PE20060936A1 - Derivados de 4-monoamino-pirimidinas como antagonistas del receptor de prostaglandina d2 (pgd2) - Google Patents

Derivados de 4-monoamino-pirimidinas como antagonistas del receptor de prostaglandina d2 (pgd2)

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Publication number
PE20060936A1
PE20060936A1 PE2005001214A PE2005001214A PE20060936A1 PE 20060936 A1 PE20060936 A1 PE 20060936A1 PE 2005001214 A PE2005001214 A PE 2005001214A PE 2005001214 A PE2005001214 A PE 2005001214A PE 20060936 A1 PE20060936 A1 PE 20060936A1
Authority
PE
Peru
Prior art keywords
metoxy
phenyl
pyrimidin
pgd2
prostaglandin
Prior art date
Application number
PE2005001214A
Other languages
English (en)
Inventor
Sungtaek Lim
Keith John Harris
Charles J Gardner
Ray Boffey
Joacy Aguilar
Elsa Amandine Dechaux
Hazel Joan Dyke
Timothy Gillespy
Bin Cao
David Stefany
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of PE20060936A1 publication Critical patent/PE20060936A1/es

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    • A61K31/50—Pyridazines; Hydrogenated pyridazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pulmonology (AREA)
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  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I) DONDE Cy1 ES CICLOALQUILO, HETEROCICLILO, CICLOALQUENILO, ENTRE OTROS; Cy2 ES CICLOALQUENILO, HETEROCICLENILO, ARILO, ENTRE OTROS; L1 ES UN ALQUILENO(C2-C6), -CH2-(C1-C5)HALOALQUILENO, CICLOALQUILENO(C3-C7); R1 ES ALQUILO(C1-C4), ALCOXI (C1-C4), Y4 Y5 N-, DONDE Y4 E Y5 SON H, ALQUILO(C1-C4); L2 ES UN ENLACE, -O-, -CH2-O-. SON COMPUESTOS PREFERIDOS: 3-{6-[2-(3-FLUORO-4-METOXI-FENIL)-ETILAMINO]-2-METOXI-PIRIMIDIN-4-IL}-BENZONITRILO, [6-(3-AMINO-FENIL)-2-METOXI-PIRIMIDIN-4-IL]-[2-(4-METOXI-FENIL)-ETIL]AMINO, 3-{2-METOXI-6-[2-(4-METOXI-FENIL)-ETILAMINO]-PIRIMIDIN-4-IL}-BENCENOSULFONAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE PROSTAGLANDINA D2 (PGD2) INHIBIENDO LA INFLAMACION EN LAS VIAS RESPIRATORIAS EN ENFERMEDADES TALES COMO ASMA BRONQUIAL, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA, RINITIS ALERGICA
PE2005001214A 2004-10-15 2005-10-14 Derivados de 4-monoamino-pirimidinas como antagonistas del receptor de prostaglandina d2 (pgd2) PE20060936A1 (es)

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GT200600457A (es) * 2005-10-13 2007-04-27 Aventis Pharma Inc Sal de fosfato dihidrogeno como antagonistas del receptor de prostaglandina d2
AR060403A1 (es) * 2006-04-12 2008-06-11 Sanofi Aventis Compuestos de amino- pirimidina 2,6- sustituidos -4- monosustituidos como antagonistas del receptor de prostaglandina d2
WO2008039882A1 (en) * 2006-09-30 2008-04-03 Sanofi-Aventis U.S. Llc A combination of niacin and a prostaglandin d2 receptor antagonist
CA2682629C (en) * 2007-03-30 2013-03-19 Sanofi-Aventis Pyrimidine hydrazide compounds as pgds inhibitors
BRPI0810719A8 (pt) * 2007-04-30 2016-03-08 Abbott Lab Inibidores da enzima diacilglicerol o-acetiltansferase tipo 1
EP2014657A1 (de) * 2007-06-21 2009-01-14 Bayer Schering Pharma Aktiengesellschaft Diaminopyrimidine als Modulatoren des EP2-Rezeptors
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