GB1237034A - Substituted indolines - Google Patents

Substituted indolines

Info

Publication number
GB1237034A
GB1237034A GB3844669A GB3844669A GB1237034A GB 1237034 A GB1237034 A GB 1237034A GB 3844669 A GB3844669 A GB 3844669A GB 3844669 A GB3844669 A GB 3844669A GB 1237034 A GB1237034 A GB 1237034A
Authority
GB
United Kingdom
Prior art keywords
alkyl
compounds
july
cycloalkyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3844669A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Original Assignee
Dr Karl Thomae GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19681795034 external-priority patent/DE1795034C3/en
Application filed by Dr Karl Thomae GmbH filed Critical Dr Karl Thomae GmbH
Publication of GB1237034A publication Critical patent/GB1237034A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1,237,034. Indoline derivatives. DR. KARL THOMAE G.m.b.H. 31 July, 1969 [31 July, 1968; 20 June, 1969], No. 38446/69. Heading C2C. The invention comprises compounds of formula and their acid addition salts, wherein R 1 is C 1-5 alkyl, R 2 and R 3 are each H, Cl, Me, Et, MeO or EtO, R 4 and R 5 are each C 1-5 alkyl, cycloalkyl. C 1-5 alkyl, C 3-5 alkenyl or C 5-7 cycloalkyl (or NR 4 R 5 forms a saturated-possibly C 1-3 alkyl or Ph substituted-monocyclic heterocyclic 5- or 6-membered ring which may contain O or a further N atom), A is a C 2-4 bivalent aliphatic hydrocarbon group and n is 1 or 2. These compounds, prepared by reduction of the corresponding pseudoindoles, may be separated into stereoisomers, and the latter may be resolved into optical isomers. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have analgesic, antiphlogistic and antitussive activity.
GB3844669A 1968-07-31 1969-07-31 Substituted indolines Expired GB1237034A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19681795034 DE1795034C3 (en) 1968-07-31 Racemic cis-3- (2-dimethylamino-1-propyl) -2-methyl-3-phenylindoline, its salts, process for their preparation and pharmaceuticals
DE19691931477 DE1931477A1 (en) 1968-07-31 1969-06-20 Optically active isomers of basic substituted indolines

Publications (1)

Publication Number Publication Date
GB1237034A true GB1237034A (en) 1971-06-30

Family

ID=25756099

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3844669A Expired GB1237034A (en) 1968-07-31 1969-07-31 Substituted indolines

Country Status (16)

Country Link
BE (1) BE736919A (en)
BG (1) BG17789A3 (en)
BR (1) BR6911182D0 (en)
CA (1) CA954134A (en)
CS (1) CS158250B2 (en)
DE (1) DE1931477A1 (en)
DK (1) DK135421B (en)
FI (1) FI52855C (en)
FR (1) FR2014088B1 (en)
GB (1) GB1237034A (en)
IE (1) IE33249B1 (en)
IL (1) IL32740A (en)
PL (1) PL80258B1 (en)
RO (1) RO56642A (en)
SE (1) SE360654B (en)
YU (1) YU34181B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7100655A (en) * 1970-01-19 1971-07-21
DE2825192A1 (en) * 1978-06-08 1979-12-20 Thomae Gmbh Dr K 2,3-DIHYDRO-2-METHYL-3 SQUARE CLAMP ON 2- (DIMETHYLAMINO) -PROPYL SQUARE CLAMP TO -3-PHENYL-1H-INDOL-1-CARBOXALDEHYDE, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINERS

Also Published As

Publication number Publication date
FR2014088A1 (en) 1970-04-10
IE33249B1 (en) 1974-05-01
FI52855B (en) 1977-08-31
YU34181B (en) 1979-02-28
FI52855C (en) 1977-12-12
DE1931477A1 (en) 1970-12-23
YU198269A (en) 1978-09-18
FR2014088B1 (en) 1974-02-01
DK135421B (en) 1977-04-25
BR6911182D0 (en) 1973-04-26
CS158250B2 (en) 1974-10-15
IL32740A (en) 1972-12-29
PL80258B1 (en) 1975-08-30
CA954134A (en) 1974-09-03
IE33249L (en) 1970-01-31
BG17789A3 (en) 1973-12-25
DK135421C (en) 1977-10-10
RO56642A (en) 1974-09-01
BE736919A (en) 1970-02-02
SE360654B (en) 1973-10-01

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