GB1248430A - 4-phenyl-quinazolinone derivatives - Google Patents
4-phenyl-quinazolinone derivativesInfo
- Publication number
- GB1248430A GB1248430A GB5792/71A GB579271A GB1248430A GB 1248430 A GB1248430 A GB 1248430A GB 5792/71 A GB5792/71 A GB 5792/71A GB 579271 A GB579271 A GB 579271A GB 1248430 A GB1248430 A GB 1248430A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alkoxy
- compounds
- oct
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
Abstract
1,248,430. 2(1H)-quinazolinone derivatives. SANDOZ Ltd. 28 Oct., 1968 [30 Oct., 1967; 26 Feb., 1968; 1 July, 1968], No. 5792/71. Divided out of 1,248,428. Heading C2C. The invention comprises compounds of formula wherein R is F, C1, Br, NO 2 , CF 3 or C 1-4 alkyl, alkoxy or alkylthio, n is 1 or 2 and R 2 is Ph possibly containing up to 2 F, C1 or C 1-4 alkyl or alkoxy substituents or 1 Br or CF 3 substituent, provided that (a) when n = 1, R is not halogen, and if R is 7-Me, then R 2 is substituted Ph, (b) when n = 2 the R's may be the same or different and are halogen, alkyl or alkoxy. The compounds are prepared by reacting a correspondingly substituted o-isopropylaminobenzophenone with a C 1-5 -alkyl carbamate in presence of a Lewis acid at at least 140 C. Therapeutic compositions for oral or parenteral administration comprise compounds of the above formula, which have anti-inflammatory, analgesic, antipyretic and anti-bradykinin activity. Reference has been directed by the Comptroller to Specification 1,181,570.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67920167A | 1967-10-30 | 1967-10-30 | |
| US70793268A | 1968-02-26 | 1968-02-26 | |
| US74180468A | 1968-07-01 | 1968-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1248430A true GB1248430A (en) | 1971-10-06 |
Family
ID=27418344
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5792/71A Expired GB1248430A (en) | 1967-10-30 | 1968-10-28 | 4-phenyl-quinazolinone derivatives |
| GB50943/68A Expired GB1248428A (en) | 1967-10-30 | 1968-10-28 | omicron-ISOPROPYLAMINOBENZOPHENONES |
| GB5791/71A Expired GB1248429A (en) | 1967-10-30 | 1968-10-28 | 4-phenyl-quinazolinone derivative |
| GB9822/69A Expired GB1259813A (en) | 1967-10-30 | 1969-02-24 | Quinazolinone derivatives |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50943/68A Expired GB1248428A (en) | 1967-10-30 | 1968-10-28 | omicron-ISOPROPYLAMINOBENZOPHENONES |
| GB5791/71A Expired GB1248429A (en) | 1967-10-30 | 1968-10-28 | 4-phenyl-quinazolinone derivative |
| GB9822/69A Expired GB1259813A (en) | 1967-10-30 | 1969-02-24 | Quinazolinone derivatives |
Country Status (20)
| Country | Link |
|---|---|
| JP (1) | JPS4821950B1 (en) |
| AT (4) | AT311351B (en) |
| BE (2) | BE723041A (en) |
| BG (2) | BG16442A3 (en) |
| CA (1) | CA956953A (en) |
| CH (3) | CH502292A (en) |
| CY (2) | CY766A (en) |
| DE (3) | DE1818012C3 (en) |
| ES (1) | ES374924A1 (en) |
| FI (1) | FI54300C (en) |
| FR (4) | FR1591655A (en) |
| GB (4) | GB1248430A (en) |
| IE (1) | IE32475B1 (en) |
| IL (1) | IL30973A0 (en) |
| IT (1) | IT7827864A0 (en) |
| MY (2) | MY7400279A (en) |
| NL (2) | NL165459C (en) |
| OA (1) | OA03388A (en) |
| SE (1) | SE386169B (en) |
| YU (1) | YU34196B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4442084A (en) * | 1979-04-10 | 1984-04-10 | Sandoz Ltd. | Analgesic and myotonolytic preparations |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1241294B (en) * | 1960-10-22 | 1967-05-24 | Albert Sturm | Folding garage carried by a motor vehicle |
| JPS555505B2 (en) * | 1971-11-11 | 1980-02-07 | ||
| BE790804A (en) * | 1971-11-18 | 1973-04-30 | Sandoz Sa | PROCESS FOR PREPARING QUINAZOLINE DERIVATIVES |
| BE792942A (en) * | 1972-03-09 | 1973-06-18 | Sandoz Sa | NEW DERIVATIVE OF QUINAZOLINONE, ITS PREPARATION AND APPLICATION IN THERAPEUTICS |
| JPS53141220U (en) * | 1977-04-12 | 1978-11-08 | ||
| DE3009415A1 (en) * | 1980-03-12 | 1981-09-17 | Hermann 7407 Rottenburg Maurer | Storage box for flexible car cover - has free standing support with roller to draw in cover |
| US4731480A (en) * | 1985-07-29 | 1988-03-15 | Ortho Pharmaceutical Corporation | Process for preparing 2-acyl-3,4-dialkoxyanilines |
| AR038658A1 (en) | 2001-06-15 | 2005-01-26 | Novartis Ag | DERIVATIVES OF 4-ARIL-2 (1H) QUINAZOLINONA AND 4-ARIL-QUINAZOLINA 2-SUBSTITUTES, A PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH DERIVATIVES FOR THE PREPARATION OF A MEDICINAL PRODUCT |
| GB0230015D0 (en) | 2002-12-23 | 2003-01-29 | Novartis Ag | Organic compounds |
-
1967
- 1967-10-30 BG BG010296A patent/BG16442A3/en unknown
-
1968
- 1968-10-07 CH CH1492468A patent/CH502292A/en not_active IP Right Cessation
- 1968-10-07 CH CH1079870A patent/CH502351A/en not_active IP Right Cessation
- 1968-10-09 SE SE7113876A patent/SE386169B/en unknown
- 1968-10-11 NL NL6814559.A patent/NL165459C/en not_active IP Right Cessation
- 1968-10-17 FI FI2951/68A patent/FI54300C/en active
- 1968-10-26 DE DE1818012A patent/DE1818012C3/en not_active Expired
- 1968-10-26 DE DE1805501A patent/DE1805501C3/en not_active Expired
- 1968-10-28 YU YU2500/68A patent/YU34196B/en unknown
- 1968-10-28 BE BE723041D patent/BE723041A/xx not_active IP Right Cessation
- 1968-10-28 FR FR1591655D patent/FR1591655A/fr not_active Expired
- 1968-10-28 IE IE1294/68A patent/IE32475B1/en unknown
- 1968-10-28 IL IL30973A patent/IL30973A0/en unknown
- 1968-10-28 AT AT784470A patent/AT311351B/en not_active IP Right Cessation
- 1968-10-28 GB GB5792/71A patent/GB1248430A/en not_active Expired
- 1968-10-28 GB GB50943/68A patent/GB1248428A/en not_active Expired
- 1968-10-28 GB GB5791/71A patent/GB1248429A/en not_active Expired
- 1968-10-29 JP JP43078367A patent/JPS4821950B1/ja active Pending
- 1968-10-29 OA OA53401A patent/OA03388A/en unknown
- 1968-10-30 BG BG12957A patent/BG17801A3/xx unknown
-
1969
- 1969-01-27 FR FR183232A patent/FR8248M/fr not_active Expired
- 1969-01-27 FR FR183233A patent/FR8249M/fr not_active Expired
- 1969-02-12 CH CH208869A patent/CH503744A/en not_active IP Right Cessation
- 1969-02-24 GB GB9822/69A patent/GB1259813A/en not_active Expired
- 1969-02-24 AT AT158671A patent/AT303741B/en not_active IP Right Cessation
- 1969-02-24 CA CA043,768A patent/CA956953A/en not_active Expired
- 1969-02-24 FR FR6904638A patent/FR2002598A1/fr not_active Withdrawn
- 1969-02-24 AT AT183469A patent/AT303736B/en not_active IP Right Cessation
- 1969-02-24 BE BE728869D patent/BE728869A/xx unknown
- 1969-02-24 DE DE1909110A patent/DE1909110C3/en not_active Expired
- 1969-02-24 AT AT158871A patent/AT303743B/en not_active IP Right Cessation
- 1969-02-26 NL NL6902968A patent/NL6902968A/xx not_active Application Discontinuation
- 1969-12-26 ES ES374924A patent/ES374924A1/en not_active Expired
-
1974
- 1974-11-07 CY CY76674A patent/CY766A/en unknown
- 1974-11-07 CY CY76574A patent/CY765A/en unknown
- 1974-12-30 MY MY279/74A patent/MY7400279A/en unknown
- 1974-12-30 MY MY278/74A patent/MY7400278A/en unknown
-
1978
- 1978-09-19 IT IT7827864A patent/IT7827864A0/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4442084A (en) * | 1979-04-10 | 1984-04-10 | Sandoz Ltd. | Analgesic and myotonolytic preparations |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |