ES341324A1 - Access for the preparation of pyrazinoyl- and pyrazinamido-guanidines - Google Patents

Access for the preparation of pyrazinoyl- and pyrazinamido-guanidines

Info

Publication number
ES341324A1
ES341324A1 ES341324A ES341324A ES341324A1 ES 341324 A1 ES341324 A1 ES 341324A1 ES 341324 A ES341324 A ES 341324A ES 341324 A ES341324 A ES 341324A ES 341324 A1 ES341324 A1 ES 341324A1
Authority
ES
Spain
Prior art keywords
alkyl
phenyl
pyrazinamido
pyrazinoyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES341324A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES341324A1 publication Critical patent/ES341324A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

(3,5 - Diamino - 6 - chloro - pyrazinoyl and -pyrazinamido)-guanidines of the general formula wherein R1 and R2, which are the same or different, are hydrogen, C 1-5 alkyl or phenyl-C 1-5 alkyl R3 is hydrogen, C 1-5 alkyl, hydroxy- C 1-5 alkyl, pyridyl-C 1-5 alkyl, phenyl-C 1-5 alkyl, halophenyl-C 1-5 alkyl, (C 1-5 alkyl-phenyl)-C 1-5 alkyl or (C 1-5 alkoxy-phenyl)-C 1-5 alkyl R4 is hydrogen, C 1-5 alkyl, phenyl-C 1-5, alkyl, halophenyl-C 1-5 alkyl, (C 1-5 alkylphenyl)-C 1-5 alkyl or (C 1-5 alkoxy-phenyl)-C 1-5 alkyl or R3 and R4 are linked together to form, with the nitrogen atom to which they are attached, a group having the formula wherein x is 4, 5, 6 or 7 R5 is hydrogen or C 1-5 alkyl or R4 and R5 are linked together to form an ethylene or trimethylene radical and n is 0 or 1 and acid addition salts thereof are prepared by reaction of a (3,5-diamino-pyrazinoyl or -pyrazinamido)-guanidine of the general formula with chlorine, followed by optional conversion of the product to an acid addition salt thereof. (3,5 - Diamino - pyrazinoyl or - pyrazinamido)-guanidines of the second general formula above are prepared by reaction of a C 1-5 alkyl ester of a 3-amino-5-NR1R2-pyrazinoate with a guanidine or aminoguanidine of the general formula
ES341324A 1966-08-25 1967-06-02 Access for the preparation of pyrazinoyl- and pyrazinamido-guanidines Expired ES341324A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57492266A 1966-08-25 1966-08-25

Publications (1)

Publication Number Publication Date
ES341324A1 true ES341324A1 (en) 1968-10-01

Family

ID=24298194

Family Applications (1)

Application Number Title Priority Date Filing Date
ES341324A Expired ES341324A1 (en) 1966-08-25 1967-06-02 Access for the preparation of pyrazinoyl- and pyrazinamido-guanidines

Country Status (8)

Country Link
BE (1) BE699438A (en)
CH (1) CH487169A (en)
DE (1) DE1695421A1 (en)
ES (1) ES341324A1 (en)
GB (1) GB1145934A (en)
IL (1) IL27897A (en)
NL (1) NL6707570A (en)
SE (1) SE333146B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
KR101578235B1 (en) 2007-12-10 2015-12-16 노파르티스 아게 Oarganic compounds
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
BR112015014178A2 (en) 2012-12-17 2017-07-11 Parion Sciences Inc 3,5-diamino-6-chloro-n- (n- (4-phenylbutyl) carbamimidoyl) pyrazine-2-carboxamide compounds
PT2931713T (en) 2012-12-17 2017-02-22 Parion Sciences Inc Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Also Published As

Publication number Publication date
IL27897A (en) 1972-02-29
SE333146B (en) 1971-03-08
DE1695421A1 (en) 1971-04-15
BE699438A (en) 1967-12-04
CH487169A (en) 1970-03-15
GB1145934A (en) 1969-03-19
NL6707570A (en) 1968-02-26

Similar Documents

Publication Publication Date Title
ES449418A1 (en) 1-Phenoxy-{8 imidazolyl-(1){9 -2-hydroxy-alkanes
ES349034A1 (en) 2-cycloalkylamino-oxazolines
ES439927A1 (en) 7-Methoxy-6-thiatetracyclines and their preparation
ES341324A1 (en) Access for the preparation of pyrazinoyl- and pyrazinamido-guanidines
ES400452A1 (en) Plant growth regulant compositions containing 2-haloethanesulphinic acid compounds
ES341322A1 (en) Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines
GB1412616A (en) Stabilisation of rubber products with 1,3,5-triazine derivatives
ES341321A1 (en) Preparation of pyrazinoylguanidine and pyrazinamidoguanidine products
ES380355A1 (en) Process for the preparation of 4-pyrazolidinols
US3888893A (en) Unsaturated amides
ES346350A1 (en) Benzothiopyrone compounds
ES374154A1 (en) Certain benzimidazole as rodenticides
ES352463A1 (en) Procedure for obtaining a product to combat weeds, especially for employment in viticulture. (Machine-translation by Google Translate, not legally binding)
GB1116308A (en) Novels-triazolo[3,4-a]isoquinolines and the preparation thereof
ES397454A1 (en) N-phenylpropylene substituted tetrahydro-isoquinolines
GB1199040A (en) Diisoeugenol Derivatives
GB1154075A (en) Cyclohexane Dithiocarbamates and their Use as Herbicides.
GB1266718A (en)
GB1299053A (en) Substituted 6-nitroaniline derivatives, processes for their preparation, and their use as herbicidal agents
ES359288A1 (en) Aminoalkyl phosphonates
GB1084153A (en)
ES375323A1 (en) New n-alkoxyalkylene-alkyl ureas and compositions containing them
ES401174A1 (en) 3-Aryl-5-oxo-2-pyrazoline-4-carboxanilides and process therefor
GB1199107A (en) Pyrazolidine Derivatives
GB1044245A (en) Nitrososemicarbazides