BR112012033075A2 - composto piperidina substituído antagonista de receptor c5a, composição farmacêutica, e, uso do composto. - Google Patents

composto piperidina substituído antagonista de receptor c5a, composição farmacêutica, e, uso do composto.

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Publication number
BR112012033075A2
BR112012033075A2 BR112012033075A BR112012033075A BR112012033075A2 BR 112012033075 A2 BR112012033075 A2 BR 112012033075A2 BR 112012033075 A BR112012033075 A BR 112012033075A BR 112012033075 A BR112012033075 A BR 112012033075A BR 112012033075 A2 BR112012033075 A2 BR 112012033075A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
receptor antagonist
substituted piperidine
receptors
Prior art date
Application number
BR112012033075A
Other languages
English (en)
Other versions
BR112012033075B1 (pt
Inventor
Hiroko Tanaka
Jay Powers
Ju Yang
Kevin Lloyd Greenman
Manmohan Reddy Leleti
Pingchen Fan
Yandong Li
Yibin Zeng
Original Assignee
Chemocentryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/823,039 external-priority patent/US20100311753A1/en
Priority claimed from US13/072,616 external-priority patent/US20110275639A1/en
Application filed by Chemocentryx Inc filed Critical Chemocentryx Inc
Publication of BR112012033075A2 publication Critical patent/BR112012033075A2/pt
Publication of BR112012033075B1 publication Critical patent/BR112012033075B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

composto, composição farmacêutica, e, métodos para tratar um mamífero que sofre de ou susceptível a uma doença ou distúrbio que envolve a ativação patológica de receptores c5a, para inibir a quimiotaxia celular. compostos são fornecidos que são moduladores do receptor de c5a. os compostos são piperidinas substituídas e são úteis em composições farmacêuticas, métodos para o tratamento de doenças e distúrbios que envolvem a ativação patológica de receptores de c5a.
BR112012033075-6A 2010-06-24 2011-06-24 Composto piperidina substituído antagonista de receptor c5a, composição farmacêutica, e, uso do composto BR112012033075B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/823,039 US20100311753A1 (en) 2008-12-22 2010-06-24 C5aR ANTAGONISTS
US12/823,039 2010-06-24
US13/072,616 US20110275639A1 (en) 2008-12-22 2011-03-25 C5aR ANTAGONISTS
US13/072,616 2011-03-25
PCT/US2011/041910 WO2011163640A1 (en) 2010-06-24 2011-06-24 C5ar antagonists

Publications (2)

Publication Number Publication Date
BR112012033075A2 true BR112012033075A2 (pt) 2017-01-17
BR112012033075B1 BR112012033075B1 (pt) 2021-06-01

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