CL2013002194A1 - Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras. - Google Patents
Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras.Info
- Publication number
- CL2013002194A1 CL2013002194A1 CL2013002194A CL2013002194A CL2013002194A1 CL 2013002194 A1 CL2013002194 A1 CL 2013002194A1 CL 2013002194 A CL2013002194 A CL 2013002194A CL 2013002194 A CL2013002194 A CL 2013002194A CL 2013002194 A1 CL2013002194 A1 CL 2013002194A1
- Authority
- CL
- Chile
- Prior art keywords
- piperidine
- methyl
- perhydro
- quinazolin
- quinolin
- Prior art date
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 title abstract 2
- 206010003246 arthritis Diseases 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 208000037976 chronic inflammation Diseases 0.000 title abstract 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 201000006417 multiple sclerosis Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- -1 1- (naphthalen-2-yl) methyl Chemical group 0.000 title 1
- PAMIQIKDUOTOBW-UHFFFAOYSA-N 1-methylpiperidine Chemical compound CN1CCCCC1 PAMIQIKDUOTOBW-UHFFFAOYSA-N 0.000 title 1
- 125000004260 quinazolin-2-yl group Chemical group [H]C1=NC(*)=NC2=C1C([H])=C([H])C([H])=C2[H] 0.000 title 1
- 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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Abstract
COMPUESTOS DERIVADOS DE 1-(1-(QUINAZOLIN-2—IL) O QUINOLIN-2-IL)-METIL-PIPERIDINA, 1-(NAFTALEN-2-IL)-METIL)- (PIPERIDINA O PERHIDRO-AZEPINA) Y OTROS DERIVADOS DE LOS MISMOS DE FÓRMULA (1) SU COMPOSICIÓN FARMACÉUTICA; Y USO COMO MODULADORES DE LA ACTIVIDAD DE LOS RECEPTORES DE SIP, EN EL TRATAMIENTO DE ESCLEROSIS MÚLTIPLE, ENFERMEDADES AUTOINMUNES, TRÁSTORNOS INFLAMATORIOS CRÓNICOS, ASMA, ARTRITIS ENTRE OTRAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US201161440254P | 2011-02-07 | 2011-02-07 |
Publications (1)
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CL2013002194A1 true CL2013002194A1 (es) | 2014-01-31 |
Family
ID=46638909
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Application Number | Title | Priority Date | Filing Date |
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CL2013002194A CL2013002194A1 (es) | 2011-02-07 | 2013-07-31 | Compuestos derivados de 1-(1-(quinazolin-2-il) o quinolin-2-il)metil-piperidina, 1-(naftalen-2-il)metil)-(piperidina o perhidro-azepina) y otros derivados de los mismos; su composicion farmaceutica; y uso como moduladores de la actividad de los receptores de s1p, en el tratamiento de esclerosis multiple, enfermedades autoinmunes, trastornos inflamatorios cronicos, asma, artritis, entre otras. |
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CN (2) | CN103533835B (es) |
AR (1) | AR085150A1 (es) |
AU (2) | AU2012214707B2 (es) |
BR (1) | BR112013019683B1 (es) |
CA (1) | CA2825069C (es) |
CL (1) | CL2013002194A1 (es) |
CO (1) | CO6781554A2 (es) |
CY (1) | CY1118212T1 (es) |
DK (1) | DK2672823T3 (es) |
EA (2) | EA026745B8 (es) |
ES (3) | ES2772258T3 (es) |
HR (1) | HRP20161361T1 (es) |
HU (1) | HUE031658T2 (es) |
IL (2) | IL227348A0 (es) |
LT (1) | LT2672823T (es) |
ME (1) | ME02556B (es) |
MX (1) | MX342145B (es) |
MY (1) | MY163274A (es) |
PH (1) | PH12016501389A1 (es) |
PL (1) | PL2672823T3 (es) |
PT (1) | PT2672823T (es) |
RS (1) | RS55339B1 (es) |
SG (1) | SG191875A1 (es) |
SI (1) | SI2672823T1 (es) |
SM (1) | SMT201600407B (es) |
TW (1) | TWI655186B (es) |
UA (1) | UA113507C2 (es) |
WO (1) | WO2012109108A1 (es) |
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