ES308890A1 - Benzene derivatives - Google Patents
Benzene derivativesInfo
- Publication number
- ES308890A1 ES308890A1 ES0308890A ES308890A ES308890A1 ES 308890 A1 ES308890 A1 ES 308890A1 ES 0308890 A ES0308890 A ES 0308890A ES 308890 A ES308890 A ES 308890A ES 308890 A1 ES308890 A1 ES 308890A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- alkyl radical
- reaction
- acceptable salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention comprises tetrafluorobenzene derivatives of the formula <FORM:1031082/C2/1> and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or an alkyl radical optionally bearing one or more hydroxy substituents, R2 is hydrogen or an alkyl or cycloalkyl radical or NR1R2 together form a heterocyclic radical optionally bearing one or more alkyl substituents, and R3 is hydrogen or an alkyl radical, but excluding 2,3,5,6-tetrafluoro-sulphanilamide and its pharmaceutically-acceptable salts. The compounds are made by reaction of the corresponding pentafluorobenzenesulphonamide with an amine NHR1R2 or, if desired, in the case where R1 is to be hydrogen and R2 and R3 the same alkyl radical, by reaction of a pentafluorosulphonyl halide with two equivalents of a monoalkylamine or, if R3 is to be an alkyl radical, by alkylating a tetrafluorobenzenesulphonamide, bearing a substituent NR1R2 in the 4-position. Pharmaceutical preparations having anti-convulsant activity comprise the above compounds of the invention in admixture with a diluent or carrier in forms suitable for oral, parenteral or rectal administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4664/64A GB1031082A (en) | 1964-02-04 | 1964-02-04 | Benzene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES308890A1 true ES308890A1 (en) | 1965-12-16 |
Family
ID=9781462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES0308890A Expired ES308890A1 (en) | 1964-02-04 | 1965-02-03 | Benzene derivatives |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE659230A (en) |
| ES (1) | ES308890A1 (en) |
| FR (2) | FR1453262A (en) |
| GB (1) | GB1031082A (en) |
| NL (1) | NL6501375A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008075353A1 (en) | 2006-12-19 | 2008-06-26 | Pharmos Corporation | Sulfonamide derivatives with therapeutic indications |
| LT6064B (en) | 2012-10-15 | 2014-08-25 | Vilniaus Universitetas | Fluorinated benzenesulfonamides as inhibitors of carbonic anhydrase |
-
1964
- 1964-02-04 GB GB4664/64A patent/GB1031082A/en not_active Expired
-
1965
- 1965-02-03 BE BE659230A patent/BE659230A/xx unknown
- 1965-02-03 NL NL6501375A patent/NL6501375A/xx unknown
- 1965-02-03 ES ES0308890A patent/ES308890A1/en not_active Expired
- 1965-02-04 FR FR4432A patent/FR1453262A/en not_active Expired
- 1965-05-03 FR FR15584A patent/FR4749M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1453262A (en) | 1966-06-03 |
| BE659230A (en) | 1965-08-03 |
| GB1031082A (en) | 1966-05-25 |
| NL6501375A (en) | 1965-08-05 |
| FR4749M (en) | 1967-01-16 |
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