ES341322A1 - Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines - Google Patents
Process for the preparation o Pyrazinoyl-and Pyrazinamido-GuanidinesInfo
- Publication number
- ES341322A1 ES341322A1 ES341322A ES341322A ES341322A1 ES 341322 A1 ES341322 A1 ES 341322A1 ES 341322 A ES341322 A ES 341322A ES 341322 A ES341322 A ES 341322A ES 341322 A1 ES341322 A1 ES 341322A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- pyrazinamido
- pyrazinoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
(3,5 - Diamino - 6 - halo - pyrazinoyl and -pyrazinamido)-guanidines of the general formula wherein R is chlorine or bromine R1 and R2 are each hydrogen, C 1-5 alkyl, C 3-5 alkenyl or C 4-8 (cycloalkyl-alkyl) R3 is hydrogen, C 1-5 alkyl, hydroxy-C 1-5 alkyl, phenyl-C 1-5 alkyl, (halophenyl) - C 1-5 alkyl, (C 1-5 alkyl-phenyl) - C 1-5 alkyl, (C 1-5 alkoxyphenyl)-C 1-5 alkyl or pyridyl- C 1-5 alkyl R4 is hydrogen, C 1-5 alkyl or phenyl- C 1-5 alkyl or when R3 and R4 are each C 1-5 alkyl they can be linked together to form a cyclic structure with the nitrogen atom to which they are attached, thereby forming a group of the structure where x is 4, 5, 6 or 7 R5 is hydrogen or C 1-5 alkyl or when R4 and R5 are each C 1-5 alkyl they can be linked together with the nitrogen atoms to which they are attached to form a cyclic structure wherein y is 2 or 3 and n is 0 or 1 and acid addition salts thereof are prepared by reaction under anhydrous conditions in the presence of a solvent having a boiling-point of at least 100 C. of a 3,5-diamino-6-halopyrazinoic acid and a guanidine or aminoguanidine of the respective formul[mu] followed optionally by salification.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57491066A | 1966-08-25 | 1966-08-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES341322A1 true ES341322A1 (en) | 1968-10-01 |
Family
ID=24298148
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES341322A Expired ES341322A1 (en) | 1966-08-25 | 1967-06-02 | Process for the preparation o Pyrazinoyl-and Pyrazinamido-Guanidines |
Country Status (6)
Country | Link |
---|---|
BE (1) | BE699436A (en) |
CH (1) | CH487167A (en) |
DK (1) | DK115846B (en) |
ES (1) | ES341322A1 (en) |
GB (1) | GB1158399A (en) |
NL (1) | NL6707564A (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4224447A (en) * | 1979-03-27 | 1980-09-23 | Merck & Co., Inc. | Novel pyrazinecarboxamides and processes for preparing same |
US4246406A (en) * | 1979-03-27 | 1981-01-20 | Merck & Co., Inc. | Heterocyclic substituted pyrazinoylguanidines |
US6858615B2 (en) | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
CN101939054B (en) * | 2007-12-10 | 2014-10-29 | 诺华股份有限公司 | organic compounds |
AR086745A1 (en) | 2011-06-27 | 2014-01-22 | Parion Sciences Inc | 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE |
KR20150095870A (en) | 2012-12-17 | 2015-08-21 | 패리온 사이언스 인코퍼레이티드 | 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl)pyrazine-2-carboxamide compounds |
CN105073717B (en) | 2012-12-17 | 2018-05-22 | 帕里昂科学公司 | Chloro-pyrazine carboxamides derivatives available for treatment disease as caused by mucous membrane aquation deficiency |
US9102633B2 (en) | 2013-12-13 | 2015-08-11 | Parion Sciences, Inc. | Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds |
-
1967
- 1967-05-31 NL NL6707564A patent/NL6707564A/xx unknown
- 1967-06-01 DK DK286567A patent/DK115846B/en unknown
- 1967-06-02 BE BE699436D patent/BE699436A/xx unknown
- 1967-06-02 ES ES341322A patent/ES341322A1/en not_active Expired
- 1967-06-07 GB GB2621167A patent/GB1158399A/en not_active Expired
- 1967-06-07 CH CH803567A patent/CH487167A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NL6707564A (en) | 1968-02-26 |
CH487167A (en) | 1970-03-15 |
GB1158399A (en) | 1969-07-16 |
DK115846B (en) | 1969-11-17 |
BE699436A (en) | 1967-12-04 |
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