JPS579769A - 2-benzimidazolinone derivative - Google Patents
2-benzimidazolinone derivativeInfo
- Publication number
- JPS579769A JPS579769A JP8539780A JP8539780A JPS579769A JP S579769 A JPS579769 A JP S579769A JP 8539780 A JP8539780 A JP 8539780A JP 8539780 A JP8539780 A JP 8539780A JP S579769 A JPS579769 A JP S579769A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- lower alkyl
- halogen
- benzimidazolinone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:Compounds of formula I (R1, R2 are H, lower alkyl, phenyl lower alkyl; R3 is halogen, lower alkyl, lower alkoxy, cyano, lower alkylthio; n is 0W3; A is lower alkylene that can bear a hydroxyl as a substituent).
EXAMPLE: 5-[3-(4-Phenylpiperazinyl)propoxy]-2-benzimidazolinone.
USE: Central nervous system depressant and antihistamic: the dose is 40μgW2mg/kg on the basis of the active ingredient and they are given in 3W4 portions a day.
PREPARATION: For example, the reaction of a compound of formula II with another compound of formula III (X1, X2 are halogen, alkane and arylsulfonyloxy) is conducted in the absence or presence of an inert solvent at 60W120°C for several to 24hr to form a compound of formula IV, which is made to react with a compound of formula V in the same manner as the above reaction to give the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8539780A JPS579769A (en) | 1980-06-23 | 1980-06-23 | 2-benzimidazolinone derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8539780A JPS579769A (en) | 1980-06-23 | 1980-06-23 | 2-benzimidazolinone derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS579769A true JPS579769A (en) | 1982-01-19 |
JPS6326753B2 JPS6326753B2 (en) | 1988-05-31 |
Family
ID=13857632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8539780A Granted JPS579769A (en) | 1980-06-23 | 1980-06-23 | 2-benzimidazolinone derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS579769A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10248925A1 (en) * | 2002-10-15 | 2004-04-29 | Proteosys Ag | New compounds with dopaminergic and / or serotonergic activity |
JP2010532382A (en) * | 2007-06-29 | 2010-10-07 | エモリー・ユニバーシテイ | NMDA receptor antagonist for neuroprotection |
JP2011520815A (en) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | NMDA receptor antagonist for the treatment of neuropsychiatric disorders |
-
1980
- 1980-06-23 JP JP8539780A patent/JPS579769A/en active Granted
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10248925A1 (en) * | 2002-10-15 | 2004-04-29 | Proteosys Ag | New compounds with dopaminergic and / or serotonergic activity |
WO2004035534A3 (en) * | 2002-10-15 | 2004-06-17 | Proteosys Ag | Novel compounds having a dopaminergic and/or serotoninergic activity |
JP2010532382A (en) * | 2007-06-29 | 2010-10-07 | エモリー・ユニバーシテイ | NMDA receptor antagonist for neuroprotection |
JP2011520815A (en) * | 2008-05-09 | 2011-07-21 | エモリー・ユニバーシテイ | NMDA receptor antagonist for the treatment of neuropsychiatric disorders |
Also Published As
Publication number | Publication date |
---|---|
JPS6326753B2 (en) | 1988-05-31 |
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