GB1143882A - - Google Patents
Info
- Publication number
- GB1143882A GB1143882A GB1143882DA GB1143882A GB 1143882 A GB1143882 A GB 1143882A GB 1143882D A GB1143882D A GB 1143882DA GB 1143882 A GB1143882 A GB 1143882A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- piperazinealkanamides
- alk
- alkanoyl
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
Abstract
1,143,882. 4 - Alkanoyl - 1 - piperazinealkanamides. G. D. SEARLE & CO. 20 June, 1967 [21 June, 1966], No. 28476/67. Heading C2C. Novel 4-alkanoyl- 1 -piperazinealkanamides of the general formula wherein R is an aliphatic hydrocarbon group containing from 1 to 29 carbon atoms; Alk is an alkylene radical containing up to 6 carbon atoms; and R<SP>1</SP> and R<SP>11</SP> are hydrogen atoms or alkyl, phenyl or substituted phenyl radicals in which the substituents are one or more halogen atoms or methyl or alkoxy radicals; or R<SP>1</SP> and R<SP>11</SP> are combined so that the group -NR<SP>1</SP>R<SP>11</SP> provides a cyclic amino group, such as a 1- pyrrolidinyl, piperidino or morpholino radical, and pharmaceutically acceptable salts and quaternary ammonium derivatives thereof are prepared (a) by reaction of a piperazinealkanamide of the general formula with an appropriate acid chloride or anhydride or (b) by reaction of a monoacylpiperazine of the general formula with either an alkanamide of the general formula or, when Alk is ethylene, an appropriate acrylamide, followed optionally by conversion of the product to a pharmaceutically acceptable salt or quaternary ammonium derivative thereof.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US559086A US3352866A (en) | 1966-06-21 | 1966-06-21 | 4-alkanoyl-1-piperazinealkanamides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1143882A true GB1143882A (en) |
Family
ID=24232231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1143882D Active GB1143882A (en) | 1966-06-21 |
Country Status (2)
| Country | Link |
|---|---|
| US (1) | US3352866A (en) |
| GB (1) | GB1143882A (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1982003861A1 (en) * | 1981-05-08 | 1982-11-11 | Tominaga Michiaki | Aniline derivatives,process for their preparation,and cardiotonics |
| SE8304361D0 (en) * | 1983-08-10 | 1983-08-10 | Ferrosan Ab | NOVEL 1-ACYLPIPERAZINE DERIVATIVES NOVEL 1-ACYLPIPERAZINE DERIVATIVES |
| US5565567A (en) * | 1993-06-04 | 1996-10-15 | Henkel Corporation. | Polymerizable N,N'-substituted piperazine acrylamide compounds |
| AU6956394A (en) * | 1993-06-04 | 1995-01-03 | Henkel Corporation | Polymerizable compounds |
| US5922820A (en) * | 1993-06-04 | 1999-07-13 | Henkel Corporation | Polymerizable compounds |
| US5756742A (en) * | 1995-12-22 | 1998-05-26 | Henkel Corporation | Polymerizable compounds |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| EP0977773A1 (en) | 1997-04-14 | 2000-02-09 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| JP2002513412A (en) * | 1997-04-14 | 2002-05-08 | シーオーアール セラピューティクス インコーポレイテッド | Selective factor Xa inhibitor |
| JP2001521524A (en) * | 1997-04-14 | 2001-11-06 | シーオーアール セラピューティクス インコーポレイテッド | Selective factor Xa inhibitor |
| CA2285685A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| AU3390000A (en) | 1999-03-03 | 2000-09-21 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3244718A (en) * | 1964-02-17 | 1966-04-05 | Biel John Hans | Piperazine derivatives |
-
0
- GB GB1143882D patent/GB1143882A/en active Active
-
1966
- 1966-06-21 US US559086A patent/US3352866A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US3352866A (en) | 1967-11-14 |
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