SV2006002272A - Pirimidinas como antagonistas del receptor de prostaglandina d2 - Google Patents

Pirimidinas como antagonistas del receptor de prostaglandina d2

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Publication number
SV2006002272A
SV2006002272A SV2005002272A SV2005002272A SV2006002272A SV 2006002272 A SV2006002272 A SV 2006002272A SV 2005002272 A SV2005002272 A SV 2005002272A SV 2005002272 A SV2005002272 A SV 2005002272A SV 2006002272 A SV2006002272 A SV 2006002272A
Authority
SV
El Salvador
Prior art keywords
pharmaceutically
formula
allergic
patient
prostaglandina
Prior art date
Application number
SV2005002272A
Other languages
English (en)
Inventor
Sungtaek Lim
David Stefany
Charles J Gardner
Bin Cao
Ray Boffey
Timothy Alan Gillespy
Joacy Aguiar
Hazel Joan Dyke
Elsa Amandine Dechaux
Keith John Harris
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of SV2006002272A publication Critical patent/SV2006002272A/es

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C07—ORGANIC CHEMISTRY
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN COMPUESTO DE FÓRMULA (I) (VER FÓRMULA) EN LA QUE CY1, CY2, L1, L2 Y R1 SON COMO SE DIFINENE EN ESTE DOCUMENTO, A UNA COMPOSICIÓN FARMACÉUTICA QUE COMPRENDE UNA CANTIDAD FARMACÉUTICAMENTE EFICAZ DE UNO O MÁS COMPUESTOS DE ACUERDO CON LA FÓRMULA (I) EN MEZCLA CON UN VEHÍCULO FARMACÉUTICAMENTE ACEPTABLE, A UN MÉTODO PARA TRATAR A UN PACIENTE QUE PADECE UN TRASTORNO MEDIADO POR LA PGD2 INCLUYENDO, PERO SIN LIMITACIÓN, ASMA BRONQUIAL, ENFERMEDAD PULMONAR OBSTRUCTIVA CRÓNICA (COPD), RINITIS ALÉRGICA, DEMATITIS ALERGICA, CONJUNTIVITIS ALÉRGICA, BRONQUITIS, MASTOCITOSIS SISTÉMATICA Y LESIÓN DE REPERFUSIÓNINQUÉMICA POR MEDIO DE LA ADMINISTRACIÓN A DICHO PACIENTE DE UNA CANTIDAD FARMACÉUTICAMENTE EFICAZ DE UN COMPUESTO DE ACUERDO CON LA FÓRMULA (I)
SV2005002272A 2004-10-15 2005-10-14 Pirimidinas como antagonistas del receptor de prostaglandina d2 SV2006002272A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61927204P 2004-10-15 2004-10-15

Publications (1)

Publication Number Publication Date
SV2006002272A true SV2006002272A (es) 2006-06-28

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US (2) US7517889B2 (es)
EP (1) EP1891019B1 (es)
JP (1) JP4970274B2 (es)
KR (1) KR101280268B1 (es)
CN (1) CN101039920B (es)
AR (1) AR053770A1 (es)
AU (1) AU2005295502B2 (es)
BR (1) BRPI0516482A (es)
CA (1) CA2583742C (es)
CR (1) CR9003A (es)
DK (1) DK1891019T3 (es)
EC (1) ECSP077398A (es)
ES (1) ES2392091T3 (es)
GT (1) GT200500284A (es)
HK (1) HK1108429A1 (es)
HN (1) HN2005000795A (es)
IL (1) IL182090A (es)
MA (1) MA29071B1 (es)
MX (1) MX2007003155A (es)
MY (2) MY157036A (es)
NO (1) NO339772B1 (es)
NZ (1) NZ553919A (es)
PA (1) PA8649801A1 (es)
PE (1) PE20060936A1 (es)
PL (1) PL1891019T3 (es)
PT (1) PT1891019E (es)
RU (1) RU2417990C2 (es)
SG (1) SG156653A1 (es)
SI (1) SI1891019T1 (es)
SV (1) SV2006002272A (es)
TN (1) TNSN07098A1 (es)
TW (1) TWI372751B (es)
UA (1) UA88485C2 (es)
UY (1) UY29167A1 (es)
WO (1) WO2006044732A2 (es)
ZA (1) ZA200702209B (es)

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WO2008039882A1 (en) * 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
WO2008121670A1 (en) * 2007-03-30 2008-10-09 Sanofi-Aventis Pyrimidine hydrazide compounds as pgds inhibitors
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EP2014657A1 (de) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
ATE531699T1 (de) 2007-06-29 2011-11-15 Sanofi Sa Verfahren zur herstellung von 2-(3-ä6-ä2-(2,4-
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EP2214675B1 (en) * 2007-10-25 2013-11-20 Genentech, Inc. Process for making thienopyrimidine compounds
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