NO20084564L - Stramme "Constrained" forbindelser som CGRP-reseptor antagonister - Google Patents

Stramme "Constrained" forbindelser som CGRP-reseptor antagonister

Info

Publication number
NO20084564L
NO20084564L NO20084564A NO20084564A NO20084564L NO 20084564 L NO20084564 L NO 20084564L NO 20084564 A NO20084564 A NO 20084564A NO 20084564 A NO20084564 A NO 20084564A NO 20084564 L NO20084564 L NO 20084564L
Authority
NO
Norway
Prior art keywords
receptor antagonists
cgrp receptor
constrained
tight
compounds
Prior art date
Application number
NO20084564A
Other languages
English (en)
Inventor
Prasad V Chaturvelda
Steven E Mercer
Haiquan Fang
Xiaojun Han
Guanglin Luo
Gene M Dubowchik
Graham S Poindexter
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of NO20084564L publication Critical patent/NO20084564L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Oppfinnelsen omfatter sterisk hindrede bicykliske og tricykliske CGRP-reseptorantagonister, metoder for å identifisere dem, farmasøytiske preparater omfattende dem og metoder for anvendelse av dem i terapi for behandling av migrene og andre hodepiner, nevrogen vasodilatasjon, nevrogen inflammasjon, termisk skade, kretsløpssjokk, rødming forbundet med menopause, luftveisinflammatoriske sykdommer, så som astma og kronisk obstruktiv lungesykdom (KOLS) og andre lidelser der behandlingen kan utføres ved antagonismen av CGRP-reseptorer. I II
NO20084564A 2006-05-03 2008-10-30 Stramme "Constrained" forbindelser som CGRP-reseptor antagonister NO20084564L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79740006P 2006-05-03 2006-05-03
US11/742,626 US7470680B2 (en) 2006-05-03 2007-05-01 Constrained compounds as CGRP-receptor antagonists
PCT/US2007/067998 WO2007131020A2 (en) 2006-05-03 2007-05-02 Constrained compounds as cgrp-receptor antagonists

Publications (1)

Publication Number Publication Date
NO20084564L true NO20084564L (no) 2008-12-02

Family

ID=38544174

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20084564A NO20084564L (no) 2006-05-03 2008-10-30 Stramme "Constrained" forbindelser som CGRP-reseptor antagonister

Country Status (14)

Country Link
US (1) US7470680B2 (no)
EP (1) EP2013214B1 (no)
JP (1) JP2009535429A (no)
KR (1) KR20090018930A (no)
AR (1) AR060845A1 (no)
AU (1) AU2007248038A1 (no)
BR (1) BRPI0709759A2 (no)
CA (1) CA2651033A1 (no)
IL (1) IL195027A0 (no)
MX (1) MX2008013760A (no)
NO (1) NO20084564L (no)
PE (1) PE20080232A1 (no)
TW (1) TW200813063A (no)
WO (1) WO2007131020A2 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7384931B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
AU2007342532A1 (en) * 2006-12-20 2008-07-17 Merck Sharp & Dohme Corp. Benzazepine compounds as CGRP receptor antagonists
US8796260B2 (en) * 2008-02-19 2014-08-05 Merck Sharp & Dohme Corp. Imidazobenzazepine CGRP receptor antagonists
WO2011159857A1 (en) 2010-06-16 2011-12-22 Bristol-Myers Squibb Company Carboline carboxamide compounds useful as kinase inhibitors
US10919914B2 (en) 2016-06-08 2021-02-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7288559B2 (en) 2003-03-14 2007-10-30 Merck + Co, Inc. Carboxamide spirohydantoin CGRP receptor antagonists
WO2004087649A2 (en) 2003-03-14 2004-10-14 Merck & Co., Inc. Benodiazepine spirohydantoin cgrp receptor antagonists
DE602004027021D1 (de) 2003-04-15 2010-06-17 Merck Sharp & Dohme Cgrp-rezeptorantagonisten
JO2355B1 (en) * 2003-04-15 2006-12-12 ميرك شارب اند دوم كوربوريشن Hereditary calcitonin polypeptide receptor antagonists
AU2004263080B2 (en) 2003-06-26 2008-12-18 Merck Sharp & Dohme Corp. Benzodiazepine CGRP receptor antagonists
CN1812982B (zh) 2003-06-26 2010-10-27 默沙东公司 苯并二氮杂*cgrp受体拮抗剂
US7491713B2 (en) 2004-01-29 2009-02-17 Merck + Co., Inc. CGRP receptor antagonists
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
CN101072771B (zh) 2004-10-07 2010-09-29 默沙东公司 Cgrp受体拮抗剂
CA2583536A1 (en) 2004-10-13 2006-04-27 Merck & Co., Inc. Cgrp receptor antagonists
CN101039718A (zh) 2004-10-14 2007-09-19 默克公司 Cgrp受体拮抗剂
US7745427B2 (en) 2004-10-22 2010-06-29 Merck Sharp & Dohme Corp. CGRP receptor antagonists
US7384931B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384930B2 (en) * 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7632832B2 (en) 2005-01-18 2009-12-15 Merck & Co., Inc. CGRP receptor antagonists
JP2008533147A (ja) 2005-03-14 2008-08-21 メルク エンド カムパニー インコーポレーテッド Ｃｇｒｐ受容体拮抗薬
CA2615463A1 (en) 2005-07-29 2007-02-08 Merck & Co., Inc. Heterocyclic benzodiazepine cgrp receptor antagonists
AU2007342532A1 (en) 2006-12-20 2008-07-17 Merck Sharp & Dohme Corp. Benzazepine compounds as CGRP receptor antagonists

Also Published As

Publication number Publication date
IL195027A0 (en) 2009-08-03
PE20080232A1 (es) 2008-04-11
BRPI0709759A2 (pt) 2011-10-25
TW200813063A (en) 2008-03-16
AR060845A1 (es) 2008-07-16
WO2007131020A2 (en) 2007-11-15
CA2651033A1 (en) 2007-11-15
US7470680B2 (en) 2008-12-30
JP2009535429A (ja) 2009-10-01
MX2008013760A (es) 2008-11-14
WO2007131020A3 (en) 2008-01-17
EP2013214B1 (en) 2015-06-24
AU2007248038A1 (en) 2007-11-15
EP2013214A2 (en) 2009-01-14
US20070259851A1 (en) 2007-11-08
KR20090018930A (ko) 2009-02-24

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