AR048343A1 - Agentes terapeuticos para el tratamiento de la migrana - Google Patents

Agentes terapeuticos para el tratamiento de la migrana

Info

Publication number
AR048343A1
AR048343A1 ARP050101201A ARP050101201A AR048343A1 AR 048343 A1 AR048343 A1 AR 048343A1 AR P050101201 A ARP050101201 A AR P050101201A AR P050101201 A ARP050101201 A AR P050101201A AR 048343 A1 AR048343 A1 AR 048343A1
Authority
AR
Argentina
Prior art keywords
treatment
methods
migrana
therapeutic agents
cgrp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
ARP050101201A
Other languages
English (en)
Inventor
Andrew P Degnan
Xiaojun Han
Gene M Dubowchik
John E Macor
Stephen E Mercer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol-Myers Co
Bristol-Myers Squibb Co
Original Assignee
Bristol-Myers Co
Bristol-Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Co, Bristol-Myers Squibb Co filed Critical Bristol-Myers Co
Publication of AR048343A1 publication Critical patent/AR048343A1/es
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuestos de la formula (1) como antagonistas de los receptores péptidos relacionados con el gen de calcitonina ("receptor CGRP"), composuiciones farmacéuticas que los comprenden, métodos para su identificacion, métodos de tratamiento que los usan y su uso en terapia para tratamiento de la vasodilatacion neurogénica, inflamacion neurogénica, migrana y otros dolores de cabeza, lesion térmica, choque circulatorio, sofocaciones asociadas con la menopausia, enfermedades inflamatorias de las vías aéreas tales como asma y enfermedad pulmonar obstructiva cronica (COPD), y otras condiciones, el tratamiento de las cuales se puede efectuar por el antagonismo de los receptores CGRP.
ARP050101201A 2004-03-29 2005-03-28 Agentes terapeuticos para el tratamiento de la migrana Withdrawn AR048343A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US55740804P 2004-03-29 2004-03-29

Publications (1)

Publication Number Publication Date
AR048343A1 true AR048343A1 (es) 2006-04-19

Family

ID=34964257

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101201A Withdrawn AR048343A1 (es) 2004-03-29 2005-03-28 Agentes terapeuticos para el tratamiento de la migrana

Country Status (16)

Country Link
US (1) US7772244B2 (es)
EP (1) EP1730137A1 (es)
JP (1) JP2007530701A (es)
KR (1) KR20070007857A (es)
CN (1) CN1972929A (es)
AR (1) AR048343A1 (es)
AU (1) AU2005228881A1 (es)
BR (1) BRPI0509341A (es)
CA (1) CA2562039A1 (es)
IL (1) IL178291A0 (es)
NO (1) NO20064888L (es)
PE (1) PE20060286A1 (es)
RU (1) RU2006138195A (es)
TW (1) TW200533398A (es)
WO (1) WO2005095383A1 (es)
ZA (1) ZA200608037B (es)

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US7696195B2 (en) 2004-04-22 2010-04-13 Boehringer Ingelheim International Gmbh Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions
DE102004019492A1 (de) * 2004-04-22 2005-11-10 Boehringer Ingelheim Pharma Gmbh & Co. Kg Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel
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US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
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AU2007221220A1 (en) * 2006-02-22 2007-09-07 Vertex Pharmaceuticals Incorporated Spiro condensed piperidnes as modulators of muscarinic receptors
RU2008137593A (ru) 2006-02-22 2010-03-27 Вертекс Фармасьютикалз Инкорпорейтед (Us) Модуляторы мускариновых рецепторов
US7858790B2 (en) * 2006-06-29 2010-12-28 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
WO2008021375A2 (en) * 2006-08-15 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
CA2660974A1 (en) 2006-08-18 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
JP2010508358A (ja) * 2006-11-01 2010-03-18 ブリストル−マイヤーズ スクイブ カンパニー グルココルチコイド受容体、ＡＰ−１、および／またはＮＦ−κＢ活性の調節剤、並びにその使用
JP2010540640A (ja) * 2007-10-03 2010-12-24 バーテックス ファーマシューティカルズ インコーポレイテッド ムスカリン作用性レセプターのモジュレーター
FR3008978A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
JO3669B1 (ar) 2015-01-06 2020-08-27 Ferring Bv بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين
JOP20200116A1 (ar) 2015-04-24 2017-06-16 Amgen Inc طرق لعلاج أو الوقاية من الصداع النصفي
GB201519194D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP receptor antagonists
GB201519195D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
GB201519196D0 (en) 2015-10-30 2015-12-16 Heptares Therapeutics Ltd CGRP Receptor Antagonists
EP3366286A1 (en) 2017-02-22 2018-08-29 Johannes Keller Compounds for treating sepsis
BR112020013621A2 (pt) 2018-01-12 2020-12-01 Amgen Inc. anticorpos contra pac1 e usos dos mesmos

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Also Published As

Publication number Publication date
TW200533398A (en) 2005-10-16
BRPI0509341A (pt) 2007-09-04
US7772244B2 (en) 2010-08-10
ZA200608037B (en) 2008-06-25
KR20070007857A (ko) 2007-01-16
CN1972929A (zh) 2007-05-30
WO2005095383A1 (en) 2005-10-13
IL178291A0 (en) 2006-12-31
CA2562039A1 (en) 2005-10-13
JP2007530701A (ja) 2007-11-01
NO20064888L (no) 2006-10-26
RU2006138195A (ru) 2008-05-10
PE20060286A1 (es) 2006-04-25
AU2005228881A1 (en) 2005-10-13
US20050215576A1 (en) 2005-09-29
EP1730137A1 (en) 2006-12-13

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