JPS6463518A - Antiarrhythmic agent - Google Patents

Antiarrhythmic agent

Info

Publication number
JPS6463518A
JPS6463518A JP62221142A JP22114287A JPS6463518A JP S6463518 A JPS6463518 A JP S6463518A JP 62221142 A JP62221142 A JP 62221142A JP 22114287 A JP22114287 A JP 22114287A JP S6463518 A JPS6463518 A JP S6463518A
Authority
JP
Japan
Prior art keywords
alkyl
antiarrhythmic agent
phenylalkyl
bond
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62221142A
Other languages
Japanese (ja)
Inventor
Fujio Tafusa
Kazuyoshi Ei
Yoshinori Tsutsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP62221142A priority Critical patent/JPS6463518A/en
Publication of JPS6463518A publication Critical patent/JPS6463518A/en
Pending legal-status Critical Current

Links

Abstract

PURPOSE:To obtain an antiarrhythmic agent suppressing irritation formation abnormality occurring during ischemia almost without influencing contractive force of cardiac muscle, containing a specific carbostyril derivative. CONSTITUTION:An antiarrhythmic agent containing a compound shown by the formula [R<1> is H, alkyl, alkenyl, alkynyl or phenylalkyl; R<2> and R<3> are H, alkyl, cycloalkyl, pyridyl or phenylalkyl or R<2> and R<3> together with bonded N form 5--9-membered saturated or unsaturated heterocyclic ring (further may contain N, O or S); A is alkylene; R<4> is H, alkyl, phenyl, alkoxy or halogen; bond of carbostyril skeleton at 3-position and 4-position is single bond or double bond] or a salt thereof such as 3-(1-6-butylamino-1-phenylmethyl)-8- methylcarbostyril as an active ingredient. A dose of the compound is preferably 0.1-10mg/kg weight/day.
JP62221142A 1987-09-02 1987-09-02 Antiarrhythmic agent Pending JPS6463518A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62221142A JPS6463518A (en) 1987-09-02 1987-09-02 Antiarrhythmic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62221142A JPS6463518A (en) 1987-09-02 1987-09-02 Antiarrhythmic agent

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP63230457A Division JPH01125369A (en) 1988-09-14 1988-09-14 Carbostyril derivative

Publications (1)

Publication Number Publication Date
JPS6463518A true JPS6463518A (en) 1989-03-09

Family

ID=16762124

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62221142A Pending JPS6463518A (en) 1987-09-02 1987-09-02 Antiarrhythmic agent

Country Status (1)

Country Link
JP (1) JPS6463518A (en)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0382687A2 (en) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzofused-N-containing heterocycle derivatives
US5607946A (en) * 1993-03-05 1997-03-04 Merck Sharp & Dohme Ltd. Quinolone derivatives as dopamine D4 ligands
WO2001053288A1 (en) * 2000-01-20 2001-07-26 Eisai Co., Ltd. Novel piperidine compounds and drugs containing the same
USRE37395E1 (en) 1987-09-10 2001-10-02 Saint-Gobain Glass France Method of centering windshield glazings
WO2007117778A2 (en) * 2006-02-24 2007-10-18 Kalypsys, Inc. Quinolones useful as inducible nitric oxide synthase inhibitors
JP2009502869A (en) * 2005-07-28 2009-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Antibacterial quinoline derivatives
US20100210836A1 (en) * 2009-02-13 2010-08-19 University Of Southern California Small molecule inhibitors of lymphoid tyrosine phosphatase
US7939545B2 (en) * 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
US8354429B2 (en) 2007-11-16 2013-01-15 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8377960B2 (en) 2007-11-15 2013-02-19 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
WO2022056068A1 (en) * 2020-09-09 2022-03-17 The Regents Of The University Ofcalifornia Small molecule inhibitors of enpp1

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE37395E1 (en) 1987-09-10 2001-10-02 Saint-Gobain Glass France Method of centering windshield glazings
EP0382687A2 (en) * 1989-02-06 1990-08-16 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzofused-N-containing heterocycle derivatives
US5607946A (en) * 1993-03-05 1997-03-04 Merck Sharp & Dohme Ltd. Quinolone derivatives as dopamine D4 ligands
WO2001053288A1 (en) * 2000-01-20 2001-07-26 Eisai Co., Ltd. Novel piperidine compounds and drugs containing the same
US6784192B2 (en) 2000-01-20 2004-08-31 Eisai Co., Ltd. Piperidine compound and pharmaceutical composition thereof
JP2009502869A (en) * 2005-07-28 2009-01-29 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Antibacterial quinoline derivatives
EP1912948B1 (en) * 2005-07-28 2015-09-09 Janssen Pharmaceutica NV Antibacterial quinoline derivatives
US7915292B2 (en) * 2005-07-28 2011-03-29 Janssen Pharmaceutica Nv Antibacterial quinoline derivatives
WO2007117778A2 (en) * 2006-02-24 2007-10-18 Kalypsys, Inc. Quinolones useful as inducible nitric oxide synthase inhibitors
WO2007117778A3 (en) * 2006-02-24 2008-02-07 Kalypsys Inc Quinolones useful as inducible nitric oxide synthase inhibitors
US7939545B2 (en) * 2006-05-16 2011-05-10 Boehringer Ingelheim International Gmbh Inhibitors of human immunodeficiency virus replication
US8377960B2 (en) 2007-11-15 2013-02-19 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8354429B2 (en) 2007-11-16 2013-01-15 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8710230B2 (en) 2007-11-16 2014-04-29 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US20100210836A1 (en) * 2009-02-13 2010-08-19 University Of Southern California Small molecule inhibitors of lymphoid tyrosine phosphatase
WO2022056068A1 (en) * 2020-09-09 2022-03-17 The Regents Of The University Ofcalifornia Small molecule inhibitors of enpp1

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