JPS5724366A - 2- 1-imidazolyl amidine - Google Patents
2- 1-imidazolyl amidineInfo
- Publication number
- JPS5724366A JPS5724366A JP9917180A JP9917180A JPS5724366A JP S5724366 A JPS5724366 A JP S5724366A JP 9917180 A JP9917180 A JP 9917180A JP 9917180 A JP9917180 A JP 9917180A JP S5724366 A JPS5724366 A JP S5724366A
- Authority
- JP
- Japan
- Prior art keywords
- imidazolyl
- compound
- formula
- alkyl
- alkoxycarbonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004173 1-benzimidazolyl group Chemical group [H]C1=NC2=C([H])C([H])=C([H])C([H])=C2N1* 0.000 abstract 1
- -1 1-imidazolyl Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 238000009835 boiling Methods 0.000 abstract 1
- 230000003327 cancerostatic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
Landscapes
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The compound of formula I (R is cycloalkyl, alkenyl, alkoxycarbonyl, benzoyl, thiazolyl, naphthyl, or phenyl which may have substituent group selected from alkyl, alkoxy, etc.; R' is 1-benzimidazolyl or 1-imidazolyl which may have alkyl substituent; X is alkyl, alkoxy, halogen, or alkoxycarbonyl; n is 0W3; the dotted line denotes that the tautomeric isomer is permissible).
EXAMPLE: N-(4-Chlorophenyl)-N'-(4'-methoxyphenyl)-1-(1-imidazolyl)formanidine.
USE: Carcinostatic agent. Dose: 1.0W40mg/kg daily by oral administration.
PROCESS: The compound of formula I is prepared by reacting the compound of formula II with N,N'-thionyldiimidazole in an inert solvent at room temperature or by heating near the boiling point of the solvent.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9917180A JPS5724366A (en) | 1980-07-18 | 1980-07-18 | 2- 1-imidazolyl amidine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9917180A JPS5724366A (en) | 1980-07-18 | 1980-07-18 | 2- 1-imidazolyl amidine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5724366A true JPS5724366A (en) | 1982-02-08 |
| JPH0133466B2 JPH0133466B2 (en) | 1989-07-13 |
Family
ID=14240196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9917180A Granted JPS5724366A (en) | 1980-07-18 | 1980-07-18 | 2- 1-imidazolyl amidine |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5724366A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001007029A3 (en) * | 1999-07-21 | 2001-08-23 | Kadmus Pharmaceuticals Inc | Substituted guanidines and the use thereof |
| WO2002020526A3 (en) * | 2000-09-07 | 2002-05-30 | Bayer Ag | Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents |
| EP1413302A2 (en) * | 1999-07-21 | 2004-04-28 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines for the treatment of pain |
| US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5013533A (en) * | 1973-04-27 | 1975-02-13 |
-
1980
- 1980-07-18 JP JP9917180A patent/JPS5724366A/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5013533A (en) * | 1973-04-27 | 1975-02-13 |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001007029A3 (en) * | 1999-07-21 | 2001-08-23 | Kadmus Pharmaceuticals Inc | Substituted guanidines and the use thereof |
| EP1413302A2 (en) * | 1999-07-21 | 2004-04-28 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines for the treatment of pain |
| EP1413302A3 (en) * | 1999-07-21 | 2004-05-12 | Kadmus Pharmaceuticals, Inc. | Substituted guanidines for the treatment of pain |
| US6875759B1 (en) | 1999-07-21 | 2005-04-05 | Kadmus Pharmaceuticals | Substituted guanidines and the use thereof |
| WO2002020526A3 (en) * | 2000-09-07 | 2002-05-30 | Bayer Ag | Cyclic and acyclic amidines and pharmaceutical compositions containing them for use as progesterone receptor binding agents |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0133466B2 (en) | 1989-07-13 |
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