ES397454A1 - N-phenylpropylene substituted tetrahydro-isoquinolines - Google Patents

N-phenylpropylene substituted tetrahydro-isoquinolines

Info

Publication number
ES397454A1
ES397454A1 ES397454A ES397454A ES397454A1 ES 397454 A1 ES397454 A1 ES 397454A1 ES 397454 A ES397454 A ES 397454A ES 397454 A ES397454 A ES 397454A ES 397454 A1 ES397454 A1 ES 397454A1
Authority
ES
Spain
Prior art keywords
acid addition
group
phenylpropylene
isoquinolines
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES397454A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES397454A1 publication Critical patent/ES397454A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/788—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with keto groups bound to a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Procedure for the preparation of tetrahydro-isoquinoline derivatives of the general formula **(See formula)** where R represents a lower alkyl or lower cycloalkyl group, R'represents an atom of hydrogen or a lower alkanoyl group and R2 and R3 each represent a lower alkyl group or together represent a trimethylene, tetramethylene or butadiene- (1,3) -ylene- (1,4) group, and its acid addition salts, the process of which involves reducing a compound of the general formula **(See formula)** wherein R, R2 and R3 have the same meaning as attributed to them above, or a respective acid addition salt, and, if desired, subject the reduction product to lower alkanoylation and, also if desired, converting the product of reduction or lower alkanoylation to the free base or an acid addition salt. (Machine-translation by Google Translate, not legally binding)
ES397454A 1970-11-30 1971-11-29 N-phenylpropylene substituted tetrahydro-isoquinolines Expired ES397454A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5670270 1970-11-30

Publications (1)

Publication Number Publication Date
ES397454A1 true ES397454A1 (en) 1974-06-01

Family

ID=10477318

Family Applications (1)

Application Number Title Priority Date Filing Date
ES397454A Expired ES397454A1 (en) 1970-11-30 1971-11-29 N-phenylpropylene substituted tetrahydro-isoquinolines

Country Status (24)

Country Link
US (1) US3812133A (en)
AT (1) AT317215B (en)
AU (1) AU454027B2 (en)
BE (1) BE775949A (en)
BG (1) BG20355A3 (en)
BR (1) BR7107706D0 (en)
CH (1) CH559725A5 (en)
CS (1) CS164916B2 (en)
DD (1) DD95232A5 (en)
DE (1) DE2156049A1 (en)
DK (1) DK129236B (en)
EG (1) EG10512A (en)
ES (1) ES397454A1 (en)
FI (1) FI49605C (en)
FR (1) FR2115493B1 (en)
GB (1) GB1313017A (en)
HU (1) HU162419B (en)
IL (1) IL38066A0 (en)
MY (1) MY7400044A (en)
NL (1) NL7116272A (en)
RO (1) RO60141A (en)
SE (1) SE374110B (en)
SU (1) SU453837A3 (en)
ZA (1) ZA717308B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766131A (en) * 1980-10-17 1988-08-23 Pennwalt Corporation 2-amino (or hydroxy) phenethyl-1,2,3,4-tetrahydroisoquinolines as analgesics

Also Published As

Publication number Publication date
AU454027B2 (en) 1974-10-17
BR7107706D0 (en) 1973-07-12
IL38066A0 (en) 1972-01-27
CS164916B2 (en) 1975-11-28
FI49605C (en) 1975-08-11
FR2115493B1 (en) 1974-11-15
AU3529771A (en) 1973-05-10
ZA717308B (en) 1972-11-29
EG10512A (en) 1976-03-31
BG20355A3 (en) 1975-11-05
DD95232A5 (en) 1973-01-20
HU162419B (en) 1973-02-28
FR2115493A1 (en) 1972-07-07
DK129236C (en) 1975-02-03
RO60141A (en) 1976-07-15
BE775949A (en) 1972-05-29
SU453837A3 (en) 1974-12-15
US3812133A (en) 1974-05-21
CH559725A5 (en) 1975-03-14
NL7116272A (en) 1972-06-01
DE2156049A1 (en) 1972-06-08
FI49605B (en) 1975-04-30
MY7400044A (en) 1974-12-31
AT317215B (en) 1974-08-26
SE374110B (en) 1975-02-24
GB1313017A (en) 1973-04-11
DK129236B (en) 1974-09-16

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