SG11201506875YA - Boron-containing diacylhydrazines - Google Patents

Boron-containing diacylhydrazines

Info

Publication number
SG11201506875YA
SG11201506875YA SG11201506875YA SG11201506875YA SG11201506875YA SG 11201506875Y A SG11201506875Y A SG 11201506875YA SG 11201506875Y A SG11201506875Y A SG 11201506875YA SG 11201506875Y A SG11201506875Y A SG 11201506875YA SG 11201506875Y A SG11201506875Y A SG 11201506875YA
Authority
SG
Singapore
Prior art keywords
boron
diacylhydrazines
containing diacylhydrazines
Prior art date
Application number
SG11201506875YA
Inventor
Sheela K Chellappan
Robert E Hormann
Inna Shulman
Original Assignee
Intrexon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intrexon Corp filed Critical Intrexon Corp
Publication of SG11201506875YA publication Critical patent/SG11201506875YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/025Boronic and borinic acid compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/027Organoboranes and organoborohydrides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02Boron compounds
    • C07F5/04Esters of boric acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/0803Compounds with Si-C or Si-Si linkages
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N55/00Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur
    • A01N55/08Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing boron
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
SG11201506875YA 2013-03-15 2014-03-14 Boron-containing diacylhydrazines SG11201506875YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361792412P 2013-03-15 2013-03-15
PCT/US2014/028768 WO2014144380A1 (en) 2013-03-15 2014-03-14 Boron-containing diacylhydrazines

Publications (1)

Publication Number Publication Date
SG11201506875YA true SG11201506875YA (en) 2015-09-29

Family

ID=51529908

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201506875YA SG11201506875YA (en) 2013-03-15 2014-03-14 Boron-containing diacylhydrazines

Country Status (21)

Country Link
US (4) US9127024B2 (en)
EP (1) EP2970106B1 (en)
JP (1) JP6379173B2 (en)
KR (1) KR20150129034A (en)
CN (1) CN105283439B (en)
AR (1) AR095601A1 (en)
AU (2) AU2014227571B2 (en)
BR (1) BR112015022994A2 (en)
CA (1) CA2904436C (en)
DK (1) DK2970106T3 (en)
ES (1) ES2683329T3 (en)
HK (1) HK1220441A1 (en)
IL (1) IL241119B (en)
MX (1) MX361717B (en)
NZ (1) NZ712167A (en)
PH (1) PH12015502099A1 (en)
RU (1) RU2637946C2 (en)
SG (1) SG11201506875YA (en)
TW (1) TWI636986B (en)
WO (1) WO2014144380A1 (en)
ZA (1) ZA201506985B (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102905733B (en) 2009-10-06 2014-10-15 明尼苏达大学董事会 Bioresorbable embolization microspheres
PL3412676T3 (en) 2010-08-10 2021-04-06 Melinta Therapeutics, Inc. Cyclic boronic acid ester derivatives, method for the preparation and therapeutic uses thereof
US10070649B2 (en) 2013-01-30 2018-09-11 Agrofresh Inc. Volatile applications against pathogens
US11039617B2 (en) 2013-01-30 2021-06-22 Agrofresh Inc. Large scale methods of uniformly coating packaging surfaces with a volatile antimicrobial to preserve food freshness
BR112015022994A2 (en) * 2013-03-15 2017-11-14 Intrexon Corp boron-containing diacylhydrazines
MX2016015093A (en) 2014-05-19 2017-03-27 Rempex Pharmaceuticals Inc Boronic acid derivatives and therapeutic uses thereof.
WO2016044390A1 (en) * 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds
US10662205B2 (en) 2014-11-18 2020-05-26 Qpex Biopharma, Inc. Cyclic boronic acid ester derivatives and therapeutic uses thereof
WO2016149393A1 (en) 2015-03-17 2016-09-22 Rempex Pharmaceuticals, Inc. Boronic acid derivatives and therapeutic uses thereof
CN105675559B (en) * 2016-01-14 2018-01-30 中国科学院理化技术研究所 A kind of method by the use of carbon point as fluorescence probe detection dopamine
RS64770B1 (en) 2016-03-07 2023-11-30 Agrofresh Inc Synergistic methods of using benzoxaborole compounds and preservative gases as an antimicrobial for crops
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
US11446398B2 (en) 2016-04-11 2022-09-20 Obsidian Therapeutics, Inc. Regulated biocircuit systems
DK3478693T3 (en) 2016-06-30 2021-09-20 Qpex Biopharma Inc BORONIC ACID DERIVATIVES AND THERAPEUTIC USES THEREOF
CN117169508A (en) * 2016-09-16 2023-12-05 武田药品工业株式会社 Metabolite biomarkers for diseases associated with contact activation systems
EA201992153A1 (en) 2016-10-05 2020-02-25 Зе Глобал Эллайенс Фо Тб Драг Девелопмент, Инк. Heteroaryl trifluoroborate compounds for the treatment of mycobacterial infections
CN109119689B (en) * 2017-06-26 2020-11-20 比亚迪股份有限公司 Nonaqueous electrolyte solution and lithium ion battery
MX2020007318A (en) 2017-09-29 2020-08-24 Takeda Pharmaceuticals Co Heterocyclic compound.
JP7377545B2 (en) 2017-10-11 2023-11-10 キューペックス バイオファーマ, インコーポレイテッド Boronic acid derivatives and their synthesis
CN112592364A (en) * 2020-12-22 2021-04-02 江西同和药业股份有限公司 Kribotron intermediate, preparation method and application thereof in preparation of Kribotron

Family Cites Families (113)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
DK483586A (en) * 1985-10-21 1987-04-22 Rohm & Haas INSECTICIDE N'-SUBSTITUTED-N, N'-DIACYL HYDRAZINES
US5117057A (en) 1985-10-21 1992-05-26 Rohm And Haas Company Insecticidal N' substituted-N-N'-disubstituted-hydrazines
US4985461A (en) 1985-10-21 1991-01-15 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5424333A (en) 1985-10-21 1995-06-13 Rohm And Haas Company Anthelmintic N'-substituted-N,N'-disubstitutedhydrazines
US5354762A (en) 1986-07-14 1994-10-11 Rohm And Haas Company Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines
DE3683749D1 (en) 1985-12-09 1992-03-12 American Cyanamid Co INSECT KILLING DIACYL HYDRAZINE COMPOUNDS.
US4814349A (en) 1985-12-09 1989-03-21 American Cyanamid Company Insecticidal substituted and unsubstituted benzoic acid 1-alkyl, 2 alkyl and 2-cycloalkylhydrazides
CA1338289C (en) 1986-01-22 1996-04-30 Raymond August Murphy Insecticidal n'-substituted-n-alkylcarbonyl- n'-acylhydrazines
CA1295618C (en) 1986-02-28 1992-02-11 Adam Chi-Tung Hsu Insecticidal n'-substituted-n-acyl -n'-alkylcarbonylhydrazines
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
CA1281716C (en) 1986-05-01 1991-03-19 Raymond August Murphy Insecticidal n-substituted-n'-substituted-n,n'- diacylhydrazines
US5225443A (en) 1986-05-01 1993-07-06 Rohm And Haas Company Insecticidal N'-substituted-N'-substituted N,N'-diacylhydrazines
ES2037709T3 (en) 1986-07-14 1996-07-16 Rohm & Haas HETERO-CYCLE DERIVATIVES OF SIX MEMBERS OF N, N'-DIACILHIDRAZINAS N'-SUBSTITUTED.
US5071773A (en) 1986-10-24 1991-12-10 The Salk Institute For Biological Studies Hormone receptor-related bioassays
ATE61044T1 (en) 1987-04-15 1991-03-15 Rohm & Haas INSECTICIDES N-(OPTIONAL SUBSTITUTES)-N'SUBSTITUTES-N,N'-DISUBSTITUTES HYDRAZINS.
US4906280A (en) 1987-10-14 1990-03-06 Pennwalt Corporation Tertiary butylhydrazides as plant growth regulators
US4981784A (en) 1987-12-02 1991-01-01 The Salk Institute For Biological Studies Retinoic acid receptor method
US5171671A (en) 1987-12-02 1992-12-15 The Salk Institute For Biological Studies Retinoic acid receptor composition
US5429952A (en) 1988-02-02 1995-07-04 Biocode, Inc. Marking of products to establish identity and source
US5110986A (en) 1988-04-26 1992-05-05 Rohm And Haas Company Synthesis of n-t-alkyl-1,2-diacylhydrazines
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
EP0413763B1 (en) 1988-06-13 1996-11-06 American Biogenetic Sciences, Inc. Method for the production of monoclonal antibodies utilizing a germfree animal
NZ229536A (en) 1988-06-15 1992-05-26 Rohm & Haas N'-substituted-n'-substituted carbonyl-n-substituted carbonyl-hydrazines and pesticidal compositions
NZ229555A (en) 1988-06-16 1992-03-26 Rohm & Haas Pharmaceutical compositions for combating helminths in animals
JPH02207066A (en) 1989-02-07 1990-08-16 Ishihara Sangyo Kaisha Ltd Hydrazine-based compound, production thereof and controller against harmful animal containing same
US4950666A (en) 1989-03-30 1990-08-21 Fmc Corporation Difluoroalkane and difluoroalkenylalkane pesticides
US4954655A (en) 1989-03-31 1990-09-04 Rohm And Haas Company Preparation of alkylhydrazines
EP0395581A1 (en) 1989-04-27 1990-10-31 Ciba-Geigy Ag N-sulfenyl and N-sulfinyl-N,N'-diacylhydrazides
NZ228936A (en) 1989-05-01 1992-04-28 Rohm & Haas Method for treating insect infestation in rice plants comprising applying diacylhydrazine derivatives
JPH03141245A (en) 1989-10-24 1991-06-17 Ishihara Sangyo Kaisha Ltd Hydrazine-based compound, production thereof and controlling agent against noxious animal containing the same
JPH03145447A (en) 1989-10-31 1991-06-20 Nissan Chem Ind Ltd Dibenzoylhydrazine compound and insecticide
US5283173A (en) 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
WO1991012258A1 (en) 1990-02-09 1991-08-22 The Salk Institute For Biological Studies Retinoid receptor compositions and methods
AU7492291A (en) 1990-02-26 1991-09-18 Board Of Trustees Of The Leland Stanford Junior University Identification and expression of insect steroid receptor dna sequences
US7119077B1 (en) 1990-03-22 2006-10-10 The Salk Institute For Biological Studies Multimeric forms of members of the steroid/thyroid superfamily of receptors with the ultraspiracle receptor
US5641652A (en) 1990-03-22 1997-06-24 The Salk Institute For Biological Studies Insect retinoid-like receptor compositions and methods
JPH11508121A (en) 1990-03-22 1999-07-21 ザ ソーク インスティテュート フォア バイオロジカル スタディーズ Insect retinoid receptor compositions and methods
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
CA2043775A1 (en) 1990-06-14 1991-12-15 Dat P. Le Dibenzoylakylcyanohydrazines
JP2885902B2 (en) 1990-08-01 1999-04-26 日本化薬株式会社 N'-tert-butyl-N-halogenomethylsulfenyl-N, N'-dibenzoylhydrazine derivative and insecticidal composition containing the same as active ingredient
JPH0539252A (en) 1990-08-01 1993-02-19 Nippon Kayaku Co Ltd N, n'-dibenzoyl-butylhydrazine derivative and insecticidal composition comprising the same derivative as active ingredient
JP3068846B2 (en) 1990-08-01 2000-07-24 日本化薬株式会社 Novel hydrazine derivative and insecticidal composition containing the same as active ingredient
US5075471A (en) 1990-10-09 1991-12-24 Rohm And Haas Company Insecticidal ferrocenoyl acylhydrazines
JP3087854B2 (en) 1991-01-09 2000-09-11 日本化薬株式会社 Novel hydrazine derivative and insecticidal composition containing the same as active ingredient
IL100643A (en) 1991-01-25 1996-10-31 Nippon Kayaku Kk Hydrazine derivatives and pesticidal compositions comprising such derivatives as effective component
US5668175A (en) 1991-08-23 1997-09-16 The Salk Institute For Biological Studies Use of selective ligands for treatment of disease states responsive to steroid or steroid-like retinoids
CA2114936C (en) 1991-08-23 2004-02-10 Ronald M. Evans Use of selective ligands for treatment of disease states responsive to steroid or steroid-like hormones
ATE215601T1 (en) 1991-09-17 2002-04-15 Salk Inst For Biological Studi RECEPTORS OF THE STEROID/THYROID SUPERFAMILY OF RECEPTORS
AU666348B2 (en) 1991-12-06 1996-02-08 Salk Institute For Biological Studies, The Multimeric forms of members of the steroid/thyroid superfamily of receptors
US5344958A (en) 1992-11-23 1994-09-06 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US5530028A (en) 1992-11-23 1996-06-25 Rohm And Haas Company Insecticidal N'-substituted-N,N'-diacylhydrazines
US6013836A (en) 1992-02-28 2000-01-11 Rohm And Haas Company Insecticidal N'-substituted-N,N'-disubstitutedhydrazines
JPH06172342A (en) 1992-12-07 1994-06-21 Nippon Kayaku Co Ltd New hydrazine derivative and insecticide composition containing the same as active ingredient
JP3298954B2 (en) 1992-12-16 2002-07-08 三共株式会社 Novel N, N'-dibenzoylhydrazine derivative and insecticidal composition
PT705279E (en) 1993-05-27 2003-07-31 Selectide Corp LIBRARIES IN SOLID PHASE CODIFIED, TOPOLOGICALLY SEGREGATED
US5358966A (en) 1993-06-08 1994-10-25 Rohm And Haas Company Turfgrass insecticides
ES2109613T3 (en) 1993-08-19 1998-01-16 Rohm & Haas PREPARATION OF 1,2-DIACIL-2- (T-ALKYL) HYDRAZINES.
FR2714830B1 (en) 1994-01-10 1996-03-22 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
FR2715847B1 (en) 1994-02-08 1996-04-12 Rhone Poulenc Rorer Sa Composition containing nucleic acids, preparation and uses.
US5482962A (en) 1994-07-22 1996-01-09 Rohm And Haas Company Insecticidal N,N'-disubstituted-N-N'-diacylhydrazines
FR2727679B1 (en) 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa NEW TRANSFECTION AGENTS AND THEIR PHARMACEUTICAL APPLICATIONS
EP0809509A4 (en) 1995-01-13 2000-02-02 Salk Inst For Biological Studi Allosteric control of nuclear hormone receptors
FR2730637B1 (en) 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa PHARMACEUTICAL COMPOSITION CONTAINING NUCLEIC ACIDS, AND USES THEREOF
JPH08231529A (en) 1995-02-27 1996-09-10 Nippon Kayaku Co Ltd Hydrazine derivative and insecticidal composition containing the same as active ingredient
JP3600298B2 (en) 1995-02-27 2004-12-15 日本化薬株式会社 Novel hydrazine derivative and insecticidal composition containing the same as active ingredient
ATE293699T1 (en) 1995-03-03 2005-05-15 Syngenta Participations Ag CONTROL OF PLANT GENE EXPRESSION THROUGH RECEPTOR-MEDIATED TRANSACTIVATION IN THE PRESENCE OF A CHEMICAL LIGAND
TR199701436T1 (en) 1995-05-26 1998-03-21 Zeneca Limited A gene switch involving an ecdysone receptor.
JPH09100262A (en) 1995-06-06 1997-04-15 Rohm & Haas Co Production of n,n'-diacyl-n'-t-alkylhydrazine compound
CA2200423C (en) 1996-03-26 2006-12-19 Sietse Mosselman Novel estrogen receptor
EP0910652B1 (en) 1996-04-05 2014-10-08 The Salk Institute For Biological Studies Hormone-mediated methods for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6723531B2 (en) 1996-04-05 2004-04-20 The Salk Institute For Biological Studies Method for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6025483A (en) 1996-06-05 2000-02-15 The Regents Of The University Of California Maize and cauliflower apetalai gene products and nucleic acid molecules encoding same
US5919667A (en) 1996-06-20 1999-07-06 The Salk Institute For Biological Studies Modular assembly retroviral vectors and uses thereof
US5948406A (en) 1996-08-12 1999-09-07 Rohm And Haas Company Immunogens, antibodies formed therefrom, and coating antigens useful in a diacylhydrazine immunoassay method
EP0998560A1 (en) 1997-07-10 2000-05-10 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in regulation of transgene expression
US6300488B1 (en) 1997-07-10 2001-10-09 The Salk Institute For Biological Studies Modified lepidopteran receptors and hybrid multifunctional proteins for use in transcription and regulation of transgene expression
DE19837620A1 (en) 1997-08-22 1999-02-25 Novartis Ag New diphenylmethyl-substituted hydrazine derivatives useful
JP2003524368A (en) 1997-08-26 2003-08-19 アリアド ジーン セラピューティクス インコーポレイテッド Fusion protein comprising a dimerization domain, a trimerization domain or a tetramerization domain and a complementary heterologous transcriptional activation domain, a transcription repression domain, a DNA binding domain or a ligand binding domain
US6756491B2 (en) 1998-01-09 2004-06-29 The Salk Institute For Biological Studies Steroid-activated nuclear receptors and uses therefor
AUPP135698A0 (en) 1998-01-15 1998-02-05 Commonwealth Scientific And Industrial Research Organisation Insectical modalities
US6333318B1 (en) * 1998-05-14 2001-12-25 The Salk Institute For Biological Studies Formulations useful for modulating expression of exogenous genes in mammalian systems, and products related thereto
US6258603B1 (en) 1998-06-17 2001-07-10 Rohm And Haas Company Ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
JP2000026423A (en) 1998-07-09 2000-01-25 Otsuka Chem Co Ltd Isonicotinoylhydrazine derivative and insect pest controlling agent containing the same derivative as active ingredient
DE19831710A1 (en) 1998-07-15 2000-01-20 Merck Patent Gmbh New diacyl-hydrazine derivatives, are integrin inhibitors useful for treating e.g. thrombosis, cardiac infarction, tumors, osteoporosis, inflammation or infection
EP0984009A1 (en) 1998-08-25 2000-03-08 Rohm And Haas Company Benzodioxincarboxylic acid hydrazides as insecticides
US6117639A (en) 1998-08-31 2000-09-12 Vertex Pharmaceuticals Incorporated Fusion proteins, DNA molecules, vectors, and host cells useful for measuring protease activity
US5989863A (en) 1998-10-14 1999-11-23 Incyte Pharmaceuticals, Inc. Human ankyrin family protein
CN1177813C (en) 1999-09-06 2004-12-01 华东理工大学 1,2-alkyl (aryl) acyl aroyl hydrazines insect growth regulator and its preparation and application
US7057015B1 (en) 1999-10-20 2006-06-06 The Salk Institute For Biological Studies Hormone receptor functional dimers and methods of their use
WO2001062780A1 (en) 2000-02-24 2001-08-30 The Salk Institute For Biological Studies Gene expression system based on chimeric receptors
DE60122685T2 (en) 2000-03-22 2007-08-23 Rheogene Holdings Inc. INDUCED GENE EXPRESSION SYSTEM BASED ON ECDYSON RECEPTORS
US20040033600A1 (en) 2001-03-21 2004-02-19 Palli Subba Reddy Ecdysone receptor-based inducible gene expression system
US8105825B2 (en) 2000-10-03 2012-01-31 Intrexon Corporation Multiple inducible gene regulation system
US6576422B1 (en) 2000-10-17 2003-06-10 Rohm And Haas Company Method for identifying products employing gene expression
DK1456346T3 (en) 2001-02-20 2012-05-29 Intrexon Corp NEW INDUCERABLE Gene EXPRESSION SYSTEM BASED ON ECDYSON RECEPTOR / INVERTEBRATE-RETINOID-X RECEPTOR
WO2002066612A2 (en) 2001-02-20 2002-08-29 Rheogene, Inc. Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
EP1572862B1 (en) 2001-02-20 2012-08-01 Intrexon Corporation Chimeric retinoid x receptors and their use in a novel ecdysone receptor-based inducible gene expression system
AU2002248500B2 (en) 2001-02-20 2007-12-13 Intrexon Corporation Novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system
CN1161325C (en) 2001-03-26 2004-08-11 江苏省农药研究所 Diacyl hydrazide compounds as insecticide, intermediate for preparing said compounds and their preparing process
US6761759B2 (en) * 2001-03-30 2004-07-13 Seiko Epson Corporation Ink composition, ink jet recording method and recorded matter
WO2003027289A1 (en) 2001-09-26 2003-04-03 Rheo Gene Holdings, Inc. Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
CA2459807C (en) 2001-09-26 2013-09-03 Jianzhong Zhang Whitefly ecdysone receptor nucleic acids, polypeptides, and uses thereof
US20050228016A1 (en) 2002-06-13 2005-10-13 Enrique Michelotti Tetrahydroquinolines for modulating the expression of exogenous genes via an ecdysone receptor complex
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7304161B2 (en) 2003-02-10 2007-12-04 Intrexon Corporation Diaclhydrazine ligands for modulating the expression of exogenous genes in mammalian systems via an ecdysone receptor complex
US7304162B2 (en) 2003-02-21 2007-12-04 Intrexon Corporation Oxadiazoline ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7456315B2 (en) 2003-02-28 2008-11-25 Intrexon Corporation Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US7935510B2 (en) 2004-04-30 2011-05-03 Intrexon Corporation Mutant receptors and their use in a nuclear receptor-based inducible gene expression system
US9034650B2 (en) 2005-02-02 2015-05-19 Intrexon Corporation Site-specific serine recombinases and methods of their use
CN101848887A (en) 2007-05-29 2010-09-29 英特拉克森公司 Chiral diachylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
BR112015022994A2 (en) * 2013-03-15 2017-11-14 Intrexon Corp boron-containing diacylhydrazines
WO2016044390A1 (en) 2014-09-17 2016-03-24 Intrexon Corporation Boron-containing diacylhydrazine compounds

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PH12015502099B1 (en) 2016-01-18
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