AR053770A1 - Pirimidinas como antagonistas del receptor de prostaglandina d2. composiciones farmaceuticas. - Google Patents

Pirimidinas como antagonistas del receptor de prostaglandina d2. composiciones farmaceuticas.

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AR053770A1
AR053770A1 ARP050104318A ARP050104318A AR053770A1 AR 053770 A1 AR053770 A1 AR 053770A1 AR P050104318 A ARP050104318 A AR P050104318A AR P050104318 A ARP050104318 A AR P050104318A AR 053770 A1 AR053770 A1 AR 053770A1
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alkyl
substituted
hydroxy
aryl
heteroaryl
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Aventis Pharma Inc
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Abstract

Un compuesto de formula (1) en la que: (A) Cy1 es cicloalquilo, heterociclilo, cicloalquenilo, heterociclenilo, heteroarilo, arilo, alcarilo multicíclico, cada uno de los cuales puede estar sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre los siguientes grupos sustituyentes de Cy1 que consisten en: acilo, ciano, halogeno, nitro, carboxi, hidroxi, alquiltio, alquilsulfonilo, alquilsulfinilo, cicloalquilo, heterociclilo, cicloalquenilo, heterociclenilo, arilo, heteroarilo, alcarilo multicíclico, aroílo, arilalcoxicarbonilo, arilalquiltio, ariloxi, ariloxicarbonilo, arilsulfinilo, arilsulfonilo, ariltio, heteroariloxi, heteroarilalcoxicarbonilo, N-metoxisulfamoílo, R2-C(=N-OR3)-; Y1Y2N-, Y1Y2NC(=O)- , Y1Y2NC(=O)-O-, Y1Y2NSO2-, alquil-O-C(=O)-alquileno C1-6-Z1, Y1Y2N-C(=O)-alquileno C1-6)-Z1, Y1Y2N-alquileno (C2-6)Z1-, alquil-C(=O)-N(R5)-SO2-, alquil-O-C(=O)-N(R5)-, alquil-O-C(=O)-N(R5)-SO2, alquil-O-N(R5)-SO2-, alquil-O-N(R5)-C(=O)-, alquil-SO2- N(R5)-C()=O)-, aril-SO2-N(R5)-C(=O)-, alquil-SO2-N(R5)-, R6-C(=O)-N(R5)- o R7-NH-C(=O)-NH-; alquenilo, que puede estar sustituido con alcoxi o hidroxi; alcoxicarbonilo, que puede estar sustituido con Y1Y2N-; alquinilo, que puede estar sustituido con hidroxi o alcoxi; alquilo, que puede estar sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre halogeno, carboxi, ciano, hidroxi, Y1Y2N-, Y1Y2N-C(=O)-, H2N-C(=NH)-NH-O-, R6-C(=O)-N(R5)-, alquil-O-C(=O)-N(R5)-, alquil-SO2- N(R5)-, R8-SO2-N(R5)-C(=O)-, aril-N(R5)-C(=O)-, heteroaril-N(R5)-C(=O)-, heterociclil-N(R5)-C(=O)-, alcoxicarbonilo, cicloalquilo, heterociclilo, cicloalquenilo, heterociclenilo, arilo, heteroarilo, alcarilo multicíclico, alcoxi que puede estar sustituido con carboxi, arilo o heteroarilo; o alcoxicarbonilo, que puede estar sustituido con Y1Y2N-; y alcoxi, que pude estar sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre carboxi, alcoxicarbonilo, ciano, halogeno, -NY1Y2, Y1Y2N-C(=O)-, cicloalquilo, heterociclilo, cicloalquenilo, heterociclenilo, arilo, heteroarilo o alcarilo multicíclico; en los que los restos arilo o heteroarilo en los grupos sustituyentes de CY1 anteriores pueden estar sustituidos independientemente con hidroxi, amino, alquilo, alcoxi, carboxi, alcoxicarbonilo o R8-SO2-N(R5)-C(=O)-; y donde los restos cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo o alcarilo multicíclico en los grupos sustituyentes de CY1 pueden estar sustituidos independientemente con hidroxi, amino, alquilo, alcoxi, oxo, carboxi, alcoxicarbonilo o R8-SO2-N(R5)-C(=O)-; y además con la condicion de que cuando CY1 es cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo o alcarilo multicíclico, cada uno de ellos también puede estar sustituido independientemente con oxo; (B) CY2 es cicloalquenilo, heterociclenilo, arilo, heteroarilo o alcarilo multicíclico, cada uno puede estar independientemente sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre alcoxi, alquilo C1-3, hidroxi, ciano, halogeno, haloalcoxi, haloalquilo, nitro, Y1Y2N- o Y1Y2N-SO2-,a rilo o heteroarilo, donde el arilo puede estar sustituido con alquilo o hidroxialquileno, y el heteroarilo puede estar sustituido con alquilo; (C) L1 es un alquileno de cadena lineal o ramificada C1-6 y puede estar sustituido con carboxi o hidroxi; o L1 es cicloalquilen C1-7 y puede estar sustituido con hidroxi; o L1 es -CH2-(C1-5)haloalquileno, o L1 y CY2 juntos representan arilcicloalquilo o cicloalquilarilo; (D) R1 es alquilo C1-4, Y4Y5N-; alcoxi C1-4 que puede estar sustituido con no a tres halogenos; o alquilo C1-4, que puede estar sustituido con uno a tres de halogeno, hidroxi o alcoxi; (E) L2 es un enlace, -O- o -CH2-O-; y donde: cada uno de R2, R3, R4 y R5 es independientemente H o alquilo; R6 es alquilo, que puede estar sustituido con hidroxi o alcoxi; R7 es H o alquilo; R8 es alquilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, donde el resto arilo o heteroarilo puede estar sustituido con halogeno; cada uno de Y1 e Y2 es independientemente H o alquilo que puede estar sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre carboxi, alcoxicarbonilo, alcoxi, hidroxi, amino, alquilamino, dialquilamino, cicloalquilo, cicloalquenilo, heterociclilo, heterociclenilo, arilo, heteroarilo o alcarilo multicíclico; donde el arilo y heteroarilo pueden estar independientemente sustituidos con hidroxi, amino, alquilo o alcoxi y donde el cicloalquilo, heterociclilo, cicloalquenilo, heterociclenilo y alcarilo multicíclico pueden estar independientemente sustituidos con hidroxi, amino, alquilo, alcoxi u oxo; o Y1 e Y2, junto con el átomo de N al que están unidos, forman un anillo carbocíclico saturado de tres a siete miembros que contiene N y que puede contener un heteroátomo adicional seleccionado entre O, S o NY3, donde Y3 es H o alquilo y donde el anillo carbocíclico puede estar sustituido con uno a tres sustituyentes iguales o diferentes seleccionados entre carboxi, hidroxi, hidroxialquilo, oxo, amino, alquilamino o dialquilamino; cada uno de Y4 e Y5 es independientemente H o alquilo C1- 4,; Z1 es C(=O)-N(R4), NR4 o S(O)n; y n es 0, 1 o 2; con la condicion de que el compuesto de formula (1) no sea éster etílico del ácido 5-{6-[2-(2,4-dicloro-fenil)-etilamino]-2-metoxi-pirimidin-4-il}-1-metil-1H-indol-2-carboxílico (con la condicion de que cuando R1 es metoxi, L1 es -CH2-CH2-, L2 es un enlace, CY2 es 2,4-diclorofenilo, entonces CY1 no es 1-metil-2-etiloxicarbonil-indol-5-ilo), o un N-oxido del mismo, o un éster profármaco del mismo o una sal, hidrato o solvato farmacéuticamente aceptable del mismo.
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