NO20064888L - Heterocykliske CGRP antagonister for behandling av migrene - Google Patents
Heterocykliske CGRP antagonister for behandling av migreneInfo
- Publication number
- NO20064888L NO20064888L NO20064888A NO20064888A NO20064888L NO 20064888 L NO20064888 L NO 20064888L NO 20064888 A NO20064888 A NO 20064888A NO 20064888 A NO20064888 A NO 20064888A NO 20064888 L NO20064888 L NO 20064888L
- Authority
- NO
- Norway
- Prior art keywords
- treatment
- migraine
- methods
- cgrp antagonists
- antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Foreliggende oppfinnelse angår forbindelser med formel (I) som antagonister av kalsitonin genbeslektet peptid reseptorer ("CGRP reseptor"), farmasøytiske preparater omfattende dem, metoder for å identifisere dem, metoder for behandling ved anvendelse av dem og anvendelse av dem i terapi for behandling av neurogen vasodilatasjon, neurogen inflammasjon, migrene og andre hodepiner, termisk skade, kretsløpssjokk, hetetokter assosiert med menopause, luftveis inflammatoriske sykdommer, slik som astma og kronisk obstruktiv pulmonal sykdom (KOLS), og andre tilstander hvor behandling kan utføres ved antagonisme av CGRP-reseptorer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55740804P | 2004-03-29 | 2004-03-29 | |
PCT/US2005/010330 WO2005095383A1 (en) | 2004-03-29 | 2005-03-28 | Heterocyclic cgrp antagonists for the treatment of migraine |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20064888L true NO20064888L (no) | 2006-10-26 |
Family
ID=34964257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20064888A NO20064888L (no) | 2004-03-29 | 2006-10-26 | Heterocykliske CGRP antagonister for behandling av migrene |
Country Status (16)
Country | Link |
---|---|
US (1) | US7772244B2 (no) |
EP (1) | EP1730137A1 (no) |
JP (1) | JP2007530701A (no) |
KR (1) | KR20070007857A (no) |
CN (1) | CN1972929A (no) |
AR (1) | AR048343A1 (no) |
AU (1) | AU2005228881A1 (no) |
BR (1) | BRPI0509341A (no) |
CA (1) | CA2562039A1 (no) |
IL (1) | IL178291A0 (no) |
NO (1) | NO20064888L (no) |
PE (1) | PE20060286A1 (no) |
RU (1) | RU2006138195A (no) |
TW (1) | TW200533398A (no) |
WO (1) | WO2005095383A1 (no) |
ZA (1) | ZA200608037B (no) |
Families Citing this family (38)
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US6374762B1 (en) * | 1997-10-27 | 2002-04-23 | Correct Craft, Inc. | Water sport towing apparatus |
AU2003237255B8 (en) * | 2002-06-05 | 2010-01-07 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
US7595312B2 (en) | 2002-10-25 | 2009-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions |
AR046787A1 (es) | 2003-12-05 | 2005-12-21 | Bristol Myers Squibb Co | Agentes antimigrana heterociclicos |
DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
DE102004018794A1 (de) * | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7696195B2 (en) | 2004-04-22 | 2010-04-13 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
DE102004019492A1 (de) * | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
EP2374455A3 (en) * | 2004-08-19 | 2012-03-28 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
US7786141B2 (en) * | 2004-08-19 | 2010-08-31 | Vertex Pharmaceuticals Incorporated | Dihydrospiroindene modulators of muscarinic receptors |
US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7384931B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
RU2007124373A (ru) * | 2004-11-29 | 2009-01-10 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецептеров |
US7449586B2 (en) * | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
CN101146799A (zh) | 2005-03-23 | 2008-03-19 | 贝林格尔·英格海姆国际有限公司 | Cgrp拮抗剂、其制备方法以及其作为药物的用途 |
EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
DE102005050892A1 (de) * | 2005-10-21 | 2007-04-26 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
RU2008130094A (ru) * | 2005-12-22 | 2010-01-27 | Вертекс Фармасьютикалз Инкорпорейтед (Us) | Модуляторы мускариновых рецепторов |
WO2007100670A1 (en) * | 2006-02-22 | 2007-09-07 | Vertex Pharmaceuticals Incorporated | Spiro condensed piperidnes as modulators of muscarinic receptors |
CN101426499A (zh) * | 2006-02-22 | 2009-05-06 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
EP2040706A2 (en) * | 2006-06-29 | 2009-04-01 | Vertex Pharmceuticals Incorporated | Modulators of muscarinic receptors |
JP2010500412A (ja) * | 2006-08-15 | 2010-01-07 | バーテックス ファーマシューティカルズ インコーポレイテッド | ムスカリン受容体の調節剤 |
CN101573121A (zh) | 2006-08-18 | 2009-11-04 | 弗特克斯药品有限公司 | 毒蕈碱受体调节剂 |
JP2010508358A (ja) * | 2006-11-01 | 2010-03-18 | ブリストル−マイヤーズ スクイブ カンパニー | グルココルチコイド受容体、AP−1、および/またはNF−κB活性の調節剤、並びにその使用 |
WO2009045519A1 (en) * | 2007-10-03 | 2009-04-09 | Vertex Pharmaceuticals Incorporated | Modulators of muscarinic receptors |
FR3008978A1 (fr) * | 2013-07-23 | 2015-01-30 | Servier Lab | "nouveaux derives d'indole et de pyrrole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent" |
JO3669B1 (ar) | 2015-01-06 | 2020-08-27 | Ferring Bv | بيبتيدات مضَادَّة لببتيد المرتبط بجين الكالسيتونين |
JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
GB201519194D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
EP3366286A1 (en) | 2017-02-22 | 2018-08-29 | Johannes Keller | Compounds for treating sepsis |
JP7339262B2 (ja) | 2018-01-12 | 2023-09-05 | アムジェン インコーポレイテッド | Pac1抗体及びその使用 |
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JP2002511836A (ja) | 1996-09-09 | 2002-04-16 | スミスクライン・ビーチャム・コーポレイション | 化合物および方法 |
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DE10250080A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
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ATE509019T1 (de) | 2003-03-14 | 2011-05-15 | Merck Sharp & Dohme | Benzodiazepinspirohydantoine als cgrp- rezeptorantagonisten |
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CA2518830A1 (en) | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Carboxamide spirohydantoin cgrp receptor antagonists |
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US20050032783A1 (en) * | 2003-07-07 | 2005-02-10 | Boehringer Ingelheim International Gmbh | Use of CGRP antagonists in treatment and prevention of hot flushes in prostate cancer patients |
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US20050065094A1 (en) * | 2003-09-05 | 2005-03-24 | Boehringer Ingelheim International Gmbh | Use of telmisartan for the prevention and treatment of vascular headache |
BR0318637A (pt) | 2003-12-05 | 2007-02-13 | Bristol Myers Squibb Co | antagonistas de receptores de peptìdios relacionados com o gene de calcitonina |
AR046787A1 (es) | 2003-12-05 | 2005-12-21 | Bristol Myers Squibb Co | Agentes antimigrana heterociclicos |
WO2005072308A2 (en) | 2004-01-29 | 2005-08-11 | Merck & Co., Inc. | Cgrp receptor antagonists |
WO2005084672A1 (de) | 2004-03-03 | 2005-09-15 | Boehringer Ingelheim International Gmbh | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
DE102004015723A1 (de) * | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7279471B2 (en) * | 2004-04-15 | 2007-10-09 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
DE102004018794A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE102004018796A1 (de) | 2004-04-15 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
DE102004018795A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
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DE102004019492A1 (de) | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
US7696195B2 (en) * | 2004-04-22 | 2010-04-13 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
DE102004027912A1 (de) | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
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US7384930B2 (en) * | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
US7449586B2 (en) | 2004-12-03 | 2008-11-11 | Bristol-Myers Squibb Company | Processes for the preparation of CGRP-receptor antagonists and intermediates thereof |
US8662081B2 (en) | 2005-02-15 | 2014-03-04 | Yale University | Intrauterine device |
-
2005
- 2005-03-23 TW TW094109010A patent/TW200533398A/zh unknown
- 2005-03-28 JP JP2007506432A patent/JP2007530701A/ja active Pending
- 2005-03-28 PE PE2005000346A patent/PE20060286A1/es not_active Application Discontinuation
- 2005-03-28 US US11/091,429 patent/US7772244B2/en active Active
- 2005-03-28 CN CNA2005800169860A patent/CN1972929A/zh active Pending
- 2005-03-28 EP EP05731205A patent/EP1730137A1/en not_active Withdrawn
- 2005-03-28 AU AU2005228881A patent/AU2005228881A1/en not_active Abandoned
- 2005-03-28 WO PCT/US2005/010330 patent/WO2005095383A1/en active Application Filing
- 2005-03-28 RU RU2006138195/04A patent/RU2006138195A/ru unknown
- 2005-03-28 BR BRPI0509341-4A patent/BRPI0509341A/pt not_active Application Discontinuation
- 2005-03-28 CA CA002562039A patent/CA2562039A1/en not_active Abandoned
- 2005-03-28 AR ARP050101201A patent/AR048343A1/es not_active Withdrawn
- 2005-03-28 KR KR1020067022467A patent/KR20070007857A/ko not_active Application Discontinuation
-
2006
- 2006-09-25 IL IL178291A patent/IL178291A0/en unknown
- 2006-09-27 ZA ZA200608037A patent/ZA200608037B/xx unknown
- 2006-10-26 NO NO20064888A patent/NO20064888L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
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AU2005228881A1 (en) | 2005-10-13 |
AR048343A1 (es) | 2006-04-19 |
RU2006138195A (ru) | 2008-05-10 |
JP2007530701A (ja) | 2007-11-01 |
PE20060286A1 (es) | 2006-04-25 |
CA2562039A1 (en) | 2005-10-13 |
EP1730137A1 (en) | 2006-12-13 |
CN1972929A (zh) | 2007-05-30 |
BRPI0509341A (pt) | 2007-09-04 |
IL178291A0 (en) | 2006-12-31 |
US7772244B2 (en) | 2010-08-10 |
KR20070007857A (ko) | 2007-01-16 |
WO2005095383A1 (en) | 2005-10-13 |
US20050215576A1 (en) | 2005-09-29 |
ZA200608037B (en) | 2008-06-25 |
TW200533398A (en) | 2005-10-16 |
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