EA201071291A3 - Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств - Google Patents

Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств

Info

Publication number
EA201071291A3
EA201071291A3 EA201071291A EA201071291A EA201071291A3 EA 201071291 A3 EA201071291 A3 EA 201071291A3 EA 201071291 A EA201071291 A EA 201071291A EA 201071291 A EA201071291 A EA 201071291A EA 201071291 A3 EA201071291 A3 EA 201071291A3
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
disorders
neuropsyatric
receptor antagonists
nmda receptor
Prior art date
Application number
EA201071291A
Other languages
English (en)
Other versions
EA201071291A2 (ru
EA020339B1 (ru
Inventor
Рэймонд Дж. Дингледин
Стефен Ф. Трейнелис
Original Assignee
Эмори Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмори Юниверсити filed Critical Эмори Юниверсити
Publication of EA201071291A2 publication Critical patent/EA201071291A2/ru
Publication of EA201071291A3 publication Critical patent/EA201071291A3/ru
Publication of EA020339B1 publication Critical patent/EA020339B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Представлены фармацевтические композиции и способы для лечения или профилактики некоторых нейропсихиатрических состояний, в частности расстройств эмоционального состояния. Данные соединения отвечают общим формулам I-V, как описано в описании к заявке.
EA201071291A 2008-05-09 2009-05-11 Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств EA020339B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12709808P 2008-05-09 2008-05-09
PCT/US2009/043502 WO2009137843A2 (en) 2008-05-09 2009-05-11 Nmda receptor antagonists for the treatment of neuropsychiatric disorders

Publications (3)

Publication Number Publication Date
EA201071291A2 EA201071291A2 (ru) 2011-04-29
EA201071291A3 true EA201071291A3 (ru) 2014-02-28
EA020339B1 EA020339B1 (ru) 2014-10-30

Family

ID=41265475

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201071291A EA020339B1 (ru) 2008-05-09 2009-05-11 Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств

Country Status (16)

Country Link
US (1) US20110160223A1 (ru)
EP (1) EP2296658A4 (ru)
JP (1) JP2011520815A (ru)
KR (1) KR20110016891A (ru)
CN (1) CN102762207A (ru)
AU (1) AU2009244082A1 (ru)
BR (1) BRPI0912362A2 (ru)
CA (1) CA2722776A1 (ru)
CO (1) CO6341558A2 (ru)
EA (1) EA020339B1 (ru)
IL (1) IL208895A0 (ru)
MX (1) MX2010012186A (ru)
NZ (1) NZ589764A (ru)
SG (1) SG195568A1 (ru)
WO (1) WO2009137843A2 (ru)
ZA (1) ZA201007958B (ru)

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KR20170065637A (ko) * 2014-10-07 2017-06-13 세이지 테라퓨틱스, 인크. 신경활성 화합물 및 그의 사용 방법
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CA2991311A1 (en) 2015-07-06 2017-01-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
IL256710B2 (en) 2015-07-06 2024-01-01 Sage Therapeutics Inc Oxysterols and methods of using them
MX2020010690A (es) 2015-07-06 2022-02-25 Sage Therapeutics Inc Oxiesteroles y metodos de uso de los mismos.
EP3383429B1 (en) 2015-11-30 2020-10-14 INSERM - Institut National de la Santé et de la Recherche Médicale Nmdar antagonists for the treatment of tumor angiogenesis
PL3436022T3 (pl) 2016-04-01 2022-08-08 Sage Therapeutics, Inc. Oksysterole i sposoby ich stosowania
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
SI3481846T1 (sl) 2016-07-07 2021-11-30 Sage Therapeutics, Inc. 11-substituirani 24-hidroksisteroli za uporabo pri zdravljenju stanj, povezanih z NMDA
ES2935057T3 (es) 2016-09-30 2023-03-01 Sage Therapeutics Inc C7 oxisteroles sustituidos y estos compuestos para su uso como moduladores de la NMDA
CA3234484A1 (en) 2016-10-18 2018-04-26 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
RU2019115112A (ru) 2016-10-18 2020-11-24 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
WO2019071394A1 (zh) * 2017-10-09 2019-04-18 华南农业大学 一种抗白色念珠菌的新型化合物及其制备方法和应用
CN112702995A (zh) 2018-10-05 2021-04-23 克雷西奥生物科技有限公司 治疗重度抑郁症的艾氯胺酮的治疗方案
CN114539129B (zh) * 2020-11-18 2023-06-09 上海中医药大学附属龙华医院 烯丙胺类双功能化合物及其用途
CA3230601A1 (en) * 2021-09-02 2023-03-09 Dennis Liotta Glun2b-subunit selective antagonists of the n-methyl-d-aspartate receptors with enhanced potency at acidic ph

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Also Published As

Publication number Publication date
EP2296658A2 (en) 2011-03-23
MX2010012186A (es) 2011-02-22
SG195568A1 (en) 2013-12-30
JP2011520815A (ja) 2011-07-21
NZ589764A (en) 2012-10-26
EA201071291A2 (ru) 2011-04-29
KR20110016891A (ko) 2011-02-18
ZA201007958B (en) 2011-07-27
CN102762207A (zh) 2012-10-31
WO2009137843A9 (en) 2010-03-11
BRPI0912362A2 (pt) 2015-10-06
AU2009244082A1 (en) 2009-11-12
CA2722776A1 (en) 2009-11-12
CO6341558A2 (es) 2011-11-21
EA020339B1 (ru) 2014-10-30
IL208895A0 (en) 2011-01-31
US20110160223A1 (en) 2011-06-30
WO2009137843A2 (en) 2009-11-12
EP2296658A4 (en) 2014-01-15

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU