BRPI0516482A - 2, 6-substituìda-4-monossubstituìda-amino-pirimidina como antagonistas receptor de prostaglandina d2 - Google Patents

2, 6-substituìda-4-monossubstituìda-amino-pirimidina como antagonistas receptor de prostaglandina d2

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Publication number
BRPI0516482A
BRPI0516482A BRPI0516482-6A BRPI0516482A BRPI0516482A BR PI0516482 A BRPI0516482 A BR PI0516482A BR PI0516482 A BRPI0516482 A BR PI0516482A BR PI0516482 A BRPI0516482 A BR PI0516482A
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BR
Brazil
Prior art keywords
formula
monosubstituted
pyrimidine
amino
substituted
Prior art date
Application number
BRPI0516482-6A
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English (en)
Inventor
Sungtaek Lim
Keith John Harris
David Stefany
Charles J Gardner
Bin Cao
Ray Boffey
Timothy Alan Gillespy
Joacy C Aguiar
Hazel J Hunt
Elisa A Dechaux
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Aventis Pharma Inc
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Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of BRPI0516482A publication Critical patent/BRPI0516482A/pt

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  • Chemical & Material Sciences (AREA)
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  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Abstract

2,6-SUBSTITUìDA-4-MONOSSUBSTITUìDA-AMINO-PIRIMIDINA COMO ANTAGONISTAS RECEPTOR DE PROSTAGLANDINA D2. A presente invenção é direcionada a um composto da Fórmula (1) como definida aqui, uma composição farmacêutica compreendendo uma quantidade farmaceuticamente eficaz de um ou mais compostos de acordo com a Fórmula (1) em admistão com um portador farmaceuticamente aceitável, e um método de tratar um paciente que sofre de um distúrbio mediado por PGD2 incluindo, mas não limitado a, doença alérgica (como rinite alérgica, conjuntivite alérgica, dermatite atópica, asma bronquial e alergia a alimentos), mastocitose sistêmica, distúrbios acompanhados por ativação sistêmica de mastócitos, choque anafilático, broncoconstrição, bronquite, urticária, eczema, doenças acompanhadas por coceira (como dermatite atópica e urticária), doenças (como catarata, descolamento da retina, inflamação, infecção e distúrbios do sono) que são geradas secundariamente como resultado de comportamento acompanhado por coceira (como arranhão e batida), inflamação, doenças pulmonares obstrutivas crónicas, lesão de reperfusão isquêmica, acidente cerebrovascular, artrite reumatóide crónica, pleurisia, colite ulcerativa e outras, administrando ao dito paciente uma quantidade farmaceuticamente eficaz de um composto de acordo com a Fórmula (1).
BRPI0516482-6A 2004-10-15 2005-10-14 2, 6-substituìda-4-monossubstituìda-amino-pirimidina como antagonistas receptor de prostaglandina d2 BRPI0516482A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61927204P 2004-10-15 2004-10-15
PCT/US2005/037148 WO2006044732A2 (en) 2004-10-15 2005-10-14 2, 6-substituted-4-monosubstitutedamino-pyrimidine as prostaglandin d2 receptor antagonists

Publications (1)

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BRPI0516482A true BRPI0516482A (pt) 2008-09-02

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BRPI0516482-6A BRPI0516482A (pt) 2004-10-15 2005-10-14 2, 6-substituìda-4-monossubstituìda-amino-pirimidina como antagonistas receptor de prostaglandina d2

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US (2) US7517889B2 (pt)
EP (1) EP1891019B1 (pt)
JP (1) JP4970274B2 (pt)
KR (1) KR101280268B1 (pt)
CN (1) CN101039920B (pt)
AR (1) AR053770A1 (pt)
AU (1) AU2005295502B2 (pt)
BR (1) BRPI0516482A (pt)
CA (1) CA2583742C (pt)
CR (1) CR9003A (pt)
DK (1) DK1891019T3 (pt)
EC (1) ECSP077398A (pt)
ES (1) ES2392091T3 (pt)
GT (1) GT200500284A (pt)
HK (1) HK1108429A1 (pt)
HN (1) HN2005000795A (pt)
IL (1) IL182090A (pt)
MA (1) MA29071B1 (pt)
MX (1) MX2007003155A (pt)
MY (2) MY142453A (pt)
NO (1) NO339772B1 (pt)
NZ (1) NZ553919A (pt)
PA (1) PA8649801A1 (pt)
PE (1) PE20060936A1 (pt)
PL (1) PL1891019T3 (pt)
PT (1) PT1891019E (pt)
RU (1) RU2417990C2 (pt)
SG (1) SG156653A1 (pt)
SI (1) SI1891019T1 (pt)
SV (1) SV2006002272A (pt)
TN (1) TNSN07098A1 (pt)
TW (1) TWI372751B (pt)
UA (1) UA88485C2 (pt)
UY (1) UY29167A1 (pt)
WO (1) WO2006044732A2 (pt)
ZA (1) ZA200702209B (pt)

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GT200600457A (es) * 2005-10-13 2007-04-27 Aventis Pharma Inc Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2
DOP2007000068A (es) * 2006-04-12 2007-10-31 Sanofi Aventis Us Llc Compuestos de amino-pirimidina 2,6-sustituidos-4-monosustituidos como antagonistas del receptor de prostaglandina d2
WO2008039882A1 (en) * 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
NZ579892A (en) * 2007-03-30 2012-03-30 Sanofi Aventis Pyrimidine hydrazide compounds as prostaglandin D synthase inhibitors
US8242139B2 (en) * 2007-04-30 2012-08-14 Abbott Laboratories Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme
EP2014657A1 (de) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
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