JPS579769A - 2-benzimidazolinone derivative - Google Patents

2-benzimidazolinone derivative

Info

Publication number
JPS579769A
JPS579769A JP8539780A JP8539780A JPS579769A JP S579769 A JPS579769 A JP S579769A JP 8539780 A JP8539780 A JP 8539780A JP 8539780 A JP8539780 A JP 8539780A JP S579769 A JPS579769 A JP S579769A
Authority
JP
Japan
Prior art keywords
formula
compound
lower alkyl
halogen
benzimidazolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8539780A
Other languages
Japanese (ja)
Other versions
JPS6326753B2 (en
Inventor
Kazuhisa Sakano
Takafumi Fujioka
Masaaki Osaki
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP8539780A priority Critical patent/JPS579769A/en
Publication of JPS579769A publication Critical patent/JPS579769A/en
Publication of JPS6326753B2 publication Critical patent/JPS6326753B2/ja
Granted legal-status Critical Current

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:Compounds of formula I (R1, R2 are H, lower alkyl, phenyl lower alkyl; R3 is halogen, lower alkyl, lower alkoxy, cyano, lower alkylthio; n is 0W3; A is lower alkylene that can bear a hydroxyl as a substituent).
EXAMPLE: 5-[3-(4-Phenylpiperazinyl)propoxy]-2-benzimidazolinone.
USE: Central nervous system depressant and antihistamic: the dose is 40μgW2mg/kg on the basis of the active ingredient and they are given in 3W4 portions a day.
PREPARATION: For example, the reaction of a compound of formula II with another compound of formula III (X1, X2 are halogen, alkane and arylsulfonyloxy) is conducted in the absence or presence of an inert solvent at 60W120°C for several to 24hr to form a compound of formula IV, which is made to react with a compound of formula V in the same manner as the above reaction to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8539780A 1980-06-23 1980-06-23 2-benzimidazolinone derivative Granted JPS579769A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8539780A JPS579769A (en) 1980-06-23 1980-06-23 2-benzimidazolinone derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8539780A JPS579769A (en) 1980-06-23 1980-06-23 2-benzimidazolinone derivative

Publications (2)

Publication Number Publication Date
JPS579769A true JPS579769A (en) 1982-01-19
JPS6326753B2 JPS6326753B2 (en) 1988-05-31

Family

ID=13857632

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8539780A Granted JPS579769A (en) 1980-06-23 1980-06-23 2-benzimidazolinone derivative

Country Status (1)

Country Link
JP (1) JPS579769A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10248925A1 (en) * 2002-10-15 2004-04-29 Proteosys Ag New compounds with dopaminergic and / or serotonergic activity
JP2010532382A (en) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ NMDA receptor antagonist for neuroprotection
JP2011520815A (en) * 2008-05-09 2011-07-21 エモリー・ユニバーシテイ NMDA receptor antagonist for the treatment of neuropsychiatric disorders

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10248925A1 (en) * 2002-10-15 2004-04-29 Proteosys Ag New compounds with dopaminergic and / or serotonergic activity
WO2004035534A3 (en) * 2002-10-15 2004-06-17 Proteosys Ag Novel compounds having a dopaminergic and/or serotoninergic activity
JP2010532382A (en) * 2007-06-29 2010-10-07 エモリー・ユニバーシテイ NMDA receptor antagonist for neuroprotection
JP2011520815A (en) * 2008-05-09 2011-07-21 エモリー・ユニバーシテイ NMDA receptor antagonist for the treatment of neuropsychiatric disorders

Also Published As

Publication number Publication date
JPS6326753B2 (en) 1988-05-31

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