IE33249B1 - Substituted indolines - Google Patents
Substituted indolinesInfo
- Publication number
- IE33249B1 IE33249B1 IE106169A IE106169A IE33249B1 IE 33249 B1 IE33249 B1 IE 33249B1 IE 106169 A IE106169 A IE 106169A IE 106169 A IE106169 A IE 106169A IE 33249 B1 IE33249 B1 IE 33249B1
- Authority
- IE
- Ireland
- Prior art keywords
- alkyl
- compounds
- july
- cycloalkyl
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,237,034. Indoline derivatives. DR. KARL THOMAE G.m.b.H. 31 July, 1969 [31 July, 1968; 20 June, 1969], No. 38446/69. Heading C2C. The invention comprises compounds of formula and their acid addition salts, wherein R 1 is C 1-5 alkyl, R 2 and R 3 are each H, Cl, Me, Et, MeO or EtO, R 4 and R 5 are each C 1-5 alkyl, cycloalkyl. C 1-5 alkyl, C 3-5 alkenyl or C 5-7 cycloalkyl (or NR 4 R 5 forms a saturated-possibly C 1-3 alkyl or Ph substituted-monocyclic heterocyclic 5- or 6-membered ring which may contain O or a further N atom), A is a C 2-4 bivalent aliphatic hydrocarbon group and n is 1 or 2. These compounds, prepared by reduction of the corresponding pseudoindoles, may be separated into stereoisomers, and the latter may be resolved into optical isomers. Therapeutic compositions for oral, parenteral or rectal administration comprise compounds of the above formula, which have analgesic, antiphlogistic and antitussive activity.
[GB1237034A]
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681795034 DE1795034C3 (en) | 1968-07-31 | Racemic cis-3- (2-dimethylamino-1-propyl) -2-methyl-3-phenylindoline, its salts, process for their preparation and pharmaceuticals | |
| DE19691931477 DE1931477A1 (en) | 1968-07-31 | 1969-06-20 | Optically active isomers of basic substituted indolines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE33249L IE33249L (en) | 1970-01-31 |
| IE33249B1 true IE33249B1 (en) | 1974-05-01 |
Family
ID=25756099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE106169A IE33249B1 (en) | 1968-07-31 | 1969-07-30 | Substituted indolines |
Country Status (16)
| Country | Link |
|---|---|
| BE (1) | BE736919A (en) |
| BG (1) | BG17789A3 (en) |
| BR (1) | BR6911182D0 (en) |
| CA (1) | CA954134A (en) |
| CS (1) | CS158250B2 (en) |
| DE (1) | DE1931477A1 (en) |
| DK (1) | DK135421B (en) |
| FI (1) | FI52855C (en) |
| FR (1) | FR2014088B1 (en) |
| GB (1) | GB1237034A (en) |
| IE (1) | IE33249B1 (en) |
| IL (1) | IL32740A (en) |
| PL (1) | PL80258B1 (en) |
| RO (1) | RO56642A (en) |
| SE (1) | SE360654B (en) |
| YU (1) | YU34181B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7100655A (en) * | 1970-01-19 | 1971-07-21 | ||
| DE2825192A1 (en) * | 1978-06-08 | 1979-12-20 | Thomae Gmbh Dr K | 2,3-DIHYDRO-2-METHYL-3 SQUARE CLAMP ON 2- (DIMETHYLAMINO) -PROPYL SQUARE CLAMP TO -3-PHENYL-1H-INDOL-1-CARBOXALDEHYDE, METHOD FOR THE PRODUCTION THEREOF AND THEIR CONTAINERS |
-
1969
- 1969-06-20 DE DE19691931477 patent/DE1931477A1/en active Pending
- 1969-07-14 FI FI208869A patent/FI52855C/en active
- 1969-07-16 RO RO6054669A patent/RO56642A/ro unknown
- 1969-07-28 SE SE1059269A patent/SE360654B/xx unknown
- 1969-07-28 CS CS524669A patent/CS158250B2/cs unknown
- 1969-07-30 BR BR21118269A patent/BR6911182D0/en unknown
- 1969-07-30 IE IE106169A patent/IE33249B1/en unknown
- 1969-07-30 YU YU198269A patent/YU34181B/en unknown
- 1969-07-30 IL IL3274069A patent/IL32740A/en unknown
- 1969-07-30 PL PL13512969A patent/PL80258B1/xx unknown
- 1969-07-30 DK DK412669A patent/DK135421B/en unknown
- 1969-07-31 FR FR6926305A patent/FR2014088B1/fr not_active Expired
- 1969-07-31 GB GB3844669A patent/GB1237034A/en not_active Expired
- 1969-07-31 BG BG012787A patent/BG17789A3/en unknown
- 1969-07-31 BE BE736919D patent/BE736919A/xx unknown
- 1969-07-31 CA CA058,375A patent/CA954134A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2014088A1 (en) | 1970-04-10 |
| FI52855B (en) | 1977-08-31 |
| YU34181B (en) | 1979-02-28 |
| FI52855C (en) | 1977-12-12 |
| DE1931477A1 (en) | 1970-12-23 |
| YU198269A (en) | 1978-09-18 |
| FR2014088B1 (en) | 1974-02-01 |
| DK135421B (en) | 1977-04-25 |
| BR6911182D0 (en) | 1973-04-26 |
| CS158250B2 (en) | 1974-10-15 |
| IL32740A (en) | 1972-12-29 |
| GB1237034A (en) | 1971-06-30 |
| PL80258B1 (en) | 1975-08-30 |
| CA954134A (en) | 1974-09-03 |
| IE33249L (en) | 1970-01-31 |
| BG17789A3 (en) | 1973-12-25 |
| DK135421C (en) | 1977-10-10 |
| RO56642A (en) | 1974-09-01 |
| BE736919A (en) | 1970-02-02 |
| SE360654B (en) | 1973-10-01 |
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