258603B1 (en) | 1998-06-17 | 2001-07-10 | Rohm And Haas Company | Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
JP2000026423A (ja) | 1998-07-09 | 2000-01-25 | Otsuka Chem Co Ltd | イソニコチノイルヒドラジン誘導体及び該誘導体を有効成分として含有する害虫防除剤 |
DE19831710A1 (de) | 1998-07-15 | 2000-01-20 | Merck Patent Gmbh | Diacylhydrazinderivate |
EP0984009A1 (en) | 1998-08-25 | 2000-03-08 | Rohm And Haas Company | Benzodioxincarboxylic acid hydrazides as insecticides |
US6117639A (en) | 1998-08-31 | 2000-09-12 | Vertex Pharmaceuticals Incorporated | Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity |
US5989863A (en) | 1998-10-14 | 1999-11-23 | Incyte Pharmaceuticals, Inc. | Human ankyrin family protein |
CN1177813C (zh) | 1999-09-06 | 2004-12-01 | 华东理工大学 | 1,2-烷(芳)酰基芳酰基肼类昆虫生长调节剂及制备和应用 |
US7057015B1 (en) | 1999-10-20 | 2006-06-06 | The Salk Institute For Biological Studies | Hormone receptor functional dimers and methods of their use |
AU2001241682A1 (en) | 2000-02-24 | 2001-09-03 | The Salk Institute For Biological Studies | Gene expression system based on chimeric receptors |
US20040033600A1 (en) | 2001-03-21 | 2004-02-19 | Palli Subba Reddy | Ecdysone receptor-based inducible gene expression system |
WO2001070816A2 (en) | 2000-03-22 | 2001-09-27 | Rohm And Haas Company | Ecdysone receptor-based inducible gene expression system |
US8105825B2 (en) | 2000-10-03 | 2012-01-31 | Intrexon Corporation | Multiple inducible gene regulation system |
US6576422B1 (en) * | 2000-10-17 | 2003-06-10 | Rohm And Haas Company | Method for identifying products employing gene expression |
EP3470520A2 (en) | 2001-02-20 | 2019-04-17 | Intrexon Corporation | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
ES2385598T3 (es) | 2001-02-20 | 2012-07-27 | Intrexon Corporation | Sistema novedoso de expresión génica inducible basado en el receptor de ecdisona/receptor X retinoide de invertebrado |
WO2002066615A2 (en) | 2001-02-20 | 2002-08-29 | Rheogene, Inc. | Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
ES2424812T3 (es) | 2001-02-20 | 2013-10-08 | Intrexon Corporation | Receptores X retinoides quiméricos y su uso en un sistema inducible de expresión génica basado en receptores de ecdisona novedoso |
CN1161325C (zh) | 2001-03-26 | 2004-08-11 | 江苏省农药研究所 | 作为杀虫剂的二酰基肼类化合物及制备此种化合物的中间体以及它们的制备方法 |
US6761759B2 (en) * | 2001-03-30 | 2004-07-13 | Seiko Epson Corporation | Ink composition, ink jet recording method and recorded matter |
EP1490686A2 (en) | 2001-09-26 | 2004-12-29 | RheoGene Holdings Inc. | Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof |
CA2459827C (en) | 2001-09-26 | 2013-09-03 | Subba Reddy Palli | Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof |
US20050228016A1 (en) | 2002-06-13 | 2005-10-13 | Enrique Michelotti | Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7304161B2 (en) | 2003-02-10 | 2007-12-04 | Intrexon Corporation | Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex |
US7304162B2 (en) | 2003-02-21 | 2007-12-04 | Intrexon Corporation | Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7456315B2 (en) | 2003-02-28 | 2008-11-25 | Intrexon Corporation | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7935510B2 (en) | 2004-04-30 | 2011-05-03 | Intrexon Corporation | Mutant receptors and their use in a nuclear receptor-based inducible gene expression system |
US9034650B2 (en) | 2005-02-02 | 2015-05-19 | Intrexon Corporation | Site-specific serine recombinases and methods of their use |
EP3357904B1 (en) * | 2007-05-29 | 2022-07-06 | Precigen, Inc. | Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
KR20150129034A (ko) * | 2013-03-15 | 2015-11-18 | 인트렉손 코포레이션 | 붕소-함유 디아실하이드라진류 |
CN107406373B (zh) | 2014-09-17 | 2020-04-28 | 英特瑞克斯顿股份有限公司 | 含硼的二酰基肼化合物 |
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