GB1143167A - Derivatives of pyrimidine - Google Patents

Derivatives of pyrimidine

Info

Publication number
GB1143167A
GB1143167A GB3774/67A GB377467A GB1143167A GB 1143167 A GB1143167 A GB 1143167A GB 3774/67 A GB3774/67 A GB 3774/67A GB 377467 A GB377467 A GB 377467A GB 1143167 A GB1143167 A GB 1143167A
Authority
GB
United Kingdom
Prior art keywords
pyrimidine
hydroxyalkylamino
halo
group
morpholino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3774/67A
Inventor
Jacques Mathieu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UCB SA
Original Assignee
UCB SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB SA filed Critical UCB SA
Priority to GB3774/67A priority Critical patent/GB1143167A/en
Priority to FR1555900D priority patent/FR1555900A/fr
Priority to US699294A priority patent/US3624084A/en
Priority to DE19681695975 priority patent/DE1695975A1/en
Priority to BE709787D priority patent/BE709787A/xx
Priority to FR145321A priority patent/FR7383M/fr
Publication of GB1143167A publication Critical patent/GB1143167A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,143,167. Pyrimidine derivatives. UCB (UNION CHIMIQUE-CHEMISCHE BEDRIJVEN) S.A. 24 Jan., 1968 [25 Jan., 1967], No. 3774/67. Heading C2C. Novel pyrimidine derivatives of formula in which R 1 is a hydrogen atom or a C 1-5 alkyl group, R 2 is a hydrogen or halogen atom or a C 1-5 alkyl, hydroxyalkylamino, #-aryl- #-hydroxyalkylamino or morpholino group, R 3 is a hydrogen atom, a C 1-5 alkyl group which may be substituted by one or more hydroxy groups, or an aralkyl group, R 4 is a C 2-5 alkyl group which is substituted by one or more hydroxy groups, each hydroxy group being separated from the nitrogen atom to which the alkyl group is attached by at least two carbon atoms, or R 3 and R 4 , together with the nitrogen atom to which they are attached, represent a morpholino group, and their acid addition salts, are prepared (a) when R 2 is a hydrogen atom or an alkyl radical, by reacting a 2-R 1 -6-halo-pyrimi. dine or 2 - R 1 - 4 - alkyl - 6 - halo - pyrimidine with a primary or secondary hydroxylamine or with morpholine, or (b) when R 2 is a halogen atom or a hydroxyalkylamino or morpholino group, by reacting a 2-R1-4,6-dihalo-pyrimidine with a primary or secondary hydroxyalkylamine or with morpholine under such conditions and in such an amount that a 2-R 1 -4-halo-6- hydroxyalkylamino - pyrimidine, 2 - R 1 - 4 - halo - 6 - morpholino - pyrimidine, 2 - R 1 - 4,6- bis - hydroxyalkylamino - pyrimidine or 2-R 1 - 4,6 - dimorpholino - pyrimidine is obtained, or (c), when R 2 is a hydroxyalkylamino, #-aryl-#- hydroxyalkylamino or morpholino group, by reacting a 2-R 1 -4-halo-6-hydroxyalkylaminopyrimidine or 2-R 1 -4-halo-6-morpholino-pyrimidine with a primary hydroxyalkylamine or #- aryl-#-hydroxyalkylamine or morpholine and, if desired, converting a resulting base into an acid addition salt. Pharmaceutical compositions having hypotensive, vasodilatory, diuretic, bronchodilatory, spasmolytic and analeptic properties, comprise one of the novel compounds together with a carrier.
GB3774/67A 1967-01-25 1967-01-25 Derivatives of pyrimidine Expired GB1143167A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB3774/67A GB1143167A (en) 1967-01-25 1967-01-25 Derivatives of pyrimidine
FR1555900D FR1555900A (en) 1967-01-25 1968-01-08
US699294A US3624084A (en) 1967-01-25 1968-01-22 2,4,6-trisubstituted derivatives of pyrimidine
DE19681695975 DE1695975A1 (en) 1967-01-25 1968-01-23 Derivatives of pyrimidine
BE709787D BE709787A (en) 1967-01-25 1968-01-24
FR145321A FR7383M (en) 1967-01-25 1968-03-25

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3774/67A GB1143167A (en) 1967-01-25 1967-01-25 Derivatives of pyrimidine

Publications (1)

Publication Number Publication Date
GB1143167A true GB1143167A (en) 1969-02-19

Family

ID=9764663

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3774/67A Expired GB1143167A (en) 1967-01-25 1967-01-25 Derivatives of pyrimidine

Country Status (5)

Country Link
US (1) US3624084A (en)
BE (1) BE709787A (en)
DE (1) DE1695975A1 (en)
FR (2) FR1555900A (en)
GB (1) GB1143167A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0459890A1 (en) * 1990-05-30 1991-12-04 L'oreal Composition for use in preventing loss of hair and for inducing and stimulating its growth, containing derivatives of 2-alkyl-4-amino(or -2,4-dialkyl)-pyrimidin-3-oxide and the new derivatives of 2-alkyl-4-amino-pyrimidin-3-oxide
EP0806418A2 (en) * 1996-05-09 1997-11-12 Nippon Shoji Kaisha, Limited Novel pyrimidine compound and anti-rotavirus agent
WO2003087064A1 (en) * 2002-04-18 2003-10-23 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
JP2005520821A (en) * 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド 4-Aminopyrimidine and its use for antimicrobial treatment of surfaces
WO2006044732A3 (en) * 2004-10-15 2006-11-23 Aventis Pharma Inc 2, 6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists
WO2011105572A1 (en) * 2010-02-26 2011-09-01 持田製薬株式会社 Novel heteroaryl derivative

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1523274A (en) * 1974-08-05 1978-08-31 Ici Ltd Herbicidal compositions containing substituted pyrimidine
FR2306697A1 (en) * 1975-04-10 1976-11-05 Sogeras NEW PYRIMIDINES FOR USE AS ANTIDIABETIC AND HYPOCHOLESTEROLEMANT MEDICINAL PRODUCTS
PH20344A (en) * 1981-01-29 1986-12-04 Sankyo Co Aminopyrimidine derivatives, processes for their preparation, and fungicidal, insecticidal and acaricidal compositions containing them
DE3905364A1 (en) * 1989-02-22 1990-08-23 Hoechst Ag SUBSTITUTED PYRIMIDINE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE AS A TOOL
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
EP1646615B1 (en) * 2003-06-06 2009-08-26 Vertex Pharmaceuticals Incorporated Pyrimidine derivatives as modulators of atp-binding cassette transporters
EP2254415B1 (en) * 2008-02-19 2013-01-23 Janssen Pharmaceutica, N.V. Aryl-hydroxyethylamino-pyrimidines and triazines as modulators of fatty acid amide hydrolase

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2994637A (en) * 1957-11-13 1961-08-01 Diamond Alkali Co Aminopyrimidines as fungicides
GB1031265A (en) * 1963-11-12 1966-06-02 Geigy Co Ltd Tri-tertiary aminopyrimidines and their production
NL127996C (en) * 1963-11-19

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2662607A1 (en) * 1990-05-30 1991-12-06 Oreal COMPOSITION FOR USE IN BRAKING THE FALL OF HAIR AND IN INDUCING AND STIMULATING THEIR GROWTH, CONTAINING ALKYL-2 AMINO-4 (OR DIALKYL-2-4) PYRIMIDINE OXIDE-3 DERIVATIVES.
US5438058A (en) * 1990-05-30 1995-08-01 L'oreal Composition intended to be used for retarding hair loss and for inducing and stimulating hair growth, containing 2-alkyl-4-aminopyrimidine (or 2,4-dialkylpyrimidine) 3-oxide derivatives and new compounds derived from 2-alkyl-4-aminopyrimidine 3-oxide
EP0459890A1 (en) * 1990-05-30 1991-12-04 L'oreal Composition for use in preventing loss of hair and for inducing and stimulating its growth, containing derivatives of 2-alkyl-4-amino(or -2,4-dialkyl)-pyrimidin-3-oxide and the new derivatives of 2-alkyl-4-amino-pyrimidin-3-oxide
EP0806418A2 (en) * 1996-05-09 1997-11-12 Nippon Shoji Kaisha, Limited Novel pyrimidine compound and anti-rotavirus agent
EP0806418A3 (en) * 1996-05-09 1997-12-03 Nippon Shoji Kaisha, Limited Novel pyrimidine compound and anti-rotavirus agent
US6080750A (en) * 1996-05-09 2000-06-27 Nippon Shoji Kaisha Ltd. Pyrimidine compound and anti-rotavirus composition
JP2005520821A (en) * 2002-03-15 2005-07-14 チバ　スペシャルティ　ケミカルズ　ホールディング　インコーポレーテッド 4-Aminopyrimidine and its use for antimicrobial treatment of surfaces
WO2003087064A1 (en) * 2002-04-18 2003-10-23 Ucb, S.A. Chemical compounds with dual activity, processes for their preparation and pharmaceutical compositions
WO2006044732A3 (en) * 2004-10-15 2006-11-23 Aventis Pharma Inc 2, 6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists
JP2008516974A (en) * 2004-10-15 2008-05-22 アベンティス・ファーマスーティカルズ・インコーポレイテツド 2,6-Substituted-4-monosubstituted amino-pyrimidines as prostaglandin D2 receptor antagonists
US7517889B2 (en) 2004-10-15 2009-04-14 Aventis Pharmaceuticals, Inc. 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
US8193183B2 (en) 2004-10-15 2012-06-05 Aventis Pharmaceuticals Inc. 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin D2 receptor antagonists
CN101039920B (en) * 2004-10-15 2013-03-20 安万特药物公司 2,6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists
NO339772B1 (en) * 2004-10-15 2017-01-30 Aventis Pharma Inc 2,6-substituted-4-monosubstituted aminopyrimidine such as prostaglandin D
WO2011105572A1 (en) * 2010-02-26 2011-09-01 持田製薬株式会社 Novel heteroaryl derivative

Also Published As

Publication number Publication date
FR7383M (en) 1969-10-27
FR1555900A (en) 1969-01-31
DE1695975A1 (en) 1971-05-19
US3624084A (en) 1971-11-30
BE709787A (en) 1968-07-24

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