DK115846B - Process for the preparation of (3,5-diamino-6-halopyrazinoyl) guanidine or (3,5-diamino-6-halopyrazinamido) guanidine compounds or acid addition salts thereof. - Google Patents

Process for the preparation of (3,5-diamino-6-halopyrazinoyl) guanidine or (3,5-diamino-6-halopyrazinamido) guanidine compounds or acid addition salts thereof.

Info

Publication number
DK115846B
DK115846B DK286567A DK286567A DK115846B DK 115846 B DK115846 B DK 115846B DK 286567 A DK286567 A DK 286567A DK 286567 A DK286567 A DK 286567A DK 115846 B DK115846 B DK 115846B
Authority
DK
Denmark
Prior art keywords
diamino
guanidine
halopyrazinoyl
halopyrazinamido
preparation
Prior art date
Application number
DK286567A
Other languages
Danish (da)
Inventor
P Pollak
R Tull
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of DK115846B publication Critical patent/DK115846B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
DK286567A 1966-08-25 1967-06-01 Process for the preparation of (3,5-diamino-6-halopyrazinoyl) guanidine or (3,5-diamino-6-halopyrazinamido) guanidine compounds or acid addition salts thereof. DK115846B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57491066A 1966-08-25 1966-08-25

Publications (1)

Publication Number Publication Date
DK115846B true DK115846B (en) 1969-11-17

Family

ID=24298148

Family Applications (1)

Application Number Title Priority Date Filing Date
DK286567A DK115846B (en) 1966-08-25 1967-06-01 Process for the preparation of (3,5-diamino-6-halopyrazinoyl) guanidine or (3,5-diamino-6-halopyrazinamido) guanidine compounds or acid addition salts thereof.

Country Status (6)

Country Link
BE (1) BE699436A (en)
CH (1) CH487167A (en)
DK (1) DK115846B (en)
ES (1) ES341322A1 (en)
GB (1) GB1158399A (en)
NL (1) NL6707564A (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4224447A (en) * 1979-03-27 1980-09-23 Merck & Co., Inc. Novel pyrazinecarboxamides and processes for preparing same
US4246406A (en) * 1979-03-27 1981-01-20 Merck & Co., Inc. Heterocyclic substituted pyrazinoylguanidines
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
AU2008334629B2 (en) * 2007-12-10 2012-04-12 Novartis Ag Organic compounds
AR086745A1 (en) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-DIAMINO-6-CHLORINE-N- (N- (4- (4- (2- (HEXIL (2,3,4,5,6-PENTAHYDROXIHEXIL)) AMINO) ETOXI) PHENYL) BUTIL) CARBAMIMIDOIL) PIRAZINA -2-CARBOXAMIDE
US9029382B2 (en) 2012-12-17 2015-05-12 Parion Sciences, Inc. 3,5-diamino-6-chloro-N-(N-(4-phenylbutyl)carbamimidoyl) pyrazine-2-carboxamide compounds
AU2013363218B2 (en) 2012-12-17 2018-03-15 Parion Sciences, Inc. Chloro-pyrazine carboxamide derivatives useful for the treatment of diseases favoured by insufficient mucosal hydration
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Also Published As

Publication number Publication date
ES341322A1 (en) 1968-10-01
NL6707564A (en) 1968-02-26
BE699436A (en) 1967-12-04
CH487167A (en) 1970-03-15
GB1158399A (en) 1969-07-16

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