GB1299247A - Benzofuran derivatives and process for preparing the same - Google Patents

Benzofuran derivatives and process for preparing the same

Info

Publication number
GB1299247A
GB1299247A GB3025770A GB3025770A GB1299247A GB 1299247 A GB1299247 A GB 1299247A GB 3025770 A GB3025770 A GB 3025770A GB 3025770 A GB3025770 A GB 3025770A GB 1299247 A GB1299247 A GB 1299247A
Authority
GB
United Kingdom
Prior art keywords
piperidino
compounds
preparing
same
pyrrolidino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3025770A
Inventor
Fernand Binon
Robert Charlier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz SA
Original Assignee
Labaz SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz SA filed Critical Labaz SA
Priority to GB3025770A priority Critical patent/GB1299247A/en
Priority to BE766392A priority patent/BE766392A/en
Priority to CH846771A priority patent/CH546756A/en
Priority to FR7121690A priority patent/FR2100806B1/fr
Priority to NL7108316A priority patent/NL7108316A/xx
Priority to DE19712130480 priority patent/DE2130480A1/en
Publication of GB1299247A publication Critical patent/GB1299247A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms

Abstract

1299247 Amino-ethers derived from 3-benzoylbenzofuran LABAZ 21 May 1971 [22 June 1970] 30257/70 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein (a) n is 3, X is Br or I, R is C 2-6 alkyl, Ph or PhCH 2 and Am is Me 2 N, Et 2 N, Pr 2 N, pyrrolidino or piperidino; (b) n is 3, X is Cl, R is Et or Bu and Am is Et 2 N, Pr 2 N, pyrrolidino or piperidino; or (c) n is 4-6, X is I, R is Et or Bu and Am is Me 2 N, Et 2 N or piperidino. These compounds are prepared by (1) condensing the corresponding bromoalkoxybenzoylbenzofuran with Am-H, or (2) (when n=3) condensing the corresponding hydroxybenzoylbenzofuran with Z-(CH 2 ) 3 -Am, where Z is halogen or p-TsO. Therapeutic compositions for the treatment of angina pectoris by oral or rectal administration comprise compounds of the above formula.
GB3025770A 1970-06-22 1970-06-22 Benzofuran derivatives and process for preparing the same Expired GB1299247A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB3025770A GB1299247A (en) 1970-06-22 1970-06-22 Benzofuran derivatives and process for preparing the same
BE766392A BE766392A (en) 1970-06-22 1971-04-28 NEW BENZOFURAN DERIVATIVES AND THERAPEUTIC COMPOSITIONS CONTAINING THEM AS WELL AS THE METHODS FOR THE PREPARATION OF THESE DERIVATIVES AND COMPOSITIONS
CH846771A CH546756A (en) 1970-06-22 1971-06-10 PROCESS FOR THE PREPARATION OF NEW DERIVATIVES OF BENZOFURAN.
FR7121690A FR2100806B1 (en) 1970-06-22 1971-06-15
NL7108316A NL7108316A (en) 1970-06-22 1971-06-17
DE19712130480 DE2130480A1 (en) 1970-06-22 1971-06-19 Benzofuran derivatives and pharmaceutical preparations containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB3025770A GB1299247A (en) 1970-06-22 1970-06-22 Benzofuran derivatives and process for preparing the same

Publications (1)

Publication Number Publication Date
GB1299247A true GB1299247A (en) 1972-12-13

Family

ID=10304784

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3025770A Expired GB1299247A (en) 1970-06-22 1970-06-22 Benzofuran derivatives and process for preparing the same

Country Status (6)

Country Link
BE (1) BE766392A (en)
CH (1) CH546756A (en)
DE (1) DE2130480A1 (en)
FR (1) FR2100806B1 (en)
GB (1) GB1299247A (en)
NL (1) NL7108316A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565828A (en) * 1983-07-18 1986-01-21 Sanofi Benzofuran derivatives and their therapeutic use
WO1994029289A1 (en) * 1993-06-16 1994-12-22 Advanced Therapies, Inc. Benzoylbenzofurane derivatives for treatment of cardiac arrhythmia
US6316487B1 (en) 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
JP2013539757A (en) * 2010-10-06 2013-10-28 ジェイファーマ株式会社 Development of potent urate transporter inhibitors: compounds designed for their uric acid excretion effect

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947470A (en) * 1974-06-20 1976-03-30 Smithkline Corporation Substituted benzofurans and benzothiophenes
WO1993022302A1 (en) * 1992-04-24 1993-11-11 Smithkline Beecham Plc N-aryloxy(thio)alkyl-azacycloalkanes useful as calcium channel antagonists

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4565828A (en) * 1983-07-18 1986-01-21 Sanofi Benzofuran derivatives and their therapeutic use
WO1994029289A1 (en) * 1993-06-16 1994-12-22 Advanced Therapies, Inc. Benzoylbenzofurane derivatives for treatment of cardiac arrhythmia
US5440054A (en) * 1993-06-16 1995-08-08 Advanced Therapies, Inc. Compound for treatment of cardiac arrhythmia, synthesis, and methods of use
US5849788A (en) * 1993-06-16 1998-12-15 Aryx Therapeutics Compound for treatment of cardiac arphythmia, synthesis, and methods of use
US6316487B1 (en) 1993-06-16 2001-11-13 Aryx Therapeutics Compounds for treatment of cardiac arrhythmia synthesis, and methods of use
JP2013539757A (en) * 2010-10-06 2013-10-28 ジェイファーマ株式会社 Development of potent urate transporter inhibitors: compounds designed for their uric acid excretion effect
JP2016074691A (en) * 2010-10-06 2016-05-12 ジェイファーマ株式会社 Developing potent urate transporter inhibitors: compounds designed for their uricosuric action
JP2018021048A (en) * 2010-10-06 2018-02-08 ジェイファーマ株式会社 Development of potent uric acid transporter inhibitor, and compound designed for stimulating excretion of uric acid
US10005750B2 (en) 2010-10-06 2018-06-26 J-Pharma Co., Ltd. Developing potent urate transporter inhibitors: compounds designed for their uricosuric action

Also Published As

Publication number Publication date
NL7108316A (en) 1971-12-24
BE766392A (en) 1971-10-28
DE2130480A1 (en) 1972-03-09
FR2100806B1 (en) 1974-10-18
CH546756A (en) 1974-03-15
FR2100806A1 (en) 1972-03-24

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Legal Events

Date Code Title Description
PS Patent sealed
732 Registration of transactions, instruments or events in the register (sect. 32/1977)
PCNP Patent ceased through non-payment of renewal fee